Incidental Mutation 'IGL02110:Cxcl2'
ID 280104
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cxcl2
Ensembl Gene ENSMUSG00000058427
Gene Name C-X-C motif chemokine ligand 2
Synonyms MIP-2a, Mgsa-b, Mip2, CINC-2a, Gro2, GROb, Scyb, Scyb2, MIP-2
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02110
Quality Score
Status
Chromosome 5
Chromosomal Location 91051758-91053797 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 91052211 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000144334 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075433] [ENSMUST00000200681]
AlphaFold P10889
Predicted Effect probably benign
Transcript: ENSMUST00000075433
SMART Domains Protein: ENSMUSP00000074885
Gene: ENSMUSG00000058427

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
SCY 33 93 2.07e-20 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000200681
SMART Domains Protein: ENSMUSP00000144334
Gene: ENSMUSG00000058427

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
SCY 33 93 1e-22 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200919
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202317
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apol7e A G 15: 77,598,548 (GRCm39) probably null Het
Arhgef40 C T 14: 52,226,862 (GRCm39) T302M probably damaging Het
Bap1 T C 14: 30,979,371 (GRCm39) L458P probably damaging Het
Bbs12 A G 3: 37,373,336 (GRCm39) E43G probably benign Het
Bod1l C T 5: 41,973,796 (GRCm39) C2506Y probably damaging Het
Ccdc170 A G 10: 4,491,885 (GRCm39) probably null Het
Chpf2 A G 5: 24,796,710 (GRCm39) E552G probably damaging Het
Comp T A 8: 70,826,289 (GRCm39) I23N probably benign Het
Dctn5 T C 7: 121,734,374 (GRCm39) F73L probably damaging Het
Ddx5 T C 11: 106,675,835 (GRCm39) E285G probably damaging Het
Ddx60 T G 8: 62,470,281 (GRCm39) probably null Het
Dhcr24 T A 4: 106,430,998 (GRCm39) I229N probably damaging Het
Dnah7a G A 1: 53,450,739 (GRCm39) T3897I possibly damaging Het
Dvl2 T A 11: 69,898,842 (GRCm39) probably benign Het
Dytn A T 1: 63,686,632 (GRCm39) V346E possibly damaging Het
Eepd1 T C 9: 25,514,698 (GRCm39) probably benign Het
Fbln2 G T 6: 91,211,084 (GRCm39) A343S probably benign Het
Flywch1 T C 17: 23,982,066 (GRCm39) probably null Het
Gckr A T 5: 31,456,082 (GRCm39) T81S possibly damaging Het
Gm6139 T A 5: 129,700,656 (GRCm39) noncoding transcript Het
Gpcpd1 A T 2: 132,372,530 (GRCm39) C657* probably null Het
Greb1l A G 18: 10,515,271 (GRCm39) I89V probably damaging Het
Hdac4 G A 1: 91,912,127 (GRCm39) P421S probably benign Het
Iqca1l A G 5: 24,753,082 (GRCm39) probably benign Het
Klhl1 A G 14: 96,374,039 (GRCm39) L669P probably benign Het
Mios A G 6: 8,215,565 (GRCm39) R254G probably damaging Het
Mmp19 A G 10: 128,630,727 (GRCm39) N116D probably damaging Het
Muc5b T A 7: 141,401,453 (GRCm39) C566* probably null Het
Nadsyn1 T C 7: 143,367,164 (GRCm39) Y141C probably damaging Het
Nlrp4d T C 7: 10,116,491 (GRCm39) noncoding transcript Het
Nob1 A T 8: 108,142,804 (GRCm39) *160R probably null Het
Or10ac1 A G 6: 42,515,113 (GRCm39) V281A possibly damaging Het
Or1f12 T A 13: 21,722,112 (GRCm39) Q21L possibly damaging Het
Or1j17 A G 2: 36,578,697 (GRCm39) T228A probably benign Het
Or4k45 C T 2: 111,395,252 (GRCm39) C179Y probably damaging Het
Or51s1 C T 7: 102,558,402 (GRCm39) V215I probably benign Het
Or56b1b C A 7: 108,164,286 (GRCm39) A239S probably damaging Het
Phc1 T C 6: 122,298,994 (GRCm39) D658G possibly damaging Het
Pitx2 T G 3: 129,012,466 (GRCm39) S299A probably damaging Het
Plekha7 C A 7: 115,753,863 (GRCm39) probably null Het
Ptgfr A G 3: 151,541,097 (GRCm39) V137A probably damaging Het
Ptprb T C 10: 116,167,108 (GRCm39) probably benign Het
Rasl2-9 C T 7: 5,128,346 (GRCm39) A195T probably benign Het
Ripor3 T A 2: 167,836,626 (GRCm39) Q121L possibly damaging Het
Sgsh G T 11: 119,243,632 (GRCm39) A30E probably damaging Het
Sis G T 3: 72,836,032 (GRCm39) C852* probably null Het
Slc17a9 A G 2: 180,374,369 (GRCm39) probably benign Het
Slco6b1 A T 1: 96,915,607 (GRCm39) noncoding transcript Het
Smarca2 A G 19: 26,650,140 (GRCm39) Y704C possibly damaging Het
Spata6 A T 4: 111,642,003 (GRCm39) H291L possibly damaging Het
Stra8 T C 6: 34,907,289 (GRCm39) probably benign Het
Taldo1 T C 7: 140,982,647 (GRCm39) probably benign Het
Tmco6 T C 18: 36,868,219 (GRCm39) probably benign Het
Tmpo A C 10: 90,998,727 (GRCm39) S353R probably damaging Het
Tpr A T 1: 150,311,493 (GRCm39) Q1757L probably damaging Het
Ubn1 T C 16: 4,899,754 (GRCm39) probably benign Het
Vmn2r83 T C 10: 79,327,534 (GRCm39) V714A possibly damaging Het
Zfp407 G T 18: 84,577,165 (GRCm39) A1316D probably benign Het
Zzef1 T A 11: 72,803,938 (GRCm39) I2560N probably damaging Het
Other mutations in Cxcl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1559:Cxcl2 UTSW 5 91,051,871 (GRCm39) missense probably benign 0.00
R1739:Cxcl2 UTSW 5 91,052,017 (GRCm39) missense probably damaging 1.00
R4035:Cxcl2 UTSW 5 91,052,272 (GRCm39) missense possibly damaging 0.69
R4161:Cxcl2 UTSW 5 91,051,881 (GRCm39) splice site probably null
R6558:Cxcl2 UTSW 5 91,052,224 (GRCm39) missense probably damaging 1.00
R7172:Cxcl2 UTSW 5 91,051,879 (GRCm39) missense probably benign 0.00
R8293:Cxcl2 UTSW 5 91,052,088 (GRCm39) missense probably damaging 1.00
R8885:Cxcl2 UTSW 5 91,052,085 (GRCm39) nonsense probably null
R9480:Cxcl2 UTSW 5 91,052,029 (GRCm39) missense possibly damaging 0.78
Posted On 2015-04-16