Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02093:Zfp2'

279508

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp2

Ensembl Gene

ENSMUSG00000049321

Gene Name

zinc finger protein 2

Synonyms

Fnp-2, 9930007F06Rik, Zfp-2, mkr-2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.129) question?

Stock #

IGL02093

Quality Score

Status

Chromosome

Chromosomal Location

50789539-50806992 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 50791831 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 71 (P71S)

Ref Sequence

ENSEMBL: ENSMUSP00000112079 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000109128] [ENSMUST00000109129] [ENSMUST00000116378]

AlphaFold

P08043

Predicted Effect

probably benign
Transcript: ENSMUST00000109128
AA Change: P71S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000104756
Gene: ENSMUSG00000049321
AA Change: P71S

Domain	Start	End	E-Value	Type
ZnF_C2H2	100	122	4.87e-4	SMART
ZnF_C2H2	128	150	1.04e-3	SMART
ZnF_C2H2	156	178	5.59e-4	SMART
ZnF_C2H2	184	206	3.69e-4	SMART
ZnF_C2H2	212	234	9.08e-4	SMART
ZnF_C2H2	240	262	1.04e-3	SMART
ZnF_C2H2	268	290	1.58e-3	SMART
ZnF_C2H2	296	318	2.27e-4	SMART
ZnF_C2H2	324	346	9.08e-4	SMART
ZnF_C2H2	352	374	1.38e-3	SMART
ZnF_C2H2	380	402	2.43e-4	SMART
ZnF_C2H2	408	430	1.95e-3	SMART
ZnF_C2H2	436	458	2.15e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000109129
AA Change: P71S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000104757
Gene: ENSMUSG00000049321
AA Change: P71S

Domain	Start	End	E-Value	Type
ZnF_C2H2	100	122	4.87e-4	SMART
ZnF_C2H2	128	150	1.04e-3	SMART
ZnF_C2H2	156	178	5.59e-4	SMART
ZnF_C2H2	184	206	3.69e-4	SMART
ZnF_C2H2	212	234	9.08e-4	SMART
ZnF_C2H2	240	262	1.04e-3	SMART
ZnF_C2H2	268	290	1.58e-3	SMART
ZnF_C2H2	296	318	2.27e-4	SMART
ZnF_C2H2	324	346	9.08e-4	SMART
ZnF_C2H2	352	374	1.38e-3	SMART
ZnF_C2H2	380	402	2.43e-4	SMART
ZnF_C2H2	408	430	1.95e-3	SMART
ZnF_C2H2	436	458	2.15e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000116378
AA Change: P71S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000112079
Gene: ENSMUSG00000049321
AA Change: P71S

Domain	Start	End	E-Value	Type
ZnF_C2H2	100	122	4.87e-4	SMART
ZnF_C2H2	128	150	1.04e-3	SMART
ZnF_C2H2	156	178	5.59e-4	SMART
ZnF_C2H2	184	206	3.69e-4	SMART
ZnF_C2H2	212	234	9.08e-4	SMART
ZnF_C2H2	240	262	1.04e-3	SMART
ZnF_C2H2	268	290	1.58e-3	SMART
ZnF_C2H2	296	318	2.27e-4	SMART
ZnF_C2H2	324	346	9.08e-4	SMART
ZnF_C2H2	352	374	1.38e-3	SMART
ZnF_C2H2	380	402	2.43e-4	SMART
ZnF_C2H2	408	430	1.95e-3	SMART
ZnF_C2H2	436	458	2.15e-5	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124748

