Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02120:Vmn2r9'

280552

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r9

Ensembl Gene

ENSMUSG00000091624

Gene Name

vomeronasal 2, receptor 9

Synonyms

EG435864

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.118) question?

Stock #

IGL02120

Quality Score

Status

Chromosome

Chromosomal Location

108990813-109000376 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 108991502 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 620 (L620F)

Ref Sequence

ENSEMBL: ENSMUSP00000129520 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170419]

AlphaFold

K7N6Z8

Predicted Effect

probably damaging
Transcript: ENSMUST00000170419
AA Change: L620F

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: L620F

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	77	412	8.1e-29	PFAM
Pfam:NCD3G	507	561	2.3e-16	PFAM
Pfam:7tm_3	592	829	3.4e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb11	T	C	2: 69,087,654 (GRCm39)	Y1037C	probably damaging	Het
Aldh16a1	G	A	7: 44,795,459 (GRCm39)	P400L	probably damaging	Het
Ankrd33b	T	C	15: 31,367,202 (GRCm39)	T113A	possibly damaging	Het
Aox3	T	A	1: 58,166,809 (GRCm39)	N177K	probably benign	Het
Arhgap29	T	A	3: 121,797,906 (GRCm39)	V532E	probably benign	Het
Brd8	C	T	18: 34,735,780 (GRCm39)	S899N	probably damaging	Het
Caskin1	G	T	17: 24,719,916 (GRCm39)	G401V	probably damaging	Het
Cemip	A	T	7: 83,600,771 (GRCm39)	M950K	probably damaging	Het
Cfap107	C	T	4: 144,144,981 (GRCm39)	R195H	probably benign	Het
Chrd	T	C	16: 20,553,291 (GRCm39)	V211A	probably damaging	Het
Ckap2l	T	C	2: 129,127,542 (GRCm39)	N212S	possibly damaging	Het
Clip1	T	C	5: 123,785,946 (GRCm39)	D246G	probably damaging	Het
Dlst	T	C	12: 85,165,342 (GRCm39)	S82P	probably benign	Het
Dmxl1	T	A	18: 50,027,245 (GRCm39)	L2118M	possibly damaging	Het
Dnah7a	T	C	1: 53,534,876 (GRCm39)	K2795E	possibly damaging	Het
Enpp5	T	A	17: 44,391,736 (GRCm39)	M55K	probably benign	Het
Epdr1	A	T	13: 19,778,641 (GRCm39)	S50T	probably damaging	Het
Gm7808	T	A	9: 19,839,313 (GRCm39)		probably benign	Het
Huwe1	T	A	X: 150,690,386 (GRCm39)	F2485I	possibly damaging	Het
Kcnb2	C	T	1: 15,780,085 (GRCm39)	T319M	probably damaging	Het
Lama1	G	A	17: 68,023,784 (GRCm39)	V60M	probably damaging	Het
Lingo3	A	T	10: 80,671,693 (GRCm39)	L79Q	probably damaging	Het
Magi2	T	A	5: 20,433,451 (GRCm39)		probably null	Het
Mob2	C	A	7: 141,564,035 (GRCm39)	V33L	possibly damaging	Het
Mus81	G	A	19: 5,535,661 (GRCm39)		probably benign	Het
Nup210l	G	A	3: 90,044,169 (GRCm39)	G490D	probably damaging	Het
Or13n4	A	C	7: 106,422,905 (GRCm39)	V276G	possibly damaging	Het
Pbp2	A	G	6: 135,286,816 (GRCm39)	V177A	probably damaging	Het
Pomt2	T	C	12: 87,158,326 (GRCm39)	D656G	probably benign	Het
Ppp2r1b	A	G	9: 50,773,069 (GRCm39)		probably benign	Het
Prp2rt	G	T	13: 97,235,285 (GRCm39)		probably benign	Het
Ptprq	T	C	10: 107,503,333 (GRCm39)	E775G	probably damaging	Het
Rad54l	T	C	4: 115,956,181 (GRCm39)	I549V	probably benign	Het
Ranbp10	T	C	8: 106,532,214 (GRCm39)	Y145C	probably damaging	Het
Runx1t1	A	T	4: 13,846,884 (GRCm39)	T223S	probably benign	Het
Stxbp6	G	T	12: 44,948,831 (GRCm39)		probably benign	Het
Syne2	A	G	12: 75,993,480 (GRCm39)	D2085G	probably damaging	Het
Szt2	C	T	4: 118,245,761 (GRCm39)	R1064Q	probably benign	Het
Taar3	A	G	10: 23,826,065 (GRCm39)	T204A	probably benign	Het
Tdpoz1	A	G	3: 93,577,750 (GRCm39)	S345P	probably damaging	Het
Tgm4	T	A	9: 122,875,594 (GRCm39)	I149N	probably damaging	Het
Tubal3	T	A	13: 3,980,675 (GRCm39)	I129N	probably damaging	Het
Vegfc	T	C	8: 54,634,436 (GRCm39)	F372L	possibly damaging	Het
Vwf	C	A	6: 125,592,997 (GRCm39)	L786M	probably benign	Het

