Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02115:Vmn2r67'

280327

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r67

Ensembl Gene

ENSMUSG00000095664

Gene Name

vomeronasal 2, receptor 67

Synonyms

EG620672

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.111) question?

Stock #

IGL02115

Quality Score

Status

Chromosome

Chromosomal Location

84785448-84805110 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 84800787 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 383 (M383K)

Ref Sequence

ENSEMBL: ENSMUSP00000126007 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168730]

AlphaFold

K7N6T2

Predicted Effect

probably damaging
Transcript: ENSMUST00000168730
AA Change: M383K

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000126007
Gene: ENSMUSG00000095664
AA Change: M383K

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:ANF_receptor	77	464	2.1e-31	PFAM
Pfam:NCD3G	507	559	4.8e-19	PFAM
Pfam:7tm_3	590	827	1.4e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933440M02Rik	A	T	7: 124,930,781 (GRCm39)		noncoding transcript	Het
Abca7	A	T	10: 79,833,913 (GRCm39)	N76Y	probably damaging	Het
Apob	A	G	12: 8,042,923 (GRCm39)	K755R	probably benign	Het
BC034090	A	T	1: 155,108,397 (GRCm39)		probably benign	Het
Brinp1	T	C	4: 68,680,635 (GRCm39)	T632A	probably benign	Het
Cdcp1	C	A	9: 123,014,462 (GRCm39)	C104F	probably damaging	Het
Cfap206	C	T	4: 34,722,623 (GRCm39)	V153I	possibly damaging	Het
Chd1l	A	T	3: 97,497,220 (GRCm39)		probably null	Het
Ckb	A	G	12: 111,636,415 (GRCm39)	F271L	possibly damaging	Het
Col6a3	T	A	1: 90,735,373 (GRCm39)	I759L	probably damaging	Het
Ddr2	A	T	1: 169,822,278 (GRCm39)	M390K	probably benign	Het
Dhx8	C	T	11: 101,643,214 (GRCm39)	P762L	probably damaging	Het
Dnah3	A	T	7: 119,628,277 (GRCm39)	V1449E	probably damaging	Het
Dzip3	T	C	16: 48,768,848 (GRCm39)	I629M	probably benign	Het
Ep300	T	C	15: 81,533,019 (GRCm39)	I1692T	unknown	Het
Ercc6	T	A	14: 32,298,950 (GRCm39)	L1446Q	probably damaging	Het
Gm10092	T	C	16: 35,957,993 (GRCm39)		noncoding transcript	Het
Gm6900	A	T	7: 10,390,503 (GRCm39)		noncoding transcript	Het
Gpr149	T	C	3: 62,502,336 (GRCm39)	T507A	probably benign	Het
Hmcn1	T	A	1: 150,506,479 (GRCm39)	D3776V	probably damaging	Het
Irgm2	A	G	11: 58,110,948 (GRCm39)	E225G	probably benign	Het
Kif14	T	C	1: 136,424,305 (GRCm39)		probably benign	Het
Klhl22	T	C	16: 17,594,459 (GRCm39)	V196A	probably damaging	Het
Lig4	T	C	8: 10,023,247 (GRCm39)	S178G	possibly damaging	Het
Lzts2	A	G	19: 45,014,809 (GRCm39)		probably benign	Het
Mcoln3	C	T	3: 145,843,056 (GRCm39)	S380L	probably damaging	Het
Med12l	A	T	3: 58,975,740 (GRCm39)	T223S	probably benign	Het
Mrpl54	A	G	10: 81,101,483 (GRCm39)		probably null	Het
Myo1c	A	T	11: 75,552,417 (GRCm39)	I397F	probably damaging	Het
Nbas	A	T	12: 13,367,693 (GRCm39)		probably benign	Het
Ncoa2	G	A	1: 13,223,041 (GRCm39)	H1195Y	probably damaging	Het
Nol3	A	G	8: 106,006,263 (GRCm39)	M171V	probably benign	Het
Or2l5	A	T	16: 19,333,853 (GRCm39)	C178S	probably damaging	Het
Or52s1	A	G	7: 102,861,681 (GRCm39)	T194A	probably damaging	Het
Pdpr	C	T	8: 111,830,630 (GRCm39)	L107F	probably damaging	Het
Ppfibp2	G	A	7: 107,338,525 (GRCm39)		probably benign	Het
Rusc2	T	C	4: 43,426,136 (GRCm39)		probably benign	Het
Sdk2	G	T	11: 113,725,639 (GRCm39)		probably benign	Het
Sema7a	T	C	9: 57,868,183 (GRCm39)	C539R	probably damaging	Het
Senp6	T	C	9: 80,029,208 (GRCm39)	C524R	probably damaging	Het
Setdb2	C	T	14: 59,639,764 (GRCm39)	R709Q	probably damaging	Het
Slc15a1	A	T	14: 121,718,073 (GRCm39)	Y269N	possibly damaging	Het
Synj2	T	A	17: 6,067,865 (GRCm39)	Y113N	probably damaging	Het
Tm6sf1	A	T	7: 81,525,551 (GRCm39)	Y172F	probably damaging	Het
Trpv4	T	C	5: 114,763,090 (GRCm39)	D773G	probably damaging	Het
Ttc39a	A	G	4: 109,283,491 (GRCm39)		probably benign	Het
Tut1	C	T	19: 8,942,676 (GRCm39)	R588W	probably damaging	Het
Unc79	A	T	12: 102,964,933 (GRCm39)	Y74F	probably damaging	Het
Usp53	A	T	3: 122,741,039 (GRCm39)	I737K	probably benign	Het
Zc3h4	A	G	7: 16,159,708 (GRCm39)	D426G	unknown	Het
Zfp622	A	G	15: 25,987,286 (GRCm39)	N308S	probably damaging	Het

