Incidental Mutation 'IGL02147:Ighg2b'
| ID |
281814 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Ighg2b
|
| Ensembl Gene |
ENSMUSG00000076613 |
| Gene Name |
immunoglobulin heavy constant gamma 2B |
| Synonyms |
IgG2b, gamma2b |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.057)
|
| Stock # |
IGL02147
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
12 |
| Chromosomal Location |
113267934-113271553 bp(-) (GRCm39) |
| Type of Mutation |
makesense |
| DNA Base Change (assembly) |
A to T
at 113270011 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Stop codon to Arginine
at position 336
(*336R)
|
| Gene Model |
predicted gene model for transcript(s):
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000103418
AA Change: *336R
|
| SMART Domains |
Protein: ENSMUSP00000100214
Gene: ENSMUSG00000076613
AA Change: *336R
| Domain | Start | End | E-Value | Type |
|---|
|
IGc1
|
22 |
92 |
6.9e-16 |
SMART |
|
low complexity region
|
108 |
121 |
N/A |
INTRINSIC |
|
IG_like
|
145 |
220 |
4.02e-2 |
SMART |
|
IGc1
|
251 |
324 |
1.64e-31 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000192188
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700021P04Rik |
T |
C |
19: 24,042,327 (GRCm39) |
|
noncoding transcript |
Het |
| Acadsb |
T |
A |
7: 131,027,610 (GRCm39) |
|
probably benign |
Het |
| Ambra1 |
A |
G |
2: 91,598,064 (GRCm39) |
H75R |
probably benign |
Het |
| Arhgef28 |
T |
A |
13: 98,097,822 (GRCm39) |
I931F |
probably damaging |
Het |
| Cdk5 |
T |
C |
5: 24,625,318 (GRCm39) |
N165D |
probably benign |
Het |
| Col4a2 |
A |
T |
8: 11,458,140 (GRCm39) |
Y272F |
probably benign |
Het |
| Csde1 |
T |
A |
3: 102,947,250 (GRCm39) |
D67E |
probably damaging |
Het |
| Dhx34 |
T |
C |
7: 15,937,928 (GRCm39) |
H724R |
probably benign |
Het |
| Dhx57 |
T |
C |
17: 80,567,752 (GRCm39) |
D777G |
possibly damaging |
Het |
| Fat3 |
A |
C |
9: 15,907,281 (GRCm39) |
V2907G |
probably damaging |
Het |
| Fst |
T |
C |
13: 114,590,896 (GRCm39) |
Y290C |
probably damaging |
Het |
| Igkv4-92 |
C |
T |
6: 68,732,236 (GRCm39) |
S46N |
probably damaging |
Het |
| Kdm2b |
C |
T |
5: 123,085,898 (GRCm39) |
E238K |
probably damaging |
Het |
| Lgalsl2 |
T |
A |
7: 5,362,732 (GRCm39) |
I121N |
probably damaging |
Het |
| Lmtk2 |
A |
G |
5: 144,093,754 (GRCm39) |
M244V |
possibly damaging |
Het |
| Mcoln1 |
T |
C |
8: 3,558,379 (GRCm39) |
F211S |
probably benign |
Het |
| Mib2 |
C |
A |
4: 155,742,144 (GRCm39) |
R209L |
probably benign |
Het |
| Msx3 |
C |
A |
7: 139,628,798 (GRCm39) |
V39L |
possibly damaging |
Het |
| Mtnr1b |
A |
G |
9: 15,774,672 (GRCm39) |
F129S |
probably damaging |
Het |
| Nr3c2 |
A |
G |
8: 77,635,696 (GRCm39) |
S266G |
probably damaging |
Het |
| Nup160 |
G |
T |
2: 90,534,285 (GRCm39) |
L703F |
probably benign |
Het |
| Or10c1 |
T |
A |
17: 37,521,877 (GRCm39) |
Y289F |
probably damaging |
Het |
| Or5t5 |
A |
G |
2: 86,616,494 (GRCm39) |
N140S |
probably benign |
Het |
| Pcyt1a |
T |
A |
16: 32,280,916 (GRCm39) |
N105K |
probably damaging |
Het |
| Pdhx |
A |
G |
2: 102,860,686 (GRCm39) |
