Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01975:Zswim5'

279260

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zswim5

Ensembl Gene

ENSMUSG00000033948

Gene Name

zinc finger SWIM-type containing 5

Synonyms

4933426E21Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01975

Quality Score

Status

Chromosome

Chromosomal Location

116734573-116846461 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 116822889 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 453 (I453T)

Ref Sequence

ENSEMBL: ENSMUSP00000049474 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044823]

AlphaFold

Q80TC6

Predicted Effect

probably benign
Transcript: ENSMUST00000044823
AA Change: I453T

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000049474
Gene: ENSMUSG00000033948
AA Change: I453T

Domain	Start	End	E-Value	Type
low complexity region	35	56	N/A	INTRINSIC
low complexity region	119	182	N/A	INTRINSIC
low complexity region	692	708	N/A	INTRINSIC
low complexity region	982	995	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam22	C	T	5: 8,217,396 (GRCm39)	C133Y	probably damaging	Het
Akap3	G	T	6: 126,850,963 (GRCm39)	S827I	probably damaging	Het
Arhgap20	C	T	9: 51,761,097 (GRCm39)	Q947*	probably null	Het
Csf2rb2	A	G	15: 78,173,086 (GRCm39)	I258T	probably benign	Het
Egln2	T	C	7: 26,859,745 (GRCm39)	I323V	possibly damaging	Het
Erlin1	C	A	19: 44,025,370 (GRCm39)	G348V	probably damaging	Het
Fbxo38	C	T	18: 62,648,484 (GRCm39)	A685T	probably damaging	Het
Gm10272	G	A	10: 77,542,608 (GRCm39)	C50Y	probably damaging	Het
Gm11559	G	T	11: 99,755,682 (GRCm39)	Q110H	unknown	Het
Gpr75	T	C	11: 30,841,835 (GRCm39)	S247P	probably benign	Het
Grid1	A	T	14: 35,045,383 (GRCm39)	M409L	probably benign	Het
Herc3	A	C	6: 58,893,561 (GRCm39)	D941A	possibly damaging	Het
Ilf3	T	A	9: 21,303,675 (GRCm39)	S166T	probably benign	Het
Kcnu1	A	C	8: 26,424,525 (GRCm39)	E273D	probably benign	Het
Kdm8	A	G	7: 125,051,529 (GRCm39)	S41G	probably benign	Het
Ldlr	G	A	9: 21,644,993 (GRCm39)	V174I	probably benign	Het
Lpar5	T	C	6: 125,058,750 (GRCm39)	L157P	probably damaging	Het
Mcrs1	A	G	15: 99,141,559 (GRCm39)		probably null	Het
Ndst3	T	A	3: 123,395,163 (GRCm39)	Y489F	possibly damaging	Het
Or6c69c	A	G	10: 129,911,139 (GRCm39)	I287V	probably damaging	Het
Palmd	A	T	3: 116,717,283 (GRCm39)	S405T	probably benign	Het
Ptger1	T	C	8: 84,396,149 (GRCm39)		probably benign	Het
Rbp3	A	T	14: 33,680,602 (GRCm39)	K1068M	probably damaging	Het
Rimbp2	T	C	5: 128,874,712 (GRCm39)	D293G	probably benign	Het
Rnf20	T	A	4: 49,654,473 (GRCm39)	D843E	probably benign	Het
Rxfp1	A	G	3: 79,567,385 (GRCm39)	S322P	possibly damaging	Het
Slc22a8	T	A	19: 8,582,775 (GRCm39)	I152N	probably damaging	Het
Slc6a21	T	A	7: 44,937,275 (GRCm39)	D268E	probably benign	Het
Sstr1	A	G	12: 58,260,412 (GRCm39)	N345S	probably benign	Het
Stx17	T	C	4: 48,180,670 (GRCm39)	S172P	probably damaging	Het
Syne1	A	G	10: 5,018,908 (GRCm39)		probably benign	Het
Tpte	A	G	8: 22,839,353 (GRCm39)	T467A	probably damaging	Het
Trappc12	A	G	12: 28,742,491 (GRCm39)		probably null	Het
Trav13-2	A	T	14: 53,872,823 (GRCm39)	T100S	possibly damaging	Het
Trip12	A	G	1: 84,792,534 (GRCm39)		probably benign	Het
Wdr36	A	G	18: 32,985,541 (GRCm39)	H486R	probably damaging	Het

