Incidental Mutation 'IGL02095:Lrrc27'
| ID |
279592 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Lrrc27
|
| Ensembl Gene |
ENSMUSG00000015980 |
| Gene Name |
leucine rich repeat containing 27 |
| Synonyms |
2310044E02Rik, 1700071K18Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.049)
|
| Stock # |
IGL02095
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
138792904-138822895 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 138810169 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 380
(T380I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000016124
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000016124]
[ENSMUST00000106104]
|
| AlphaFold |
Q80YS5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000016124
AA Change: T380I
PolyPhen 2
Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000016124
Gene: ENSMUSG00000015980
AA Change: T380I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
32 |
N/A |
INTRINSIC |
|
LRR_TYP
|
75 |
98 |
1.03e-2 |
SMART |
|
LRR_TYP
|
99 |
122 |
3.69e-4 |
SMART |
|
LRR
|
123 |
145 |
7.38e1 |
SMART |
|
low complexity region
|
271 |
283 |
N/A |
INTRINSIC |
|
coiled coil region
|
336 |
370 |
N/A |
INTRINSIC |
|
coiled coil region
|
463 |
491 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106104
|
| SMART Domains |
Protein: ENSMUSP00000101710
Gene: ENSMUSG00000015980
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
32 |
N/A |
INTRINSIC |
|
LRR_TYP
|
75 |
98 |
1.03e-2 |
SMART |
|
LRR_TYP
|
99 |
122 |
3.69e-4 |
SMART |
|
LRR
|
123 |
145 |
7.38e1 |
SMART |
|
low complexity region
|
271 |
283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126199
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126213
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000130248
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 48 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3425401B19Rik |
T |
A |
14: 32,383,583 (GRCm39) |
Q794L |
probably benign |
Het |
| Acrbp |
C |
A |
6: 125,030,919 (GRCm39) |
Y313* |
probably null |
Het |
| Adam9 |
A |
G |
8: 25,486,745 (GRCm39) |
S178P |
probably benign |
Het |
| Adgrv1 |
T |
C |
13: 81,727,909 (GRCm39) |
I244V |
possibly damaging |
Het |
| Atad5 |
A |
G |
11: 79,985,533 (GRCm39) |
S207G |
probably benign |
Het |
| Atp10a |
A |
G |
7: 58,457,141 (GRCm39) |
D880G |
probably damaging |
Het |
| Cadps2 |
A |
G |
6: 23,427,309 (GRCm39) |
I573T |
probably benign |
Het |
| Camsap3 |
A |
G |
8: 3,653,845 (GRCm39) |
D494G |
probably damaging |
Het |
| Cbfa2t3 |
T |
C |
8: 123,360,232 (GRCm39) |
E438G |
probably damaging |
Het |
| Cisd2 |
T |
C |
3: 135,116,980 (GRCm39) |
D37G |
possibly damaging |
Het |
| Cndp2 |
T |
C |
18: 84,699,157 (GRCm39) |
E36G |
possibly damaging |
Het |
| Ddx54 |
G |
A |
5: 120,761,856 (GRCm39) |
G544D |
possibly damaging |
Het |
| Dok2 |
G |
T |
14: 71,015,301 (GRCm39) |
G343W |
possibly damaging |
Het |
| Dscaml1 |
A |
G |
9: 45,359,001 (GRCm39) |
N87D |
probably damaging |
Het |
| Ehf |
T |
C |
2: 103,097,336 (GRCm39) |
Y237C |
probably damaging |
Het |
| Exoc3 |
T |
C |
13: 74,328,655 (GRCm39) |
T569A |
probably damaging |
Het |
| Fam151a |
T |
C |
4: 106,605,072 (GRCm39) |
V478A |
probably damaging |
Het |
| Fam227b |
T |
A |
2: 125,942,924 (GRCm39) |
H291L |
probably damaging |
Het |
| Fmn2 |
A |
G |
1: 174,330,167 (GRCm39) |
T186A |
unknown |
Het |
| Ggnbp2 |
T |
C |
11: 84,723,954 (GRCm39) |
Y660C |
probably damaging |
Het |
| Ggt5 |
G |
A |
10: 75,444,637 (GRCm39) |
M318I |
probably benign |
Het |
| Gprc5d |
A |
G |
6: 135,093,175 (GRCm39) |
I244T |
probably damaging |
Het |
| Gucy2e |
A |
G |
11: 69,123,613 (GRCm39) |
S429P |
possibly damaging |
Het |
| Igf2r |
T |
C |
17: 12,920,892 (GRCm39) |
D1341G |
probably damaging |
Het |
| Kcnq4 |
T |
C |
4: 120,557,224 (GRCm39) |
|
probably benign |
Het |
| Krt40 |
T |
C |
11: 99,432,497 (GRCm39) |
D173G |
probably damaging |
Het |
| Lrrc4c |
A |
G |
2: 97,459,749 (GRCm39) |
N125S |
probably benign |
Het |
| Mtor |
C |
T |
4: 148,628,998 (GRCm39) |
R2217C |
probably damaging |
Het |
| Nfrkb |
C |
T |
9: 31,322,527 (GRCm39) |
R866W |
probably damaging |
Het |
| Or10s1 |
T |
A |
9: 39,985,967 (GRCm39) |
Y125* |
probably null |
Het |
| Or4d10b |
C |
A |
19: 12,036,913 (GRCm39) |
V68F |
probably benign |
Het |
| P2ry6 |
T |
A |
7: 100,588,071 (GRCm39) |
D96V |
probably damaging |
Het |
