Incidental Mutation 'IGL02096:Aopep'
ID 281119
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Aopep
Ensembl Gene ENSMUSG00000021458
Gene Name aminopeptidase O
Synonyms 2010111I01Rik, ApO
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # IGL02096
Quality Score
Status
Chromosome 13
Chromosomal Location 63112707-63473910 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 63208903 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glutamic Acid at position 340 (A340E)
Ref Sequence ENSEMBL: ENSMUSP00000089148 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021911] [ENSMUST00000091560]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000021911
AA Change: A338E

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000021911
Gene: ENSMUSG00000021458
AA Change: A338E

DomainStartEndE-ValueType
low complexity region 143 154 N/A INTRINSIC
Pfam:Peptidase_M1 221 359 5.4e-11 PFAM
Pfam:Peptidase_M1 385 558 2.3e-15 PFAM
Pfam:Peptidase_MA_2 453 613 1.3e-12 PFAM
Leuk-A4-hydro_C 675 821 3.02e-37 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000091560
AA Change: A340E

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000089148
Gene: ENSMUSG00000021458
AA Change: A340E

DomainStartEndE-ValueType
low complexity region 143 154 N/A INTRINSIC
Pfam:Peptidase_M1 220 359 2.7e-11 PFAM
Pfam:Peptidase_M1 386 561 1.9e-15 PFAM
Leuk-A4-hydro_C 676 822 3.02e-37 SMART
Predicted Effect unknown
Transcript: ENSMUST00000220863
AA Change: A231E
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
PHENOTYPE: Mice homozygous for one gene trapped allele are phenotypically normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A G 11: 109,993,359 (GRCm39) L1584P probably damaging Het
Abca9 G T 11: 110,056,806 (GRCm39) H5N probably benign Het
Acox1 A T 11: 116,069,024 (GRCm39) I371N probably damaging Het
Bmp5 A G 9: 75,805,833 (GRCm39) N445S probably damaging Het
Cacna1b G T 2: 24,568,927 (GRCm39) A999E probably benign Het
Cdc27 A T 11: 104,419,394 (GRCm39) probably benign Het
Dmxl2 T C 9: 54,308,349 (GRCm39) E2134G possibly damaging Het
Dnttip2 A G 3: 122,078,062 (GRCm39) N698S possibly damaging Het
Duox1 A T 2: 122,174,655 (GRCm39) K1271M probably damaging Het
Dync1h1 T C 12: 110,599,254 (GRCm39) Y1870H possibly damaging Het
Edem3 A G 1: 151,680,470 (GRCm39) T532A probably benign Het
Epx A T 11: 87,760,294 (GRCm39) L440Q probably damaging Het
F11 A G 8: 45,699,791 (GRCm39) F432L probably benign Het
Fam185a C A 5: 21,630,341 (GRCm39) P59Q probably damaging Het
Fsip2 A G 2: 82,822,204 (GRCm39) D5979G possibly damaging Het
Furin A G 7: 80,043,207 (GRCm39) S335P probably damaging Het
Gtf3c1 T A 7: 125,258,284 (GRCm39) Q1262L probably damaging Het
Hmmr A T 11: 40,598,256 (GRCm39) V652E probably benign Het
Iapp A T 6: 142,249,199 (GRCm39) N84I probably benign Het
Katnip G A 7: 125,413,993 (GRCm39) C379Y probably benign Het
Mmp17 C T 5: 129,675,752 (GRCm39) Q304* probably null Het
Mpl T C 4: 118,314,333 (GRCm39) T55A possibly damaging Het
Mst1r G A 9: 107,794,478 (GRCm39) R1219H probably damaging Het
Muc6 T A 7: 141,226,117 (GRCm39) probably benign Het
Nalcn C T 14: 123,831,915 (GRCm39) V120I probably benign Het
Nt5dc1 A T 10: 34,275,806 (GRCm39) C134* probably null Het
Obscn A C 11: 58,971,530 (GRCm39) N2228K probably damaging Het
Or2n1c T A 17: 38,520,074 (GRCm39) *313R probably null Het
Osbpl10 T C 9: 115,046,062 (GRCm39) M566T possibly damaging Het
Pabpc1l G A 2: 163,886,267 (GRCm39) V466I probably benign Het
Pdcd11 T G 19: 47,094,860 (GRCm39) V548G probably benign Het
Prss27 G T 17: 24,263,951 (GRCm39) K212N possibly damaging Het
Ranbp2 T A 10: 58,297,789 (GRCm39) S399T probably damaging Het
Rgs19 A G 2: 181,331,076 (GRCm39) S159P probably damaging Het
Sh2b1 A G 7: 126,068,465 (GRCm39) S449P probably damaging Het
Slc6a18 T A 13: 73,820,870 (GRCm39) Y238F probably benign Het
Stx11 T C 10: 12,817,224 (GRCm39) I167V probably benign Het
Sucnr1 A G 3: 59,994,371 (GRCm39) M300V possibly damaging Het
Synj2 A G 17: 6,040,628 (GRCm39) T235A probably damaging Het
Ubxn2b T A 4: 6,214,749 (GRCm39) I261N probably damaging Het
Vmn2r43 G A 7: 8,260,512 (GRCm39) probably benign Het
Vmn2r45 A G 7: 8,484,443 (GRCm39) M454T probably damaging Het
Vsig2 T A 9: 37,451,251 (GRCm39) S51T probably damaging Het
Wdr41 T C 13: 95,153,964 (GRCm39) probably benign Het
Wdr6 A C 9: 108,453,752 (GRCm39) L44V probably damaging Het
