Incidental Mutation 'IGL02129:Fgb'
| ID |
280966 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Fgb
|
| Ensembl Gene |
ENSMUSG00000033831 |
| Gene Name |
fibrinogen beta chain |
| Synonyms |
2510049G14Rik |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.784)
|
| Stock # |
IGL02129
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
3 |
| Chromosomal Location |
82949553-82957170 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 82950725 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Methionine
at position 343
(K343M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000039472
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000048246]
|
| AlphaFold |
Q8K0E8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000048246
AA Change: K343M
PolyPhen 2
Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000039472
Gene: ENSMUSG00000033831
AA Change: K343M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
46 |
55 |
N/A |
INTRINSIC |
|
Fib_alpha
|
80 |
225 |
1.28e-64 |
SMART |
|
FBG
|
226 |
477 |
1.6e-140 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes the beta subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded preproprotein is proteolytically processed by thrombin to release an N-terminal fibrinopeptide during the conversion of fibrinogen to insoluble fibrin polymer. The encoded protein interacts with the amyloid beta peptide to form fibrin clots of abnormal structure, and may play an important role in Alzheimer's disease. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. [provided by RefSeq, Nov 2015]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atp1a3 |
T |
A |
7: 24,696,711 (GRCm39) |
H293L |
probably damaging |
Het |
| AU040320 |
A |
G |
4: 126,717,485 (GRCm39) |
Y354C |
probably damaging |
Het |
| Bag4 |
T |
C |
8: 26,258,113 (GRCm39) |
T405A |
probably damaging |
Het |
| Best1 |
T |
A |
19: 9,970,285 (GRCm39) |
Q109L |
probably benign |
Het |
| Bod1l |
G |
A |
5: 41,979,193 (GRCm39) |
T707I |
probably benign |
Het |
| Bora |
G |
A |
14: 99,294,257 (GRCm39) |
|
probably null |
Het |
| Btnl9 |
A |
C |
11: 49,060,100 (GRCm39) |
D464E |
probably damaging |
Het |
| Cebpe |
T |
A |
14: 54,949,070 (GRCm39) |
R116W |
probably damaging |
Het |
| Col6a6 |
T |
C |
9: 105,613,539 (GRCm39) |
|
probably benign |
Het |
| Copb2 |
T |
C |
9: 98,467,976 (GRCm39) |
|
probably benign |
Het |
| Ep300 |
A |
G |
15: 81,470,837 (GRCm39) |
E3G |
unknown |
Het |
| Fam117b |
A |
G |
1: 60,020,582 (GRCm39) |
H484R |
probably benign |
Het |
| Fkbpl |
C |
T |
17: 34,864,952 (GRCm39) |
T240M |
probably damaging |
Het |
| Gemin6 |
T |
C |
17: 80,535,355 (GRCm39) |
L105P |
probably damaging |
Het |
| Heatr3 |
T |
C |
8: 88,884,899 (GRCm39) |
|
probably benign |
Het |
| Itch |
C |
T |
2: 155,059,908 (GRCm39) |
|
probably benign |
Het |
| Kank3 |
C |
T |
17: 34,036,465 (GRCm39) |
P111L |
probably benign |
Het |
| Mthfsl |
T |
A |
9: 88,597,589 (GRCm39) |
I111F |
probably damaging |
Het |
| Mtor |
A |
T |
4: 148,634,302 (GRCm39) |
M2382L |
possibly damaging |
Het |
| Myh2 |
A |
G |
11: 67,076,084 (GRCm39) |
D757G |
probably benign |
Het |
| Naa35 |
A |
G |
13: 59,757,339 (GRCm39) |
D238G |
probably damaging |
Het |
| Nckap5 |
A |
T |
1: 125,955,432 (GRCm39) |
Y373* |
probably null |
Het |
| Or5an10 |
T |
A |
19: 12,275,822 (GRCm39) |
I225F |
probably damaging |
Het |
| Pigm |
G |
A |
1: 172,205,434 (GRCm39) |
W390* |
probably null |
Het |
| Plxnb2 |
A |
G |
15: 89,044,613 (GRCm39) |
V1211A |
probably benign |
Het |
| Sh3yl1 |
T |
A |
12: 30,992,876 (GRCm39) |
|
probably benign |
Het |
| Spg11 |
T |
A |
2: 121,926,167 (GRCm39) |
Q709H |
probably damaging |
Het |
| Spr-ps1 |
