Incidental Mutation 'IGL01925:Gm10717'
ID 279133
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm10717
Ensembl Gene ENSMUSG00000095891
Gene Name predicted gene 10717
Synonyms
Accession Numbers
Essential gene? Probably essential (E-score: 0.810) question?
Stock # IGL01925
Quality Score
Status
Chromosome 9
Chromosomal Location 3025417-3033289 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 3025616 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Leucine at position 67 (S67L)
Ref Sequence ENSEMBL: ENSMUSP00000096644 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075573] [ENSMUST00000099042] [ENSMUST00000099046] [ENSMUST00000099047] [ENSMUST00000099051] [ENSMUST00000177601] [ENSMUST00000177875] [ENSMUST00000179264] [ENSMUST00000179272] [ENSMUST00000179982]
AlphaFold D3Z1I8
Predicted Effect probably benign
Transcript: ENSMUST00000075573
AA Change: S67L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000096644
Gene: ENSMUSG00000095891
AA Change: S67L

DomainStartEndE-ValueType
internal_repeat_1 1 41 1.06e-10 PROSPERO
transmembrane domain 68 90 N/A INTRINSIC
internal_repeat_1 118 177 1.06e-10 PROSPERO
transmembrane domain 200 222 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099042
SMART Domains Protein: ENSMUSP00000096640
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 1 47 9.09e-8 PROSPERO
transmembrane domain 76 98 N/A INTRINSIC
internal_repeat_1 117 164 9.09e-8 PROSPERO
transmembrane domain 195 217 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099046
SMART Domains Protein: ENSMUSP00000096645
Gene: ENSMUSG00000095186

DomainStartEndE-ValueType
internal_repeat_1 1 41 4.44e-7 PROSPERO
transmembrane domain 67 89 N/A INTRINSIC
internal_repeat_1 117 177 4.44e-7 PROSPERO
transmembrane domain 197 219 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099047
SMART Domains Protein: ENSMUSP00000096646
Gene: ENSMUSG00000095547

DomainStartEndE-ValueType
internal_repeat_1 1 40 1.58e-10 PROSPERO
transmembrane domain 53 72 N/A INTRINSIC
transmembrane domain 77 99 N/A INTRINSIC
internal_repeat_1 117 176 1.58e-10 PROSPERO
transmembrane domain 199 221 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000099051
SMART Domains Protein: ENSMUSP00000096650
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 2 38 6.22e-5 PROSPERO
transmembrane domain 58 80 N/A INTRINSIC
transmembrane domain 90 109 N/A INTRINSIC
internal_repeat_1 118 174 6.22e-5 PROSPERO
transmembrane domain 185 207 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000177601
SMART Domains Protein: ENSMUSP00000136755
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_2 1 24 2.26e-6 PROSPERO
internal_repeat_1 2 37 2.26e-6 PROSPERO
internal_repeat_1 40 95 2.26e-6 PROSPERO
internal_repeat_2 118 142 2.26e-6 PROSPERO
low complexity region 147 159 N/A INTRINSIC
low complexity region 169 183 N/A INTRINSIC
transmembrane domain 186 208 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181572
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181957
Predicted Effect probably benign
Transcript: ENSMUST00000177875
SMART Domains Protein: ENSMUSP00000137419
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 1 49 1.49e-11 PROSPERO
transmembrane domain 68 90 N/A INTRINSIC
internal_repeat_1 118 186 1.49e-11 PROSPERO
transmembrane domain 197 219 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179264
SMART Domains Protein: ENSMUSP00000137451
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 1 43 5.09e-6 PROSPERO
transmembrane domain 69 91 N/A INTRINSIC
internal_repeat_1 117 179 5.09e-6 PROSPERO
transmembrane domain 196 218 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179272
SMART Domains Protein: ENSMUSP00000136170
Gene: ENSMUSG00000095547

DomainStartEndE-ValueType
internal_repeat_1 1 49 2.1e-10 PROSPERO
transmembrane domain 74 96 N/A INTRINSIC
internal_repeat_1 118 186 2.1e-10 PROSPERO
transmembrane domain 198 217 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179982
SMART Domains Protein: ENSMUSP00000136365
Gene: ENSMUSG00000095891