Other mutations in Vmn2r67

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00096:Vmn2r67	APN	7	84,801,138 (GRCm39)	missense	probably damaging	1.00
IGL01346:Vmn2r67	APN	7	84,786,127 (GRCm39)	missense	probably damaging	1.00
IGL01373:Vmn2r67	APN	7	84,785,834 (GRCm39)	missense	probably benign	0.10
IGL01674:Vmn2r67	APN	7	84,785,651 (GRCm39)	missense	probably damaging	1.00
IGL01978:Vmn2r67	APN	7	84,800,649 (GRCm39)	critical splice donor site	probably null
IGL02013:Vmn2r67	APN	7	84,800,863 (GRCm39)	missense	probably benign	0.09
IGL02250:Vmn2r67	APN	7	84,805,008 (GRCm39)	missense	probably benign
IGL02252:Vmn2r67	APN	7	84,805,008 (GRCm39)	missense	probably benign
IGL02328:Vmn2r67	APN	7	84,799,898 (GRCm39)	missense	probably benign	0.41
IGL02740:Vmn2r67	APN	7	84,785,818 (GRCm39)	missense	probably damaging	1.00
IGL02940:Vmn2r67	APN	7	84,785,951 (GRCm39)	missense	probably benign	0.07
IGL03237:Vmn2r67	APN	7	84,799,118 (GRCm39)	missense	probably damaging	1.00
R0512:Vmn2r67	UTSW	7	84,799,900 (GRCm39)	missense	probably damaging	1.00
R1029:Vmn2r67	UTSW	7	84,785,974 (GRCm39)	missense	probably damaging	1.00
R1193:Vmn2r67	UTSW	7	84,800,653 (GRCm39)	missense	probably damaging	0.98
R1282:Vmn2r67	UTSW	7	84,785,932 (GRCm39)	missense	probably benign
R1416:Vmn2r67	UTSW	7	84,800,824 (GRCm39)	missense	probably benign	0.06
R1429:Vmn2r67	UTSW	7	84,802,031 (GRCm39)	missense	possibly damaging	0.65
R1462:Vmn2r67	UTSW	7	84,805,046 (GRCm39)	missense	probably benign	0.00
R1462:Vmn2r67	UTSW	7	84,805,046 (GRCm39)	missense	probably benign	0.00
R1970:Vmn2r67	UTSW	7	84,801,013 (GRCm39)	missense	probably benign
R2229:Vmn2r67	UTSW	7	84,801,250 (GRCm39)	missense	probably benign	0.21
R2246:Vmn2r67	UTSW	7	84,785,764 (GRCm39)	missense	probably damaging	1.00
R2262:Vmn2r67	UTSW	7	84,786,182 (GRCm39)	missense	probably damaging	0.96
R2398:Vmn2r67	UTSW	7	84,785,921 (GRCm39)	missense	probably damaging	1.00
R4249:Vmn2r67	UTSW	7	84,799,722 (GRCm39)	splice site	probably null
R4666:Vmn2r67	UTSW	7	84,799,831 (GRCm39)	missense	probably benign
R4669:Vmn2r67	UTSW	7	84,799,732 (GRCm39)	missense	probably benign	0.11
R4966:Vmn2r67	UTSW	7	84,785,593 (GRCm39)	missense	probably damaging	1.00
R5264:Vmn2r67	UTSW	7	84,801,453 (GRCm39)	missense	probably damaging	1.00
R5296:Vmn2r67	UTSW	7	84,786,230 (GRCm39)	missense	probably damaging	1.00
R5327:Vmn2r67	UTSW	7	84,785,698 (GRCm39)	missense	probably damaging	1.00
R5401:Vmn2r67	UTSW	7	84,785,765 (GRCm39)	missense	probably damaging	1.00
R5510:Vmn2r67	UTSW	7	84,801,023 (GRCm39)	missense	probably benign	0.39
R5574:Vmn2r67	UTSW	7	84,801,099 (GRCm39)	missense	probably benign	0.00
R5643:Vmn2r67	UTSW	7	84,799,151 (GRCm39)	nonsense	probably null
R5914:Vmn2r67	UTSW	7	84,801,044 (GRCm39)	missense	probably damaging	1.00
