Incidental Mutation 'IGL02127:Kif5c'
ID |
280937 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Kif5c
|
Ensembl Gene |
ENSMUSG00000026764 |
Gene Name |
kinesin family member 5C |
Synonyms |
Khc |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL02127
|
Quality Score |
|
Status
|
|
Chromosome |
2 |
Chromosomal Location |
49509310-49664790 bp(+) (GRCm39) |
Type of Mutation |
splice site (5 bp from exon) |
DNA Base Change (assembly) |
G to A
at 49591122 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000117370
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028102]
[ENSMUST00000146247]
|
AlphaFold |
P28738 |
Predicted Effect |
probably null
Transcript: ENSMUST00000028102
|
SMART Domains |
Protein: ENSMUSP00000028102 Gene: ENSMUSG00000026764
Domain | Start | End | E-Value | Type |
KISc
|
6 |
335 |
2.8e-173 |
SMART |
low complexity region
|
340 |
357 |
N/A |
INTRINSIC |
coiled coil region
|
407 |
541 |
N/A |
INTRINSIC |
coiled coil region
|
592 |
803 |
N/A |
INTRINSIC |
coiled coil region
|
826 |
915 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000146247
|
SMART Domains |
Protein: ENSMUSP00000117370 Gene: ENSMUSG00000026764
Domain | Start | End | E-Value | Type |
Pfam:Kinesin
|
1 |
63 |
2.1e-23 |
PFAM |
coiled coil region
|
67 |
109 |
N/A |
INTRINSIC |
coiled coil region
|
143 |
243 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015] PHENOTYPE: Mice homezygous for disruptions in this gene are viable, fertile, and of normal size. The brain is normal but slightly reduced in size with decreased numbers of motor neurons an somewhat more sensory nerves than normal. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 47 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Actn4 |
A |
T |
7: 28,597,305 (GRCm39) |
M661K |
probably benign |
Het |
Arpin |
G |
A |
7: 79,577,941 (GRCm39) |
R163W |
probably benign |
Het |
Atm |
C |
A |
9: 53,399,283 (GRCm39) |
D1573Y |
probably damaging |
Het |
Avil |
A |
G |
10: 126,847,695 (GRCm39) |
N540S |
probably benign |
Het |
Btnl6 |
T |
C |
17: 34,733,017 (GRCm39) |
Q282R |
probably benign |
Het |
Cacna2d3 |
T |
C |
14: 28,785,832 (GRCm39) |
|
probably benign |
Het |
Cd300ld4 |
T |
C |
11: 114,913,545 (GRCm39) |
N170S |
probably benign |
Het |
Cgnl1 |
T |
A |
9: 71,633,135 (GRCm39) |
N72I |
probably damaging |
Het |
Cntnap3 |
T |
C |
13: 64,946,878 (GRCm39) |
|
probably benign |
Het |
Col27a1 |
A |
T |
4: 63,143,379 (GRCm39) |
T356S |
possibly damaging |
Het |
Csgalnact1 |
C |
A |
8: 68,854,144 (GRCm39) |
G219V |
probably damaging |
Het |
Cyp2c69 |
G |
T |
19: 39,839,501 (GRCm39) |
T374N |
probably damaging |
Het |
Cyp2d26 |
T |
C |
15: 82,675,307 (GRCm39) |
E349G |
probably benign |
Het |
Dnah1 |
T |
C |
14: 31,026,885 (GRCm39) |
E713G |
probably benign |
Het |
Dnah7b |
A |
T |
1: 46,179,035 (GRCm39) |
T903S |
probably benign |
Het |
Enthd1 |
T |
C |
15: 80,336,943 (GRCm39) |
D497G |
probably damaging |
Het |
Grk4 |
C |
T |
5: 34,867,530 (GRCm39) |
T165I |
probably benign |
Het |
Hmcn1 |
G |
A |
1: 150,598,358 (GRCm39) |
S1648L |
probably benign |
Het |
Ints11 |
A |
G |
4: 155,971,320 (GRCm39) |
Y278C |
probably damaging |
Het |
Kcnu1 |
T |
C |
