Incidental Mutation 'IGL02093:Or2ag17'
ID 279486
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2ag17
Ensembl Gene ENSMUSG00000096714
Gene Name olfactory receptor family 2 subfamily AG member 17
Synonyms MOR283-10P, GA_x6K02T2PBJ9-9168355-9167405, Olfr699
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # IGL02093
Quality Score
Status
Chromosome 7
Chromosomal Location 106389256-106390206 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 106390030 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 59 (M59I)
Ref Sequence ENSEMBL: ENSMUSP00000149112 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065024] [ENSMUST00000215952] [ENSMUST00000216307]
AlphaFold Q7TRN3
Predicted Effect probably benign
Transcript: ENSMUST00000065024
AA Change: M59I

PolyPhen 2 Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000068023
Gene: ENSMUSG00000096714
AA Change: M59I

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.3e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 303 2.1e-5 PFAM
Pfam:7tm_1 41 290 1.1e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215952
AA Change: M59I

PolyPhen 2 Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000216307
AA Change: M59I

PolyPhen 2 Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ackr1 T A 1: 173,160,396 (GRCm39) Y41F probably benign Het
Amigo1 T C 3: 108,095,214 (GRCm39) Y238H probably benign Het
Ankrd17 A G 5: 90,390,822 (GRCm39) S2283P possibly damaging Het
Apobec4 A G 1: 152,632,119 (GRCm39) H49R possibly damaging Het
Arhgap44 T C 11: 64,965,360 (GRCm39) K34R probably damaging Het
Arsg A G 11: 109,416,272 (GRCm39) Y173C possibly damaging Het
Arv1 C A 8: 125,457,617 (GRCm39) L56M probably damaging Het
B3glct A T 5: 149,656,150 (GRCm39) R194S probably benign Het
Ccdc39 T A 3: 33,886,717 (GRCm39) Y297F probably benign Het
Dnah8 A G 17: 30,936,854 (GRCm39) E1552G probably damaging Het
Dnajb9 T C 12: 44,253,987 (GRCm39) H140R probably damaging Het
Dock5 T G 14: 68,076,992 (GRCm39) probably benign Het
Egr2 G A 10: 67,375,854 (GRCm39) G92D probably damaging Het
Evi2a G A 11: 79,418,490 (GRCm39) S40L probably benign Het
Fshr A G 17: 89,309,317 (GRCm39) probably null Het
Glce G A 9: 61,977,821 (GRCm39) T21I probably damaging Het
Gucy2d C A 7: 98,092,755 (GRCm39) S44* probably null Het
Heatr5a T C 12: 51,962,858 (GRCm39) E1014G possibly damaging Het
Hnrnpll A T 17: 80,351,933 (GRCm39) H337Q probably benign Het
Jhy G T 9: 40,856,163 (GRCm39) probably null Het
Kat5 A T 19: 5,653,903 (GRCm39) M427K probably benign Het
Lama5 G A 2: 179,830,380 (GRCm39) P1876S probably damaging Het
Lamc3 C A 2: 31,777,667 (GRCm39) H104Q probably damaging Het
Lcn5 T C 2: 25,548,462 (GRCm39) Y84H probably damaging Het
Mageb18 T A X: 91,163,872 (GRCm39) K123N probably damaging Het
Mfhas1 T A 8: 36,056,498 (GRCm39) N324K probably damaging Het
Nagk T C 6: 83,776,352 (GRCm39) F189S probably damaging Het
Nbas T A 12: 13,610,963 (GRCm39) M2218K probably benign Het
Nuak2 C A 1: 132,259,850 (GRCm39) P543T probably benign Het
Or5bh3 C T X: 49,098,705 (GRCm39) M136I possibly damaging Het
Prl8a9 T C 13: 27,743,436 (GRCm39) Y123C probably damaging Het
Rapgef5 T C 12: 117,682,867 (GRCm39) F220S probably damaging Het
Rexo4 T C 2: 26,852,530 (GRCm39) D135G probably benign Het
Slc39a10 C T 1: 46,874,369 (GRCm39) R311Q probably damaging Het
Slfn10-ps A T 11: 82,923,016 (GRCm39) noncoding transcript Het
Tfrc A G 16: 32,449,012 (GRCm39) E717G probably benign Het
Tg T A 15: 66,564,223 (GRCm39) N1141K possibly damaging Het
Topors T C 4: 40,261,467 (GRCm39) S606G probably damaging Het
Usp11 A G X: 20,585,591 (GRCm39) D827G probably benign Het
Vmn2r1 A T 3: 64,012,130 (GRCm39) M664L probably benign Het
Vmn2r14 A T 5: 109,368,275 (GRCm39) M239K possibly damaging Het
Xiap T C X: 41,188,704 (GRCm39) probably benign Het
Zfp2 G A 11: 50,791,831 (GRCm39) P71S probably benign Het
Zhx1 T A 15: 57,916,264 (GRCm39) T661S probably benign Het
Other mutations in Or2ag17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Or2ag17 APN 7 106,389,796 (GRCm39) missense probably benign 0.12
IGL02404:Or2ag17 APN 7 106,389,566 (GRCm39) missense probably damaging 1.00
IGL03214:Or2ag17 APN 7 106,389,552 (GRCm39) missense probably benign
IGL03230:Or2ag17 APN 7 106,389,911 (GRCm39) missense probably damaging 1.00
R0194:Or2ag17 UTSW 7 106,390,030 (GRCm39) missense probably benign 0.12
R0523:Or2ag17 UTSW 7 106,389,533 (GRCm39) missense probably damaging 1.00
R1132:Or2ag17 UTSW 7 106,389,758 (GRCm39) missense possibly damaging 0.94
R1373:Or2ag17 UTSW 7 106,389,963 (GRCm39) missense probably benign 0.01
R1482:Or2ag17 UTSW 7 106,389,540 (GRCm39) missense probably benign 0.00
R1498:Or2ag17 UTSW 7 106,389,623 (GRCm39) missense possibly damaging 0.78
R1500:Or2ag17 UTSW 7 106,390,028 (GRCm39) missense probably damaging 1.00
R2656:Or2ag17 UTSW 7 106,389,720 (GRCm39) missense probably damaging 0.98
R4163:Or2ag17 UTSW 7 106,389,486 (GRCm39) missense probably damaging 1.00
R4638:Or2ag17 UTSW 7 106,390,205 (GRCm39) start codon destroyed probably null 1.00
R5104:Or2ag17 UTSW 7 106,389,539 (GRCm39) missense possibly damaging 0.81
R6216:Or2ag17 UTSW 7 106,389,665 (GRCm39) missense probably benign 0.23
R6976:Or2ag17 UTSW 7 106,389,434 (GRCm39) missense probably damaging 0.99
R7129:Or2ag17 UTSW 7 106,389,690 (GRCm39) missense probably benign 0.00
R7130:Or2ag17 UTSW 7 106,389,389 (GRCm39) missense probably benign 0.35
R8104:Or2ag17 UTSW 7 106,390,338 (GRCm39) start gained probably benign
R8104:Or2ag17 UTSW 7 106,390,337 (GRCm39) start gained probably benign
R9057:Or2ag17 UTSW 7 106,389,296 (GRCm39) missense probably damaging 0.99
R9445:Or2ag17 UTSW 7 106,389,464 (GRCm39) missense probably damaging 1.00
Z1177:Or2ag17 UTSW 7 106,389,477 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16