Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00956:Slc35f3'

28053

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Slc35f3

Ensembl Gene

ENSMUSG00000057060

Gene Name

solute carrier family 35, member F3

Synonyms

B230375D17Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.160) question?

Stock #

IGL00956

Quality Score

Status

Chromosome

Chromosomal Location

126865734-127122717 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 127108963 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Threonine at position 171 (A171T)

Ref Sequence

ENSEMBL: ENSMUSP00000104390 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108759]

AlphaFold

Q1LZI2

Predicted Effect

probably damaging
Transcript: ENSMUST00000108759
AA Change: A171T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000104390
Gene: ENSMUSG00000057060
AA Change: A171T

Domain	Start	End	E-Value	Type
low complexity region	25	49	N/A	INTRINSIC
Pfam:EamA	67	223	3.2e-7	PFAM
Pfam:SLC35F	145	374	3.2e-6	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cdhr2	G	T	13: 54,866,156 (GRCm39)	V319F	probably damaging	Het
Chac2	A	G	11: 30,936,225 (GRCm39)	S8P	probably damaging	Het
Clec4b2	T	A	6: 123,179,110 (GRCm39)	Y137*	probably null	Het
Dbt	G	A	3: 116,339,763 (GRCm39)	G384S	probably benign	Het
Duox1	G	T	2: 122,153,787 (GRCm39)	R370L	probably benign	Het
Hnrnpm	C	A	17: 33,868,876 (GRCm39)	R517L	probably damaging	Het
Iigp1c	A	C	18: 60,379,262 (GRCm39)	T266P	probably damaging	Het
Iqschfp	C	A	3: 68,533,184 (GRCm39)	A255E	probably damaging	Het
Kcnh7	G	A	2: 62,607,983 (GRCm39)	R533C	probably damaging	Het
Nckap5	A	C	1: 125,952,755 (GRCm39)	L1266V	probably damaging	Het
Opcml	A	G	9: 28,586,624 (GRCm39)	N121S	possibly damaging	Het
Rad54b	T	A	4: 11,597,833 (GRCm39)	N239K	probably damaging	Het
Rp1	T	C	1: 4,422,435 (GRCm39)	D215G	probably damaging	Het
Scaf8	T	C	17: 3,221,422 (GRCm39)	I303T	unknown	Het
Tlk2	T	A	11: 105,138,418 (GRCm39)	I322N	probably benign	Het
Tubb4a	A	G	17: 57,393,072 (GRCm39)	V66A	probably benign	Het
Ubxn2a	C	T	12: 4,933,956 (GRCm39)	A152T	probably benign	Het
Ush2a	A	T	1: 188,485,719 (GRCm39)	D2943V	probably damaging	Het
Wdr62	A	G	7: 29,960,764 (GRCm39)	V55A	probably damaging	Het
Zfp609	A	G	9: 65,610,045 (GRCm39)	Y973H	probably benign	Het

Other mutations in Slc35f3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00687:Slc35f3	APN	8	127,108,903 (GRCm39)	missense	probably benign	0.02
IGL01105:Slc35f3	APN	8	127,025,553 (GRCm39)	missense	probably damaging	1.00
IGL01710:Slc35f3	APN	8	127,115,900 (GRCm39)	missense	probably benign	0.00
IGL01771:Slc35f3	APN	8	127,115,951 (GRCm39)	missense	probably benign	0.00
IGL02254:Slc35f3	APN	8	127,115,862 (GRCm39)	missense	probably damaging	1.00
IGL02610:Slc35f3	APN	8	127,047,956 (GRCm39)	missense	probably damaging	1.00
R1666:Slc35f3	UTSW	8	127,115,960 (GRCm39)	missense	probably damaging	0.98
R2510:Slc35f3	UTSW	8	127,025,445 (GRCm39)	start gained	probably benign
R2520:Slc35f3	UTSW	8	127,121,312 (GRCm39)	missense	possibly damaging	0.81
R3807:Slc35f3	UTSW	8	127,115,978 (GRCm39)	missense	probably damaging	1.00
R4644:Slc35f3	UTSW	8	127,047,809 (GRCm39)	missense	possibly damaging	0.87
R4675:Slc35f3	UTSW	8	127,047,935 (GRCm39)	nonsense	probably null
R4976:Slc35f3	UTSW	8	127,116,020 (GRCm39)	splice site	probably null
R5037:Slc35f3	UTSW	8	127,116,011 (GRCm39)	missense	probably damaging	0.99
R5225:Slc35f3	UTSW	8	127,117,846 (GRCm39)	missense	probably damaging	0.98
R5259:Slc35f3	UTSW	8	127,115,872 (GRCm39)	missense	probably damaging	1.00
R5856:Slc35f3	UTSW	8	127,047,819 (GRCm39)	missense	probably benign	0.07
R5925:Slc35f3	UTSW	8	127,115,946 (GRCm39)	missense	probably benign	0.24
R6254:Slc35f3	UTSW	8	127,047,833 (GRCm39)	missense	possibly damaging	0.96
R6748:Slc35f3	UTSW	8	127,121,377 (GRCm39)	nonsense	probably null
R6785:Slc35f3	UTSW	8	127,121,198 (GRCm39)	missense	probably benign	0.02
R7002:Slc35f3	UTSW	8	127,115,773 (GRCm39)	critical splice acceptor site	unknown
R7291:Slc35f3	UTSW	8	127,121,297 (GRCm39)	missense	probably benign	0.02
R7411:Slc35f3	UTSW	8	127,115,777 (GRCm39)	critical splice acceptor site	probably benign
R7456:Slc35f3	UTSW	8	127,115,779 (GRCm39)	critical splice acceptor site	unknown
R7790:Slc35f3	UTSW	8	127,115,777 (GRCm39)	critical splice acceptor site	probably benign
R7852:Slc35f3	UTSW	8	127,121,219 (GRCm39)	missense	probably damaging	1.00
R8000:Slc35f3	UTSW	8	127,047,812 (GRCm39)	missense	probably benign
R8277:Slc35f3	UTSW	8	127,115,925 (GRCm39)	missense	possibly damaging	0.88
R8827:Slc35f3	UTSW	8	127,115,780 (GRCm39)	critical splice acceptor site	probably benign
R8983:Slc35f3	UTSW	8	127,115,775 (GRCm39)	critical splice acceptor site	probably benign
R9205:Slc35f3	UTSW	8	127,115,928 (GRCm39)	missense	probably damaging	0.96
R9355:Slc35f3	UTSW	8	127,108,967 (GRCm39)	missense	probably damaging	0.97
R9475:Slc35f3	UTSW	8	127,108,993 (GRCm39)	missense	probably damaging	1.00
R9492:Slc35f3	UTSW	8	127,048,026 (GRCm39)	missense	probably damaging	1.00
R9714:Slc35f3	UTSW	8	127,115,781 (GRCm39)	critical splice acceptor site	probably benign
R9729:Slc35f3	UTSW	8	127,115,777 (GRCm39)	critical splice acceptor site	probably benign
R9769:Slc35f3	UTSW	8	127,121,336 (GRCm39)	missense	probably damaging	0.99
X0067:Slc35f3	UTSW	8	127,109,062 (GRCm39)	missense	probably damaging	0.99

Posted On

2013-04-17