Incidental Mutation 'IGL02143:Fndc3c1'
ID281694
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fndc3c1
Ensembl Gene ENSMUSG00000033737
Gene Namefibronectin type III domain containing 3C1
SynonymsLOC333564
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.029) question?
Stock #IGL02143
Quality Score
Status
ChromosomeX
Chromosomal Location106420041-106485401 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 106472734 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000121226 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039447] [ENSMUST00000138724] [ENSMUST00000140707] [ENSMUST00000149331]
Predicted Effect probably benign
Transcript: ENSMUST00000039447
SMART Domains Protein: ENSMUSP00000038678
Gene: ENSMUSG00000033737

DomainStartEndE-ValueType
low complexity region 182 195 N/A INTRINSIC
Blast:FN3 200 303 8e-10 BLAST
low complexity region 308 332 N/A INTRINSIC
low complexity region 338 353 N/A INTRINSIC
FN3 449 537 2.64e-1 SMART
FN3 551 631 2.42e-9 SMART
FN3 646 728 1.37e-8 SMART
FN3 743 827 1.11e-3 SMART
FN3 915 994 3.42e-9 SMART
FN3 1015 1090 5.48e-8 SMART
FN3 1104 1185 2.48e-6 SMART
FN3 1200 1278 1.9e-2 SMART
low complexity region 1298 1313 N/A INTRINSIC
transmembrane domain 1333 1355 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000138724
Predicted Effect probably benign
Transcript: ENSMUST00000140707
Predicted Effect probably benign
Transcript: ENSMUST00000149331
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019N19Rik C A 19: 58,789,252 R34L possibly damaging Het
Abhd5 T C 9: 122,365,213 M1T probably null Het
Ager G A 17: 34,599,118 G183E probably damaging Het
Alcam C A 16: 52,305,619 V112L probably damaging Het
Amot T A X: 145,487,028 Q204H probably damaging Het
Ankar C T 1: 72,658,649 probably null Het
Armc9 A G 1: 86,176,865 M279V possibly damaging Het
Bpifb1 C T 2: 154,209,929 T218I probably benign Het
Cacna1f A C X: 7,613,995 probably benign Het
Cacna2d2 T C 9: 107,518,275 probably null Het
Ccdc57 A T 11: 120,861,243 C837* probably null Het
Ctbp2 G A 7: 132,991,156 A808V probably damaging Het
Dcbld2 T C 16: 58,448,526 probably null Het
Dis3 T C 14: 99,091,318 probably benign Het
Disp2 T C 2: 118,789,969 F394S probably damaging Het
Dnah1 T C 14: 31,283,289 N2336S probably damaging Het
Drap1 C A 19: 5,423,843 L66F probably damaging Het
Eif5a2 C T 3: 28,793,739 R109C probably benign Het
Enpp1 A T 10: 24,677,974 D105E probably damaging Het
Evi5l G A 8: 4,191,293 M275I probably damaging Het
Flt1 T C 5: 147,578,436 T1059A probably benign Het
Git1 T C 11: 77,505,987 V645A possibly damaging Het
Gm7735 T A 16: 89,169,549 C20* probably null Het
Ighv1-42 G T 12: 114,937,286 P60T probably benign Het
Jakmip2 A T 18: 43,563,285 L533Q probably damaging Het
Kdm2b C T 5: 122,947,835 E238K probably damaging Het
Lpin2 T C 17: 71,243,926 S694P probably damaging Het
Mab21l2 C T 3: 86,547,255 R146Q possibly damaging Het
Mmp1b A T 9: 7,386,400 S174T probably benign Het
Neb T C 2: 52,291,199 Y1132C probably damaging Het
Nhsl1 A T 10: 18,511,635 H219L possibly damaging Het
Nwd2 T A 5: 63,791,653 probably null Het
Obp1a A C X: 78,090,843 M18R possibly damaging Het
Olfr525 A T 7: 140,323,592 K298* probably null Het
Olfr695 T C 7: 106,873,973 T91A probably benign Het
Pabpc5 T A X: 119,927,991 M1K probably null Het
Paxip1 A G 5: 27,775,598 probably benign Het
Perm1 A G 4: 156,218,043 E348G probably benign Het
Pfkfb1 T C X: 150,622,142 F170L probably damaging Het
Pou3f3 A G 1: 42,698,526 M461V probably benign Het
Ppfia2 G A 10: 106,857,499 D622N probably damaging Het
Prtg T G 9: 72,892,324 S801R probably damaging Het
Rars2 T A 4: 34,623,404 probably benign Het
Rasal1 A G 5: 120,652,852 D35G probably damaging Het
Repin1 T A 6: 48,597,121 L272Q probably damaging Het
Stk36 T C 1: 74,616,569 probably benign Het
Tbxa2r A G 10: 81,334,486 T269A probably benign Het
Tmem132c G A 5: 127,563,402 R879Q probably benign Het
Vmn1r78 C A 7: 12,152,480 A6E probably benign Het
Vps45 T C 3: 96,019,646 I530V probably benign Het
Vps45 A T 3: 96,033,821 N369K probably benign Het
Zkscan16 G A 4: 58,956,911 G398R probably damaging Het
Other mutations in Fndc3c1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00670:Fndc3c1 APN X 106445777 missense probably benign
IGL01408:Fndc3c1 APN X 106432772 missense probably benign 0.45
IGL01518:Fndc3c1 APN X 106431423 missense probably damaging 1.00
IGL01718:Fndc3c1 APN X 106445928 missense probably benign
IGL02214:Fndc3c1 APN X 106425829 missense probably benign 0.16
IGL03192:Fndc3c1 APN X 106436316 splice site probably null
IGL03199:Fndc3c1 APN X 106436387 missense possibly damaging 0.86
IGL03370:Fndc3c1 APN X 106420701 missense probably benign 0.04
R0644:Fndc3c1 UTSW X 106434962 missense probably benign 0.14
R0714:Fndc3c1 UTSW X 106425366 nonsense probably null
R1928:Fndc3c1 UTSW X 106433522 missense probably benign 0.28
R1998:Fndc3c1 UTSW X 106420705 missense probably benign 0.01
R1999:Fndc3c1 UTSW X 106420705 missense probably benign 0.01
R4110:Fndc3c1 UTSW X 106444291 missense probably benign 0.07
R4785:Fndc3c1 UTSW X 106437702 missense possibly damaging 0.87
R6623:Fndc3c1 UTSW X 106435073 missense possibly damaging 0.55
Posted On2015-04-16