Incidental Mutation 'IGL02145:Cul5'
ID 281738
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cul5
Ensembl Gene ENSMUSG00000032030
Gene Name cullin 5
Synonyms VACM-1, C030032G03Rik, 4921514I20Rik, C330021I08Rik, 8430423K24Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02145
Quality Score
Status
Chromosome 9
Chromosomal Location 53525881-53578807 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 53546375 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000133144 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034529] [ENSMUST00000120122] [ENSMUST00000166367]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000034529
SMART Domains Protein: ENSMUSP00000034529
Gene: ENSMUSG00000032030

DomainStartEndE-ValueType
PDB:2WZK|A 76 461 N/A PDB
SCOP:d1ldja2 91 459 1e-109 SMART
CULLIN 510 661 1.12e-80 SMART
Cullin_Nedd8 782 849 5.12e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000082688
Predicted Effect probably benign
Transcript: ENSMUST00000120122
SMART Domains Protein: ENSMUSP00000113490
Gene: ENSMUSG00000032030

DomainStartEndE-ValueType
PDB:4JGH|D 1 258 N/A PDB
SCOP:d1ldja2 5 255 2e-75 SMART
CULLIN 306 457 1.12e-80 SMART
Cullin_Nedd8 578 645 5.12e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123499
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141180
Predicted Effect probably benign
Transcript: ENSMUST00000166367
SMART Domains Protein: ENSMUSP00000133144
Gene: ENSMUSG00000032030

