Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02096:Zfp1001'

281096

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp1001

Ensembl Gene

ENSMUSG00000095315

Gene Name

zinc finger protein 1001

Synonyms

Gm10130

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.114) question?

Stock #

IGL02096

Quality Score

Status

Chromosome

Chromosomal Location

150153370-150168933 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 150165634 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 5 (Y5H)

Ref Sequence

ENSEMBL: ENSMUSP00000117028 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051153] [ENSMUST00000133235]

AlphaFold

A0A571BEN2

Predicted Effect

probably benign
Transcript: ENSMUST00000051153

SMART Domains

Protein: ENSMUSP00000055454
Gene: ENSMUSG00000063364

Domain	Start	End	E-Value	Type
KRAB	22	84	4.09e-20	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124945

Predicted Effect

probably damaging
Transcript: ENSMUST00000133235
AA Change: Y5H

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000117028
Gene: ENSMUSG00000095315
AA Change: Y5H

Domain	Start	End	E-Value	Type
KRAB	3	66	4.56e-18	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	A	G	11: 109,993,359 (GRCm39)	L1584P	probably damaging	Het
Abca9	G	T	11: 110,056,806 (GRCm39)	H5N	probably benign	Het
Acox1	A	T	11: 116,069,024 (GRCm39)	I371N	probably damaging	Het
Aopep	C	A	13: 63,208,903 (GRCm39)	A340E	probably benign	Het
Bmp5	A	G	9: 75,805,833 (GRCm39)	N445S	probably damaging	Het
Cacna1b	G	T	2: 24,568,927 (GRCm39)	A999E	probably benign	Het
Cdc27	A	T	11: 104,419,394 (GRCm39)		probably benign	Het
Dmxl2	T	C	9: 54,308,349 (GRCm39)	E2134G	possibly damaging	Het
Dnttip2	A	G	3: 122,078,062 (GRCm39)	N698S	possibly damaging	Het
Duox1	A	T	2: 122,174,655 (GRCm39)	K1271M	probably damaging	Het
Dync1h1	T	C	12: 110,599,254 (GRCm39)	Y1870H	possibly damaging	Het
Edem3	A	G	1: 151,680,470 (GRCm39)	T532A	probably benign	Het
Epx	A	T	11: 87,760,294 (GRCm39)	L440Q	probably damaging	Het
F11	A	G	8: 45,699,791 (GRCm39)	F432L	probably benign	Het
Fam185a	C	A	5: 21,630,341 (GRCm39)	P59Q	probably damaging	Het
Fsip2	A	G	2: 82,822,204 (GRCm39)	D5979G	possibly damaging	Het
Furin	A	G	7: 80,043,207 (GRCm39)	S335P	probably damaging	Het
Gtf3c1	T	A	7: 125,258,284 (GRCm39)	Q1262L	probably damaging	Het
Hmmr	A	T	11: 40,598,256 (GRCm39)	V652E	probably benign	Het
Iapp	A	T	6: 142,249,199 (GRCm39)	N84I	probably benign	Het
Katnip	G	A	7: 125,413,993 (GRCm39)	C379Y	probably benign	Het
Mmp17	C	T	5: 129,675,752 (GRCm39)	Q304*	probably null	Het
Mpl	T	C	4: 118,314,333 (GRCm39)	T55A	possibly damaging	Het
Mst1r	G	A	9: 107,794,478 (GRCm39)	R1219H	probably damaging	Het
Muc6	T	A	7: 141,226,117 (GRCm39)		probably benign	Het
Nalcn	C	T	14: 123,831,915 (GRCm39)	V120I	probably benign	Het
Nt5dc1	A	T	10: 34,275,806 (GRCm39)	C134*	probably null	Het
Obscn	A	C	11: 58,971,530 (GRCm39)	N2228K	probably damaging	Het
Or2n1c	T	A	17: 38,520,074 (GRCm39)	*313R	probably null	Het
Osbpl10	T	C	9: 115,046,062 (GRCm39)	M566T	possibly damaging	Het
Pabpc1l	G	A	2: 163,886,267 (GRCm39)	V466I	probably benign	Het
Pdcd11	T	G	19: 47,094,860 (GRCm39)	V548G	probably benign	Het
Prss27	G	T	17: 24,263,951 (GRCm39)	K212N	possibly damaging	Het
Ranbp2	T	A	10: 58,297,789 (GRCm39)	S399T	probably damaging	Het
Rgs19	A	G	2: 181,331,076 (GRCm39)	S159P	probably damaging	Het
Sh2b1	A	G	7: 126,068,465 (GRCm39)	S449P	probably damaging	Het
Slc6a18	T	A	13: 73,820,870 (GRCm39)	Y238F	probably benign	Het
Stx11	T	C	10: 12,817,224 (GRCm39)	I167V	probably benign	Het
Sucnr1	A	G	3: 59,994,371 (GRCm39)	M300V	possibly damaging	Het
Synj2	A	G	17: 6,040,628 (GRCm39)	T235A	probably damaging	Het
Ubxn2b	T	A	4: 6,214,749 (GRCm39)	I261N	probably damaging	Het
Vmn2r43	G	A	7: 8,260,512 (GRCm39)		probably benign	Het
Vmn2r45	A	G	7: 8,484,443 (GRCm39)	M454T	probably damaging	Het
Vsig2	T	A	9: 37,451,251 (GRCm39)	S51T	probably damaging	Het
Wdr41	T	C	13: 95,153,964 (GRCm39)		probably benign	Het
Wdr6	A	C	9: 108,453,752 (GRCm39)	L44V	probably damaging	Het
Zfp592	T	C	7: 80,674,796 (GRCm39)	Y587H	probably damaging	Het
Zfp735	A	T	11: 73,602,254 (GRCm39)	K399N	probably benign	Het

Other mutations in Zfp1001

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0041:Zfp1001	UTSW	2	150,165,745 (GRCm39)	missense	possibly damaging	0.78
R0109:Zfp1001	UTSW	2	150,165,761 (GRCm39)	splice site	probably benign
R5402:Zfp1001	UTSW	2	150,204,886 (GRCm39)	missense	probably benign	0.03
R5582:Zfp1001	UTSW	2	150,204,972 (GRCm39)	unclassified	probably benign
R6910:Zfp1001	UTSW	2	150,165,987 (GRCm39)	missense	probably benign	0.03
R8499:Zfp1001	UTSW	2	150,204,907 (GRCm39)	missense	probably benign	0.00
R9055:Zfp1001	UTSW	2	150,165,753 (GRCm39)	splice site	probably benign

Posted On

2015-04-16