8: 26,382,090 (GRCm39) |
L480P |
probably damaging |
Het |
Kifbp |
C |
T |
10: 62,414,128 (GRCm39) |
R10H |
probably benign |
Het |
Klhl35 |
T |
C |
7: 99,120,888 (GRCm39) |
|
probably benign |
Het |
Lemd3 |
A |
T |
10: 120,761,933 (GRCm39) |
D807E |
possibly damaging |
Het |
Lrrc37a |
G |
A |
11: 103,395,365 (GRCm39) |
T20I |
probably benign |
Het |
Mab21l1 |
C |
T |
3: 55,691,016 (GRCm39) |
A201V |
probably benign |
Het |
Mab21l2 |
T |
C |
3: 86,454,124 (GRCm39) |
D292G |
possibly damaging |
Het |
Map3k21 |
T |
C |
8: 126,668,886 (GRCm39) |
L824P |
probably benign |
Het |
Myo5a |
T |
C |
9: 75,120,263 (GRCm39) |
V1687A |
probably benign |
Het |
Myo5c |
G |
T |
9: 75,208,184 (GRCm39) |
W1639C |
probably damaging |
Het |
Nfya |
G |
T |
17: 48,700,283 (GRCm39) |
|
probably benign |
Het |
Or4a76 |
A |
G |
2: 89,461,098 (GRCm39) |
I48T |
probably damaging |
Het |
Papolg |
A |
G |
11: 23,820,870 (GRCm39) |
|
probably benign |
Het |
Pcdh8 |
G |
A |
14: 80,006,686 (GRCm39) |
R626C |
probably damaging |
Het |
Pclo |
T |
C |
5: 14,815,159 (GRCm39) |
|
probably benign |
Het |
Pogz |
T |
C |
3: 94,782,014 (GRCm39) |
|
probably benign |
Het |
Polg |
G |
A |
7: 79,107,915 (GRCm39) |
|
probably benign |
Het |
Scn9a |
A |
G |
2: 66,377,479 (GRCm39) |
V401A |
probably damaging |
Het |
Scn9a |
A |
T |
2: 66,325,170 (GRCm39) |
I1317K |
probably damaging |
Het |
St7 |
T |
A |
6: 17,844,968 (GRCm39) |
|
probably benign |
Het |
Tdo2 |
C |
T |
3: 81,866,232 (GRCm39) |
V344M |
probably damaging |
Het |
Trmt1 |
T |
C |
8: 85,424,100 (GRCm39) |
V400A |
probably damaging |
Het |
Trrap |
A |
G |
5: 144,753,243 (GRCm39) |
N1856S |
probably benign |
Het |
Ube3a |
G |
A |
7: 58,925,789 (GRCm39) |
G210D |
probably benign |
Het |
Ubqln5 |
A |
G |
7: 103,778,689 (GRCm39) |
V45A |
probably damaging |
Het |
Wdpcp |
T |
A |
11: 21,661,958 (GRCm39) |
M410K |
possibly damaging |
Het |
Xpa |
G |
A |
4: 46,185,606 (GRCm39) |
T124M |
probably damaging |
Het |
Zpbp2 |
A |
G |
11: 98,446,367 (GRCm39) |
E172G |
probably damaging |
Het |
|
Other mutations in Kif5c |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01064:Kif5c
|
APN |
2 |
49,584,828 (GRCm39) |
missense |
possibly damaging |
0.81 |
IGL01432:Kif5c
|
APN |
2 |
49,591,089 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01459:Kif5c
|
APN |
2 |
49,625,569 (GRCm39) |
missense |
probably benign |
0.36 |
IGL03088:Kif5c
|
APN |
2 |
49,634,455 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03379:Kif5c
|
APN |
2 |
49,591,104 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL02988:Kif5c
|
UTSW |
2 |
49,509,729 (GRCm39) |
missense |
probably damaging |
0.97 |
PIT4131001:Kif5c
|
UTSW |
2 |
49,584,044 (GRCm39) |
missense |
probably damaging |
0.99 |
PIT4469001:Kif5c
|
UTSW |
2 |
49,631,360 (GRCm39) |
missense |
probably benign |
0.00 |
R0017:Kif5c
|
UTSW |
2 |
49,622,725 (GRCm39) |
missense |
probably benign |
|
R0017:Kif5c
|
UTSW |
2 |
49,622,725 (GRCm39) |
missense |
probably benign |
|
R0116:Kif5c
|
UTSW |
2 |
49,642,251 (GRCm39) |
splice site |
probably benign |
|
R0550:Kif5c
|
UTSW |
2 |
49,648,924 (GRCm39) |
missense |
possibly damaging |
0.53 |
R0760:Kif5c
|
UTSW |
2 |
