Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02123:Fndc11'

280723

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fndc11

Ensembl Gene

ENSMUSG00000047841

Gene Name

fibronectin type III domain containing 11

Synonyms

BC051628, 1700026M20Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.158) question?

Stock #

IGL02123

Quality Score

Status

Chromosome

Chromosomal Location

180861806-180864647 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 180863443 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 83 (I83V)

Ref Sequence

ENSEMBL: ENSMUSP00000056320 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050026] [ENSMUST00000108835]

AlphaFold

Q80WB0

Predicted Effect

probably benign
Transcript: ENSMUST00000050026
AA Change: I83V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000056320
Gene: ENSMUSG00000047841
AA Change: I83V

Domain	Start	End	E-Value	Type
low complexity region	23	37	N/A	INTRINSIC
low complexity region	125	137	N/A	INTRINSIC
low complexity region	140	154	N/A	INTRINSIC
SCOP:d1fna__	224	309	2e-8	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000108835
AA Change: I83V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000104463
Gene: ENSMUSG00000047841
AA Change: I83V

Domain	Start	End	E-Value	Type
low complexity region	23	37	N/A	INTRINSIC
low complexity region	125	137	N/A	INTRINSIC
low complexity region	140	154	N/A	INTRINSIC
SCOP:d1fna__	224	309	2e-8	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000117287

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acp7	T	C	7: 28,328,914 (GRCm39)	T31A	probably benign	Het
Aldh16a1	G	A	7: 44,795,459 (GRCm39)	P400L	probably damaging	Het
Ampd3	T	C	7: 110,401,766 (GRCm39)	V429A	possibly damaging	Het
Brd8	C	T	18: 34,735,780 (GRCm39)	S899N	probably damaging	Het
Cldn11	C	T	3: 31,204,336 (GRCm39)	T13M	probably benign	Het
Cngb3	C	A	4: 19,367,801 (GRCm39)	Q237K	probably damaging	Het
Col12a1	A	G	9: 79,569,740 (GRCm39)		probably null	Het
Copa	T	A	1: 171,939,695 (GRCm39)	L621H	probably damaging	Het
Dbn1	T	C	13: 55,624,553 (GRCm39)	D332G	possibly damaging	Het
Drc1	T	C	5: 30,504,448 (GRCm39)	S197P	probably benign	Het
E2f2	A	G	4: 135,900,159 (GRCm39)	N23S	probably benign	Het
Epb41l2	T	A	10: 25,336,742 (GRCm39)	L246H	probably damaging	Het
Fam13b	G	A	18: 34,578,671 (GRCm39)		probably benign	Het
Fam184b	A	G	5: 45,796,493 (GRCm39)	M30T	possibly damaging	Het
Fn3krp	G	A	11: 121,320,270 (GRCm39)	R205H	probably benign	Het
Garin2	T	C	12: 78,780,981 (GRCm39)		probably null	Het
Gm3629	C	T	14: 17,834,541 (GRCm39)	R150H	probably benign	Het
Hs6st1	T	A	1: 36,142,952 (GRCm39)	F296I	possibly damaging	Het
Igsf10	T	A	3: 59,226,081 (GRCm39)	I2531F	probably damaging	Het
Klhl40	T	C	9: 121,608,989 (GRCm39)	F385L	probably benign	Het
Krt87	A	T	15: 101,385,466 (GRCm39)	M302K	possibly damaging	Het
Lrrc43	A	T	5: 123,632,342 (GRCm39)	I162F	probably damaging	Het
Map3k21	A	G	8: 126,652,849 (GRCm39)	E325G	probably damaging	Het
Mpo	A	T	11: 87,685,621 (GRCm39)	N33I	probably benign	Het
Mpp4	A	G	1: 59,200,625 (GRCm39)		probably null	Het
Muc5b	C	T	7: 141,417,494 (GRCm39)	T3480I	possibly damaging	Het
Myo6	T	C	9: 80,171,554 (GRCm39)		probably benign	Het
Nostrin	C	T	2: 68,986,453 (GRCm39)		probably benign	Het
Nphp1	T	C	2: 127,595,969 (GRCm39)	M498V	probably benign	Het
Nr4a2	A	T	2: 57,001,667 (GRCm39)	L199Q	possibly damaging	Het
Pcdhb6	A	T	18: 37,468,873 (GRCm39)	N598I	probably damaging	Het
Pex19	T	A	1: 171,961,853 (GRCm39)	M207K	probably damaging	Het
Pfkfb4	C	T	9: 108,854,178 (GRCm39)	R351W	probably damaging	Het
Plekha2	T	C	8: 25,532,745 (GRCm39)	K409E	probably damaging	Het
Plxna2	T	C	1: 194,476,691 (GRCm39)	L1169P	probably damaging	Het
Pmpcb	A	G	5: 21,948,373 (GRCm39)		probably benign	Het
Ptrh1	T	C	2: 32,666,826 (GRCm39)		probably benign	Het
Rc3h2	T	C	2: 37,288,265 (GRCm39)	E439G	probably damaging	Het
Ric1	C	T	19: 29,572,200 (GRCm39)	A665V	probably benign	Het
Stx18	T	A	5: 38,285,447 (GRCm39)	V219D	probably damaging	Het
Taf7	A	T	18: 37,775,533 (GRCm39)		probably benign	Het
Tbc1d8	A	G	1: 39,415,988 (GRCm39)	I895T	possibly damaging	Het
Tbc1d8	A	G	1: 39,419,317 (GRCm39)	S766P	probably damaging	Het
Tekt3	C	A	11: 62,974,766 (GRCm39)	H362N	probably benign	Het
Tmem214	G	A	5: 31,030,090 (GRCm39)	A296T	probably benign	Het
Tmem94	T	C	11: 115,678,364 (GRCm39)	S196P	possibly damaging	Het
Vmn2r14	T	C	5: 109,367,933 (GRCm39)	Y353C	probably damaging	Het
Vmn2r9	G	A	5: 108,991,502 (GRCm39)	L620F	probably damaging	Het
Vmn2r90	T	G	17: 17,953,744 (GRCm39)	M636R	probably benign	Het
Vmn2r98	T	A	17: 19,300,941 (GRCm39)	C648S	probably damaging	Het
Zfpm2	G	A	15: 40,965,591 (GRCm39)	C560Y	probably damaging	Het

Other mutations in Fndc11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02006:Fndc11	APN	2	180,863,884 (GRCm39)	missense	probably damaging	0.96
R1639:Fndc11	UTSW	2	180,863,374 (GRCm39)	missense	possibly damaging	0.92
R1946:Fndc11	UTSW	2	180,863,627 (GRCm39)	missense	probably benign	0.00
R2146:Fndc11	UTSW	2	180,863,918 (GRCm39)	missense	probably damaging	1.00
R2235:Fndc11	UTSW	2	180,864,067 (GRCm39)	missense	possibly damaging	0.90
R5254:Fndc11	UTSW	2	180,863,956 (GRCm39)	missense	possibly damaging	0.77
R6044:Fndc11	UTSW	2	180,863,459 (GRCm39)	missense	probably damaging	1.00
R7271:Fndc11	UTSW	2	180,863,893 (GRCm39)	missense	possibly damaging	0.53
R8693:Fndc11	UTSW	2	180,863,864 (GRCm39)	missense	probably damaging	1.00
R9568:Fndc11	UTSW	2	180,864,046 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16