Incidental Mutation 'IGL02150:Zmym2'
ID 281986
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zmym2
Ensembl Gene ENSMUSG00000021945
Gene Name zinc finger, MYM-type 2
Synonyms SCLL, RAMP, Zfp198, FIM, MYM
Accession Numbers
Essential gene? Possibly essential (E-score: 0.569) question?
Stock # IGL02150
Quality Score
Status
Chromosome 14
Chromosomal Location 57123986-57199815 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to A at 57148526 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000022511 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022511]
AlphaFold Q9CU65
Predicted Effect probably benign
Transcript: ENSMUST00000022511
SMART Domains Protein: ENSMUSP00000022511
Gene: ENSMUSG00000021945

DomainStartEndE-ValueType
TRASH 330 366 1.55e-5 SMART
TRASH 372 412 7.69e-1 SMART
TRASH 424 459 7.5e1 SMART
TRASH 466 505 6.53e-4 SMART
Pfam:zf-FCS 527 569 1.8e-9 PFAM
TRASH 583 619 4.79e1 SMART
TRASH 638 674 8.49e-3 SMART
TRASH 680 715 7.28e-2 SMART
TRASH 726 761 1.95e-2 SMART
TRASH 767 802 3.89e1 SMART
low complexity region 881 895 N/A INTRINSIC
low complexity region 904 917 N/A INTRINSIC
low complexity region 1087 1111 N/A INTRINSIC
Pfam:DUF3504 1191 1359 7.3e-66 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a protein that contains nine MYM-type zinc finger motifs. Expression of this gene may mediate the inhibition of hematopoietic cell development during ontogeny, and the encoded protein may also play a role in transforming growth factor-beta signaling as a Smad binding protein. [provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit prenatal lethality. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankdd1a C T 9: 65,420,001 (GRCm39) G92S probably damaging Het
Arid1a A T 4: 133,414,568 (GRCm39) M1221K unknown Het
Arl10 G A 13: 54,726,662 (GRCm39) V147M probably damaging Het
Bbs4 T C 9: 59,243,651 (GRCm39) N152S probably benign Het
Cacna2d2 T G 9: 107,404,515 (GRCm39) probably benign Het
Capn9 A G 8: 125,340,582 (GRCm39) E582G probably benign Het
Cct2 A T 10: 116,898,004 (GRCm39) L61Q probably damaging Het
Clip4 A G 17: 72,106,071 (GRCm39) I85V probably damaging Het
Daam2 A T 17: 49,797,332 (GRCm39) L151Q possibly damaging Het
Dlst T A 12: 85,177,807 (GRCm39) I400N possibly damaging Het
Dock7 A T 4: 98,968,089 (GRCm39) probably benign Het
Dynlrb2 A G 8: 117,242,449 (GRCm39) N93S probably benign Het
Efl1 A G 7: 82,335,899 (GRCm39) T407A probably benign Het
Emilin1 A G 5: 31,077,517 (GRCm39) D891G possibly damaging Het
Enpp4 A C 17: 44,413,049 (GRCm39) S162A probably benign Het
Epas1 A G 17: 87,112,717 (GRCm39) D105G probably damaging Het
Fcgbpl1 T A 7: 27,846,204 (GRCm39) Y965* probably null Het
Gcn1 T A 5: 115,747,927 (GRCm39) I1778N probably damaging Het
Gm14496 A C 2: 181,633,140 (GRCm39) D41A probably damaging Het
Gm7008 T A 12: 40,273,257 (GRCm39) probably benign Het
Hcfc2 G A 10: 82,545,852 (GRCm39) S246N probably damaging Het
Hectd1 T C 12: 51,815,974 (GRCm39) N1366S probably damaging Het
Lgmn T C 12: 102,361,986 (GRCm39) R372G possibly damaging Het
Map2k7 A G 8: 4,293,818 (GRCm39) M153V possibly damaging Het
Megf8 T A 7: 25,045,842 (GRCm39) probably null Het
Mgat4c A C 10: 102,224,983 (GRCm39) E399A probably benign Het
Myorg A G 4: 41,499,183 (GRCm39) V149A possibly damaging Het