Zfp1001 T C 2: 150,165,634 (GRCm39) Y5H probably damaging Het
Zfp592 T C 7: 80,674,796 (GRCm39) Y587H probably damaging Het
Zfp735 A T 11: 73,602,254 (GRCm39) K399N probably benign Het
Other mutations in Aopep
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00229:Aopep APN 13 63,347,314 (GRCm39) splice site probably benign
IGL00329:Aopep APN 13 63,338,977 (GRCm39) missense probably damaging 1.00
IGL00336:Aopep APN 13 63,163,237 (GRCm39) missense possibly damaging 0.78
IGL01384:Aopep APN 13 63,338,290 (GRCm39) splice site probably benign
IGL01780:Aopep APN 13 63,357,939 (GRCm39) missense probably benign 0.00
IGL01876:Aopep APN 13 63,338,336 (GRCm39) missense probably damaging 1.00
IGL02166:Aopep APN 13 63,163,267 (GRCm39) missense probably benign 0.02
IGL02184:Aopep APN 13 63,215,925 (GRCm39) missense possibly damaging 0.50
PIT4378001:Aopep UTSW 13 63,163,021 (GRCm39) missense probably damaging 1.00
R0139:Aopep UTSW 13 63,338,298 (GRCm39) missense probably benign 0.01
R1209:Aopep UTSW 13 63,338,878 (GRCm39) splice site probably null
R1233:Aopep UTSW 13 63,347,334 (GRCm39) missense probably damaging 0.96
R1756:Aopep UTSW 13 63,215,875 (GRCm39) missense possibly damaging 0.95
R1786:Aopep UTSW 13 63,357,963 (GRCm39) missense probably benign 0.00
R1861:Aopep UTSW 13 63,163,597 (GRCm39) missense probably damaging 1.00
R2130:Aopep UTSW 13 63,357,963 (GRCm39) missense probably benign 0.00
R2131:Aopep UTSW 13 63,357,963 (GRCm39) missense probably benign 0.00
R3076:Aopep UTSW 13 63,387,929 (GRCm39) missense probably damaging 0.96
R3702:Aopep UTSW 13 63,163,144 (GRCm39) missense probably benign 0.01
R3912:Aopep UTSW 13 63,304,520 (GRCm39) nonsense probably null
R4512:Aopep UTSW 13 63,304,481 (GRCm39) missense probably damaging 0.99
R4593:Aopep UTSW 13 63,215,906 (GRCm39) missense probably benign 0.01
R4596:Aopep UTSW 13 63,215,906 (GRCm39) missense probably benign 0.01
R4597:Aopep UTSW 13 63,215,906 (GRCm39) missense probably benign 0.01
R4616:Aopep UTSW 13 63,446,565 (GRCm39) missense probably damaging 1.00
R4625:Aopep UTSW 13 63,215,906 (GRCm39) missense probably benign 0.01
R4627:Aopep UTSW 13 63,215,906 (GRCm39) missense probably benign 0.01
R4630:Aopep UTSW 13 63,215,906 (GRCm39) missense probably benign 0.01
R4632:Aopep UTSW 13 63,215,906 (GRCm39) missense probably benign 0.01
R4911:Aopep UTSW 13 63,318,753 (GRCm39) critical splice acceptor site probably null
R5204:Aopep UTSW 13 63,180,904 (GRCm39) missense probably benign 0.15
R5210:Aopep UTSW 13 63,215,924 (GRCm39) missense probably benign 0.00
R5849:Aopep UTSW 13 63,163,312 (GRCm39) missense probably benign 0.00
R5861:Aopep UTSW 13 63,446,626 (GRCm39) missense probably damaging 1.00
R5960:Aopep UTSW 13 63,388,087 (GRCm39) missense probably damaging 0.99
R6021:Aopep UTSW 13 63,208,896 (GRCm39) missense probably damaging 1.00
R6048:Aopep UTSW 13 63,388,139 (GRCm39) missense probably damaging 0.99
R6379:Aopep UTSW 13 63,216,057 (GRCm39) missense probably damaging 0.97
R7038:Aopep UTSW 13 63,338,339 (GRCm39) missense possibly damaging 0.54
R7493:Aopep UTSW 13 63,163,345 (GRCm39) missense probably benign 0.01
R7788:Aopep UTSW 13 63,304,407 (GRCm39) missense possibly damaging 0.89
R7970:Aopep UTSW 13 63,180,974 (GRCm39) missense probably benign 0.11
R7988:Aopep UTSW 13 63,208,954 (GRCm39) missense probably benign 0.00
R8041:Aopep UTSW 13 63,180,921 (GRCm39) missense probably damaging 1.00
R8052:Aopep UTSW 13 63,216,065 (GRCm39) missense probably damaging 1.00
R8053:Aopep UTSW 13 63,338,345 (GRCm39) nonsense probably null
R8537:Aopep UTSW 13 63,338,364 (GRCm39) missense probably damaging 1.00
R8554:Aopep UTSW 13 63,444,711 (GRCm39) missense possibly damaging 0.94
R8681:Aopep UTSW 13 63,338,373 (GRCm39) missense probably damaging 1.00
R8909:Aopep UTSW 13 63,388,111 (GRCm39) missense possibly damaging 0.95
R8945:Aopep UTSW 13 63,388,145 (GRCm39) missense probably null 1.00
R8990:Aopep UTSW 13 63,304,428 (GRCm39) missense probably damaging 1.00
R9032:Aopep UTSW 13 63,444,681 (GRCm39) nonsense probably null
R9049:Aopep UTSW 13 63,208,852 (GRCm39) missense probably benign 0.00
R9166:Aopep UTSW 13 63,318,862 (GRCm39) critical splice donor site probably null
R9590:Aopep UTSW 13 63,208,923 (GRCm39) missense probably benign
Z1177:Aopep UTSW 13 63,318,804 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16