DomainStartEndE-ValueType
internal_repeat_1 1 35 7.76e-13 PROSPERO
transmembrane domain 67 89 N/A INTRINSIC
internal_repeat_1 117 152 7.76e-13 PROSPERO
low complexity region 157 169 N/A INTRINSIC
transmembrane domain 198 220 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aloxe3 A G 11: 69,019,459 (GRCm39) D124G probably damaging Het
Arap3 C T 18: 38,117,299 (GRCm39) V926I probably benign Het
Catspere2 T A 1: 177,842,687 (GRCm39) probably benign Het
Col6a3 C T 1: 90,729,958 (GRCm39) V1176M possibly damaging Het
D5Ertd579e A T 5: 36,771,628 (GRCm39) D922E possibly damaging Het
Dipk2a A C 9: 94,402,509 (GRCm39) D384E probably damaging Het
Epm2a T A 10: 11,324,502 (GRCm39) I197N possibly damaging Het
Faim T G 9: 98,872,972 (GRCm39) probably benign Het
Fkbp15 A G 4: 62,241,450 (GRCm39) I565T probably damaging Het
Fli1 G A 9: 32,377,127 (GRCm39) P47L probably damaging Het
Gli2 T C 1: 118,781,106 (GRCm39) K187R probably damaging Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Hspa5 G A 2: 34,664,730 (GRCm39) V395I probably benign Het
Ide T C 19: 37,255,296 (GRCm39) T836A unknown Het
Il9 T A 13: 56,629,684 (GRCm39) probably benign Het
Ints8 C T 4: 11,235,617 (GRCm39) probably benign Het
Lrrc37a T A 11: 103,389,245 (GRCm39) H2060L probably benign Het
Mok T C 12: 110,774,646 (GRCm39) N208S probably benign Het
Morn3 T C 5: 123,184,825 (GRCm39) K5R probably damaging Het
Nalcn C T 14: 123,529,260 (GRCm39) C1405Y possibly damaging Het
Ndufv3 T C 17: 31,746,460 (GRCm39) S117P possibly damaging Het
Ninl A T 2: 150,812,979 (GRCm39) C226S probably damaging Het
Onecut2 T C 18: 64,474,585 (GRCm39) W360R probably damaging Het
Or10al4 A G 17: 38,037,002 (GRCm39) E29G probably benign Het
Or13f5 A G 4: 52,825,910 (GRCm39) N171S probably benign Het
Or1af1 A G 2: 37,110,058 (GRCm39) T186A probably benign Het
Or2d3b T A 7: 106,514,235 (GRCm39) F277I probably damaging Het
Or2w2 T C 13: 21,758,341 (GRCm39) D95G possibly damaging Het
Or51e1 T C 7: 102,359,410 (GRCm39) S315P probably damaging Het
Rai14 A G 15: 10,595,948 (GRCm39) S118P possibly damaging Het
Serpinb7 T C 1: 107,379,399 (GRCm39) S269P probably benign Het
Sesn3 C T 9: 14,231,696 (GRCm39) T209I probably damaging Het
Slit1 T A 19: 41,596,817 (GRCm39) N1094I probably damaging Het
Tep1 C T 14: 51,061,955 (GRCm39) probably benign Het
Top1mt A G 15: 75,528,992 (GRCm39) F584S possibly damaging Het
Trim44 A T 2: 102,230,362 (GRCm39) L223Q probably benign Het
Trim69 T A 2: 121,998,397 (GRCm39) L123Q probably damaging Het
Ubr2 A T 17: 47,265,875 (GRCm39) L1153I possibly damaging Het
Unc13a G A 8: 72,087,187 (GRCm39) T1520I possibly damaging Het
Vmn2r105 A C 17: 20,428,973 (GRCm39) I701S possibly damaging Het
Wrn T C 8: 33,809,208 (GRCm39) T263A probably benign Het
Yeats2 T G 16: 19,998,430 (GRCm39) probably benign Het
Ythdf2 T C 4: 131,938,085 (GRCm39) Y37C probably damaging Het
Zfp169 T C 13: 48,644,239 (GRCm39) probably benign Het
Other mutations in Gm10717
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01635:Gm10717 APN 9 3,025,506 (GRCm39) missense possibly damaging 0.46
IGL01635:Gm10717 APN 9 3,025,511 (GRCm39) missense probably damaging 1.00
IGL01864:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01865:Gm10717 APN 9 3,026,287 (GRCm39) missense probably damaging 0.98
IGL01865:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01866:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01873:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01875:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01877:Gm10717 APN 9 3,026,287 (GRCm39) missense probably damaging 0.98
IGL01877:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01878:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01879:Gm10717 APN 9 3,026,287 (GRCm39) missense probably damaging 0.98
IGL01880:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01882:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01886:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01887:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01892:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01893:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01897:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01901:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01903:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01904:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01907:Gm10717 APN 9 3,026,287 (GRCm39) missense probably damaging 0.98
IGL01907:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01908:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01913:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01919:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01920:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01923:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01927:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01930:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01931:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01932:Gm10717 APN 9 3,026,287 (GRCm39) missense probably damaging 0.98
IGL01935:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01941:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01948:Gm10717 APN 9 3,025,819 (GRCm39) missense probably damaging 1.00
IGL01949:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01951:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL01952:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL02106:Gm10717 APN 9 3,026,287 (GRCm39) missense probably damaging 0.98
IGL02142:Gm10717 APN 9 3,025,616 (GRCm39) missense probably benign 0.00
IGL02592:Gm10717 APN 9 3,026,287 (GRCm39) missense probably damaging 0.98
IGL02609:Gm10717 APN 9 3,026,287 (GRCm39) missense probably damaging 0.98
IGL02802:Gm10717 UTSW 9 3,031,999 (GRCm39) missense probably benign
R0277:Gm10717 UTSW 9 3,025,619 (GRCm39) missense possibly damaging 0.79
R1813:Gm10717 UTSW 9 3,026,317 (GRCm39) missense probably damaging 1.00
R1911:Gm10717 UTSW 9 3,026,317 (GRCm39) missense probably damaging 1.00
R2399:Gm10717 UTSW 9 3,025,532 (GRCm39) missense probably benign
R2874:Gm10717 UTSW 9 3,025,532 (GRCm39) missense probably benign
R3617:Gm10717 UTSW 9 3,025,532 (GRCm39) missense probably benign
R3720:Gm10717 UTSW 9 3,025,532 (GRCm39) missense probably benign
R4988:Gm10717 UTSW 9 3,026,368 (GRCm39) missense probably benign 0.00
R5002:Gm10717 UTSW 9 3,025,532 (GRCm39) missense probably benign
R5117:Gm10717 UTSW 9 3,025,625 (GRCm39) missense probably benign 0.00
R5367:Gm10717 UTSW 9 3,026,317 (GRCm39) missense probably damaging 1.00
R5539:Gm10717 UTSW 9 3,030,438 (GRCm39) missense probably damaging 1.00
R5623:Gm10717 UTSW 9 3,026,318 (GRCm39) missense probably benign
Posted On 2015-04-16