Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02096:Sucnr1'

281130

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sucnr1

Ensembl Gene

ENSMUSG00000027762

Gene Name

succinate receptor 1

Synonyms

Gpr91

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL02096

Quality Score

Status

Chromosome

Chromosomal Location

59989290-59994987 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 59994371 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 300 (M300V)

Ref Sequence

ENSEMBL: ENSMUSP00000029326 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029326]

AlphaFold

Q99MT6

Predicted Effect

possibly damaging
Transcript: ENSMUST00000029326
AA Change: M300V

PolyPhen 2 Score 0.555 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000029326
Gene: ENSMUSG00000027762
AA Change: M300V

Domain	Start	End	E-Value	Type
Pfam:7tm_1	36	290	9.3e-38	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000195544

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a knockout allele exhibit decreased renin plasma and kidney levels upon high-glucose stimulation in a diabetic or non-diabetic model. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	A	G	11: 109,993,359 (GRCm39)	L1584P	probably damaging	Het
Abca9	G	T	11: 110,056,806 (GRCm39)	H5N	probably benign	Het
Acox1	A	T	11: 116,069,024 (GRCm39)	I371N	probably damaging	Het
Aopep	C	A	13: 63,208,903 (GRCm39)	A340E	probably benign	Het
Bmp5	A	G	9: 75,805,833 (GRCm39)	N445S	probably damaging	Het
Cacna1b	G	T	2: 24,568,927 (GRCm39)	A999E	probably benign	Het
Cdc27	A	T	11: 104,419,394 (GRCm39)		probably benign	Het
Dmxl2	T	C	9: 54,308,349 (GRCm39)	E2134G	possibly damaging	Het
Dnttip2	A	G	3: 122,078,062 (GRCm39)	N698S	possibly damaging	Het
Duox1	A	T	2: 122,174,655 (GRCm39)	K1271M	probably damaging	Het
Dync1h1	T	C	12: 110,599,254 (GRCm39)	Y1870H	possibly damaging	Het
Edem3	A	G	1: 151,680,470 (GRCm39)	T532A	probably benign	Het
Epx	A	T	11: 87,760,294 (GRCm39)	L440Q	probably damaging	Het
F11	A	G	8: 45,699,791 (GRCm39)	F432L	probably benign	Het
Fam185a	C	A	5: 21,630,341 (GRCm39)	P59Q	probably damaging	Het
Fsip2	A	G	2: 82,822,204 (GRCm39)	D5979G	possibly damaging	Het
Furin	A	G	7: 80,043,207 (GRCm39)	S335P	probably damaging	Het
Gtf3c1	T	A	7: 125,258,284 (GRCm39)	Q1262L	probably damaging	Het
Hmmr	A	T	11: 40,598,256 (GRCm39)	V652E	probably benign	Het
Iapp	A	T	6: 142,249,199 (GRCm39)	N84I	probably benign	Het
Katnip	G	A	7: 125,413,993 (GRCm39)	C379Y	probably benign	Het
Mmp17	C	T	5: 129,675,752 (GRCm39)	Q304*	probably null	Het
Mpl	T	C	4: 118,314,333 (GRCm39)	T55A	possibly damaging	Het
Mst1r	G	A	9: 107,794,478 (GRCm39)	R1219H	probably damaging	Het
Muc6	T	A	7: 141,226,117 (GRCm39)		probably benign	Het
Nalcn	C	T	14: 123,831,915 (GRCm39)	V120I	probably benign	Het
Nt5dc1	A	T	10: 34,275,806 (GRCm39)	C134*	probably null	Het
Obscn	A	C	11: 58,971,530 (GRCm39)	N2228K	probably damaging	Het
Or2n1c	T	A	17: 38,520,074 (GRCm39)	*313R	probably null	Het
Osbpl10	T	C	9: 115,046,062 (GRCm39)	M566T	possibly damaging	Het
Pabpc1l	G	A	2: 163,886,267 (GRCm39)	V466I	probably benign	Het
Pdcd11	T	G	19: 47,094,860 (GRCm39)	V548G	probably benign	Het
Prss27	G	T	17: 24,263,951 (GRCm39)	K212N	possibly damaging	Het
Ranbp2	T	A	10: 58,297,789 (GRCm39)	S399T	probably damaging	Het
Rgs19	A	G	2: 181,331,076 (GRCm39)	S159P	probably damaging	Het
Sh2b1	A	G	7: 126,068,465 (GRCm39)	S449P	probably damaging	Het
Slc6a18	T	A	13: 73,820,870 (GRCm39)	Y238F	probably benign	Het
Stx11	T	C	10: 12,817,224 (GRCm39)	I167V	probably benign	Het
Synj2	A	G	17: 6,040,628 (GRCm39)	T235A	probably damaging	Het
Ubxn2b	T	A	4: 6,214,749 (GRCm39)	I261N	probably damaging	Het
Vmn2r43	G	A	7: 8,260,512 (GRCm39)		probably benign	Het
Vmn2r45	A	G	7: 8,484,443 (GRCm39)	M454T	probably damaging	Het
Vsig2	T	A	9: 37,451,251 (GRCm39)	S51T	probably damaging	Het
Wdr41	T	C	13: 95,153,964 (GRCm39)		probably benign	Het
Wdr6	A	C	9: 108,453,752 (GRCm39)	L44V	probably damaging	Het
Zfp1001	T	C	2: 150,165,634 (GRCm39)	Y5H	probably damaging	Het
Zfp592	T	C	7: 80,674,796 (GRCm39)	Y587H	probably damaging	Het
Zfp735	A	T	11: 73,602,254 (GRCm39)	K399N	probably benign	Het

