Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01937:Gstm3'

279162

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gstm3

Ensembl Gene

ENSMUSG00000004038

Gene Name

glutathione S-transferase, mu 3

Synonyms

mGSTM5, Fsc2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

IGL01937

Quality Score

Status

Chromosome

Chromosomal Location

107871019-107876484 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 107874973 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 93 (E93G)

Ref Sequence

ENSEMBL: ENSMUSP00000004136 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000004136]

AlphaFold

P19639

Predicted Effect

probably damaging
Transcript: ENSMUST00000004136
AA Change: E93G

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000004136
Gene: ENSMUSG00000004038
AA Change: E93G

Domain	Start	End	E-Value	Type
Pfam:GST_N	3	82	6.6e-22	PFAM
Pfam:GST_C_3	41	190	7.7e-11	PFAM
Pfam:GST_C	104	191	1.6e-17	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8a	A	C	11: 109,974,130 (GRCm39)		probably benign	Het
Abcb11	G	T	2: 69,117,956 (GRCm39)	P474H	probably damaging	Het
Actn1	T	C	12: 80,218,537 (GRCm39)	N749S	probably benign	Het
Atf7ip2	T	A	16: 10,059,401 (GRCm39)		probably null	Het
Brinp3	A	T	1: 146,776,878 (GRCm39)	T442S	probably benign	Het
Cdh20	A	G	1: 110,065,826 (GRCm39)	N700S	probably benign	Het
Cntn4	T	A	6: 106,414,865 (GRCm39)	V132E	probably damaging	Het
Dlc1	G	T	8: 37,317,345 (GRCm39)	S443R	probably benign	Het
Evi2b	T	A	11: 79,406,893 (GRCm39)	K227N	probably damaging	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Hemgn	T	C	4: 46,396,057 (GRCm39)	Y393C	probably damaging	Het
Hepacam2	T	A	6: 3,487,117 (GRCm39)	Y4F	probably benign	Het
Hipk1	T	C	3: 103,651,320 (GRCm39)	I1148V	possibly damaging	Het
Katnip	A	G	7: 125,453,777 (GRCm39)	T1165A	probably benign	Het
Kl	A	T	5: 150,912,402 (GRCm39)	D717V	probably damaging	Het
Mmp14	T	C	14: 54,675,053 (GRCm39)		probably benign	Het
Nlrp1b	T	G	11: 71,072,233 (GRCm39)	T537P	probably damaging	Het
Or5k3	T	C	16: 58,969,827 (GRCm39)	S205P	probably benign	Het
Or8k33	A	G	2: 86,383,793 (GRCm39)	V225A	probably benign	Het
Pcnx3	A	G	19: 5,727,691 (GRCm39)	V1031A	probably benign	Het
Plk2	A	G	13: 110,535,588 (GRCm39)	D470G	possibly damaging	Het
Ppa1	G	A	10: 61,501,215 (GRCm39)	V161M	probably benign	Het
Prrc2a	A	C	17: 35,374,567 (GRCm39)	I1361S	possibly damaging	Het
Psmd6	A	T	14: 14,116,169 (GRCm38)	S140T	probably benign	Het
Ptprm	A	G	17: 67,353,158 (GRCm39)		probably benign	Het
Ranbp17	T	C	11: 33,278,520 (GRCm39)	T116A	possibly damaging	Het
Reps1	A	G	10: 17,969,584 (GRCm39)	N229S	probably benign	Het
Rfx3	A	T	19: 27,808,129 (GRCm39)	Y205N	probably damaging	Het
Robo1	A	T	16: 72,759,114 (GRCm39)	I376F	probably damaging	Het
Ryr2	T	A	13: 11,805,249 (GRCm39)	I872F	probably damaging	Het
Selenop	C	T	15: 3,308,750 (GRCm39)	T234M	probably benign	Het
Sgip1	T	C	4: 102,823,439 (GRCm39)	Y707H	probably damaging	Het
Strap	A	G	6: 137,718,333 (GRCm39)	I146V	probably benign	Het
Tcim	A	T	8: 24,928,892 (GRCm39)	H7Q	probably benign	Het
Thada	G	T	17: 84,530,194 (GRCm39)	T1725N	probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Vmn2r84	A	G	10: 130,221,755 (GRCm39)	C822R	probably damaging	Het

Other mutations in Gstm3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01585:Gstm3	APN	3	107,873,474 (GRCm39)	missense	probably benign	0.42
IGL01637:Gstm3	APN	3	107,874,949 (GRCm39)	missense	probably damaging	1.00
IGL01945:Gstm3	APN	3	107,874,973 (GRCm39)	missense	probably damaging	0.98
IGL02307:Gstm3	APN	3	107,874,929 (GRCm39)	missense	probably damaging	0.98
IGL02820:Gstm3	APN	3	107,876,074 (GRCm39)	splice site	probably benign
IGL03038:Gstm3	APN	3	107,873,485 (GRCm39)	missense	possibly damaging	0.75
IGL03108:Gstm3	APN	3	107,875,080 (GRCm39)	critical splice donor site	probably null
IGL03271:Gstm3	APN	3	107,873,513 (GRCm39)	missense	possibly damaging	0.47
IGL03097:Gstm3	UTSW	3	107,876,117 (GRCm39)	missense	probably benign
R0009:Gstm3	UTSW	3	107,875,156 (GRCm39)	missense	probably damaging	1.00
R0883:Gstm3	UTSW	3	107,873,586 (GRCm39)	splice site	probably benign
R1623:Gstm3	UTSW	3	107,875,151 (GRCm39)	missense	possibly damaging	0.80
R2108:Gstm3	UTSW	3	107,873,450 (GRCm39)	missense	probably damaging	0.99
R3005:Gstm3	UTSW	3	107,874,923 (GRCm39)	missense	probably benign	0.03
R3802:Gstm3	UTSW	3	107,871,551 (GRCm39)	missense	probably benign	0.03
R3803:Gstm3	UTSW	3	107,871,551 (GRCm39)	missense	probably benign	0.03
R3804:Gstm3	UTSW	3	107,871,551 (GRCm39)	missense	probably benign	0.03
R4604:Gstm3	UTSW	3	107,875,513 (GRCm39)	missense	possibly damaging	0.73
R4837:Gstm3	UTSW	3	107,871,531 (GRCm39)	missense	probably benign
R6593:Gstm3	UTSW	3	107,875,511 (GRCm39)	missense	probably benign	0.01
R6963:Gstm3	UTSW	3	107,874,940 (GRCm39)	missense	probably benign	0.01
R7790:Gstm3	UTSW	3	107,876,555 (GRCm39)	start gained	probably benign
R9245:Gstm3	UTSW	3	107,874,956 (GRCm39)	missense	probably benign	0.01
R9465:Gstm3	UTSW	3	107,873,431 (GRCm39)	missense	possibly damaging	0.78
R9753:Gstm3	UTSW	3	107,875,493 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16