Incidental Mutation 'IGL02098:Necab1'
ID279685
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Necab1
Ensembl Gene ENSMUSG00000040536
Gene NameN-terminal EF-hand calcium binding protein 1
Synonyms1700003H21Rik, Efcbp1, NECAB1, STIP-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.080) question?
Stock #IGL02098
Quality Score
Status
Chromosome4
Chromosomal Location14952245-15149794 bp(-) (GRCm38)
Type of Mutationutr 3 prime
DNA Base Change (assembly) T to A at 14955892 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000103908 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041606] [ENSMUST00000108273]
Predicted Effect probably benign
Transcript: ENSMUST00000041606
SMART Domains Protein: ENSMUSP00000038165
Gene: ENSMUSG00000040536

DomainStartEndE-ValueType
low complexity region 4 25 N/A INTRINSIC
EFh 30 58 4.06e-2 SMART
EFh 64 92 6.56e0 SMART
coiled coil region 135 163 N/A INTRINSIC
coiled coil region 209 244 N/A INTRINSIC
Pfam:ABM 251 326 2.1e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108273
SMART Domains Protein: ENSMUSP00000103908
Gene: ENSMUSG00000040536

DomainStartEndE-ValueType
low complexity region 4 25 N/A INTRINSIC
EFh 30 58 4.06e-2 SMART
EFh 64 92 6.56e0 SMART
coiled coil region 135 163 N/A INTRINSIC
coiled coil region 209 244 N/A INTRINSIC
Pfam:ABM 251 326 2.4e-13 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136992
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137532
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152024
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam25 C T 8: 40,755,643 P649S probably benign Het
Ano3 T A 2: 110,666,441 R788* probably null Het
Ccdc18 A G 5: 108,202,111 E1043G probably damaging Het
Chd3 A T 11: 69,359,829 H691Q probably damaging Het
Cts7 G T 13: 61,356,529 F73L probably damaging Het
Cyp2c66 A G 19: 39,171,029 Y308C probably damaging Het
Eef1a2 G T 2: 181,152,789 P206T probably benign Het
Gcsh G T 8: 116,989,136 S69R probably damaging Het
Gm13023 T A 4: 143,793,678 probably null Het
Gm9989 T A 3: 81,922,221 noncoding transcript Het
Igkv6-25 C T 6: 70,215,735 T42I probably damaging Het
Iqca T C 1: 90,047,941 Y684C probably damaging Het
Kif6 G A 17: 49,870,894 G602D probably benign Het
Klb C A 5: 65,379,885 R853S probably benign Het
Mad1l1 A C 5: 140,310,589 probably benign Het
Magi1 T C 6: 93,678,787 N1077D probably damaging Het
Med12l T A 3: 59,275,855 S1858T possibly damaging Het
Ncapg2 A G 12: 116,444,332 E984G possibly damaging Het
Nexn G A 3: 152,243,903 R253* probably null Het
Npc1l1 A G 11: 6,214,581 L1156P probably damaging Het
Olfr1385 T A 11: 49,495,397 I288N probably damaging Het
Olfr1451 A G 19: 12,999,573 I196V probably benign Het
Olfr146 A G 9: 39,018,891 S217P probably damaging Het
Olfr194 A T 16: 59,120,070 probably benign Het
Rassf7 T C 7: 141,218,290 S381P possibly damaging Het
Rdh7 G T 10: 127,884,738 T255K probably benign Het
Scn10a T A 9: 119,691,478 I119F possibly damaging Het
Slc15a3 T A 19: 10,848,678 F244L probably damaging Het
Syde1 T C 10: 78,589,371 S269G probably damaging Het
Teddm2 C T 1: 153,850,335 probably benign Het
Tenm3 T C 8: 48,276,576 D1465G possibly damaging Het
Zkscan2 A T 7: 123,499,841 S43T probably benign Het
Other mutations in Necab1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00429:Necab1 APN 4 15052656 missense probably damaging 1.00
IGL01314:Necab1 APN 4 15005079 missense probably damaging 0.96
IGL01751:Necab1 APN 4 14978171 missense probably damaging 1.00
IGL02381:Necab1 APN 4 15148812 splice site probably null
IGL03247:Necab1 APN 4 14960046 missense probably benign
R0095:Necab1 UTSW 4 14960027 missense possibly damaging 0.95
R0095:Necab1 UTSW 4 14960027 missense possibly damaging 0.95
R0321:Necab1 UTSW 4 14960083 missense probably damaging 0.99
R0698:Necab1 UTSW 4 15005041 missense probably benign 0.26
R1125:Necab1 UTSW 4 15111257 missense probably damaging 1.00
R1251:Necab1 UTSW 4 15111192 critical splice donor site probably null
R1400:Necab1 UTSW 4 14975185 missense possibly damaging 0.71
R1505:Necab1 UTSW 4 14960047 missense probably benign 0.26
R1771:Necab1 UTSW 4 15111267 missense probably damaging 1.00
R1776:Necab1 UTSW 4 15111267 missense probably damaging 1.00
R2080:Necab1 UTSW 4 15140219 splice site probably benign
R4705:Necab1 UTSW 4 15052628 missense probably damaging 1.00
R4780:Necab1 UTSW 4 14989248 missense probably benign 0.18
R4795:Necab1 UTSW 4 15111208 missense possibly damaging 0.84
R4972:Necab1 UTSW 4 14978216 missense probably damaging 1.00
R5009:Necab1 UTSW 4 14947503 unclassified probably benign
R6102:Necab1 UTSW 4 14989211 missense probably benign 0.05
R6968:Necab1 UTSW 4 14957852 missense probably damaging 1.00
Posted On2015-04-16