|
probably benign |
Het |
| Qpct |
T |
C |
17: 79,378,145 (GRCm39) |
V105A |
probably damaging |
Het |
| Ros1 |
A |
C |
10: 51,996,991 (GRCm39) |
F1227C |
probably damaging |
Het |
| Rrp12 |
A |
T |
19: 41,874,620 (GRCm39) |
V342E |
probably damaging |
Het |
| Sart3 |
A |
G |
5: 113,901,004 (GRCm39) |
|
probably benign |
Het |
| Slc6a18 |
T |
A |
13: 73,816,281 (GRCm39) |
K366M |
probably damaging |
Het |
| Smarca4 |
A |
G |
9: 21,546,999 (GRCm39) |
N175D |
probably damaging |
Het |
| Sox14 |
T |
C |
9: 99,757,598 (GRCm39) |
K47R |
probably damaging |
Het |
| Trcg1 |
A |
T |
9: 57,153,132 (GRCm39) |
I592F |
probably benign |
Het |
| Ush2a |
T |
C |
1: 188,596,900 (GRCm39) |
M3880T |
probably benign |
Het |
| Usp20 |
T |
C |
2: 30,896,413 (GRCm39) |
F172S |
probably damaging |
Het |
| Vmn2r4 |
C |
T |
3: 64,305,782 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Ighg2b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01366:Ighg2b
|
APN |
12 |
113,270,656 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL01837:Ighg2b
|
APN |
12 |
113,270,065 (GRCm39) |
missense |
unknown |
|
|
IGL01973:Ighg2b
|
APN |
12 |
113,271,305 (GRCm39) |
missense |
unknown |
|
|
IGL01998:Ighg2b
|
APN |
12 |
113,270,709 (GRCm39) |
missense |
unknown |
|
|
IGL02183:Ighg2b
|
APN |
12 |
113,271,449 (GRCm39) |
missense |
unknown |
|
|
IGL03089:Ighg2b
|
APN |
12 |
113,270,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4453001:Ighg2b
|
UTSW |
12 |
113,270,492 (GRCm39) |
missense |
unknown |
|
|
R4199:Ighg2b
|
UTSW |
12 |
113,270,907 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4459:Ighg2b
|
UTSW |
12 |
113,270,578 (GRCm39) |
missense |
unknown |
|
|
R4577:Ighg2b
|
UTSW |
12 |
113,270,512 (GRCm39) |
missense |
unknown |
|
|
R4589:Ighg2b
|
UTSW |
12 |
113,270,104 (GRCm39) |
missense |
unknown |
|
|
R4807:Ighg2b
|
UTSW |
12 |
113,267,965 (GRCm39) |
unclassified |
probably benign |
|
|
R4822:Ighg2b
|
UTSW |
12 |
113,270,011 (GRCm39) |
makesense |
probably null |
|
|
R5424:Ighg2b
|
UTSW |
12 |
113,271,550 (GRCm39) |
missense |
unknown |
|
|
R5641:Ighg2b
|
UTSW |
12 |
113,270,767 (GRCm39) |
missense |
unknown |
|
|
R6297:Ighg2b
|
UTSW |
12 |
113,270,512 (GRCm39) |
missense |
unknown |
|
|
R6701:Ighg2b
|
UTSW |
12 |
113,270,699 (GRCm39) |
missense |
unknown |
|
|
R6703:Ighg2b
|
UTSW |
12 |
113,268,653 (GRCm39) |
unclassified |
probably benign |
|
|
R6880:Ighg2b
|
UTSW |
12 |
113,270,726 (GRCm39) |
missense |
|
|
|
R7342:Ighg2b
|
UTSW |
12 |
113,270,050 (GRCm39) |
missense |
|
|
|
R7505:Ighg2b
|
UTSW |
12 |
113,268,600 (GRCm39) |
missense |
|
|
|
R7908:Ighg2b
|
UTSW |
12 |
113,270,074 (GRCm39) |
missense |
|
|
|
R8543:Ighg2b
|
UTSW |
12 |
113,270,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8951:Ighg2b
|
UTSW |
12 |
113,270,926 (GRCm39) |
missense |
probably benign |
|
|
R9237:Ighg2b
|
UTSW |
12 |
113,270,217 (GRCm39) |
missense |
|
|
|
R9539:Ighg2b
|
UTSW |
12 |
113,270,498 (GRCm39) |
missense |
|
|
|
R9789:Ighg2b
|
UTSW |
12 |
113,270,304 (GRCm39) |
missense |
|
|
|
| Posted On |
2015-04-16 |
Incidental Mutation