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150903

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151027

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ackr1	T	A	1: 173,160,396 (GRCm39)	Y41F	probably benign	Het
Amigo1	T	C	3: 108,095,214 (GRCm39)	Y238H	probably benign	Het
Ankrd17	A	G	5: 90,390,822 (GRCm39)	S2283P	possibly damaging	Het
Apobec4	A	G	1: 152,632,119 (GRCm39)	H49R	possibly damaging	Het
Arhgap44	T	C	11: 64,965,360 (GRCm39)	K34R	probably damaging	Het
Arsg	A	G	11: 109,416,272 (GRCm39)	Y173C	possibly damaging	Het
Arv1	C	A	8: 125,457,617 (GRCm39)	L56M	probably damaging	Het
B3glct	A	T	5: 149,656,150 (GRCm39)	R194S	probably benign	Het
Ccdc39	T	A	3: 33,886,717 (GRCm39)	Y297F	probably benign	Het
Dnah8	A	G	17: 30,936,854 (GRCm39)	E1552G	probably damaging	Het
Dnajb9	T	C	12: 44,253,987 (GRCm39)	H140R	probably damaging	Het
Dock5	T	G	14: 68,076,992 (GRCm39)		probably benign	Het
Egr2	G	A	10: 67,375,854 (GRCm39)	G92D	probably damaging	Het
Evi2a	G	A	11: 79,418,490 (GRCm39)	S40L	probably benign	Het
Fshr	A	G	17: 89,309,317 (GRCm39)		probably null	Het
Glce	G	A	9: 61,977,821 (GRCm39)	T21I	probably damaging	Het
Gucy2d	C	A	7: 98,092,755 (GRCm39)	S44*	probably null	Het
Heatr5a	T	C	12: 51,962,858 (GRCm39)	E1014G	possibly damaging	Het
Hnrnpll	A	T	17: 80,351,933 (GRCm39)	H337Q	probably benign	Het
Jhy	G	T	9: 40,856,163 (GRCm39)		probably null	Het
Kat5	A	T	19: 5,653,903 (GRCm39)	M427K	probably benign	Het
Lama5	G	A	2: 179,830,380 (GRCm39)	P1876S	probably damaging	Het
Lamc3	C	A	2: 31,777,667 (GRCm39)	H104Q	probably damaging	Het
Lcn5	T	C	2: 25,548,462 (GRCm39)	Y84H	probably damaging	Het
Mageb18	T	A	X: 91,163,872 (GRCm39)	K123N	probably damaging	Het
Mfhas1	T	A	8: 36,056,498 (GRCm39)	N324K	probably damaging	Het
Nagk	T	C	6: 83,776,352 (GRCm39)	F189S	probably damaging	Het
Nbas	T	A	12: 13,610,963 (GRCm39)	M2218K	probably benign	Het
Nuak2	C	A	1: 132,259,850 (GRCm39)	P543T	probably benign	Het
Or2ag17	C	T	7: 106,390,030 (GRCm39)	M59I	probably benign	Het
Or5bh3	C	T	X: 49,098,705 (GRCm39)	M136I	possibly damaging	Het
Prl8a9	T	C	13: 27,743,436 (GRCm39)	Y123C	probably damaging	Het
Rapgef5	T	C	12: 117,682,867 (GRCm39)	F220S	probably damaging	Het
Rexo4	T	C	2: 26,852,530 (GRCm39)	D135G	probably benign	Het
Slc39a10	C	T	1: 46,874,369 (GRCm39)	R311Q	probably damaging	Het
Slfn10-ps	A	T	11: 82,923,016 (GRCm39)		noncoding transcript	Het
Tfrc	A	G	16: 32,449,012 (GRCm39)	E717G	probably benign	Het
Tg	T	A	15: 66,564,223 (GRCm39)	N1141K	possibly damaging	Het
Topors	T	C	4: 40,261,467 (GRCm39)	S606G	probably damaging	Het
Usp11	A	G	X: 20,585,591 (GRCm39)	D827G	probably benign	Het
Vmn2r1	A	T	3: 64,012,130 (GRCm39)	M664L	probably benign	Het
Vmn2r14	A	T	5: 109,368,275 (GRCm39)	M239K	possibly damaging	Het
Xiap	T	C	X: 41,188,704 (GRCm39)		probably benign	Het
Zhx1	T	A	15: 57,916,264 (GRCm39)	T661S	probably benign	Het

Other mutations in Zfp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
inanes	UTSW	11	50,791,234 (GRCm39)	missense	probably damaging	1.00
R0689:Zfp2	UTSW	11	50,791,734 (GRCm39)	missense	probably benign	0.00
R1851:Zfp2	UTSW	11	50,791,915 (GRCm39)	missense	probably benign	0.06
R1938:Zfp2	UTSW	11	50,790,809 (GRCm39)	missense	possibly damaging	0.61
R2084:Zfp2	UTSW	11	50,791,789 (GRCm39)	missense	probably benign
R3859:Zfp2	UTSW	11	50,790,923 (GRCm39)	missense	possibly damaging	0.93
R4899:Zfp2	UTSW	11	50,790,841 (GRCm39)	missense	probably damaging	1.00
R5294:Zfp2	UTSW	11	50,792,068 (GRCm39)	start gained	probably benign
R5511:Zfp2	UTSW	11	50,790,851 (GRCm39)	missense	probably damaging	0.97
R5583:Zfp2	UTSW	11	50,790,984 (GRCm39)	missense	possibly damaging	0.83
R6358:Zfp2	UTSW	11	50,791,428 (GRCm39)	missense	probably damaging	0.99
R6511:Zfp2	UTSW	11	50,791,234 (GRCm39)	missense	probably damaging	1.00
R7290:Zfp2	UTSW	11	50,791,570 (GRCm39)	missense	probably damaging	1.00
R7740:Zfp2	UTSW	11	50,791,605 (GRCm39)	missense	probably damaging	1.00
R8534:Zfp2	UTSW	11	50,791,627 (GRCm39)	missense	possibly damaging	0.73
R8894:Zfp2	UTSW	11	50,791,843 (GRCm39)	missense	possibly damaging	0.72
R9375:Zfp2	UTSW	11	50,791,042 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16