Incidental Mutation 'IGL02112:Or7d10'
ID 280190
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7d10
Ensembl Gene ENSMUSG00000051118
Gene Name olfactory receptor family 7 subfamily D member 10
Synonyms 18A, Olfr77, GA_x6K02T2PVTD-13660026-13660964, MOR143-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # IGL02112
Quality Score
Status
Chromosome 9
Chromosomal Location 19828525-19833806 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19831821 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 105 (N105K)
Ref Sequence ENSEMBL: ENSMUSP00000149055 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057596] [ENSMUST00000217347]
AlphaFold Q8VEY9
Predicted Effect possibly damaging
Transcript: ENSMUST00000057596
AA Change: N105K

PolyPhen 2 Score 0.479 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000058810
Gene: ENSMUSG00000051118
AA Change: N105K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3e-53 PFAM
Pfam:7tm_1 41 290 1.2e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000217347
AA Change: N105K

PolyPhen 2 Score 0.479 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34 T A 8: 44,104,175 (GRCm39) Y490F possibly damaging Het
Appbp2 A T 11: 85,092,446 (GRCm39) H271Q probably benign Het
Arhgap17 A T 7: 122,917,640 (GRCm39) D181E possibly damaging Het
Arhgap25 T A 6: 87,444,919 (GRCm39) Y286F possibly damaging Het
Atf2 T C 2: 73,649,381 (GRCm39) K352R probably damaging Het
Bdp1 G A 13: 100,174,308 (GRCm39) T2076I probably benign Het
C1s2 A G 6: 124,602,267 (GRCm39) V642A probably benign Het
Cldn18 T A 9: 99,580,128 (GRCm39) T170S probably benign Het
Cntnap5c T A 17: 58,620,853 (GRCm39) H977Q probably benign Het
Col15a1 T A 4: 47,253,985 (GRCm39) probably benign Het
Csmd1 A T 8: 16,131,719 (GRCm39) Y1669N probably benign Het
Csmd3 A C 15: 48,177,265 (GRCm39) S424R possibly damaging Het
Cyp4a31 A G 4: 115,428,180 (GRCm39) D306G probably damaging Het
E2f2 A G 4: 135,920,145 (GRCm39) T377A probably benign Het
Edil3 A G 13: 89,328,374 (GRCm39) D276G probably damaging Het
Ei24 A T 9: 36,693,638 (GRCm39) Y305N probably damaging Het
Erbin T C 13: 103,998,844 (GRCm39) N181D probably benign Het
Gli3 A G 13: 15,837,099 (GRCm39) Q494R probably damaging Het
Gm16519 T C 17: 71,236,291 (GRCm39) I80T probably damaging Het
Haus8 T A 8: 71,708,205 (GRCm39) E163V probably damaging Het
Hephl1 G T 9: 14,993,111 (GRCm39) probably benign Het
Hnrnph3 A G 10: 62,852,184 (GRCm39) probably null Het
Liat1 G T 11: 75,894,214 (GRCm39) C197F probably benign Het
Mast2 A T 4: 116,176,961 (GRCm39) C437S probably damaging Het
Mef2a A C 7: 66,914,620 (GRCm39) S91R probably damaging Het
Mfge8 A T 7: 78,793,088 (GRCm39) V126D probably benign Het
Nrdc A G 4: 108,884,629 (GRCm39) probably benign Het
Panx2 A G 15: 88,953,772 (GRCm39) T576A probably benign Het
Per3 T C 4: 151,113,640 (GRCm39) Y306C probably benign Het
Ppm1h G A 10: 122,638,305 (GRCm39) G192R possibly damaging Het
Prss22 T C 17: 24,212,945 (GRCm39) E264G probably damaging Het
Rasa3 A G 8: 13,635,042 (GRCm39) probably benign Het
Rpl7a-ps8 C A 7: 19,687,985 (GRCm39) probably benign Het
Rundc1 A G 11: 101,324,425 (GRCm39) D377G probably benign Het