DomainStartEndE-ValueType
PDB:2WZK|A 76 434 N/A PDB
SCOP:d1ldja2 91 432 9e-99 SMART
CULLIN 483 634 1.12e-80 SMART
Cullin_Nedd8 755 822 5.12e-17 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit complete embryonic lethality. Mice heterozygous for a null allele exhibit decreased susceptibility to LPS-induced lung injury. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agt A G 8: 125,291,187 (GRCm39) L40P probably damaging Het
Ahnak T C 19: 8,980,219 (GRCm39) I501T probably benign Het
Aldh2 A G 5: 121,706,056 (GRCm39) *196Q probably null Het
Ankrd65 A G 4: 155,875,848 (GRCm39) D23G possibly damaging Het
Anln A T 9: 22,250,292 (GRCm39) probably null Het
Armc3 C T 2: 19,301,671 (GRCm39) S663L possibly damaging Het
Armc3 G A 2: 19,290,948 (GRCm39) probably null Het
Cyba T C 8: 123,151,796 (GRCm39) I134V probably damaging Het
Cybb T A X: 9,323,257 (GRCm39) Q93H probably damaging Het
Cyp4f37 G T 17: 32,849,009 (GRCm39) K292N probably benign Het
Dmxl2 T C 9: 54,281,981 (GRCm39) I2850V probably benign Het
Ep300 T C 15: 81,485,367 (GRCm39) I118T unknown Het
Ercc6l G T X: 101,189,148 (GRCm39) P454T probably benign Het
Grxcr1 A G 5: 68,267,821 (GRCm39) E190G probably damaging Het
Heatr3 C T 8: 88,871,227 (GRCm39) R194C probably benign Het
Hspa12b C T 2: 130,985,655 (GRCm39) probably benign Het
Inpp5d T C 1: 87,642,777 (GRCm39) V644A probably damaging Het
Kif26a G A 12: 112,143,409 (GRCm39) R1221H probably benign Het
Klra8 T C 6: 130,102,199 (GRCm39) N79D probably benign Het
Kntc1 T C 5: 123,900,661 (GRCm39) I253T possibly damaging Het
Lamp5 T C 2: 135,901,509 (GRCm39) V111A possibly damaging Het
Lmo7 T C 14: 102,139,659 (GRCm39) S859P probably benign Het
Mgarp T C 3: 51,296,453 (GRCm39) Q205R possibly damaging Het
Morf4l1 A G 9: 89,975,848 (GRCm39) Y315H probably benign Het
Naip6 A T 13: 100,433,486 (GRCm39) V1117E possibly damaging Het
Nipal1 A G 5: 72,824,274 (GRCm39) D206G probably damaging Het
Notch3 A G 17: 32,373,715 (GRCm39) S498P probably benign Het
Npepps A G 11: 97,109,328 (GRCm39) probably null Het
Or14c46 C A 7: 85,918,466 (GRCm39) C177F probably damaging Het
Or2ak6 T C 11: 58,592,886 (GRCm39) Y120H probably damaging Het
Phlpp1 A G 1: 106,317,613 (GRCm39) H1278R probably damaging Het
Pprc1 C A 19: 46,053,329 (GRCm39) probably benign Het
Rab8b A T 9: 66,755,000 (GRCm39) probably benign Het
Ripor2 T A 13: 24,901,554 (GRCm39) I875N probably damaging Het
Samd9l T C 6: 3,374,105 (GRCm39) E1052G probably benign Het
Slit3 A T 11: 35,520,569 (GRCm39) I569F probably damaging Het
Spata2l C T 8: 123,960,770 (GRCm39) G173D possibly damaging Het
Stc2 T G 11: 31,317,875 (GRCm39) probably benign Het
Tm6sf1 C A 7: 81,513,000 (GRCm39) Y65* probably null Het
Tspan15 A G 10: 62,029,751 (GRCm39) probably benign Het
Vmn2r14 A T 5: 109,368,454 (GRCm39) Y179* probably null Het
Washc5 C A 15: 59,241,060 (GRCm39) V92L probably benign Het
Wiz A G 17: 32,575,893 (GRCm39) S838P probably benign Het
Zp2 T A 7: 119,739,074 (GRCm39) probably null Het
Other mutations in Cul5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01674:Cul5 APN 9 53,546,307 (GRCm39) missense probably damaging 1.00
IGL02043:Cul5 APN 9 53,569,973 (GRCm39) missense probably benign 0.26
IGL02261:Cul5 APN 9 53,546,337 (GRCm39) missense probably damaging 1.00
IGL02281:Cul5 APN 9 53,546,349 (GRCm39) missense possibly damaging 0.87
IGL02639:Cul5 APN 9 53,566,642 (GRCm39) missense possibly damaging 0.89
IGL02697:Cul5 APN 9 53,566,631 (GRCm39) missense probably benign
IGL02752:Cul5 APN 9 53,546,278 (GRCm39) missense probably damaging 0.98
IGL03017:Cul5 APN 9 53,555,785 (GRCm39) critical splice donor site probably null
IGL03031:Cul5 APN 9 53,553,975 (GRCm39) splice site probably benign
IGL03196:Cul5 APN 9 53,537,180 (GRCm39) missense probably damaging 0.99
R0142:Cul5 UTSW 9 53,546,350 (GRCm39) missense probably damaging 0.98
R0415:Cul5 UTSW 9 53,578,370 (GRCm39) missense probably benign 0.00
R1619:Cul5 UTSW 9 53,569,893 (GRCm39) missense probably benign 0.00
R1675:Cul5 UTSW 9 53,557,983 (GRCm39) missense probably benign 0.00
R2031:Cul5 UTSW 9 53,578,480 (GRCm39) missense probably benign
R2059:Cul5 UTSW 9 53,578,456 (GRCm39) missense probably damaging 0.98
R3401:Cul5 UTSW 9 53,532,512 (GRCm39) missense probably benign 0.02
R3427:Cul5 UTSW 9 53,529,190 (GRCm39) missense probably benign
R3701:Cul5 UTSW 9 53,540,516 (GRCm39) missense probably damaging 0.99
R3702:Cul5 UTSW 9 53,540,516 (GRCm39) missense probably damaging 0.99
R3815:Cul5 UTSW 9 53,534,243 (GRCm39) missense probably benign 0.31
R3848:Cul5 UTSW 9 53,529,286 (GRCm39) missense probably benign 0.34
R3849:Cul5 UTSW 9 53,529,286 (GRCm39) missense probably benign 0.34
R3850:Cul5 UTSW 9 53,529,286 (GRCm39) missense probably benign 0.34
R4592:Cul5 UTSW 9 53,545,027 (GRCm39) splice site probably benign
R4690:Cul5 UTSW 9 53,534,171 (GRCm39) missense probably damaging 1.00
R5154:Cul5 UTSW 9 53,537,167 (GRCm39) missense probably damaging 1.00
R5173:Cul5 UTSW 9 53,554,034 (GRCm39) missense probably benign
R5645:Cul5 UTSW 9 53,534,243 (GRCm39) missense probably benign 0.17
R5868:Cul5 UTSW 9 53,569,973 (GRCm39) missense probably benign 0.26
R5975:Cul5 UTSW 9 53,534,093 (GRCm39) missense probably damaging 1.00
R6251:Cul5 UTSW 9 53,558,094 (GRCm39) missense probably benign 0.40
R6284:Cul5 UTSW 9 53,535,035 (GRCm39) missense probably damaging 1.00
R6415:Cul5 UTSW 9 53,557,983 (GRCm39) missense probably benign 0.00
R7178:Cul5 UTSW 9 53,555,826 (GRCm39) missense probably benign 0.01
R7511:Cul5 UTSW 9 53,537,269 (GRCm39) missense probably damaging 1.00
R7923:Cul5 UTSW 9 53,535,466 (GRCm39) missense probably benign 0.00
R7940:Cul5 UTSW 9 53,535,069 (GRCm39) missense probably benign 0.21
R8481:Cul5 UTSW 9 53,558,123 (GRCm39) missense probably benign 0.00
R9483:Cul5 UTSW 9 53,532,474 (GRCm39) missense probably benign 0.10
X0018:Cul5 UTSW 9 53,534,229 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16