Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02149:Fbxw20'

281922

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fbxw20

Ensembl Gene

ENSMUSG00000061701

Gene Name

F-box and WD-40 domain protein 20

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL02149

Quality Score

Status

Chromosome

Chromosomal Location

109046500-109063822 bp(-) (GRCm39)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to G at 109062886 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000143126 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079548] [ENSMUST00000197329]

AlphaFold

Q5U467

Predicted Effect

probably null
Transcript: ENSMUST00000079548

SMART Domains

Protein: ENSMUSP00000078503
Gene: ENSMUSG00000061701

Domain	Start	End	E-Value	Type
FBOX	5	45	2.37e-6	SMART
SCOP:d1tbga_	116	249	5e-8	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000197329

SMART Domains

Protein: ENSMUSP00000143126
Gene: ENSMUSG00000061701

Domain	Start	End	E-Value	Type
FBOX	5	45	1.5e-8	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198261

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam10	A	T	9: 70,610,713 (GRCm39)	H67L	probably damaging	Het
Adgrb1	C	T	15: 74,412,326 (GRCm39)	T435I	probably damaging	Het
Adgrd1	T	A	5: 129,256,325 (GRCm39)	F652Y	probably damaging	Het
Adgrl4	T	A	3: 151,205,991 (GRCm39)	F250Y	possibly damaging	Het
Aebp2	C	T	6: 140,588,010 (GRCm39)	A360V	probably benign	Het
AW551984	A	C	9: 39,504,220 (GRCm39)	M582R	probably benign	Het
B430306N03Rik	T	C	17: 48,624,020 (GRCm39)	V107A	probably benign	Het
Cage1	T	C	13: 38,206,505 (GRCm39)	N447D	probably damaging	Het
Col17a1	T	C	19: 47,657,071 (GRCm39)	D524G	probably benign	Het
Dpp6	A	T	5: 27,743,022 (GRCm39)	I218F	probably benign	Het
Ep300	T	G	15: 81,512,621 (GRCm39)		probably benign	Het
Ephb2	C	T	4: 136,421,225 (GRCm39)	C375Y	probably damaging	Het
Fastk	A	G	5: 24,649,051 (GRCm39)	V112A	probably damaging	Het
Fbxo11	T	A	17: 88,301,187 (GRCm39)	R775S	possibly damaging	Het
Hamp2	G	T	7: 30,622,122 (GRCm39)	A50E	probably damaging	Het
Il22b	C	A	10: 118,130,902 (GRCm39)		probably benign	Het
Ints1	G	A	5: 139,737,715 (GRCm39)	R2139C	probably damaging	Het
Itgae	T	A	11: 72,994,720 (GRCm39)	V24E	probably benign	Het
Jakmip3	G	A	7: 138,609,075 (GRCm39)	V60M	possibly damaging	Het
Kcnk10	A	C	12: 98,485,099 (GRCm39)		probably benign	Het
Klra1	A	T	6: 130,352,293 (GRCm39)	C150S	probably damaging	Het
Lhx9	A	T	1: 138,759,172 (GRCm39)	V376E	probably damaging	Het
Mdm1	T	A	10: 117,983,970 (GRCm39)	F199I	probably damaging	Het
Nipal3	G	T	4: 135,194,163 (GRCm39)	T290K	possibly damaging	Het
Obsl1	C	T	1: 75,480,464 (GRCm39)	E387K	probably damaging	Het
Or8b43	A	G	9: 38,360,693 (GRCm39)	H175R	probably damaging	Het
Oxct1	A	G	15: 4,120,711 (GRCm39)	Y265C	probably damaging	Het
Pccb	G	A	9: 100,867,243 (GRCm39)	H411Y	probably damaging	Het
Pkp1	A	G	1: 135,814,485 (GRCm39)	S279P	probably benign	Het
Prdm14	C	A	1: 13,195,663 (GRCm39)	G133C	probably benign	Het
Prkaa2	A	T	4: 104,897,285 (GRCm39)	N309K	probably benign	Het
Shc2	T	C	10: 79,458,102 (GRCm39)	D527G	probably damaging	Het
Shkbp1	C	T	7: 27,042,064 (GRCm39)		probably benign	Het
Skil	T	C	3: 31,151,856 (GRCm39)	V126A	possibly damaging	Het
Slc25a36	A	T	9: 96,975,122 (GRCm39)		probably benign	Het
Slc2a13	T	C	15: 91,227,924 (GRCm39)	T423A	probably benign	Het
Spty2d1	A	G	7: 46,657,892 (GRCm39)		probably benign	Het
Stag1	A	G	9: 100,769,442 (GRCm39)	D519G	probably benign	Het
Tmprss2	G	T	16: 97,400,479 (GRCm39)		probably benign	Het
Trim66	G	T	7: 109,060,109 (GRCm39)	T759K	possibly damaging	Het
Trpc4ap	C	A	2: 155,481,467 (GRCm39)	A530S	probably damaging	Het
Ttn	A	T	2: 76,642,099 (GRCm39)	D11625E	probably damaging	Het
Ube4b	T	C	4: 149,483,141 (GRCm39)	I42M	possibly damaging	Het
Ubxn10	A	G	4: 138,448,584 (GRCm39)	S31P	probably benign	Het
Ubxn7	A	G	16: 32,194,088 (GRCm39)	Y220C	probably damaging	Het
Vmn1r234	A	G	17: 21,449,269 (GRCm39)	Y61C	probably benign	Het