Nfat5 C T 8: 108,094,584 (GRCm39) Q942* probably null Het
Notch4 A G 17: 34,803,587 (GRCm39) E1502G probably damaging Het
Optn A C 2: 5,037,963 (GRCm39) I410M probably damaging Het
Or6b9 G T 7: 106,555,763 (GRCm39) P127T probably damaging Het
Or8c17 A T 9: 38,180,564 (GRCm39) I252L possibly damaging Het
Ppp1ca G A 19: 4,244,698 (GRCm39) probably benign Het
Pramel5 C A 4: 143,999,771 (GRCm39) L105F possibly damaging Het
Rad54b T A 4: 11,610,502 (GRCm39) N706K probably damaging Het
Rgs11 A T 17: 26,421,968 (GRCm39) T6S probably benign Het
Sbf1 T C 15: 89,179,683 (GRCm39) H1308R probably benign Het
Scart2 G A 7: 139,877,772 (GRCm39) G918D possibly damaging Het
Sec31a T C 5: 100,533,984 (GRCm39) probably benign Het
Sh2d5 G A 4: 137,985,553 (GRCm39) D334N probably benign Het
Skint5 T A 4: 113,742,988 (GRCm39) I360F unknown Het
Slc12a1 G A 2: 125,026,735 (GRCm39) D457N probably damaging Het
Slco2a1 C T 9: 102,962,017 (GRCm39) A563V probably damaging Het
Snrnp35 G A 5: 124,628,471 (GRCm39) A95T probably damaging Het
Snx25 C A 8: 46,569,318 (GRCm39) R193L possibly damaging Het
Stxbp5 T G 10: 9,638,565 (GRCm39) Q1078P probably damaging Het
Tmc2 A T 2: 130,082,073 (GRCm39) I419F probably damaging Het
Tmem87a A T 2: 120,190,557 (GRCm39) W525R probably damaging Het
Trhde A T 10: 114,428,013 (GRCm39) S428T probably damaging Het
Trp73 G A 4: 154,165,943 (GRCm39) A42V possibly damaging Het
Ttn T C 2: 76,679,316 (GRCm39) probably benign Het
Ttn C T 2: 76,598,846 (GRCm39) V19356M probably damaging Het
Vmn1r170 T A 7: 23,306,465 (GRCm39) L289* probably null Het
Vwa5b2 A T 16: 20,423,576 (GRCm39) Q1163L probably benign Het
Washc2 T A 6: 116,208,593 (GRCm39) probably benign Het
Wdr70 T G 15: 8,112,030 (GRCm39) K71T possibly damaging Het
Zbtb41 T C 1: 139,368,186 (GRCm39) S625P possibly damaging Het
Zfp518b A G 5: 38,830,686 (GRCm39) S440P probably damaging Het
Zfp518b A G 5: 38,831,132 (GRCm39) V291A probably damaging Het
Other mutations in Zmym2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00516:Zmym2 APN 14 57,185,394 (GRCm39) splice site probably benign
IGL00587:Zmym2 APN 14 57,140,817 (GRCm39) missense possibly damaging 0.86
IGL00736:Zmym2 APN 14 57,140,668 (GRCm39) missense probably benign 0.01
IGL00753:Zmym2 APN 14 57,194,517 (GRCm39) nonsense probably null
IGL01608:Zmym2 APN 14 57,185,472 (GRCm39) missense possibly damaging 0.57
IGL01744:Zmym2 APN 14 57,184,029 (GRCm39) missense probably benign 0.24
IGL02186:Zmym2 APN 14 57,180,808 (GRCm39) missense probably benign 0.09
IGL02654:Zmym2 APN 14 57,148,772 (GRCm39) missense probably damaging 1.00
IGL02960:Zmym2 APN 14 57,175,870 (GRCm39) missense probably benign 0.09
IGL03104:Zmym2 APN 14 57,187,784 (GRCm39) missense possibly damaging 0.88
IGL03162:Zmym2 APN 14 57,151,500 (GRCm39) missense probably benign 0.24
IGL03356:Zmym2 APN 14 57,194,517 (GRCm39) nonsense probably null
IGL03412:Zmym2 APN 14 57,197,176 (GRCm39) nonsense probably null
R5038_Zmym2_756 UTSW 14 57,193,637 (GRCm39) missense possibly damaging 0.86
R0131:Zmym2 UTSW 14 57,180,715 (GRCm39) missense probably benign
R0131:Zmym2 UTSW 14 57,180,715 (GRCm39) missense probably benign
R0132:Zmym2 UTSW 14 57,180,715 (GRCm39) missense probably benign
