Incidental Mutation 'IGL02098:Kif6'
ID 279682
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kif6
Ensembl Gene ENSMUSG00000023999
Gene Name kinesin family member 6
Synonyms D130084M03Rik, D130004B10Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # IGL02098
Quality Score
Status
Chromosome 17
Chromosomal Location 49922164-50216875 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 50177922 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 602 (G602D)
Ref Sequence ENSEMBL: ENSMUSP00000124674 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162854]
AlphaFold E9PX57
Predicted Effect probably benign
Transcript: ENSMUST00000162854
AA Change: G602D

PolyPhen 2 Score 0.357 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000124674
Gene: ENSMUSG00000023999
AA Change: G602D

DomainStartEndE-ValueType
KISc 3 353 1.67e-121 SMART
coiled coil region 358 385 N/A INTRINSIC
Blast:KISc 400 606 1e-85 BLAST
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozgyos for an ENU-induced allele exhibit normal exercise capacity and cardiac function. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam25 C T 8: 41,208,680 (GRCm39) P649S probably benign Het
Ano3 T A 2: 110,496,786 (GRCm39) R788* probably null Het
Ccdc18 A G 5: 108,349,977 (GRCm39) E1043G probably damaging Het
Chd3 A T 11: 69,250,655 (GRCm39) H691Q probably damaging Het
Cts7 G T 13: 61,504,343 (GRCm39) F73L probably damaging Het
Cyp2c66 A G 19: 39,159,473 (GRCm39) Y308C probably damaging Het
Eef1a2 G T 2: 180,794,582 (GRCm39) P206T probably benign Het
Gcsh G T 8: 117,715,875 (GRCm39) S69R probably damaging Het
Gm9989 T A 3: 81,829,528 (GRCm39) noncoding transcript Het
Igkv6-25 C T 6: 70,192,719 (GRCm39) T42I probably damaging Het
Iqca1 T C 1: 89,975,663 (GRCm39) Y684C probably damaging Het
Klb C A 5: 65,537,228 (GRCm39) R853S probably benign Het
Mad1l1 A C 5: 140,296,344 (GRCm39) probably benign Het
Magi1 T C 6: 93,655,768 (GRCm39) N1077D probably damaging Het
Med12l T A 3: 59,183,276 (GRCm39) S1858T possibly damaging Het
Ncapg2 A G 12: 116,407,952 (GRCm39) E984G possibly damaging Het
Necab1 T A 4: 14,955,892 (GRCm39) probably benign Het
Nexn G A 3: 151,949,540 (GRCm39) R253* probably null Het
Npc1l1 A G 11: 6,164,581 (GRCm39) L1156P probably damaging Het
Or2y1 T A 11: 49,386,224 (GRCm39) I288N probably damaging Het
Or5ac15 A T 16: 58,940,433 (GRCm39) probably benign Het
Or5b99 A G 19: 12,976,937 (GRCm39) I196V probably benign Het
Or8g17 A G 9: 38,930,187 (GRCm39) S217P probably damaging Het
Pramel25 T A 4: 143,520,248 (GRCm39) probably null Het
Rassf7 T C 7: 140,798,203 (GRCm39) S381P possibly damaging Het
Rdh7 G T 10: 127,720,607 (GRCm39) T255K probably benign Het
Scn10a T A 9: 119,520,544 (GRCm39) I119F possibly damaging Het
Slc15a3 T A 19: 10,826,042 (GRCm39) F244L probably damaging Het
Syde1 T C 10: 78,425,205 (GRCm39) S269G probably damaging Het
Teddm2 C T 1: 153,726,081 (GRCm39) probably benign Het
Tenm3 T C 8: 48,729,611 (GRCm39) D1465G possibly damaging Het
Zkscan2 A T 7: 123,099,064 (GRCm39) S43T probably benign Het
Other mutations in Kif6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01793:Kif6 APN 17 49,931,521 (GRCm39) missense probably damaging 0.99
IGL02259:Kif6 APN 17 50,202,919 (GRCm39) splice site probably benign
IGL03003:Kif6 APN 17 50,060,899 (GRCm39) nonsense probably null
PIT4280001:Kif6 UTSW 17 50,062,148 (GRCm39) missense probably benign 0.32
R0044:Kif6 UTSW 17 50,139,284 (GRCm39) splice site probably benign
R1180:Kif6 UTSW 17 50,139,284 (GRCm39) splice site probably benign
R1432:Kif6 UTSW 17 49,927,728 (GRCm39) missense probably damaging 1.00
R1522:Kif6 UTSW 17 50,021,141 (GRCm39) missense probably damaging 0.99
R1760:Kif6 UTSW 17 49,922,311 (GRCm39) missense probably benign 0.00
R1770:Kif6 UTSW 17 50,210,677 (GRCm39) missense possibly damaging 0.92
R1809:Kif6 UTSW 17 50,208,812 (GRCm39) missense probably benign 0.00
R1854:Kif6 UTSW 17 50,208,799 (GRCm39) missense probably benign 0.25
R2176:Kif6 UTSW 17 50,062,258 (GRCm39) missense probably damaging 1.00
R3766:Kif6 UTSW 17 50,065,671 (GRCm39) splice site probably benign
R4620:Kif6 UTSW 17 50,208,324 (GRCm39) missense probably benign
R4661:Kif6 UTSW 17 50,060,909 (GRCm39) missense probably benign 0.21
R4972:Kif6 UTSW 17 50,014,647 (GRCm39) missense probably damaging 1.00
R5735:Kif6 UTSW 17 50,139,210 (GRCm39) missense probably damaging 1.00
R5950:Kif6 UTSW 17 50,022,116 (GRCm39) missense probably damaging 0.99
R6364:Kif6 UTSW 17 49,927,651 (GRCm39) missense probably benign 0.01
R7604:Kif6 UTSW 17 49,978,129 (GRCm39) missense probably damaging 1.00
R7879:Kif6 UTSW 17 50,139,214 (GRCm39) missense probably benign 0.08
R7966:Kif6 UTSW 17 49,993,453 (GRCm39) missense probably damaging 0.98
R8246:Kif6 UTSW 17 50,065,542 (GRCm39) nonsense probably null
R8487:Kif6 UTSW 17 49,978,164 (GRCm39) missense probably damaging 1.00
X0067:Kif6 UTSW 17 50,139,195 (GRCm39) missense probably benign 0.01
Z1177:Kif6 UTSW 17 50,022,128 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16