Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00965:Tango6'

28064

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tango6

Ensembl Gene

ENSMUSG00000041949

Gene Name

transport and golgi organization 6

Synonyms

Tango6, Tmco7

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL00965

Quality Score

Status

Chromosome

Chromosomal Location

107409700-107578071 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 107468642 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000043953 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048359]

AlphaFold

Q8C3S2

Predicted Effect

probably benign
Transcript: ENSMUST00000048359

SMART Domains

Protein: ENSMUSP00000043953
Gene: ENSMUSG00000041949

Domain	Start	End	E-Value	Type
low complexity region	2	13	N/A	INTRINSIC
low complexity region	20	41	N/A	INTRINSIC
low complexity region	102	115	N/A	INTRINSIC
low complexity region	246	259	N/A	INTRINSIC
low complexity region	334	350	N/A	INTRINSIC
low complexity region	472	486	N/A	INTRINSIC
Pfam:RTP1_C1	824	935	1.6e-35	PFAM
low complexity region	998	1013	N/A	INTRINSIC
Pfam:RTP1_C2	1026	1059	7.5e-14	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212764

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acot8	C	T	2: 164,646,735 (GRCm39)	M1I	probably null	Het
Adam33	T	C	2: 130,896,183 (GRCm39)		probably benign	Het
Adgrl1	C	T	8: 84,664,332 (GRCm39)	T1236I	probably damaging	Het
Ago4	A	G	4: 126,387,107 (GRCm39)	V832A	probably benign	Het
Ankrd26	G	T	6: 118,536,319 (GRCm39)	Y91*	probably null	Het
Atp9a	C	A	2: 168,482,600 (GRCm39)	V845L	probably benign	Het
Cfap100	C	T	6: 90,392,787 (GRCm39)	E108K	probably benign	Het
Chrdl2	T	A	7: 99,655,860 (GRCm39)		probably null	Het
Cibar2	T	C	8: 120,893,429 (GRCm39)	Q254R	probably benign	Het
Cilk1	A	G	9: 78,071,821 (GRCm39)	I498V	probably benign	Het
Erbb4	A	T	1: 68,110,789 (GRCm39)	L1008*	probably null	Het
Gm42688	C	T	6: 83,080,373 (GRCm39)		probably benign	Het
H2-Eb2	T	A	17: 34,544,771 (GRCm39)		probably null	Het
Hmcn2	T	C	2: 31,233,108 (GRCm39)	V219A	probably damaging	Het
Hsf2	C	T	10: 57,388,196 (GRCm39)	P447S	probably damaging	Het
Hsph1	A	T	5: 149,554,269 (GRCm39)	I162N	probably damaging	Het
Il12rb2	T	C	6: 67,337,561 (GRCm39)	T107A	probably damaging	Het
Lnx1	T	A	5: 74,846,378 (GRCm39)	N24I	probably benign	Het
Mgat3	C	A	15: 80,096,634 (GRCm39)	A487D	probably damaging	Het
Or10h5	C	T	17: 33,434,947 (GRCm39)	V124M	probably benign	Het
Or52ae9	T	A	7: 103,390,172 (GRCm39)	I92F	probably benign	Het
Or6b2	T	C	1: 92,407,746 (GRCm39)	D199G	probably damaging	Het
Or6c65	T	A	10: 129,603,455 (GRCm39)	L30Q	probably null	Het
Ppargc1b	A	G	18: 61,456,235 (GRCm39)	Y75H	probably damaging	Het
Rgl2	G	T	17: 34,154,910 (GRCm39)	C638F	probably benign	Het
Rhpn1	C	A	15: 75,583,735 (GRCm39)	R407S	probably damaging	Het
Sipa1l2	A	G	8: 126,174,613 (GRCm39)	S1222P	probably benign	Het
Tonsl	G	A	15: 76,516,080 (GRCm39)		probably benign	Het
Vmn1r77	G	A	7: 11,775,223 (GRCm39)		probably null	Het
Vmn2r13	A	C	5: 109,303,964 (GRCm39)	F822L	probably damaging	Het

