Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02093:Vmn2r14'

279476

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r14

Ensembl Gene

ENSMUSG00000091059

Gene Name

vomeronasal 2, receptor 14

Synonyms

EG231591

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.469) question?

Stock #

IGL02093

Quality Score

Status

Chromosome

Chromosomal Location

109362822-109372488 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 109368275 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 239 (M239K)

Ref Sequence

ENSEMBL: ENSMUSP00000128015 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170341]

AlphaFold

E9Q759

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170341
AA Change: M239K

PolyPhen 2 Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000128015
Gene: ENSMUSG00000091059
AA Change: M239K

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	76	466	8.3e-31	PFAM
Pfam:NCD3G	507	561	1.1e-17	PFAM
Pfam:7tm_3	594	829	1.2e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ackr1	T	A	1: 173,160,396 (GRCm39)	Y41F	probably benign	Het
Amigo1	T	C	3: 108,095,214 (GRCm39)	Y238H	probably benign	Het
Ankrd17	A	G	5: 90,390,822 (GRCm39)	S2283P	possibly damaging	Het
Apobec4	A	G	1: 152,632,119 (GRCm39)	H49R	possibly damaging	Het
Arhgap44	T	C	11: 64,965,360 (GRCm39)	K34R	probably damaging	Het
Arsg	A	G	11: 109,416,272 (GRCm39)	Y173C	possibly damaging	Het
Arv1	C	A	8: 125,457,617 (GRCm39)	L56M	probably damaging	Het
B3glct	A	T	5: 149,656,150 (GRCm39)	R194S	probably benign	Het
Ccdc39	T	A	3: 33,886,717 (GRCm39)	Y297F	probably benign	Het
Dnah8	A	G	17: 30,936,854 (GRCm39)	E1552G	probably damaging	Het
Dnajb9	T	C	12: 44,253,987 (GRCm39)	H140R	probably damaging	Het
Dock5	T	G	14: 68,076,992 (GRCm39)		probably benign	Het
Egr2	G	A	10: 67,375,854 (GRCm39)	G92D	probably damaging	Het
Evi2a	G	A	11: 79,418,490 (GRCm39)	S40L	probably benign	Het
Fshr	A	G	17: 89,309,317 (GRCm39)		probably null	Het
Glce	G	A	9: 61,977,821 (GRCm39)	T21I	probably damaging	Het
Gucy2d	C	A	7: 98,092,755 (GRCm39)	S44*	probably null	Het
Heatr5a	T	C	12: 51,962,858 (GRCm39)	E1014G	possibly damaging	Het
Hnrnpll	A	T	17: 80,351,933 (GRCm39)	H337Q	probably benign	Het
Jhy	G	T	9: 40,856,163 (GRCm39)		probably null	Het
Kat5	A	T	19: 5,653,903 (GRCm39)	M427K	probably benign	Het
Lama5	G	A	2: 179,830,380 (GRCm39)	P1876S	probably damaging	Het
Lamc3	C	A	2: 31,777,667 (GRCm39)	H104Q	probably damaging	Het
Lcn5	T	C	2: 25,548,462 (GRCm39)	Y84H	probably damaging	Het
Mageb18	T	A	X: 91,163,872 (GRCm39)	K123N	probably damaging	Het
Mfhas1	T	A	8: 36,056,498 (GRCm39)	N324K	probably damaging	Het
Nagk	T	C	6: 83,776,352 (GRCm39)	F189S	probably damaging	Het
Nbas	T	A	12: 13,610,963 (GRCm39)	M2218K	probably benign	Het
Nuak2	C	A	1: 132,259,850 (GRCm39)	P543T	probably benign	Het
Or2ag17	C	T	7: 106,390,030 (GRCm39)	M59I	probably benign	Het
Or5bh3	C	T	X: 49,098,705 (GRCm39)	M136I	possibly damaging	Het
Prl8a9	T	C	13: 27,743,436 (GRCm39)	Y123C	probably damaging	Het
Rapgef5	T	C	12: 117,682,867 (GRCm39)	F220S	probably damaging	Het
Rexo4	T	C	2: 26,852,530 (GRCm39)	D135G	probably benign	Het
Slc39a10	C	T	1: 46,874,369 (GRCm39)	R311Q	probably damaging	Het
Slfn10-ps	A	T	11: 82,923,016 (GRCm39)		noncoding transcript	Het
Tfrc	A	G	16: 32,449,012 (GRCm39)	E717G	probably benign	Het
Tg	T	A	15: 66,564,223 (GRCm39)	N1141K	possibly damaging	Het
Topors	T	C	4: 40,261,467 (GRCm39)	S606G	probably damaging	Het
Usp11	A	G	X: 20,585,591 (GRCm39)	D827G	probably benign	Het
Vmn2r1	A	T	3: 64,012,130 (GRCm39)	M664L	probably benign	Het
Xiap	T	C	X: 41,188,704 (GRCm39)		probably benign	Het
Zfp2	G	A	11: 50,791,831 (GRCm39)	P71S	probably benign	Het
Zhx1	T	A	15: 57,916,264 (GRCm39)	T661S	probably benign	Het

