Incidental Mutation 'IGL02106:Fcmr'
ID279991
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fcmr
Ensembl Gene ENSMUSG00000042474
Gene NameFc fragment of IgM receptor
Synonyms1810037B05Rik, FcmuR, Faim3
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02106
Quality Score
Status
Chromosome1
Chromosomal Location130865669-130880791 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 130875135 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 162 (S162P)
Ref Sequence ENSEMBL: ENSMUSP00000048303 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038829]
Predicted Effect probably benign
Transcript: ENSMUST00000038829
AA Change: S162P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000048303
Gene: ENSMUSG00000042474
AA Change: S162P

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:V-set 21 122 1.3e-10 PFAM
low complexity region 212 223 N/A INTRINSIC
transmembrane domain 264 283 N/A INTRINSIC
low complexity region 285 311 N/A INTRINSIC
low complexity region 344 363 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126821
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145446
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149355
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
PHENOTYPE: Mice homozygous for knock-out alleles exhibit a slight decrease in B cell numbers reduced sensitivity to Gal-induced liver damage, increased granulocyte production of ROS and increased sensitivity to infection by Listeria monocytogenes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcl9l A G 9: 44,509,199 N1264D probably benign Het
Bmyc A G 2: 25,707,070 K49E probably damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Ceacam2 A G 7: 25,530,741 S147P probably benign Het
Cep152 G T 2: 125,602,936 probably null Het
Cnbd1 G T 4: 18,894,993 P250T possibly damaging Het
Col6a4 A G 9: 106,063,105 C1209R possibly damaging Het
Coro1c T C 5: 113,852,273 T116A probably benign Het
Ddx46 A G 13: 55,677,603 probably benign Het
Dnaaf5 T C 5: 139,151,513 I207T probably damaging Het
Erap1 A G 13: 74,646,639 D139G probably benign Het
Fbxw22 A T 9: 109,402,019 I121N possibly damaging Het
Gadl1 A G 9: 115,937,157 probably benign Het
Gli2 T A 1: 118,836,735 S1229C probably benign Het
Gm10717 A T 9: 3,026,287 Y195F probably damaging Het
Gne T C 4: 44,037,306 N692D probably damaging Het
Knl1 A G 2: 119,072,008 T1397A possibly damaging Het
Lama3 C A 18: 12,468,314 A1016E probably damaging Het
Lhfpl2 A G 13: 94,191,911 D160G probably benign Het
Lmtk2 T A 5: 144,175,951 V1163E probably benign Het
Lrrtm2 G T 18: 35,212,815 S478* probably null Het
Nfatc2ip T C 7: 126,390,564 probably null Het
Nlrp12 A G 7: 3,233,944 I775T probably benign Het
Npr1 A G 3: 90,464,858 F216L probably benign Het
Olfr1451 G T 19: 12,999,565 S193I possibly damaging Het
Olfr206 T A 16: 59,345,024 N226Y probably benign Het
Olfr734 A T 14: 50,320,160 L225H probably damaging Het
Pkd1l1 C A 11: 8,833,800 G2052C probably damaging Het
Ppp1r16b A G 2: 158,746,531 N112S possibly damaging Het
Prr11 A G 11: 87,103,315 probably benign Het
Scap A G 9: 110,381,656 probably benign Het
Sirt1 C T 10: 63,335,829 R191Q probably damaging Het
Slc38a6 A C 12: 73,350,546 S321R possibly damaging Het
Sp140 T C 1: 85,643,219 V460A probably benign Het
Spdye4c A T 2: 128,592,666 K54N possibly damaging Het
Spta1 T A 1: 174,203,294 N947K probably benign Het
Srgap1 A G 10: 121,785,693 V965A possibly damaging Het
Tmem209 A C 6: 30,508,660 probably null Het
Trim37 A T 11: 87,201,404 K123* probably null Het
Trio T C 15: 27,744,158 T2563A possibly damaging Het
Utrn A T 10: 12,413,973 S734T possibly damaging Het
Vars2 A G 17: 35,664,621 probably benign Het
Xrn1 G A 9: 95,977,805 E417K probably benign Het
Yeats2 T A 16: 20,193,220 V515E possibly damaging Het
Other mutations in Fcmr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01638:Fcmr APN 1 130875122 missense probably benign 0.06
IGL01652:Fcmr APN 1 130878507 missense probably benign 0.25
IGL03270:Fcmr APN 1 130876042 missense possibly damaging 0.63
R1635:Fcmr UTSW 1 130876185 splice site probably null
R1651:Fcmr UTSW 1 130878251 missense probably benign
R1728:Fcmr UTSW 1 130875974 missense probably benign
R1728:Fcmr UTSW 1 130878269 missense probably benign 0.00
R1729:Fcmr UTSW 1 130875974 missense probably benign
R1729:Fcmr UTSW 1 130878269 missense probably benign 0.00
R1730:Fcmr UTSW 1 130875974 missense probably benign
R1730:Fcmr UTSW 1 130878269 missense probably benign 0.00
R1739:Fcmr UTSW 1 130875974 missense probably benign
R1739:Fcmr UTSW 1 130878269 missense probably benign 0.00
R1762:Fcmr UTSW 1 130875974 missense probably benign
R1762:Fcmr UTSW 1 130878269 missense probably benign 0.00
R1783:Fcmr UTSW 1 130875974 missense probably benign
R1783:Fcmr UTSW 1 130878269 missense probably benign 0.00
R1784:Fcmr UTSW 1 130875974 missense probably benign
R1784:Fcmr UTSW 1 130878269 missense probably benign 0.00
R1785:Fcmr UTSW 1 130875974 missense probably benign
R1785:Fcmr UTSW 1 130878269 missense probably benign 0.00
R2037:Fcmr UTSW 1 130878333 missense possibly damaging 0.61
R6111:Fcmr UTSW 1 130877829 missense probably damaging 0.96
R6217:Fcmr UTSW 1 130878323 missense probably damaging 0.96
R6538:Fcmr UTSW 1 130875025 missense possibly damaging 0.72
R6712:Fcmr UTSW 1 130877851 missense probably damaging 0.99
R6965:Fcmr UTSW 1 130875987 missense possibly damaging 0.65
X0025:Fcmr UTSW 1 130874267 missense probably damaging 1.00
Posted On2015-04-16