Other mutations in Vmn2r9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00920:Vmn2r9	APN	5	108,995,890 (GRCm39)	missense	possibly damaging	0.79
IGL00972:Vmn2r9	APN	5	108,996,903 (GRCm39)	missense	probably benign	0.02
IGL01102:Vmn2r9	APN	5	108,990,811 (GRCm39)	splice site	probably null
IGL01892:Vmn2r9	APN	5	108,995,700 (GRCm39)	missense	probably damaging	1.00
IGL02086:Vmn2r9	APN	5	108,995,433 (GRCm39)	missense	probably damaging	1.00
IGL02118:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02119:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02121:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02123:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02131:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02132:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02171:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02185:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02186:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02346:Vmn2r9	APN	5	108,990,850 (GRCm39)	missense	probably benign	0.07
IGL02508:Vmn2r9	APN	5	108,996,067 (GRCm39)	missense	possibly damaging	0.70
IGL02815:Vmn2r9	APN	5	108,990,856 (GRCm39)	missense	possibly damaging	0.69
IGL03077:Vmn2r9	APN	5	108,996,173 (GRCm39)	splice site	probably benign
IGL03269:Vmn2r9	APN	5	108,995,820 (GRCm39)	missense	probably damaging	1.00
IGL03293:Vmn2r9	APN	5	108,995,997 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn2r9	UTSW	5	108,990,991 (GRCm39)	missense	probably damaging	1.00
R0328:Vmn2r9	UTSW	5	108,995,405 (GRCm39)	missense	probably benign	0.11
R0382:Vmn2r9	UTSW	5	108,995,463 (GRCm39)	missense	probably damaging	1.00
R0521:Vmn2r9	UTSW	5	108,996,154 (GRCm39)	nonsense	probably null
R0975:Vmn2r9	UTSW	5	108,991,169 (GRCm39)	missense	probably damaging	1.00
R1216:Vmn2r9	UTSW	5	108,995,440 (GRCm39)	missense	probably damaging	1.00
R1458:Vmn2r9	UTSW	5	108,996,850 (GRCm39)	missense	probably benign	0.44
R1469:Vmn2r9	UTSW	5	108,991,694 (GRCm39)	missense	probably benign
R1469:Vmn2r9	UTSW	5	108,991,694 (GRCm39)	missense	probably benign
R1704:Vmn2r9	UTSW	5	108,994,266 (GRCm39)	missense	probably damaging	1.00
R1967:Vmn2r9	UTSW	5	108,995,388 (GRCm39)	missense	probably benign	0.03
R1991:Vmn2r9	UTSW	5	108,994,305 (GRCm39)	missense	probably damaging	0.99
R2410:Vmn2r9	UTSW	5	108,996,123 (GRCm39)	missense	probably damaging	1.00
R3419:Vmn2r9	UTSW	5	108,994,299 (GRCm39)	missense	probably damaging	0.96
R3852:Vmn2r9	UTSW	5	108,995,997 (GRCm39)	missense	probably damaging	1.00
R3873:Vmn2r9	UTSW	5	108,995,701 (GRCm39)	missense	probably benign	0.14
R3905:Vmn2r9	UTSW	5	108,995,785 (GRCm39)	missense	probably benign	0.37
R3908:Vmn2r9	UTSW	5	108,995,785 (GRCm39)	missense	probably benign	0.37
R3921:Vmn2r9	UTSW	5	108,996,921 (GRCm39)	missense	probably benign
R4156:Vmn2r9	UTSW	5	108,995,743 (GRCm39)	missense	possibly damaging	0.64
R4477:Vmn2r9	UTSW	5	108,994,143 (GRCm39)	missense	probably benign
R4478:Vmn2r9	UTSW	5	108,994,143 (GRCm39)	missense	probably benign
R4544:Vmn2r9	UTSW	5	108,995,551 (GRCm39)	missense	probably benign	0.00
R4546:Vmn2r9	UTSW	5	108,995,551 (GRCm39)	missense	probably benign	0.00
R4627:Vmn2r9	UTSW	5	108,995,463 (GRCm39)	missense	probably damaging	1.00
R5215:Vmn2r9	UTSW	5	108,994,351 (GRCm39)	missense	probably benign	0.03
R5361:Vmn2r9	UTSW	5	108,995,929 (GRCm39)	missense	probably damaging	1.00
R5587:Vmn2r9	UTSW	5	108,995,427 (GRCm39)	missense	probably damaging	1.00
R6054:Vmn2r9	UTSW	5	108,996,126 (GRCm39)	missense	probably damaging	0.99
R6106:Vmn2r9	UTSW	5	108,992,902 (GRCm39)	missense	probably benign
R6125:Vmn2r9	UTSW	5	108,990,836 (GRCm39)	missense	probably benign	0.01
R6137:Vmn2r9	UTSW	5	108,996,882 (GRCm39)	missense	probably benign	0.00
R6920:Vmn2r9	UTSW	5	108,996,912 (GRCm39)	missense	possibly damaging	0.72
R7579:Vmn2r9	UTSW	5	108,992,948 (GRCm39)	missense	probably damaging	1.00
R8683:Vmn2r9	UTSW	5	108,996,873 (GRCm39)	missense	probably benign
R8964:Vmn2r9	UTSW	5	108,996,031 (GRCm39)	missense	probably benign	0.05
R9022:Vmn2r9	UTSW	5	108,992,923 (GRCm39)	missense	possibly damaging	0.90
R9118:Vmn2r9	UTSW	5	108,990,937 (GRCm39)	missense	probably damaging	0.99
R9125:Vmn2r9	UTSW	5	108,996,047 (GRCm39)	missense
R9240:Vmn2r9	UTSW	5	108,996,099 (GRCm39)	missense	possibly damaging	0.78
R9327:Vmn2r9	UTSW	5	108,996,841 (GRCm39)	missense	probably damaging	0.96
R9412:Vmn2r9	UTSW	5	108,991,484 (GRCm39)	missense	probably damaging	1.00
R9499:Vmn2r9	UTSW	5	108,995,584 (GRCm39)	missense	probably damaging	1.00
R9757:Vmn2r9	UTSW	5	108,995,908 (GRCm39)	missense	possibly damaging	0.87
R9790:Vmn2r9	UTSW	5	108,995,409 (GRCm39)	missense	probably damaging	0.99
R9791:Vmn2r9	UTSW	5	108,995,409 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16