R6248:Vmn2r67	UTSW	7	84,799,768 (GRCm39)	missense	probably damaging	0.99
R6291:Vmn2r67	UTSW	7	84,799,142 (GRCm39)	missense	possibly damaging	0.88
R6309:Vmn2r67	UTSW	7	84,801,124 (GRCm39)	missense	probably benign
R6442:Vmn2r67	UTSW	7	84,805,046 (GRCm39)	missense	possibly damaging	0.82
R6665:Vmn2r67	UTSW	7	84,785,900 (GRCm39)	missense	probably benign	0.07
R6701:Vmn2r67	UTSW	7	84,802,023 (GRCm39)	missense	probably damaging	1.00
R6848:Vmn2r67	UTSW	7	84,801,840 (GRCm39)	missense	probably benign	0.00
R6852:Vmn2r67	UTSW	7	84,801,361 (GRCm39)	missense	probably damaging	0.99
R6991:Vmn2r67	UTSW	7	84,804,953 (GRCm39)	missense	possibly damaging	0.55
R7143:Vmn2r67	UTSW	7	84,801,846 (GRCm39)	missense	probably benign
R7197:Vmn2r67	UTSW	7	84,785,774 (GRCm39)	missense	possibly damaging	0.77
R7393:Vmn2r67	UTSW	7	84,805,086 (GRCm39)	missense	probably null	0.87
R7420:Vmn2r67	UTSW	7	84,785,944 (GRCm39)	missense	possibly damaging	0.52
R7622:Vmn2r67	UTSW	7	84,785,662 (GRCm39)	missense	probably damaging	1.00
R7664:Vmn2r67	UTSW	7	84,805,019 (GRCm39)	missense	probably benign	0.21
R7665:Vmn2r67	UTSW	7	84,801,196 (GRCm39)	nonsense	probably null
R7896:Vmn2r67	UTSW	7	84,785,920 (GRCm39)	missense	probably damaging	1.00
R7913:Vmn2r67	UTSW	7	84,801,036 (GRCm39)	missense	possibly damaging	0.87
R8026:Vmn2r67	UTSW	7	84,785,924 (GRCm39)	missense	probably damaging	1.00
R8114:Vmn2r67	UTSW	7	84,805,097 (GRCm39)	missense	probably benign	0.01
R8317:Vmn2r67	UTSW	7	84,785,834 (GRCm39)	missense	probably benign	0.10
R8363:Vmn2r67	UTSW	7	84,804,969 (GRCm39)	missense	probably benign	0.00
R8421:Vmn2r67	UTSW	7	84,785,893 (GRCm39)	missense	probably damaging	0.98
R8444:Vmn2r67	UTSW	7	84,785,854 (GRCm39)	missense	probably benign	0.01
R8751:Vmn2r67	UTSW	7	84,801,450 (GRCm39)	missense	probably benign	0.01
R8810:Vmn2r67	UTSW	7	84,786,346 (GRCm39)	missense	probably damaging	1.00
R8811:Vmn2r67	UTSW	7	84,799,895 (GRCm39)	missense	probably damaging	0.98
R9215:Vmn2r67	UTSW	7	84,802,008 (GRCm39)	missense	probably benign	0.00
R9342:Vmn2r67	UTSW	7	84,785,788 (GRCm39)	missense	probably benign	0.00
R9433:Vmn2r67	UTSW	7	84,804,917 (GRCm39)	missense	possibly damaging	0.60
R9453:Vmn2r67	UTSW	7	84,800,697 (GRCm39)	missense	probably benign	0.32
R9471:Vmn2r67	UTSW	7	84,799,723 (GRCm39)	critical splice donor site	probably null
R9526:Vmn2r67	UTSW	7	84,785,834 (GRCm39)	missense	probably benign	0.10
R9538:Vmn2r67	UTSW	7	84,801,327 (GRCm39)	missense
R9544:Vmn2r67	UTSW	7	84,786,317 (GRCm39)	missense	possibly damaging	0.53
R9574:Vmn2r67	UTSW	7	84,786,017 (GRCm39)	missense	probably benign	0.00
R9599:Vmn2r67	UTSW	7	84,804,941 (GRCm39)	missense	probably damaging	0.96
R9768:Vmn2r67	UTSW	7	84,802,037 (GRCm39)	missense	probably benign	0.23

Posted On

2015-04-16