Other mutations in Fbxw20

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00228:Fbxw20	APN	9	109,063,770 (GRCm39)	start codon destroyed	probably damaging	0.97
IGL01764:Fbxw20	APN	9	109,052,427 (GRCm39)	missense	possibly damaging	0.71
IGL02307:Fbxw20	APN	9	109,062,601 (GRCm39)	missense	possibly damaging	0.70
IGL02335:Fbxw20	APN	9	109,052,377 (GRCm39)	missense	possibly damaging	0.91
IGL02338:Fbxw20	APN	9	109,055,046 (GRCm39)	missense	probably benign	0.00
PIT4377001:Fbxw20	UTSW	9	109,050,795 (GRCm39)	missense	probably benign	0.00
PIT4434001:Fbxw20	UTSW	9	109,052,500 (GRCm39)	missense	probably damaging	1.00
R0652:Fbxw20	UTSW	9	109,061,400 (GRCm39)	missense	probably damaging	1.00
R1018:Fbxw20	UTSW	9	109,050,404 (GRCm39)	missense	probably benign	0.03
R1114:Fbxw20	UTSW	9	109,052,550 (GRCm39)	missense	probably damaging	1.00
R1596:Fbxw20	UTSW	9	109,050,368 (GRCm39)	missense	probably damaging	1.00
R1692:Fbxw20	UTSW	9	109,050,777 (GRCm39)	missense	possibly damaging	0.73
R1967:Fbxw20	UTSW	9	109,046,578 (GRCm39)	missense	probably benign	0.00
R2055:Fbxw20	UTSW	9	109,050,442 (GRCm39)	missense	probably damaging	0.99
R2224:Fbxw20	UTSW	9	109,062,650 (GRCm39)	missense	possibly damaging	0.50
R4394:Fbxw20	UTSW	9	109,061,398 (GRCm39)	missense	probably benign	0.00
R4617:Fbxw20	UTSW	9	109,046,631 (GRCm39)	missense	probably damaging	1.00
R4858:Fbxw20	UTSW	9	109,063,763 (GRCm39)	missense	possibly damaging	0.54
R5794:Fbxw20	UTSW	9	109,062,668 (GRCm39)	missense	possibly damaging	0.95
R5794:Fbxw20	UTSW	9	109,052,358 (GRCm39)	missense	probably damaging	0.97
R6090:Fbxw20	UTSW	9	109,052,431 (GRCm39)	missense	probably benign	0.03
R7161:Fbxw20	UTSW	9	109,055,048 (GRCm39)	missense	probably damaging	1.00
R7328:Fbxw20	UTSW	9	109,061,383 (GRCm39)	missense	probably damaging	1.00
R8004:Fbxw20	UTSW	9	109,050,449 (GRCm39)	missense	probably damaging	1.00
R8258:Fbxw20	UTSW	9	109,063,763 (GRCm39)	missense	probably benign	0.18
R8259:Fbxw20	UTSW	9	109,063,763 (GRCm39)	missense	probably benign	0.18
R8770:Fbxw20	UTSW	9	109,046,596 (GRCm39)	missense	probably benign	0.00
R9006:Fbxw20	UTSW	9	109,062,530 (GRCm39)	splice site	probably benign
R9090:Fbxw20	UTSW	9	109,050,423 (GRCm39)	missense	probably benign	0.02
R9131:Fbxw20	UTSW	9	109,052,514 (GRCm39)	missense	probably damaging	1.00
R9271:Fbxw20	UTSW	9	109,050,423 (GRCm39)	missense	probably benign	0.02
R9464:Fbxw20	UTSW	9	109,050,399 (GRCm39)	missense	probably damaging	1.00
Z1177:Fbxw20	UTSW	9	109,054,955 (GRCm39)	frame shift	probably null

Posted On

2015-04-16