Incidental Mutation 'IGL02134:Or10q1'
ID 281217
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10q1
Ensembl Gene ENSMUSG00000050865
Gene Name olfactory receptor family 10 subfamily Q member 1
Synonyms MOR266-1, Olfr1494, GA_x6K02T2RE5P-4082427-4083374
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # IGL02134
Quality Score
Status
Chromosome 19
Chromosomal Location 13726472-13727419 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 13727165 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 232 (R232S)
Ref Sequence ENSEMBL: ENSMUSP00000146563 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051768] [ENSMUST00000207836]
AlphaFold Q8VGP8
Predicted Effect probably benign
Transcript: ENSMUST00000051768
AA Change: R232S

PolyPhen 2 Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000056291
Gene: ENSMUSG00000050865
AA Change: R232S

DomainStartEndE-ValueType
low complexity region 13 27 N/A INTRINSIC
Pfam:7tm_4 35 313 3.2e-53 PFAM
Pfam:7tm_1 45 295 7.5e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207836
AA Change: R232S

PolyPhen 2 Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214479
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214697
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf4 T C 17: 42,980,581 (GRCm39) N168S probably damaging Het
Angptl3 A T 4: 98,919,349 (GRCm39) R36S probably damaging Het
Ap5z1 T C 5: 142,460,214 (GRCm39) F514L probably benign Het
Arhgef39 C A 4: 43,497,578 (GRCm39) probably null Het
Aste1 A G 9: 105,275,043 (GRCm39) S11G probably damaging Het
Cadm4 T C 7: 24,198,986 (GRCm39) V87A probably benign Het
Cd177 A G 7: 24,451,777 (GRCm39) I413T probably benign Het
Col5a2 A G 1: 45,430,230 (GRCm39) probably null Het
Dera C T 6: 137,807,269 (GRCm39) A239V probably damaging Het
Ecm1 T C 3: 95,643,499 (GRCm39) E283G probably damaging Het
Eml6 G T 11: 29,709,066 (GRCm39) H24N probably benign Het
Etl4 A G 2: 20,811,240 (GRCm39) K1425E possibly damaging Het
Fgd3 G A 13: 49,450,225 (GRCm39) S8L possibly damaging Het
Gli1 T C 10: 127,172,369 (GRCm39) E228G probably benign Het
Hivep3 A G 4: 119,990,771 (GRCm39) probably benign Het
Iqcc A G 4: 129,512,818 (GRCm39) S11P probably damaging Het
Itpkc G A 7: 26,927,300 (GRCm39) Q205* probably null Het
Jmjd1c T A 10: 67,056,171 (GRCm39) S530R possibly damaging Het
Kcnq1 A G 7: 142,737,453 (GRCm39) H257R possibly damaging Het
Kcnt2 G A 1: 140,304,121 (GRCm39) V164I probably benign Het
Lgr5 T C 10: 115,288,763 (GRCm39) H603R possibly damaging Het
Lrp2 T C 2: 69,343,723 (GRCm39) probably null Het
Lrrn2 A G 1: 132,865,555 (GRCm39) M207V possibly damaging Het
Miip A G 4: 147,949,735 (GRCm39) probably benign Het
Mrps35 T C 6: 146,949,808 (GRCm39) probably benign Het
Nuf2 A T 1: 169,341,069 (GRCm39) M184K probably benign Het
Or14j2 C T 17: 37,886,249 (GRCm39) E22K probably benign Het
Or2f2 A G 6: 42,767,398 (GRCm39) T142A probably benign Het
Or4a15 A T 2: 89,193,172 (GRCm39) N200K probably damaging Het
Or8g32 A T 9: 39,305,830 (GRCm39) I248F probably damaging Het
Os9 T C 10: 126,956,861 (GRCm39) I42V possibly damaging Het
Rapgef4 A C 2: 72,010,405 (GRCm39) Q177P probably damaging Het
Rhpn2 T C 7: 35,070,536 (GRCm39) probably benign Het
Scn5a T C 9: 119,314,958 (GRCm39) R1916G probably damaging Het
Serpine1 T A 5: 137,095,889 (GRCm39) probably benign Het
Snd1 C T 6: 28,880,278 (GRCm39) P684L possibly damaging Het
Tgds T C 14: 118,350,534 (GRCm39) N340D probably benign Het
Trpc4 A T 3: 54,223,075 (GRCm39) Y706F possibly damaging Het
Ttn T A 2: 76,584,166 (GRCm39) D22314V probably damaging Het
Utrn G A 10: 12,519,163 (GRCm39) T2263I probably damaging Het
Vmn1r11 A T 6: 57,115,022 (GRCm39) T229S possibly damaging Het
Zfp142 T G 1: 74,609,022 (GRCm39) H1488P probably damaging Het
Zfp219 A G 14: 52,246,758 (GRCm39) L78P probably damaging Het
Zfp629 T A 7: 127,211,042 (GRCm39) T256S probably benign Het
Other mutations in Or10q1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02335:Or10q1 APN 19 13,727,298 (GRCm39) missense probably benign 0.01
IGL02388:Or10q1 APN 19 13,726,994 (GRCm39) missense possibly damaging 0.91
IGL03231:Or10q1 APN 19 13,726,749 (GRCm39) missense probably benign 0.35
R0133:Or10q1 UTSW 19 13,727,352 (GRCm39) missense probably damaging 1.00
R0142:Or10q1 UTSW 19 13,726,619 (GRCm39) missense probably benign 0.00
R0561:Or10q1 UTSW 19 13,726,662 (GRCm39) missense probably damaging 1.00
R0783:Or10q1 UTSW 19 13,727,040 (GRCm39) missense probably damaging 0.99
R1826:Or10q1 UTSW 19 13,726,711 (GRCm39) missense probably benign 0.05
R1967:Or10q1 UTSW 19 13,727,417 (GRCm39) makesense probably null
R3706:Or10q1 UTSW 19 13,726,476 (GRCm39) missense probably benign 0.42
R5417:Or10q1 UTSW 19 13,727,217 (GRCm39) missense probably benign 0.18
R6508:Or10q1 UTSW 19 13,726,718 (GRCm39) missense probably damaging 1.00
R7126:Or10q1 UTSW 19 13,726,887 (GRCm39) missense possibly damaging 0.90
R7262:Or10q1 UTSW 19 13,726,535 (GRCm39) missense probably benign 0.02
R7395:Or10q1 UTSW 19 13,726,502 (GRCm39) missense probably damaging 0.98
R7740:Or10q1 UTSW 19 13,727,328 (GRCm39) missense probably benign 0.00
R7744:Or10q1 UTSW 19 13,727,419 (GRCm39) makesense probably null
R7864:Or10q1 UTSW 19 13,726,710 (GRCm39) missense probably benign 0.03
R8495:Or10q1 UTSW 19 13,726,593 (GRCm39) missense possibly damaging 0.95
R9372:Or10q1 UTSW 19 13,727,069 (GRCm39) missense probably benign 0.14
Posted On 2015-04-16