| Pcdh18 |
A |
T |
3: 49,710,605 (GRCm39) |
S237T |
probably benign |
Het |
| Pck2 |
G |
A |
14: 55,779,967 (GRCm39) |
R72Q |
probably benign |
Het |
| Pik3c2a |
C |
T |
7: 115,945,423 (GRCm39) |
R1461Q |
probably damaging |
Het |
| Polr3a |
A |
G |
14: 24,504,678 (GRCm39) |
V1130A |
possibly damaging |
Het |
| Ppm1d |
T |
A |
11: 85,217,832 (GRCm39) |
D198E |
probably benign |
Het |
| Rasa1 |
T |
A |
13: 85,364,274 (GRCm39) |
E1022D |
probably benign |
Het |
| Rbm25 |
T |
C |
12: 83,718,748 (GRCm39) |
Y507H |
probably damaging |
Het |
| Rbm26 |
A |
T |
14: 105,381,696 (GRCm39) |
I488K |
probably damaging |
Het |
| Ryr2 |
T |
A |
13: 11,774,645 (GRCm39) |
E1170D |
probably damaging |
Het |
| Sdk2 |
T |
G |
11: 113,725,656 (GRCm39) |
T1198P |
probably damaging |
Het |
| Sema3g |
C |
T |
14: 30,949,781 (GRCm39) |
T654I |
probably benign |
Het |
| Spag9 |
A |
T |
11: 93,999,408 (GRCm39) |
H1108L |
probably damaging |
Het |
| Trgc2 |
T |
A |
13: 19,491,580 (GRCm39) |
|
probably benign |
Het |
| Ubap2 |
T |
C |
4: 41,229,709 (GRCm39) |
N142S |
probably benign |
Het |
| Usp33 |
T |
C |
3: 152,087,431 (GRCm39) |
F699L |
possibly damaging |
Het |
| Ythdc2 |
A |
G |
18: 45,006,207 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Lrrc27 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01668:Lrrc27
|
APN |
7 |
138,807,827 (GRCm39) |
intron |
probably benign |
|
|
IGL02489:Lrrc27
|
APN |
7 |
138,805,977 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03080:Lrrc27
|
APN |
7 |
138,810,153 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0372:Lrrc27
|
UTSW |
7 |
138,806,103 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1466:Lrrc27
|
UTSW |
7 |
138,810,224 (GRCm39) |
unclassified |
probably benign |
|
|
R2401:Lrrc27
|
UTSW |
7 |
138,803,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2876:Lrrc27
|
UTSW |
7 |
138,808,600 (GRCm39) |
intron |
probably benign |
|
|
R3113:Lrrc27
|
UTSW |
7 |
138,798,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4214:Lrrc27
|
UTSW |
7 |
138,803,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4707:Lrrc27
|
UTSW |
7 |
138,822,614 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4784:Lrrc27
|
UTSW |
7 |
138,822,614 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5070:Lrrc27
|
UTSW |
7 |
138,794,715 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5855:Lrrc27
|
UTSW |
7 |
138,798,251 (GRCm39) |
unclassified |
probably benign |
|
|
R6408:Lrrc27
|
UTSW |
7 |
138,798,184 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6993:Lrrc27
|
UTSW |
7 |
138,822,540 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7332:Lrrc27
|
UTSW |
7 |
138,822,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Lrrc27
|
UTSW |
7 |
138,806,022 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7460:Lrrc27
|
UTSW |
7 |
138,803,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7502:Lrrc27
|
UTSW |
7 |
138,794,748 (GRCm39) |
missense |
probably benign |
|
|
R8020:Lrrc27
|
UTSW |
7 |
138,816,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Lrrc27
|
UTSW |
7 |
138,816,902 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8518:Lrrc27
|
UTSW |
7 |
138,808,690 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8728:Lrrc27
|
UTSW |
7 |
138,822,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8734:Lrrc27
|
UTSW |
7 |
138,796,515 (GRCm39) |
unclassified |
probably benign |
|
|
R9141:Lrrc27
|
UTSW |
7 |
138,807,861 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9355:Lrrc27
|
UTSW |
7 |
138,822,648 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9387:Lrrc27
|
UTSW |
7 |
138,807,837 (GRCm39) |
nonsense |
probably null |
|
|
R9627:Lrrc27
|
UTSW |
7 |
138,808,582 (GRCm39) |
intron |
probably benign |
|
|
R9742:Lrrc27
|
UTSW |
7 |
138,806,229 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9779:Lrrc27
|
UTSW |
7 |
138,816,886 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9800:Lrrc27
|
UTSW |
7 |
138,807,913 (GRCm39) |
missense |
probably benign |
0.16 |
|
RF018:Lrrc27
|
UTSW |
7 |
138,806,016 (GRCm39) |
missense |
probably benign |
0.03 |
|
X0065:Lrrc27
|
UTSW |
7 |
138,810,162 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0065:Lrrc27
|
UTSW |
7 |
138,810,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Lrrc27
|
UTSW |
7 |
138,822,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation