Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02149:Ubxn10'

281890

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ubxn10

Ensembl Gene

ENSMUSG00000043621

Gene Name

UBX domain protein 10

Synonyms

Ubxd3, 5730509E04Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL02149

Quality Score

Status

Chromosome

Chromosomal Location

138437148-138464478 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 138448584 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 31 (S31P)

Ref Sequence

ENSEMBL: ENSMUSP00000117219 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030530] [ENSMUST00000105808] [ENSMUST00000105809] [ENSMUST00000105810] [ENSMUST00000105811] [ENSMUST00000124660] [ENSMUST00000146415]

AlphaFold

Q8BG34

Predicted Effect

probably benign
Transcript: ENSMUST00000030530

SMART Domains

Protein: ENSMUSP00000030530
Gene: ENSMUSG00000028750

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
PA2c	21	143	1.83e-50	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000105808

SMART Domains

Protein: ENSMUSP00000101434
Gene: ENSMUSG00000028750

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
PA2c	21	143	1.83e-50	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000105809
AA Change: S31P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000101435
Gene: ENSMUSG00000043621
AA Change: S31P

Domain	Start	End	E-Value	Type
low complexity region	60	77	N/A	INTRINSIC
UBX	188	270	5.36e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000105810
AA Change: S31P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000101436
Gene: ENSMUSG00000043621
AA Change: S31P

Domain	Start	End	E-Value	Type
low complexity region	60	77	N/A	INTRINSIC
UBX	188	270	5.36e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000105811
AA Change: S31P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000101437
Gene: ENSMUSG00000043621
AA Change: S31P

Domain	Start	End	E-Value	Type
low complexity region	60	77	N/A	INTRINSIC
UBX	188	270	5.36e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000124660

SMART Domains

Protein: ENSMUSP00000124341
Gene: ENSMUSG00000028750

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
PA2c	21	128	1.4e-37	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000146415
AA Change: S31P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000117219
Gene: ENSMUSG00000043621
AA Change: S31P

Domain	Start	End	E-Value	Type
low complexity region	60	77	N/A	INTRINSIC
UBX	188	270	5.36e-4	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam10	A	T	9: 70,610,713 (GRCm39)	H67L	probably damaging	Het
Adgrb1	C	T	15: 74,412,326 (GRCm39)	T435I	probably damaging	Het
Adgrd1	T	A	5: 129,256,325 (GRCm39)	F652Y	probably damaging	Het
Adgrl4	T	A	3: 151,205,991 (GRCm39)	F250Y	possibly damaging	Het
Aebp2	C	T	6: 140,588,010 (GRCm39)	A360V	probably benign	Het
AW551984	A	C	9: 39,504,220 (GRCm39)	M582R	probably benign	Het
B430306N03Rik	T	C	17: 48,624,020 (GRCm39)	V107A	probably benign	Het
Cage1	T	C	13: 38,206,505 (GRCm39)	N447D	probably damaging	Het
Col17a1	T	C	19: 47,657,071 (GRCm39)	D524G	probably benign	Het
Dpp6	A	T	5: 27,743,022 (GRCm39)	I218F	probably benign	Het
Ep300	T	G	15: 81,512,621 (GRCm39)		probably benign	Het
Ephb2	C	T	4: 136,421,225 (GRCm39)	C375Y	probably damaging	Het
Fastk	A	G	5: 24,649,051 (GRCm39)	V112A	probably damaging	Het
Fbxo11	T	A	17: 88,301,187 (GRCm39)	R775S	possibly damaging	Het
Fbxw20	A	G	9: 109,062,886 (GRCm39)		probably null	Het
Hamp2	G	T	7: 30,622,122 (GRCm39)	A50E	probably damaging	Het
Il22b	C	A	10: 118,130,902 (GRCm39)		probably benign	Het
Ints1	G	A	5: 139,737,715 (GRCm39)	R2139C	probably damaging	Het
Itgae	T	A	11: 72,994,720 (GRCm39)	V24E	probably benign	Het
Jakmip3	G	A	7: 138,609,075 (GRCm39)	V60M	possibly damaging	Het
Kcnk10	A	C	12: 98,485,099 (GRCm39)		probably benign	Het
Klra1	A	T	6: 130,352,293 (GRCm39)	C150S	probably damaging	Het
Lhx9	A	T	1: 138,759,172 (GRCm39)	V376E	probably damaging	Het
Mdm1	T	A	10: 117,983,970 (GRCm39)	F199I	probably damaging	Het
Nipal3	G	T	4: 135,194,163 (GRCm39)	T290K	possibly damaging	Het
Obsl1	C	T	1: 75,480,464 (GRCm39)	E387K	probably damaging	Het
Or8b43	A	G	9: 38,360,693 (GRCm39)	H175R	probably damaging	Het
Oxct1	A	G	15: 4,120,711 (GRCm39)	Y265C	probably damaging	Het
Pccb	G	A	9: 100,867,243 (GRCm39)	H411Y	probably damaging	Het
Pkp1	A	G	1: 135,814,485 (GRCm39)	S279P	probably benign	Het
Prdm14	C	A	1: 13,195,663 (GRCm39)	G133C	probably benign	Het
Prkaa2	A	T	4: 104,897,285 (GRCm39)	N309K	probably benign	Het
Shc2	T	C	10: 79,458,102 (GRCm39)	D527G	probably damaging	Het
Shkbp1	C	T	7: 27,042,064 (GRCm39)		probably benign	Het
Skil	T	C	3: 31,151,856 (GRCm39)	V126A	possibly damaging	Het
Slc25a36	A	T	9: 96,975,122 (GRCm39)		probably benign	Het
Slc2a13	T	C	15: 91,227,924 (GRCm39)	T423A	probably benign	Het
Spty2d1	A	G	7: 46,657,892 (GRCm39)		probably benign	Het
Stag1	A	G	9: 100,769,442 (GRCm39)	D519G	probably benign	Het
Tmprss2	G	T	16: 97,400,479 (GRCm39)		probably benign	Het
Trim66	G	T	7: 109,060,109 (GRCm39)	T759K	possibly damaging	Het
Trpc4ap	C	A	2: 155,481,467 (GRCm39)	A530S	probably damaging	Het
Ttn	A	T	2: 76,642,099 (GRCm39)	D11625E	probably damaging	Het
Ube4b	T	C	4: 149,483,141 (GRCm39)	I42M	possibly damaging	Het
Ubxn7	A	G	16: 32,194,088 (GRCm39)	Y220C	probably damaging	Het
Vmn1r234	A	G	17: 21,449,269 (GRCm39)	Y61C	probably benign	Het

Other mutations in Ubxn10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03216:Ubxn10	APN	4	138,448,050 (GRCm39)	missense	probably damaging	1.00
PIT1430001:Ubxn10	UTSW	4	138,448,199 (GRCm39)	missense	probably benign	0.01
R0885:Ubxn10	UTSW	4	138,447,881 (GRCm39)	missense	probably damaging	1.00
R2031:Ubxn10	UTSW	4	138,448,574 (GRCm39)	missense	possibly damaging	0.92
R4117:Ubxn10	UTSW	4	138,448,276 (GRCm39)	missense	probably benign	0.01
R4461:Ubxn10	UTSW	4	138,448,187 (GRCm39)	missense	probably benign	0.31
R4737:Ubxn10	UTSW	4	138,463,259 (GRCm39)	intron	probably benign
R4804:Ubxn10	UTSW	4	138,448,515 (GRCm39)	missense	possibly damaging	0.71
R5739:Ubxn10	UTSW	4	138,448,134 (GRCm39)	missense	probably benign	0.01
R6524:Ubxn10	UTSW	4	138,448,194 (GRCm39)	nonsense	probably null
R7252:Ubxn10	UTSW	4	138,448,187 (GRCm39)	missense	probably benign
R8824:Ubxn10	UTSW	4	138,463,178 (GRCm39)	critical splice donor site	probably null
R9189:Ubxn10	UTSW	4	138,448,133 (GRCm39)	missense	possibly damaging	0.81

Posted On

2015-04-16