Sh3bp1 T C 15: 78,790,084 (GRCm39) probably null Het
Sobp A G 10: 42,897,873 (GRCm39) S571P probably benign Het
Styxl2 C A 1: 165,927,240 (GRCm39) E791* probably null Het
Syce1 C A 7: 140,359,545 (GRCm39) M114I probably benign Het
Tdrd6 G A 17: 43,940,242 (GRCm39) R269W probably damaging Het
Tmprss13 T C 9: 45,250,702 (GRCm39) S408P probably damaging Het
Tonsl T C 15: 76,517,602 (GRCm39) T706A probably benign Het
Tpcn2 A G 7: 144,810,529 (GRCm39) S603P probably benign Het
Trmt12 A T 15: 58,744,665 (GRCm39) Q21L probably damaging Het
Vmn1r68 C T 7: 10,261,787 (GRCm39) G104S probably damaging Het
Vmn2r82 T C 10: 79,231,833 (GRCm39) W611R probably benign Het
Vmn2r90 C A 17: 17,932,465 (GRCm39) T124K probably damaging Het
Vmn2r99 A G 17: 19,600,494 (GRCm39) E506G probably null Het
Other mutations in Or7d10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01152:Or7d10 APN 9 19,832,245 (GRCm39) missense possibly damaging 0.87
IGL01318:Or7d10 APN 9 19,832,054 (GRCm39) missense probably benign 0.44
IGL01547:Or7d10 APN 9 19,832,197 (GRCm39) missense probably benign 0.00
IGL01635:Or7d10 APN 9 19,831,780 (GRCm39) missense probably damaging 1.00
IGL02858:Or7d10 APN 9 19,831,747 (GRCm39) missense probably damaging 0.99
IGL02904:Or7d10 APN 9 19,832,393 (GRCm39) missense probably damaging 1.00
IGL02956:Or7d10 APN 9 19,832,348 (GRCm39) missense possibly damaging 0.87
IGL03066:Or7d10 APN 9 19,831,667 (GRCm39) missense probably benign 0.12
R0662:Or7d10 UTSW 9 19,831,796 (GRCm39) missense probably damaging 1.00
R1222:Or7d10 UTSW 9 19,832,344 (GRCm39) missense possibly damaging 0.87
R1572:Or7d10 UTSW 9 19,832,208 (GRCm39) missense probably benign 0.35
R1761:Or7d10 UTSW 9 19,832,445 (GRCm39) makesense probably null
R2409:Or7d10 UTSW 9 19,832,077 (GRCm39) missense probably damaging 1.00
R2409:Or7d10 UTSW 9 19,832,072 (GRCm39) missense probably benign 0.31
R3621:Or7d10 UTSW 9 19,832,209 (GRCm39) missense probably damaging 0.99
R3849:Or7d10 UTSW 9 19,832,105 (GRCm39) missense probably damaging 1.00
R3850:Or7d10 UTSW 9 19,832,105 (GRCm39) missense probably damaging 1.00
R4277:Or7d10 UTSW 9 19,831,685 (GRCm39) missense possibly damaging 0.91
R4768:Or7d10 UTSW 9 19,831,841 (GRCm39) missense possibly damaging 0.56
R4979:Or7d10 UTSW 9 19,831,655 (GRCm39) missense probably benign 0.03
R5276:Or7d10 UTSW 9 19,831,917 (GRCm39) missense possibly damaging 0.87
R5503:Or7d10 UTSW 9 19,831,675 (GRCm39) missense probably benign 0.36
R5760:Or7d10 UTSW 9 19,832,050 (GRCm39) missense probably benign 0.00
R5778:Or7d10 UTSW 9 19,832,337 (GRCm39) missense probably benign 0.20
R5930:Or7d10 UTSW 9 19,832,206 (GRCm39) missense probably damaging 0.99
R6012:Or7d10 UTSW 9 19,832,237 (GRCm39) missense probably damaging 0.99
R7269:Or7d10 UTSW 9 19,831,631 (GRCm39) missense possibly damaging 0.95
R7977:Or7d10 UTSW 9 19,831,610 (GRCm39) missense possibly damaging 0.48
R7987:Or7d10 UTSW 9 19,831,610 (GRCm39) missense possibly damaging 0.48
R8174:Or7d10 UTSW 9 19,832,020 (GRCm39) missense probably damaging 1.00
Z1088:Or7d10 UTSW 9 19,832,008 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16