Other mutations in Zswim5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00753:Zswim5	APN	4	116,842,933 (GRCm39)	missense	possibly damaging	0.93
IGL01700:Zswim5	APN	4	116,843,658 (GRCm39)	unclassified	probably benign
IGL02334:Zswim5	APN	4	116,843,841 (GRCm39)	missense	probably damaging	1.00
IGL02505:Zswim5	APN	4	116,819,749 (GRCm39)	missense	probably benign	0.43
IGL02712:Zswim5	APN	4	116,842,892 (GRCm39)	missense	probably damaging	0.99
PIT4243001:Zswim5	UTSW	4	116,841,975 (GRCm39)	missense	probably benign	0.10
R0324:Zswim5	UTSW	4	116,844,103 (GRCm39)	missense	probably damaging	1.00
R0611:Zswim5	UTSW	4	116,843,874 (GRCm39)	splice site	probably null
R0730:Zswim5	UTSW	4	116,842,943 (GRCm39)	missense	possibly damaging	0.75
R1663:Zswim5	UTSW	4	116,844,092 (GRCm39)	missense	probably damaging	1.00
R1843:Zswim5	UTSW	4	116,734,896 (GRCm39)	missense	unknown
R2070:Zswim5	UTSW	4	116,837,109 (GRCm39)	missense	probably benign	0.14
R2176:Zswim5	UTSW	4	116,830,238 (GRCm39)	missense	probably damaging	0.99
R3715:Zswim5	UTSW	4	116,819,755 (GRCm39)	missense	probably benign	0.21
R4044:Zswim5	UTSW	4	116,843,899 (GRCm39)	missense	probably damaging	1.00
R4063:Zswim5	UTSW	4	116,735,177 (GRCm39)	missense	unknown
R4118:Zswim5	UTSW	4	116,844,016 (GRCm39)	missense	possibly damaging	0.93
R4612:Zswim5	UTSW	4	116,843,901 (GRCm39)	missense	probably damaging	1.00
R4782:Zswim5	UTSW	4	116,830,169 (GRCm39)	missense	probably benign	0.00
R4799:Zswim5	UTSW	4	116,830,169 (GRCm39)	missense	probably benign	0.00
R4983:Zswim5	UTSW	4	116,842,883 (GRCm39)	missense	possibly damaging	0.60
R5294:Zswim5	UTSW	4	116,836,774 (GRCm39)	missense	possibly damaging	0.93
R5836:Zswim5	UTSW	4	116,842,000 (GRCm39)	missense	probably benign	0.27
R6025:Zswim5	UTSW	4	116,808,106 (GRCm39)	missense	probably damaging	1.00
R6041:Zswim5	UTSW	4	116,819,818 (GRCm39)	missense	probably benign	0.01
R6042:Zswim5	UTSW	4	116,819,818 (GRCm39)	missense	probably benign	0.01
R6043:Zswim5	UTSW	4	116,819,818 (GRCm39)	missense	probably benign	0.01
R6159:Zswim5	UTSW	4	116,836,876 (GRCm39)	missense	probably damaging	1.00
R6198:Zswim5	UTSW	4	116,735,204 (GRCm39)	missense	probably benign	0.13
R6415:Zswim5	UTSW	4	116,838,063 (GRCm39)	missense	possibly damaging	0.89
R6442:Zswim5	UTSW	4	116,808,202 (GRCm39)	missense	probably damaging	1.00
R6547:Zswim5	UTSW	4	116,844,100 (GRCm39)	missense	probably damaging	1.00
R6616:Zswim5	UTSW	4	116,843,938 (GRCm39)	missense	possibly damaging	0.93
R6745:Zswim5	UTSW	4	116,832,401 (GRCm39)	missense	probably damaging	1.00
R7144:Zswim5	UTSW	4	116,833,173 (GRCm39)	critical splice donor site	probably null
R7260:Zswim5	UTSW	4	116,819,843 (GRCm39)	missense	probably damaging	1.00
R7300:Zswim5	UTSW	4	116,833,102 (GRCm39)	missense	probably damaging	1.00
R7310:Zswim5	UTSW	4	116,841,885 (GRCm39)	missense	probably benign	0.01
R7326:Zswim5	UTSW	4	116,838,031 (GRCm39)	missense	possibly damaging	0.75
R7429:Zswim5	UTSW	4	116,833,054 (GRCm39)	missense	possibly damaging	0.87
R7430:Zswim5	UTSW	4	116,833,054 (GRCm39)	missense	possibly damaging	0.87
R7607:Zswim5	UTSW	4	116,843,939 (GRCm39)	missense	possibly damaging	0.93
R7811:Zswim5	UTSW	4	116,734,673 (GRCm39)	missense	unknown
R7993:Zswim5	UTSW	4	116,808,291 (GRCm39)	missense	probably benign	0.10
R8221:Zswim5	UTSW	4	116,735,219 (GRCm39)	missense	probably benign	0.09
R8341:Zswim5	UTSW	4	116,843,989 (GRCm39)	missense	probably damaging	1.00
R8433:Zswim5	UTSW	4	116,844,007 (GRCm39)	missense	possibly damaging	0.90
R8690:Zswim5	UTSW	4	116,842,002 (GRCm39)	missense	probably damaging	1.00
R8766:Zswim5	UTSW	4	116,816,004 (GRCm39)	missense	probably damaging	1.00
R8808:Zswim5	UTSW	4	116,822,887 (GRCm39)	missense	probably benign	0.34
R9175:Zswim5	UTSW	4	116,822,941 (GRCm39)	missense	probably benign	0.38
R9354:Zswim5	UTSW	4	116,844,232 (GRCm39)	missense	probably damaging	1.00
R9639:Zswim5	UTSW	4	116,836,714 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16