Incidental Mutation 'IGL01937:Olfr195'
ID279164
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr195
Ensembl Gene ENSMUSG00000062608
Gene Nameolfactory receptor 195
SynonymsMOR184-5, GA_x54KRFPKG5P-55369823-55370749
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.122) question?
Stock #IGL01937
Quality Score
Status
Chromosome16
Chromosomal Location59147046-59150777 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 59149464 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 205 (S205P)
Ref Sequence ENSEMBL: ENSMUSP00000150249 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075381] [ENSMUST00000216957]
Predicted Effect probably benign
Transcript: ENSMUST00000075381
AA Change: S205P

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000073737
Gene: ENSMUSG00000062608
AA Change: S205P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.1e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 161 2.7e-8 PFAM
Pfam:7tm_1 41 307 9.4e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208239
Predicted Effect probably benign
Transcript: ENSMUST00000216957
AA Change: S205P

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a A C 11: 110,083,304 probably benign Het
Abcb11 G T 2: 69,287,612 P474H probably damaging Het
Actn1 T C 12: 80,171,763 N749S probably benign Het
Atf7ip2 T A 16: 10,241,537 probably null Het
Brinp3 A T 1: 146,901,140 T442S probably benign Het
Cdh7 A G 1: 110,138,096 N700S probably benign Het
Cntn4 T A 6: 106,437,904 V132E probably damaging Het
D430042O09Rik A G 7: 125,854,605 T1165A probably benign Het
Dlc1 G T 8: 36,850,191 S443R probably benign Het
Evi2b T A 11: 79,516,067 K227N probably damaging Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gstm3 T C 3: 107,967,657 E93G probably damaging Het
Hemgn T C 4: 46,396,057 Y393C probably damaging Het
Hepacam2 T A 6: 3,487,117 Y4F probably benign Het
Hipk1 T C 3: 103,744,004 I1148V possibly damaging Het
Kl A T 5: 150,988,937 D717V probably damaging Het
Mmp14 T C 14: 54,437,596 probably benign Het
Nlrp1b T G 11: 71,181,407 T537P probably damaging Het
Olfr1080 A G 2: 86,553,449 V225A probably benign Het
Pcnx3 A G 19: 5,677,663 V1031A probably benign Het
Plk2 A G 13: 110,399,054 D470G possibly damaging Het
Ppa1 G A 10: 61,665,436 V161M probably benign Het
Prrc2a A C 17: 35,155,591 I1361S possibly damaging Het
Psmd6 A T 14: 14,116,169 S140T probably benign Het
Ptprm A G 17: 67,046,163 probably benign Het
Ranbp17 T C 11: 33,328,520 T116A possibly damaging Het
Reps1 A G 10: 18,093,836 N229S probably benign Het
Rfx3 A T 19: 27,830,729 Y205N probably damaging Het
Robo1 A T 16: 72,962,226 I376F probably damaging Het
Ryr2 T A 13: 11,790,363 I872F probably damaging Het
Selenop C T 15: 3,279,268 T234M probably benign Het
Sgip1 T C 4: 102,966,242 Y707H probably damaging Het
Strap A G 6: 137,741,335 I146V probably benign Het
Tcim A T 8: 24,438,876 H7Q probably benign Het
Thada G T 17: 84,222,766 T1725N probably benign Het
Vmn2r84 A G 10: 130,385,886 C822R probably damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Other mutations in Olfr195
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01945:Olfr195 APN 16 59149464 missense probably benign 0.01
R0071:Olfr195 UTSW 16 59149215 missense probably benign 0.23
R0390:Olfr195 UTSW 16 59149299 missense probably benign 0.01
R0601:Olfr195 UTSW 16 59149754 missense probably benign 0.00
R1499:Olfr195 UTSW 16 59148924 missense probably benign
R1612:Olfr195 UTSW 16 59149624 missense probably benign 0.00
R1785:Olfr195 UTSW 16 59149297 missense probably damaging 1.00
R2082:Olfr195 UTSW 16 59148885 missense probably damaging 0.99
R3605:Olfr195 UTSW 16 59149483 missense probably damaging 1.00
R4168:Olfr195 UTSW 16 59149000 missense probably benign 0.00
R4839:Olfr195 UTSW 16 59149030 missense probably damaging 1.00
R4989:Olfr195 UTSW 16 59149618 missense probably damaging 1.00
R5285:Olfr195 UTSW 16 59149270 missense probably damaging 1.00
R7107:Olfr195 UTSW 16 59148916 missense probably benign 0.10
R7136:Olfr195 UTSW 16 59148964 missense probably damaging 1.00
R7317:Olfr195 UTSW 16 59149321 missense possibly damaging 0.80
Posted On2015-04-16