Other mutations in Sucnr1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00340:Sucnr1	APN	3	59,994,053 (GRCm39)	missense	probably benign	0.03
IGL01656:Sucnr1	APN	3	59,993,832 (GRCm39)	missense	possibly damaging	0.67
R0727:Sucnr1	UTSW	3	59,994,081 (GRCm39)	missense	probably benign	0.14
R4110:Sucnr1	UTSW	3	59,994,215 (GRCm39)	missense	probably damaging	1.00
R4112:Sucnr1	UTSW	3	59,994,215 (GRCm39)	missense	probably damaging	1.00
R4620:Sucnr1	UTSW	3	59,994,190 (GRCm39)	missense	possibly damaging	0.68
R4831:Sucnr1	UTSW	3	59,994,069 (GRCm39)	missense	probably damaging	1.00
R5068:Sucnr1	UTSW	3	59,994,288 (GRCm39)	missense	probably damaging	1.00
R5263:Sucnr1	UTSW	3	59,994,190 (GRCm39)	missense	possibly damaging	0.68
R6258:Sucnr1	UTSW	3	59,993,778 (GRCm39)	missense	probably damaging	1.00
R6505:Sucnr1	UTSW	3	59,994,144 (GRCm39)	missense	probably benign	0.23
R6574:Sucnr1	UTSW	3	59,994,020 (GRCm39)	missense	probably damaging	1.00
R7022:Sucnr1	UTSW	3	59,993,699 (GRCm39)	missense	probably benign	0.03
R7072:Sucnr1	UTSW	3	59,993,604 (GRCm39)	missense	probably damaging	1.00
R7439:Sucnr1	UTSW	3	59,994,117 (GRCm39)	missense	probably benign
R7918:Sucnr1	UTSW	3	59,993,790 (GRCm39)	missense	probably damaging	1.00
R8098:Sucnr1	UTSW	3	59,994,162 (GRCm39)	missense	probably damaging	1.00
R8342:Sucnr1	UTSW	3	59,994,155 (GRCm39)	missense	probably damaging	0.96
R8891:Sucnr1	UTSW	3	59,994,263 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16