R0270:Zmym2 UTSW 14 57,187,141 (GRCm39) splice site probably null
R0834:Zmym2 UTSW 14 57,194,420 (GRCm39) missense probably damaging 1.00
R1071:Zmym2 UTSW 14 57,197,278 (GRCm39) missense possibly damaging 0.93
R1386:Zmym2 UTSW 14 57,150,548 (GRCm39) missense probably damaging 1.00
R1442:Zmym2 UTSW 14 57,180,784 (GRCm39) missense probably damaging 0.99
R1472:Zmym2 UTSW 14 57,148,640 (GRCm39) missense probably benign 0.20
R1595:Zmym2 UTSW 14 57,158,187 (GRCm39) missense probably benign 0.25
R1598:Zmym2 UTSW 14 57,151,524 (GRCm39) missense probably damaging 1.00
R1598:Zmym2 UTSW 14 57,140,226 (GRCm39) missense possibly damaging 0.94
R1916:Zmym2 UTSW 14 57,197,299 (GRCm39) missense probably damaging 1.00
R2261:Zmym2 UTSW 14 57,165,719 (GRCm39) missense probably damaging 1.00
R2393:Zmym2 UTSW 14 57,158,180 (GRCm39) missense probably benign 0.17
R2866:Zmym2 UTSW 14 57,165,705 (GRCm39) missense probably damaging 1.00
R3727:Zmym2 UTSW 14 57,156,806 (GRCm39) splice site probably benign
R3847:Zmym2 UTSW 14 57,158,956 (GRCm39) splice site probably benign
R4043:Zmym2 UTSW 14 57,195,765 (GRCm39) splice site probably benign
R4074:Zmym2 UTSW 14 57,140,461 (GRCm39) missense probably damaging 0.99
R4343:Zmym2 UTSW 14 57,159,019 (GRCm39) missense probably damaging 0.99
R4420:Zmym2 UTSW 14 57,194,335 (GRCm39) missense probably damaging 0.98
R4645:Zmym2 UTSW 14 57,165,764 (GRCm39) missense probably damaging 1.00
R5015:Zmym2 UTSW 14 57,159,051 (GRCm39) missense probably damaging 1.00
R5038:Zmym2 UTSW 14 57,193,637 (GRCm39) missense possibly damaging 0.86
R5223:Zmym2 UTSW 14 57,183,971 (GRCm39) missense probably benign
R5364:Zmym2 UTSW 14 57,158,102 (GRCm39) missense possibly damaging 0.58
R5488:Zmym2 UTSW 14 57,193,712 (GRCm39) missense possibly damaging 0.56
R5489:Zmym2 UTSW 14 57,193,712 (GRCm39) missense possibly damaging 0.56
R5818:Zmym2 UTSW 14 57,183,986 (GRCm39) missense probably benign
R6160:Zmym2 UTSW 14 57,187,766 (GRCm39) missense probably damaging 1.00
R6437:Zmym2 UTSW 14 57,140,461 (GRCm39) missense probably damaging 1.00
R7107:Zmym2 UTSW 14 57,140,169 (GRCm39) missense probably benign 0.01
R7153:Zmym2 UTSW 14 57,187,659 (GRCm39) missense probably benign 0.16
R7337:Zmym2 UTSW 14 57,181,557 (GRCm39) missense probably benign 0.04
R7535:Zmym2 UTSW 14 57,194,536 (GRCm39) missense probably damaging 1.00
R7730:Zmym2 UTSW 14 57,193,638 (GRCm39) missense possibly damaging 0.95
R7779:Zmym2 UTSW 14 57,165,740 (GRCm39) missense probably damaging 1.00
R7849:Zmym2 UTSW 14 57,184,020 (GRCm39) missense probably benign 0.03
R8219:Zmym2 UTSW 14 57,163,316 (GRCm39) missense probably benign 0.07
R8493:Zmym2 UTSW 14 57,151,606 (GRCm39) missense probably damaging 1.00
R8885:Zmym2 UTSW 14 57,185,329 (GRCm39) intron probably benign
R9162:Zmym2 UTSW 14 57,163,361 (GRCm39) missense probably benign 0.02
R9165:Zmym2 UTSW 14 57,185,464 (GRCm39) missense probably damaging 0.98
R9250:Zmym2 UTSW 14 57,148,732 (GRCm39) missense probably damaging 1.00
R9453:Zmym2 UTSW 14 57,180,770 (GRCm39) missense probably damaging 1.00
R9677:Zmym2 UTSW 14 57,187,115 (GRCm39) missense probably benign 0.01
Z1176:Zmym2 UTSW 14 57,150,456 (GRCm39) missense possibly damaging 0.94
Z1177:Zmym2 UTSW 14 57,151,419 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16