Incidental Mutation 'IGL02103:Olfr125'
ID279822
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr125
Ensembl Gene ENSMUSG00000050613
Gene Nameolfactory receptor 125
SynonymsGA_x6K02T2PSCP-2291580-2292542, MOR218-8
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.100) question?
Stock #IGL02103
Quality Score
Status
Chromosome17
Chromosomal Location37832949-37838490 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 37835278 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Arginine at position 93 (Q93R)
Ref Sequence ENSEMBL: ENSMUSP00000149602 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050255] [ENSMUST00000213857]
Predicted Effect possibly damaging
Transcript: ENSMUST00000050255
AA Change: Q93R

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000055221
Gene: ENSMUSG00000050613
AA Change: Q93R

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.7e-47 PFAM
Pfam:7tm_1 38 318 7.6e-28 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213857
AA Change: Q93R

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd4 G A 12: 84,612,364 T206M probably benign Het
Adcy3 T A 12: 4,134,390 V22D possibly damaging Het
Alb G A 5: 90,464,131 E140K probably benign Het
Aph1a G A 3: 95,895,813 V193I probably damaging Het
Asb2 G A 12: 103,333,496 R178* probably null Het
Celf3 A T 3: 94,486,801 Q137L probably damaging Het
Cmya5 T C 13: 93,092,127 D2151G probably benign Het
Cuedc1 T A 11: 88,188,799 S353T probably damaging Het
Dlg5 A C 14: 24,144,346 L1709R probably damaging Het
Dst T C 1: 34,190,118 I1939T possibly damaging Het
Emx2 A T 19: 59,461,698 N149I probably benign Het
Fancm A G 12: 65,095,784 D472G probably benign Het
Fasn T C 11: 120,811,936 Y1700C probably damaging Het
Fat2 T A 11: 55,289,296 R1406S probably damaging Het
Fat4 C A 3: 38,889,199 T747K probably damaging Het
Fer A G 17: 64,138,928 M795V probably benign Het
Gm5916 A G 9: 36,128,674 L6P probably damaging Het
Gpr139 A G 7: 119,145,132 F77L possibly damaging Het
Kcnu1 T C 8: 25,905,948 S654P possibly damaging Het
Kdm5c T A X: 152,248,766 F408L probably damaging Het
Kel A G 6: 41,702,389 S147P probably benign Het
Klra5 A T 6: 129,911,344 probably null Het
Mastl A G 2: 23,139,998 S239P probably benign Het
Med18 A T 4: 132,459,666 V174D probably damaging Het
Mgat4a A T 1: 37,462,926 M247K possibly damaging Het
Mx2 A C 16: 97,544,595 D71A probably damaging Het
Nxt1 G T 2: 148,675,644 E102* probably null Het
Olfr410 A G 11: 74,335,036 F65S probably damaging Het
Olfr828 T C 9: 18,815,709 N195S probably damaging Het
Pcdhb16 T A 18: 37,480,108 V707E probably benign Het
Pdzrn4 T A 15: 92,769,887 V640E probably damaging Het
Piwil4 T C 9: 14,725,986 probably null Het
Pla2g4a A T 1: 149,901,199 D55E probably damaging Het
Plekhg2 C A 7: 28,360,076 R1276L probably damaging Het
Psd4 G A 2: 24,400,528 W539* probably null Het
Rae1 G A 2: 173,003,513 E33K probably damaging Het
Rbm12b1 T A 4: 12,145,563 F512I probably damaging Het
Rfx6 A G 10: 51,726,856 D823G possibly damaging Het
Samt3 A T X: 86,047,153 Q217L probably damaging Het
Selenbp2 A G 3: 94,698,131 N134S probably null Het
Selenoo T C 15: 89,099,970 V663A probably damaging Het
Sp4 G T 12: 118,299,549 T254N probably damaging Het
Spdya A G 17: 71,578,247 K232R probably benign Het
Stom A T 2: 35,320,389 V201E probably benign Het
Sycp3 A G 10: 88,466,472 K108R possibly damaging Het
Usp2 A G 9: 44,089,128 probably benign Het
Vmn1r226 T C 17: 20,687,664 S53P probably damaging Het
Vmn2r14 C T 5: 109,224,483 G47D probably damaging Het
Vwf T G 6: 125,646,355 L1805W probably damaging Het
Washc3 A T 10: 88,201,825 Q22L probably damaging Het
Wdr81 T A 11: 75,444,720 D1761V probably damaging Het
Other mutations in Olfr125
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01943:Olfr125 APN 17 37835053 missense probably benign
IGL02121:Olfr125 APN 17 37835941 missense probably benign 0.01
IGL02183:Olfr125 APN 17 37835413 missense probably damaging 1.00
IGL02208:Olfr125 APN 17 37835524 missense probably damaging 1.00
IGL02822:Olfr125 APN 17 37835643 missense possibly damaging 0.95
IGL02833:Olfr125 APN 17 37835940 missense probably benign 0.02
IGL03324:Olfr125 APN 17 37835274 missense probably benign 0.23
R1689:Olfr125 UTSW 17 37835604 missense possibly damaging 0.88
R1719:Olfr125 UTSW 17 37835353 missense possibly damaging 0.76
R1878:Olfr125 UTSW 17 37835362 missense probably benign 0.03
R2064:Olfr125 UTSW 17 37835002 start codon destroyed probably null 0.06
R2696:Olfr125 UTSW 17 37835107 missense probably benign 0.00
R3800:Olfr125 UTSW 17 37835957 missense probably benign
R4469:Olfr125 UTSW 17 37835716 missense probably benign 0.35
R4801:Olfr125 UTSW 17 37835349 missense probably damaging 1.00
R4802:Olfr125 UTSW 17 37835349 missense probably damaging 1.00
R5473:Olfr125 UTSW 17 37835739 missense probably benign 0.04
R6743:Olfr125 UTSW 17 37835803 missense probably damaging 1.00
Posted On2015-04-16