Other mutations in Vmn2r14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01472:Vmn2r14	APN	5	109,364,180 (GRCm39)	nonsense	probably null
IGL01504:Vmn2r14	APN	5	109,369,285 (GRCm39)	missense	probably benign	0.01
IGL01828:Vmn2r14	APN	5	109,372,443 (GRCm39)	missense	possibly damaging	0.71
IGL02103:Vmn2r14	APN	5	109,372,349 (GRCm39)	missense	probably damaging	0.96
IGL02123:Vmn2r14	APN	5	109,367,933 (GRCm39)	missense	probably damaging	1.00
IGL02145:Vmn2r14	APN	5	109,368,454 (GRCm39)	nonsense	probably null
IGL02676:Vmn2r14	APN	5	109,367,882 (GRCm39)	missense	probably benign	0.03
IGL02720:Vmn2r14	APN	5	109,369,305 (GRCm39)	missense	probably damaging	1.00
IGL02877:Vmn2r14	APN	5	109,368,054 (GRCm39)	missense	probably damaging	0.99
IGL02974:Vmn2r14	APN	5	109,369,292 (GRCm39)	missense	possibly damaging	0.55
IGL03151:Vmn2r14	APN	5	109,364,260 (GRCm39)	missense	probably damaging	1.00
IGL03297:Vmn2r14	APN	5	109,363,973 (GRCm39)	missense	probably damaging	1.00
IGL03386:Vmn2r14	APN	5	109,368,350 (GRCm39)	missense	possibly damaging	0.90
IGL03394:Vmn2r14	APN	5	109,367,702 (GRCm39)	missense	probably null	0.83
ANU74:Vmn2r14	UTSW	5	109,366,910 (GRCm39)	missense	probably benign	0.00
R0316:Vmn2r14	UTSW	5	109,366,762 (GRCm39)	missense	probably benign	0.07
R0755:Vmn2r14	UTSW	5	109,364,226 (GRCm39)	missense	possibly damaging	0.81
R1219:Vmn2r14	UTSW	5	109,372,440 (GRCm39)	missense	probably benign	0.17
R1321:Vmn2r14	UTSW	5	109,364,117 (GRCm39)	missense	probably benign	0.08
R1465:Vmn2r14	UTSW	5	109,368,195 (GRCm39)	missense	possibly damaging	0.47
R1465:Vmn2r14	UTSW	5	109,368,195 (GRCm39)	missense	possibly damaging	0.47
R1509:Vmn2r14	UTSW	5	109,363,862 (GRCm39)	missense	probably benign	0.00
R1551:Vmn2r14	UTSW	5	109,369,283 (GRCm39)	missense	probably damaging	1.00
R1628:Vmn2r14	UTSW	5	109,367,838 (GRCm39)	missense	probably benign	0.00
R1668:Vmn2r14	UTSW	5	109,366,913 (GRCm39)	nonsense	probably null
R2013:Vmn2r14	UTSW	5	109,369,109 (GRCm39)	missense	probably benign	0.00
R2201:Vmn2r14	UTSW	5	109,366,698 (GRCm39)	splice site	probably null
R2417:Vmn2r14	UTSW	5	109,372,329 (GRCm39)	missense	probably benign	0.00
R3029:Vmn2r14	UTSW	5	109,363,776 (GRCm39)	missense	probably damaging	1.00
R3120:Vmn2r14	UTSW	5	109,372,431 (GRCm39)	missense	probably null	0.00
R3729:Vmn2r14	UTSW	5	109,364,095 (GRCm39)	missense	probably damaging	1.00
R3762:Vmn2r14	UTSW	5	109,368,033 (GRCm39)	missense	probably benign	0.02
R3943:Vmn2r14	UTSW	5	109,363,930 (GRCm39)	missense	probably damaging	1.00
R3944:Vmn2r14	UTSW	5	109,363,930 (GRCm39)	missense	probably damaging	1.00
R4222:Vmn2r14	UTSW	5	109,364,149 (GRCm39)	missense	probably benign	0.00
R4224:Vmn2r14	UTSW	5	109,364,149 (GRCm39)	missense	probably benign	0.00
R4239:Vmn2r14	UTSW	5	109,364,277 (GRCm39)	critical splice acceptor site	probably null
R4240:Vmn2r14	UTSW	5	109,364,277 (GRCm39)	critical splice acceptor site	probably null
R4782:Vmn2r14	UTSW	5	109,369,370 (GRCm39)	missense	probably benign	0.01
R4832:Vmn2r14	UTSW	5	109,363,976 (GRCm39)	missense	probably damaging	1.00
