Incidental Mutation 'IGL00964:Dusp26'
ID 28058
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dusp26
Ensembl Gene ENSMUSG00000039661
Gene Name dual specificity phosphatase 26
Synonyms 2310043K02Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00964
Quality Score
Status
Chromosome 8
Chromosomal Location 31579555-31587074 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 31584136 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 81 (R81L)
Ref Sequence ENSEMBL: ENSMUSP00000126397 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036631] [ENSMUST00000161713] [ENSMUST00000170204]
AlphaFold Q9D700
Predicted Effect probably benign
Transcript: ENSMUST00000036631
AA Change: R81L

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000046794
Gene: ENSMUSG00000039661
AA Change: R81L

DomainStartEndE-ValueType
DSPc 61 204 3.1e-39 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160700
Predicted Effect probably benign
Transcript: ENSMUST00000161713
AA Change: R81L

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000124949
Gene: ENSMUSG00000039661
AA Change: R81L

DomainStartEndE-ValueType
DSPc 61 204 3.1e-39 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162551
Predicted Effect probably benign
Transcript: ENSMUST00000170204
AA Change: R81L

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000126397
Gene: ENSMUSG00000039661
AA Change: R81L

DomainStartEndE-ValueType
DSPc 61 204 3.1e-39 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700008O03Rik T A 7: 44,009,610 (GRCm39) *197C probably null Het
Acsl6 A G 11: 54,216,472 (GRCm39) Y213C probably damaging Het
Agt T C 8: 125,284,634 (GRCm39) probably benign Het
Aifm3 A G 16: 17,318,228 (GRCm39) D144G probably damaging Het
Alad T C 4: 62,432,330 (GRCm39) I32V probably benign Het
Astn2 T A 4: 66,103,424 (GRCm39) M330L unknown Het
AU040320 T A 4: 126,748,199 (GRCm39) C1029* probably null Het
Brca2 T A 5: 150,455,775 (GRCm39) I172N probably damaging Het
Brme1 T C 8: 84,893,343 (GRCm39) I170T probably benign Het
Cdk5rap3 A G 11: 96,800,765 (GRCm39) probably null Het
Dync2h1 T C 9: 7,174,881 (GRCm39) probably benign Het
Ehd4 A G 2: 119,958,163 (GRCm39) C141R probably benign Het
Ftsj3 G T 11: 106,143,941 (GRCm39) A261D probably benign Het
Gm5431 G A 11: 48,780,094 (GRCm39) T554I probably damaging Het
Hyls1 A G 9: 35,473,408 (GRCm39) probably benign Het
Ifi213 T A 1: 173,421,518 (GRCm39) T124S possibly damaging Het
Ints10 T A 8: 69,264,638 (GRCm39) I457N probably damaging Het
Klk1b1 T G 7: 43,620,593 (GRCm39) S228A possibly damaging Het
Lpar2 T C 8: 70,279,162 (GRCm39) S319P probably benign Het
Lsr T C 7: 30,671,421 (GRCm39) N104S probably damaging Het
Mybpc1 T A 10: 88,391,604 (GRCm39) probably null Het
Nalcn T A 14: 123,532,796 (GRCm39) probably benign Het
Ovol2 G A 2: 144,147,599 (GRCm39) A217V probably damaging Het
Pcdh12 T A 18: 38,415,784 (GRCm39) Q447L probably benign Het
Pdgfra T C 5: 75,335,726 (GRCm39) I453T probably damaging Het
Ptprd C T 4: 75,916,793 (GRCm39) W1037* probably null Het
Rabgef1 T C 5: 130,219,863 (GRCm39) S109P probably damaging Het
Rev3l T C 10: 39,740,802 (GRCm39) I2995T probably benign Het
Slamf6 T A 1: 171,745,347 (GRCm39) C25S probably null Het
Slc28a2b A T 2: 122,347,527 (GRCm39) Q229H probably damaging Het
Sorbs2 A C 8: 46,248,714 (GRCm39) N520T probably damaging Het
Spr-ps1 C A 6: 85,132,016 (GRCm39) noncoding transcript Het
Stx4a A G 7: 127,441,898 (GRCm39) Q92R probably benign Het
Tab2 A C 10: 7,785,837 (GRCm39) V638G probably benign Het
Trim41 C A 11: 48,703,190 (GRCm39) R79S possibly damaging Het
Ttll5 A G 12: 85,896,057 (GRCm39) Y135C possibly damaging Het
Zan T C 5: 137,404,203 (GRCm39) probably benign Het
Zdhhc14 T A 17: 5,762,756 (GRCm39) L220Q probably damaging Het
Other mutations in Dusp26
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0037:Dusp26 UTSW 8 31,586,388 (GRCm39) missense unknown
R0394:Dusp26 UTSW 8 31,581,987 (GRCm39) missense probably benign 0.16
R1792:Dusp26 UTSW 8 31,581,963 (GRCm39) missense probably benign 0.01
R4454:Dusp26 UTSW 8 31,584,172 (GRCm39) missense probably damaging 0.99
R4854:Dusp26 UTSW 8 31,584,165 (GRCm39) missense probably damaging 1.00
R5638:Dusp26 UTSW 8 31,584,169 (GRCm39) missense probably damaging 1.00
R6212:Dusp26 UTSW 8 31,584,252 (GRCm39) missense probably damaging 1.00
R6337:Dusp26 UTSW 8 31,586,325 (GRCm39) missense probably damaging 1.00
R7083:Dusp26 UTSW 8 31,581,747 (GRCm39) intron probably benign
R8754:Dusp26 UTSW 8 31,581,805 (GRCm39) intron probably benign
R8945:Dusp26 UTSW 8 31,586,367 (GRCm39) missense unknown
R8970:Dusp26 UTSW 8 31,584,232 (GRCm39) missense probably damaging 1.00
R9742:Dusp26 UTSW 8 31,584,198 (GRCm39) missense probably benign 0.00
Posted On 2013-04-17