Other mutations in Tango6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00905:Tango6	APN	8	107,469,104 (GRCm39)	critical splice donor site	probably null
IGL00925:Tango6	APN	8	107,422,077 (GRCm39)	splice site	probably benign
IGL01412:Tango6	APN	8	107,545,131 (GRCm39)	missense	probably benign	0.02
IGL02888:Tango6	APN	8	107,447,297 (GRCm39)	missense	probably damaging	1.00
IGL02892:Tango6	APN	8	107,468,642 (GRCm39)	splice site	probably benign
R0241:Tango6	UTSW	8	107,473,993 (GRCm39)	splice site	probably benign
R0494:Tango6	UTSW	8	107,462,314 (GRCm39)	splice site	probably benign
R1127:Tango6	UTSW	8	107,415,527 (GRCm39)	missense	probably benign	0.00
R1440:Tango6	UTSW	8	107,415,671 (GRCm39)	missense	probably damaging	1.00
R1547:Tango6	UTSW	8	107,508,418 (GRCm39)	missense	probably damaging	0.98
R1921:Tango6	UTSW	8	107,415,426 (GRCm39)	missense	probably benign	0.06
R2255:Tango6	UTSW	8	107,415,926 (GRCm39)	critical splice donor site	probably null
R2761:Tango6	UTSW	8	107,425,664 (GRCm39)	missense	possibly damaging	0.93
R4211:Tango6	UTSW	8	107,415,856 (GRCm39)	missense	probably benign	0.02
R4463:Tango6	UTSW	8	107,415,706 (GRCm39)	missense	probably benign	0.29
R4696:Tango6	UTSW	8	107,426,863 (GRCm39)	missense	possibly damaging	0.73
R4867:Tango6	UTSW	8	107,545,158 (GRCm39)	missense	probably damaging	1.00
R4946:Tango6	UTSW	8	107,444,722 (GRCm39)	nonsense	probably null
R5459:Tango6	UTSW	8	107,576,921 (GRCm39)	missense	probably damaging	1.00
R5522:Tango6	UTSW	8	107,422,230 (GRCm39)	critical splice donor site	probably null
R5795:Tango6	UTSW	8	107,444,709 (GRCm39)	missense	probably damaging	1.00
R5878:Tango6	UTSW	8	107,415,800 (GRCm39)	missense	possibly damaging	0.77
R6318:Tango6	UTSW	8	107,545,129 (GRCm39)	missense	probably benign
R6335:Tango6	UTSW	8	107,419,308 (GRCm39)	missense	possibly damaging	0.94
R6633:Tango6	UTSW	8	107,444,637 (GRCm39)	missense	probably benign	0.00
R6664:Tango6	UTSW	8	107,468,746 (GRCm39)	missense	probably damaging	1.00
R6838:Tango6	UTSW	8	107,468,706 (GRCm39)	missense	probably benign	0.00
R6866:Tango6	UTSW	8	107,469,104 (GRCm39)	critical splice donor site	probably null
R7046:Tango6	UTSW	8	107,533,748 (GRCm39)	missense	possibly damaging	0.86
R7130:Tango6	UTSW	8	107,533,733 (GRCm39)	missense	probably damaging	1.00
R7199:Tango6	UTSW	8	107,415,791 (GRCm39)	missense	probably benign	0.01
R7418:Tango6	UTSW	8	107,415,466 (GRCm39)	missense	probably benign	0.26
R7480:Tango6	UTSW	8	107,423,359 (GRCm39)	missense	possibly damaging	0.63
R7704:Tango6	UTSW	8	107,425,621 (GRCm39)	missense	probably benign	0.03
R7809:Tango6	UTSW	8	107,415,926 (GRCm39)	critical splice donor site	probably null
R7826:Tango6	UTSW	8	107,419,245 (GRCm39)	missense	probably benign	0.02
R8085:Tango6	UTSW	8	107,447,366 (GRCm39)	missense	probably benign	0.32
R8098:Tango6	UTSW	8	107,468,990 (GRCm39)	missense	possibly damaging	0.81
R8162:Tango6	UTSW	8	107,409,882 (GRCm39)	missense	possibly damaging	0.93
R8892:Tango6	UTSW	8	107,468,845 (GRCm39)	missense	probably benign	0.00
R8970:Tango6	UTSW	8	107,415,871 (GRCm39)	missense	probably damaging	0.98
R9336:Tango6	UTSW	8	107,415,701 (GRCm39)	missense	probably benign	0.03
R9760:Tango6	UTSW	8	107,576,911 (GRCm39)	missense	probably damaging	1.00
Z1177:Tango6	UTSW	8	107,423,248 (GRCm39)	missense	probably damaging	1.00
Z1177:Tango6	UTSW	8	107,415,424 (GRCm39)	missense	probably benign

Posted On

2013-04-17