A |
G |
6: 85,132,804 (GRCm39) |
|
noncoding transcript |
Het |
| Tc2n |
T |
C |
12: 101,656,048 (GRCm39) |
N208D |
probably damaging |
Het |
| Tdo2 |
C |
T |
3: 81,866,232 (GRCm39) |
V344M |
probably damaging |
Het |
| Ttll1 |
G |
A |
15: 83,368,450 (GRCm39) |
P403S |
probably benign |
Het |
| Usp20 |
T |
C |
2: 30,894,462 (GRCm39) |
V126A |
probably benign |
Het |
| Zfp109 |
T |
C |
7: 23,936,054 (GRCm39) |
T2A |
possibly damaging |
Het |
|
| Other mutations in Fgb |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00839:Fgb
|
APN |
3 |
82,950,598 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02148:Fgb
|
APN |
3 |
82,950,594 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02286:Fgb
|
APN |
3 |
82,950,633 (GRCm39) |
missense |
probably benign |
|
|
IGL02601:Fgb
|
APN |
3 |
82,952,367 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02721:Fgb
|
APN |
3 |
82,950,674 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
G1patch:Fgb
|
UTSW |
3 |
82,951,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1217:Fgb
|
UTSW |
3 |
82,950,564 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1424:Fgb
|
UTSW |
3 |
82,954,070 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1913:Fgb
|
UTSW |
3 |
82,952,287 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1990:Fgb
|
UTSW |
3 |
82,951,560 (GRCm39) |
nonsense |
probably null |
|
|
R2063:Fgb
|
UTSW |
3 |
82,956,996 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2065:Fgb
|
UTSW |
3 |
82,956,996 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2066:Fgb
|
UTSW |
3 |
82,956,996 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2067:Fgb
|
UTSW |
3 |
82,956,996 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2251:Fgb
|
UTSW |
3 |
82,950,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4682:Fgb
|
UTSW |
3 |
82,950,572 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5045:Fgb
|
UTSW |
3 |
82,950,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5573:Fgb
|
UTSW |
3 |
82,956,984 (GRCm39) |
splice site |
probably null |
|
|
R5766:Fgb
|
UTSW |
3 |
82,953,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6103:Fgb
|
UTSW |
3 |
82,951,170 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6315:Fgb
|
UTSW |
3 |
82,952,362 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6469:Fgb
|
UTSW |
3 |
82,953,449 (GRCm39) |
nonsense |
probably null |
|
|
R6664:Fgb
|
UTSW |
3 |
82,954,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6725:Fgb
|
UTSW |
3 |
82,951,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6727:Fgb
|
UTSW |
3 |
82,954,094 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6830:Fgb
|
UTSW |
3 |
82,952,332 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7016:Fgb
|
UTSW |
3 |
82,953,371 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7132:Fgb
|
UTSW |
3 |
82,954,053 (GRCm39) |
nonsense |
probably null |
|
|
R7371:Fgb
|
UTSW |
3 |
82,953,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7430:Fgb
|
UTSW |
3 |
82,954,014 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7681:Fgb
|
UTSW |
3 |
82,957,139 (GRCm39) |
start gained |
probably benign |
|
|
R7811:Fgb
|
UTSW |
3 |
82,957,004 (GRCm39) |
missense |
probably benign |
|
|
R8171:Fgb
|
UTSW |
3 |
82,949,822 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8787:Fgb
|
UTSW |
3 |
82,953,969 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9526:Fgb
|
UTSW |
3 |
82,957,122 (GRCm39) |
start gained |
probably benign |
|
|
R9562:Fgb
|
UTSW |
3 |
82,952,409 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Fgb
|
UTSW |
3 |
82,952,363 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Posted On |
2015-04-16 |
Incidental Mutation