Incidental Mutation 'IGL02117:Olfr740'
ID280414
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr740
Ensembl Gene ENSMUSG00000095917
Gene Nameolfactory receptor 740
SynonymsMOR106-4, GA_x6K02T2PMLR-6167145-6168080
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.127) question?
Stock #IGL02117
Quality Score
Status
Chromosome14
Chromosomal Location50445545-50456933 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 50453942 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Glycine at position 297 (R297G)
Ref Sequence ENSEMBL: ENSMUSP00000148916 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089838] [ENSMUST00000214792]
Predicted Effect possibly damaging
Transcript: ENSMUST00000089838
AA Change: R297G

PolyPhen 2 Score 0.908 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000087276
Gene: ENSMUSG00000095917
AA Change: R297G

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 2.3e-56 PFAM
Pfam:7tm_1 45 294 1.6e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214792
AA Change: R297G

PolyPhen 2 Score 0.908 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik T A 2: 151,473,546 M71L probably benign Het
Abcb11 A G 2: 69,323,825 probably benign Het
Ago4 T C 4: 126,516,852 T249A probably benign Het
Ahr A T 12: 35,512,923 C92* probably null Het
Arhgap17 G A 7: 123,286,773 probably benign Het
Arid1a G T 4: 133,692,815 T992K unknown Het
Camk2a A G 18: 60,977,989 I83M probably damaging Het
Ccdc154 T C 17: 25,167,818 probably null Het
Chtf18 T C 17: 25,722,203 H607R possibly damaging Het
Col25a1 T C 3: 130,519,773 probably benign Het
Col9a1 C T 1: 24,237,493 Q530* probably null Het
Cryl1 G T 14: 57,286,447 D219E probably damaging Het
Cul3 A T 1: 80,323,064 probably benign Het
Cul9 C A 17: 46,540,375 R373L probably benign Het
Exo1 A G 1: 175,893,743 Y316C possibly damaging Het
Fam114a1 G A 5: 65,030,122 V408M probably benign Het
Hmcn2 A T 2: 31,457,173 S4792C possibly damaging Het
Hps5 A G 7: 46,783,516 F260S probably damaging Het
Hrh4 T C 18: 13,022,420 S339P probably benign Het
Ist1 A T 8: 109,678,952 L152Q probably damaging Het
Marco A G 1: 120,490,954 V190A probably benign Het
Mdn1 T C 4: 32,709,364 V1711A probably benign Het
Mmp9 A G 2: 164,949,724 Y179C probably damaging Het
Mrgprb5 A G 7: 48,168,994 probably benign Het
Mrgprx1 G T 7: 48,021,623 C125* probably null Het
Msh6 A G 17: 87,990,806 probably benign Het
Myot C A 18: 44,355,110 R441S probably benign Het
Paf1 A G 7: 28,398,690 probably benign Het
Pde11a A G 2: 75,991,262 L891P probably damaging Het
Prkar2a T A 9: 108,719,261 I135N probably damaging Het
Rap1gap C T 4: 137,727,044 T646M probably damaging Het
Rgs7bp T C 13: 104,951,579 D229G possibly damaging Het
Rhobtb3 C T 13: 75,877,428 S523N probably damaging Het
Setd7 A T 3: 51,521,405 Y335N probably damaging Het
Setdb2 C T 14: 59,402,315 R709Q probably damaging Het
Socs4 T C 14: 47,290,807 Y400H probably damaging Het
Spag16 A T 1: 69,870,320 H192L probably damaging Het
Ssh1 A T 5: 113,946,480 C566* probably null Het
Stap1 T G 5: 86,086,693 I98S possibly damaging Het
Tgs1 C T 4: 3,585,836 H238Y probably damaging Het
Tifab T C 13: 56,176,462 Y56C probably benign Het
Tssk2 A G 16: 17,899,789 E352G probably benign Het
Vmn2r57 A T 7: 41,400,450 V625D probably benign Het
Wbp1l T C 19: 46,644,437 Y75H probably benign Het
Wnt5a T C 14: 28,506,120 probably benign Het
Other mutations in Olfr740
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01663:Olfr740 APN 14 50453150 missense probably benign 0.04
IGL02663:Olfr740 APN 14 50453852 missense probably benign 0.02
IGL02858:Olfr740 APN 14 50453050 utr 5 prime probably benign
IGL02955:Olfr740 APN 14 50453985 missense probably damaging 0.99
IGL03210:Olfr740 APN 14 50453983 missense probably benign 0.10
IGL03249:Olfr740 APN 14 50453211 missense probably damaging 0.98
R0946:Olfr740 UTSW 14 50453673 missense probably benign 0.13
R1449:Olfr740 UTSW 14 50453921 missense probably damaging 1.00
R1465:Olfr740 UTSW 14 50453177 missense possibly damaging 0.91
R1465:Olfr740 UTSW 14 50453177 missense possibly damaging 0.91
R1513:Olfr740 UTSW 14 50453681 missense probably benign 0.00
R1908:Olfr740 UTSW 14 50453838 missense probably damaging 0.99
R2422:Olfr740 UTSW 14 50453436 missense probably damaging 1.00
R3406:Olfr740 UTSW 14 50453196 missense probably benign 0.14
R4184:Olfr740 UTSW 14 50453370 missense probably damaging 1.00
R4795:Olfr740 UTSW 14 50453417 missense probably damaging 0.96
R5028:Olfr740 UTSW 14 50453739 missense probably damaging 1.00
R5436:Olfr740 UTSW 14 50453727 missense probably damaging 1.00
R6057:Olfr740 UTSW 14 50453744 nonsense probably null
R6455:Olfr740 UTSW 14 50453585 missense possibly damaging 0.92
R6903:Olfr740 UTSW 14 50453955 missense possibly damaging 0.93
R6998:Olfr740 UTSW 14 50453433 missense probably benign 0.29
X0066:Olfr740 UTSW 14 50453658 missense probably benign 0.00
Posted On2015-04-16