Incidental Mutation 'IGL02101:Mrgpra3'
| ID |
279743 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Mrgpra3
|
| Ensembl Gene |
ENSMUSG00000078698 |
| Gene Name |
MAS-related GPR, member A3 |
| Synonyms |
G protein-coupled receptor, MrgA3 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.048)
|
| Stock # |
IGL02101
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
47238698-47251120 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 47239300 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Arginine
at position 209
(C209R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135437
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000176369]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176369
AA Change: C209R
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000135437
Gene: ENSMUSG00000078698
AA Change: C209R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
31 |
N/A |
INTRINSIC |
|
Pfam:7TM_GPCR_Srx
|
48 |
234 |
6.3e-7 |
PFAM |
|
Pfam:7tm_1
|
57 |
286 |
2.7e-9 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 27 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Cd163 |
T |
A |
6: 124,284,246 (GRCm39) |
C139* |
probably null |
Het |
| Ces2g |
A |
G |
8: 105,691,769 (GRCm39) |
|
probably null |
Het |
| Ckap5 |
T |
C |
2: 91,402,885 (GRCm39) |
|
probably benign |
Het |
| Cmtm7 |
T |
C |
9: 114,592,336 (GRCm39) |
H87R |
probably damaging |
Het |
| Dennd3 |
A |
G |
15: 73,399,794 (GRCm39) |
D220G |
possibly damaging |
Het |
| Dpp10 |
T |
C |
1: 123,339,555 (GRCm39) |
Y324C |
probably damaging |
Het |
| Dsc3 |
C |
T |
18: 20,134,963 (GRCm39) |
R7Q |
probably benign |
Het |
| Ezh1 |
T |
C |
11: 101,086,392 (GRCm39) |
K598E |
possibly damaging |
Het |
| Ighv7-3 |
A |
G |
12: 114,117,045 (GRCm39) |
L39P |
probably damaging |
Het |
| Il1rap |
T |
A |
16: 26,442,932 (GRCm39) |
S9R |
possibly damaging |
Het |
| Oc90 |
G |
T |
15: 65,769,638 (GRCm39) |
P73Q |
probably damaging |
Het |
| Or2m12 |
T |
C |
16: 19,105,363 (GRCm39) |
I43M |
probably benign |
Het |
| Or3a1b |
G |
A |
11: 74,012,571 (GRCm39) |
W152* |
probably null |
Het |
| Pccb |
A |
G |
9: 100,869,894 (GRCm39) |
F346L |
possibly damaging |
Het |
| Pdxdc1 |
A |
G |
16: 13,687,720 (GRCm39) |
I225T |
probably damaging |
Het |
| Pold3 |
A |
T |
7: 99,749,703 (GRCm39) |
M154K |
probably damaging |
Het |
| Polr1a |
T |
G |
6: 71,927,786 (GRCm39) |
C846G |
probably benign |
Het |
| Ppip5k1 |
C |
A |
2: 121,162,089 (GRCm39) |
R978L |
possibly damaging |
Het |
| Ptpn4 |
A |
G |
1: 119,615,408 (GRCm39) |
V582A |
probably damaging |
Het |
| Sez6l |
G |
T |
5: 112,620,612 (GRCm39) |
Q323K |
probably damaging |
Het |
| Slc27a5 |
A |
T |
7: 12,727,270 (GRCm39) |
I384N |
possibly damaging |
Het |
| Slc39a10 |
G |
A |
1: 46,857,288 (GRCm39) |
A696V |
probably damaging |
Het |
| Slc7a2 |
T |
C |
8: 41,355,631 (GRCm39) |
F227L |
probably benign |
Het |
| Smad4 |
C |
A |
18: 73,791,723 (GRCm39) |
A273S |
probably benign |
Het |
| Spata17 |
T |
C |
1: 186,849,657 (GRCm39) |
I84V |
probably benign |
Het |
| Sphkap |
T |
C |
1: 83,268,708 (GRCm39) |
T95A |
probably damaging |
Het |
| Tie1 |
T |
C |
4: 118,329,995 (GRCm39) |
D1076G |
probably benign |
Het |
|
| Other mutations in Mrgpra3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00162:Mrgpra3
|
APN |
7 |
47,239,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02097:Mrgpra3
|
APN |
7 |
47,239,204 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03071:Mrgpra3
|
APN |
7 |
47,238,929 (GRCm39) |
utr 3 prime |
probably benign |
|
|
PIT4445001:Mrgpra3
|
UTSW |
7 |
47,239,908 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0828:Mrgpra3
|
UTSW |
7 |
47,239,884 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1118:Mrgpra3
|
UTSW |
7 |
47,239,039 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1835:Mrgpra3
|
UTSW |
7 |
47,239,694 (GRCm39) |
nonsense |
probably null |
|
|
R2258:Mrgpra3
|
UTSW |
7 |
47,239,842 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2393:Mrgpra3
|
UTSW |
7 |
47,239,365 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R3437:Mrgpra3
|
UTSW |
7 |
47,239,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3973:Mrgpra3
|
UTSW |
7 |
47,239,414 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4273:Mrgpra3
|
UTSW |
7 |
47,239,180 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4495:Mrgpra3
|
UTSW |
7 |
47,239,813 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4768:Mrgpra3
|
UTSW |
7 |
47,239,476 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4822:Mrgpra3
|
UTSW |
7 |
47,239,716 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4967:Mrgpra3
|
UTSW |
7 |
47,239,267 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5207:Mrgpra3
|
UTSW |
7 |
47,239,909 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5569:Mrgpra3
|
UTSW |
7 |
47,239,759 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5763:Mrgpra3
|
UTSW |
7 |
47,239,355 (GRCm39) |
nonsense |
probably null |
|
|
R6102:Mrgpra3
|
UTSW |
7 |
47,239,897 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6612:Mrgpra3
|
UTSW |
7 |
47,239,783 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6718:Mrgpra3
|
UTSW |
7 |
47,239,444 (GRCm39) |
missense |
probably benign |
0.25 |
|
R6859:Mrgpra3
|
UTSW |
7 |
47,239,781 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7029:Mrgpra3
|
UTSW |
7 |
47,239,290 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7034:Mrgpra3
|
UTSW |
7 |
47,239,838 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7036:Mrgpra3
|
UTSW |
7 |
47,239,838 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7097:Mrgpra3
|
UTSW |
7 |
47,239,389 (GRCm39) |
missense |
probably benign |
|
|
R7475:Mrgpra3
|
UTSW |
7 |
47,239,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8289:Mrgpra3
|
UTSW |
7 |
47,239,468 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8315:Mrgpra3
|
UTSW |
7 |
47,251,051 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
R9500:Mrgpra3
|
UTSW |
7 |
47,239,400 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Mrgpra3
|
UTSW |
7 |
47,251,049 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation