Incidental Mutation 'IGL02134:Or4a15'
ID 281237
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or4a15
Ensembl Gene ENSMUSG00000075090
Gene Name olfactory receptor family 4 subfamily A member 15
Synonyms Olfr1234, MOR231-2, GA_x6K02T2Q125-50805620-50804676
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # IGL02134
Quality Score
Status
Chromosome 2
Chromosomal Location 89190357-89195209 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 89193172 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 200 (N200K)
Ref Sequence ENSEMBL: ENSMUSP00000149303 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099783] [ENSMUST00000111543] [ENSMUST00000137692]
AlphaFold A2AVK5
Predicted Effect probably damaging
Transcript: ENSMUST00000099783
AA Change: N200K

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000097371
Gene: ENSMUSG00000075090
AA Change: N200K

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 5.9e-32 PFAM
Pfam:7tm_4 137 278 1.5e-37 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111543
AA Change: N200K

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000107168
Gene: ENSMUSG00000075090
AA Change: N200K

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 3.2e-46 PFAM
Pfam:7tm_1 39 285 7.2e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000137692
AA Change: N200K

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf4 T C 17: 42,980,581 (GRCm39) N168S probably damaging Het
Angptl3 A T 4: 98,919,349 (GRCm39) R36S probably damaging Het
Ap5z1 T C 5: 142,460,214 (GRCm39) F514L probably benign Het
Arhgef39 C A 4: 43,497,578 (GRCm39) probably null Het
Aste1 A G 9: 105,275,043 (GRCm39) S11G probably damaging Het
Cadm4 T C 7: 24,198,986 (GRCm39) V87A probably benign Het
Cd177 A G 7: 24,451,777 (GRCm39) I413T probably benign Het
Col5a2 A G 1: 45,430,230 (GRCm39) probably null Het
Dera C T 6: 137,807,269 (GRCm39) A239V probably damaging Het
Ecm1 T C 3: 95,643,499 (GRCm39) E283G probably damaging Het
Eml6 G T 11: 29,709,066 (GRCm39) H24N probably benign Het
Etl4 A G 2: 20,811,240 (GRCm39) K1425E possibly damaging Het
Fgd3 G A 13: 49,450,225 (GRCm39) S8L possibly damaging Het
Gli1 T C 10: 127,172,369 (GRCm39) E228G probably benign Het
Hivep3 A G 4: 119,990,771 (GRCm39) probably benign Het
Iqcc A G 4: 129,512,818 (GRCm39) S11P probably damaging Het
Itpkc G A 7: 26,927,300 (GRCm39) Q205* probably null Het
Jmjd1c T A 10: 67,056,171 (GRCm39) S530R possibly damaging Het
Kcnq1 A G 7: 142,737,453 (GRCm39) H257R possibly damaging Het
Kcnt2 G A 1: 140,304,121 (GRCm39) V164I probably benign Het
Lgr5 T C 10: 115,288,763 (GRCm39) H603R possibly damaging Het
Lrp2 T C 2: 69,343,723 (GRCm39) probably null Het
Lrrn2 A G 1: 132,865,555 (GRCm39) M207V possibly damaging Het
Miip A G 4: 147,949,735 (GRCm39) probably benign Het
Mrps35 T C 6: 146,949,808 (GRCm39) probably benign Het
Nuf2 A T 1: 169,341,069 (GRCm39) M184K probably benign Het
Or10q1 C A 19: 13,727,165 (GRCm39) R232S probably benign Het
Or14j2 C T 17: 37,886,249 (GRCm39) E22K probably benign Het
Or2f2 A G 6: 42,767,398 (GRCm39) T142A probably benign Het
Or8g32 A T 9: 39,305,830 (GRCm39) I248F probably damaging Het
Os9 T C 10: 126,956,861 (GRCm39) I42V possibly damaging Het
Rapgef4 A C 2: 72,010,405 (GRCm39) Q177P probably damaging Het
Rhpn2 T C 7: 35,070,536 (GRCm39) probably benign Het
Scn5a T C 9: 119,314,958 (GRCm39) R1916G probably damaging Het
Serpine1 T A 5: 137,095,889 (GRCm39) probably benign Het
Snd1 C T 6: 28,880,278 (GRCm39) P684L possibly damaging Het
Tgds T C 14: 118,350,534 (GRCm39) N340D probably benign Het
Trpc4 A T 3: 54,223,075 (GRCm39) Y706F possibly damaging Het
Ttn T A 2: 76,584,166 (GRCm39) D22314V probably damaging Het
Utrn G A 10: 12,519,163 (GRCm39) T2263I probably damaging Het
Vmn1r11 A T 6: 57,115,022 (GRCm39) T229S possibly damaging Het
Zfp142 T G 1: 74,609,022 (GRCm39) H1488P probably damaging Het
Zfp219 A G 14: 52,246,758 (GRCm39) L78P probably damaging Het
Zfp629 T A 7: 127,211,042 (GRCm39) T256S probably benign Het
Other mutations in Or4a15
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0945:Or4a15 UTSW 2 89,193,599 (GRCm39) missense probably damaging 0.98
R1018:Or4a15 UTSW 2 89,193,523 (GRCm39) missense possibly damaging 0.95
R1419:Or4a15 UTSW 2 89,193,666 (GRCm39) missense probably damaging 1.00
R1872:Or4a15 UTSW 2 89,192,933 (GRCm39) missense probably damaging 1.00
R1929:Or4a15 UTSW 2 89,193,353 (GRCm39) missense probably benign 0.01
R2143:Or4a15 UTSW 2 89,193,447 (GRCm39) missense probably damaging 1.00
R3499:Or4a15 UTSW 2 89,193,294 (GRCm39) missense probably benign 0.07
R3776:Or4a15 UTSW 2 89,193,108 (GRCm39) missense possibly damaging 0.69
R4595:Or4a15 UTSW 2 89,193,669 (GRCm39) missense probably damaging 0.98
R6287:Or4a15 UTSW 2 89,193,363 (GRCm39) nonsense probably null
R7256:Or4a15 UTSW 2 89,192,838 (GRCm39) missense probably benign 0.21
R7516:Or4a15 UTSW 2 89,193,719 (GRCm39) missense probably benign 0.01
R7636:Or4a15 UTSW 2 89,193,583 (GRCm39) nonsense probably null
R7975:Or4a15 UTSW 2 89,193,413 (GRCm39) missense probably benign 0.23
R8240:Or4a15 UTSW 2 89,192,896 (GRCm39) missense probably benign 0.01
R8514:Or4a15 UTSW 2 89,193,573 (GRCm39) missense probably benign 0.06
R8680:Or4a15 UTSW 2 89,193,065 (GRCm39) missense probably benign 0.00
R8780:Or4a15 UTSW 2 89,193,652 (GRCm39) missense probably damaging 1.00
R8898:Or4a15 UTSW 2 89,192,957 (GRCm39) missense possibly damaging 0.56
R9402:Or4a15 UTSW 2 89,193,123 (GRCm39) nonsense probably null
R9434:Or4a15 UTSW 2 89,193,692 (GRCm39) missense probably benign 0.02
R9451:Or4a15 UTSW 2 89,193,243 (GRCm39) missense probably damaging 1.00
R9632:Or4a15 UTSW 2 89,193,065 (GRCm39) missense probably damaging 0.96
Posted On 2015-04-16