R4884:Vmn2r14	UTSW	5	109,369,384 (GRCm39)	splice site	probably null
R4896:Vmn2r14	UTSW	5	109,368,246 (GRCm39)	missense	probably benign	0.19
R5004:Vmn2r14	UTSW	5	109,368,246 (GRCm39)	missense	probably benign	0.19
R5117:Vmn2r14	UTSW	5	109,363,961 (GRCm39)	missense	probably benign	0.16
R5285:Vmn2r14	UTSW	5	109,365,442 (GRCm39)	missense	probably damaging	0.98
R5413:Vmn2r14	UTSW	5	109,369,154 (GRCm39)	missense	probably benign	0.29
R5569:Vmn2r14	UTSW	5	109,368,261 (GRCm39)	missense	probably benign	0.44
R5701:Vmn2r14	UTSW	5	109,367,816 (GRCm39)	missense	probably damaging	1.00
R5726:Vmn2r14	UTSW	5	109,365,486 (GRCm39)	missense	possibly damaging	0.95
R5763:Vmn2r14	UTSW	5	109,363,724 (GRCm39)	missense	possibly damaging	0.49
R5872:Vmn2r14	UTSW	5	109,369,222 (GRCm39)	missense	probably benign
R5985:Vmn2r14	UTSW	5	109,368,082 (GRCm39)	missense	possibly damaging	0.89
R6268:Vmn2r14	UTSW	5	109,369,283 (GRCm39)	missense	possibly damaging	0.87
R6273:Vmn2r14	UTSW	5	109,369,133 (GRCm39)	missense	probably benign	0.44
R6409:Vmn2r14	UTSW	5	109,364,096 (GRCm39)	missense	probably benign	0.09
R6944:Vmn2r14	UTSW	5	109,364,140 (GRCm39)	missense	probably benign	0.06
R6944:Vmn2r14	UTSW	5	109,363,925 (GRCm39)	missense	probably benign	0.22
R7608:Vmn2r14	UTSW	5	109,369,276 (GRCm39)	missense	probably benign	0.03
R7740:Vmn2r14	UTSW	5	109,368,324 (GRCm39)	missense	probably benign	0.41
R7768:Vmn2r14	UTSW	5	109,368,086 (GRCm39)	missense	probably benign	0.01
R7804:Vmn2r14	UTSW	5	109,368,324 (GRCm39)	missense	probably benign	0.41
R7872:Vmn2r14	UTSW	5	109,369,219 (GRCm39)	missense	probably benign	0.02
R7993:Vmn2r14	UTSW	5	109,363,862 (GRCm39)	missense	probably benign	0.00
R8006:Vmn2r14	UTSW	5	109,368,324 (GRCm39)	missense	probably benign	0.41
R8007:Vmn2r14	UTSW	5	109,368,324 (GRCm39)	missense	probably benign	0.41
R8187:Vmn2r14	UTSW	5	109,368,420 (GRCm39)	missense	probably benign	0.03
R8369:Vmn2r14	UTSW	5	109,369,342 (GRCm39)	missense	probably damaging	1.00
R8463:Vmn2r14	UTSW	5	109,369,340 (GRCm39)	missense	probably benign	0.30
R8968:Vmn2r14	UTSW	5	109,365,533 (GRCm39)	missense	probably benign	0.01
R9008:Vmn2r14	UTSW	5	109,367,893 (GRCm39)	missense	probably benign	0.00
R9030:Vmn2r14	UTSW	5	109,368,054 (GRCm39)	missense	probably damaging	0.99
R9039:Vmn2r14	UTSW	5	109,367,902 (GRCm39)	nonsense	probably null
R9150:Vmn2r14	UTSW	5	109,367,783 (GRCm39)	missense	probably damaging	1.00
R9164:Vmn2r14	UTSW	5	109,364,087 (GRCm39)	missense	probably damaging	1.00
R9216:Vmn2r14	UTSW	5	109,369,112 (GRCm39)	missense	probably benign	0.01
R9225:Vmn2r14	UTSW	5	109,369,288 (GRCm39)	missense	probably damaging	1.00
R9245:Vmn2r14	UTSW	5	109,368,176 (GRCm39)	missense	possibly damaging	0.89
R9342:Vmn2r14	UTSW	5	109,368,428 (GRCm39)	missense	probably damaging	1.00
R9472:Vmn2r14	UTSW	5	109,367,962 (GRCm39)	missense	probably benign	0.00
R9678:Vmn2r14	UTSW	5	109,364,041 (GRCm39)	missense	probably damaging	1.00
R9774:Vmn2r14	UTSW	5	109,369,126 (GRCm39)	missense	probably benign	0.07
Z1177:Vmn2r14	UTSW	5	109,367,741 (GRCm39)	missense	probably benign	0.33

Posted On

2015-04-16