Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02137:Vmn1r167'

281358

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r167

Ensembl Gene

ENSMUSG00000090715

Gene Name

vomeronasal 1 receptor 167

Synonyms

Gm6279

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL02137

Quality Score

Status

Chromosome

Chromosomal Location

23204067-23205014 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 23204864 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 51 (S51T)

Ref Sequence

ENSEMBL: ENSMUSP00000153774 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164527] [ENSMUST00000227713]

AlphaFold

G3UW71

Predicted Effect

probably damaging
Transcript: ENSMUST00000164527
AA Change: S51T

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000129193
Gene: ENSMUSG00000090715
AA Change: S51T

Domain	Start	End	E-Value	Type
Pfam:TAS2R	19	307	1.5e-13	PFAM
Pfam:7tm_1	41	299	3.8e-6	PFAM
Pfam:V1R	52	306	2.1e-18	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000227713
AA Change: S51T

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930595M18Rik	T	C	X: 80,501,262 (GRCm39)	D116G	probably benign	Het
Acp2	G	T	2: 91,034,028 (GRCm39)	G66V	probably damaging	Het
Adam32	C	T	8: 25,362,610 (GRCm39)	G605D	probably damaging	Het
Adam4	T	C	12: 81,467,877 (GRCm39)	D248G	possibly damaging	Het
Adamts15	C	A	9: 30,821,956 (GRCm39)	G494W	probably damaging	Het
Arfgef1	A	T	1: 10,283,338 (GRCm39)	N190K	probably damaging	Het
Bach2	C	T	4: 32,501,621 (GRCm39)		probably benign	Het
Bloc1s1	T	C	10: 128,758,517 (GRCm39)		probably benign	Het
Casz1	G	T	4: 149,017,925 (GRCm39)	A405S	possibly damaging	Het
Cplx4	T	C	18: 66,090,125 (GRCm39)	D98G	probably benign	Het
Dync2h1	T	C	9: 7,134,349 (GRCm39)	N1553D	probably benign	Het
Erich5	G	A	15: 34,470,900 (GRCm39)	C43Y	probably damaging	Het
Exosc10	A	C	4: 148,645,590 (GRCm39)	R123S	probably damaging	Het
Hoatz	T	C	9: 50,997,408 (GRCm39)		probably benign	Het
Inpp5f	T	C	7: 128,296,853 (GRCm39)	V377A	probably damaging	Het
Lrp1b	T	C	2: 40,620,700 (GRCm39)		probably benign	Het
Mrps17	G	A	5: 129,793,847 (GRCm39)	V14M	probably benign	Het
Mtrr	G	A	13: 68,716,920 (GRCm39)	S431F	possibly damaging	Het
Myo5a	T	C	9: 75,068,817 (GRCm39)		probably null	Het
Nsfl1c	T	A	2: 151,351,509 (GRCm39)	I291N	probably damaging	Het
Ntsr1	T	A	2: 180,180,628 (GRCm39)		probably null	Het
Or4n4	T	C	14: 50,519,135 (GRCm39)	T192A	probably benign	Het
Park7	T	C	4: 150,988,288 (GRCm39)	I102M	probably benign	Het
Pik3c2a	T	A	7: 115,950,039 (GRCm39)	Q1326L	probably benign	Het
Rapgef3	T	C	15: 97,648,025 (GRCm39)	D693G	probably benign	Het
Rep15	G	A	6: 146,934,845 (GRCm39)	R228H	probably benign	Het
Slc25a1	A	G	16: 17,745,234 (GRCm39)	V100A	probably benign	Het
Slc9a4	T	C	1: 40,640,059 (GRCm39)	F284L	possibly damaging	Het
Sox10	G	T	15: 79,043,393 (GRCm39)	D52E	probably benign	Het
St3gal5	C	A	6: 72,105,266 (GRCm39)	T6N	probably benign	Het
Tbc1d22a	A	G	15: 86,183,870 (GRCm39)	D243G	probably benign	Het
Tll1	T	C	8: 64,469,132 (GRCm39)	Y997C	possibly damaging	Het
Tmem8b	A	T	4: 43,689,434 (GRCm39)	H276L	probably benign	Het
Tnpo3	T	C	6: 29,609,450 (GRCm39)	Y12C	probably damaging	Het
Tns3	A	T	11: 8,442,578 (GRCm39)	M595K	possibly damaging	Het
Trav18	T	A	14: 54,069,192 (GRCm39)	M78K	probably benign	Het
Uba7	A	G	9: 107,856,952 (GRCm39)		probably benign	Het
Vmn1r83	A	T	7: 12,055,761 (GRCm39)	Y99N	probably damaging	Het
Wdr38	A	T	2: 38,888,424 (GRCm39)	N7I	probably damaging	Het

Other mutations in Vmn1r167

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02261:Vmn1r167	APN	7	23,204,261 (GRCm39)	missense	probably benign	0.17
IGL02963:Vmn1r167	APN	7	23,204,975 (GRCm39)	missense	possibly damaging	0.60
R0054:Vmn1r167	UTSW	7	23,204,334 (GRCm39)	missense	possibly damaging	0.89
R0555:Vmn1r167	UTSW	7	23,204,512 (GRCm39)	missense	probably damaging	1.00
R0766:Vmn1r167	UTSW	7	23,204,548 (GRCm39)	missense	probably benign	0.01
R1312:Vmn1r167	UTSW	7	23,204,548 (GRCm39)	missense	probably benign	0.01
R1464:Vmn1r167	UTSW	7	23,204,681 (GRCm39)	missense	possibly damaging	0.62
R1464:Vmn1r167	UTSW	7	23,204,681 (GRCm39)	missense	possibly damaging	0.62
R1532:Vmn1r167	UTSW	7	23,204,204 (GRCm39)	missense	probably benign	0.01
R1937:Vmn1r167	UTSW	7	23,204,452 (GRCm39)	missense	probably benign	0.25
R2162:Vmn1r167	UTSW	7	23,204,224 (GRCm39)	missense	possibly damaging	0.91
R4639:Vmn1r167	UTSW	7	23,205,011 (GRCm39)	missense	probably benign	0.00
R4661:Vmn1r167	UTSW	7	23,204,117 (GRCm39)	missense	probably damaging	1.00
R4845:Vmn1r167	UTSW	7	23,204,158 (GRCm39)	missense	probably benign	0.01
R4868:Vmn1r167	UTSW	7	23,204,161 (GRCm39)	missense	probably benign
R4993:Vmn1r167	UTSW	7	23,204,653 (GRCm39)	missense	probably damaging	1.00
R5693:Vmn1r167	UTSW	7	23,204,646 (GRCm39)	nonsense	probably null
R6622:Vmn1r167	UTSW	7	23,205,014 (GRCm39)	start codon destroyed	probably null
R7800:Vmn1r167	UTSW	7	23,204,069 (GRCm39)	makesense	probably null
R8297:Vmn1r167	UTSW	7	23,204,215 (GRCm39)	missense	probably damaging	1.00
R8365:Vmn1r167	UTSW	7	23,204,200 (GRCm39)	missense	probably benign	0.03
R8411:Vmn1r167	UTSW	7	23,204,981 (GRCm39)	missense	possibly damaging	0.86
R9667:Vmn1r167	UTSW	7	23,204,990 (GRCm39)	missense	probably benign	0.06

Posted On

2015-04-16