49,578,765 (GRCm39) |
missense |
probably damaging |
1.00 |
R0967:Kif5c
|
UTSW |
2 |
49,588,128 (GRCm39) |
unclassified |
probably benign |
|
R1015:Kif5c
|
UTSW |
2 |
49,634,377 (GRCm39) |
missense |
probably benign |
0.13 |
R1758:Kif5c
|
UTSW |
2 |
49,613,145 (GRCm39) |
missense |
probably benign |
0.00 |
R1786:Kif5c
|
UTSW |
2 |
49,648,817 (GRCm39) |
splice site |
probably benign |
|
R1828:Kif5c
|
UTSW |
2 |
49,570,252 (GRCm39) |
critical splice donor site |
probably null |
|
R2130:Kif5c
|
UTSW |
2 |
49,648,817 (GRCm39) |
splice site |
probably benign |
|
R2132:Kif5c
|
UTSW |
2 |
49,648,817 (GRCm39) |
splice site |
probably benign |
|
R2237:Kif5c
|
UTSW |
2 |
49,584,020 (GRCm39) |
missense |
probably benign |
0.35 |
R3970:Kif5c
|
UTSW |
2 |
49,578,756 (GRCm39) |
missense |
probably damaging |
1.00 |
R4439:Kif5c
|
UTSW |
2 |
49,578,737 (GRCm39) |
missense |
possibly damaging |
0.90 |
R5260:Kif5c
|
UTSW |
2 |
49,625,602 (GRCm39) |
missense |
probably damaging |
0.99 |
R5318:Kif5c
|
UTSW |
2 |
49,561,840 (GRCm39) |
missense |
probably benign |
|
R5345:Kif5c
|
UTSW |
2 |
49,613,078 (GRCm39) |
missense |
probably benign |
|
R5490:Kif5c
|
UTSW |
2 |
49,648,870 (GRCm39) |
missense |
probably benign |
|
R5496:Kif5c
|
UTSW |
2 |
49,620,202 (GRCm39) |
missense |
possibly damaging |
0.69 |
R5567:Kif5c
|
UTSW |
2 |
49,620,211 (GRCm39) |
missense |
possibly damaging |
0.64 |
R5570:Kif5c
|
UTSW |
2 |
49,620,211 (GRCm39) |
missense |
possibly damaging |
0.64 |
R6019:Kif5c
|
UTSW |
2 |
49,625,521 (GRCm39) |
missense |
probably benign |
0.09 |
R6688:Kif5c
|
UTSW |
2 |
49,578,749 (GRCm39) |
missense |
probably benign |
0.06 |
R7006:Kif5c
|
UTSW |
2 |
49,625,526 (GRCm39) |
missense |
probably damaging |
0.97 |
R7009:Kif5c
|
UTSW |
2 |
49,647,441 (GRCm39) |
missense |
probably benign |
|
R7081:Kif5c
|
UTSW |
2 |
49,631,373 (GRCm39) |
missense |
probably benign |
0.00 |
R7372:Kif5c
|
UTSW |
2 |
49,648,671 (GRCm39) |
splice site |
probably null |
|
R7512:Kif5c
|
UTSW |
2 |
49,590,977 (GRCm39) |
missense |
probably damaging |
1.00 |
R7549:Kif5c
|
UTSW |
2 |
49,591,105 (GRCm39) |
missense |
probably benign |
0.11 |
R7764:Kif5c
|
UTSW |
2 |
49,639,339 (GRCm39) |
missense |
probably damaging |
1.00 |
R7764:Kif5c
|
UTSW |
2 |
49,617,973 (GRCm39) |
critical splice donor site |
probably null |
|
R7904:Kif5c
|
UTSW |
2 |
49,591,095 (GRCm39) |
missense |
probably damaging |
1.00 |
R8292:Kif5c
|
UTSW |
2 |
49,625,497 (GRCm39) |
missense |
probably benign |
0.05 |
R8735:Kif5c
|
UTSW |
2 |
49,584,783 (GRCm39) |
missense |
probably damaging |
1.00 |
R8816:Kif5c
|
UTSW |
2 |
49,584,799 (GRCm39) |
missense |
probably damaging |
1.00 |
R9109:Kif5c
|
UTSW |
2 |
49,620,151 (GRCm39) |
missense |
probably damaging |
1.00 |
R9139:Kif5c
|
UTSW |
2 |
49,620,291 (GRCm39) |
missense |
probably benign |
0.00 |
R9257:Kif5c
|
UTSW |
2 |
49,590,604 (GRCm39) |
nonsense |
probably null |
|
R9325:Kif5c
|
UTSW |
2 |
49,639,378 (GRCm39) |
missense |
probably benign |
0.04 |
R9368:Kif5c
|
UTSW |
2 |
49,622,792 (GRCm39) |
missense |
probably damaging |
0.99 |
R9748:Kif5c
|
UTSW |
2 |
49,584,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Posted On |
2015-04-16 |