Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02152:Zscan18'

282039

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zscan18

Ensembl Gene

ENSMUSG00000070822

Gene Name

zinc finger and SCAN domain containing 18

Synonyms

EG232875

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

IGL02152

Quality Score

Status

Chromosome

Chromosomal Location

12502017-12537562 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to T at 12509223 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046245] [ENSMUST00000210650] [ENSMUST00000211392]

AlphaFold

E9PUD6

Predicted Effect

unknown
Transcript: ENSMUST00000046245
AA Change: D92E

SMART Domains

Protein: ENSMUSP00000047088
Gene: ENSMUSG00000070822
AA Change: D92E

Domain	Start	End	E-Value	Type
low complexity region	10	21	N/A	INTRINSIC
low complexity region	30	45	N/A	INTRINSIC
low complexity region	72	102	N/A	INTRINSIC
low complexity region	118	132	N/A	INTRINSIC
low complexity region	134	154	N/A	INTRINSIC
internal_repeat_2	159	204	6.76e-5	PROSPERO
internal_repeat_1	197	221	2.66e-6	PROSPERO
low complexity region	225	256	N/A	INTRINSIC
low complexity region	262	310	N/A	INTRINSIC
low complexity region	312	335	N/A	INTRINSIC
internal_repeat_1	353	377	2.66e-6	PROSPERO
SCAN	397	509	1.16e-37	SMART
ZnF_C2H2	776	798	2.24e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209869

Predicted Effect

unknown
Transcript: ENSMUST00000210650
AA Change: D92E

Predicted Effect

probably benign
Transcript: ENSMUST00000210891

Predicted Effect

unknown
Transcript: ENSMUST00000211392
AA Change: D92E

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211665

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700028K03Rik	A	G	5: 107,695,983 (GRCm39)	T140A	probably benign	Het
4933430I17Rik	T	C	4: 62,460,991 (GRCm39)	Y289H	possibly damaging	Het
Adamts17	T	A	7: 66,774,748 (GRCm39)	S956T	probably benign	Het
Adamts6	A	T	13: 104,450,168 (GRCm39)	S290C	probably null	Het
Apaf1	A	T	10: 90,897,681 (GRCm39)	H267Q	probably benign	Het
Aplp2	G	A	9: 31,122,947 (GRCm39)	P26L	unknown	Het
Arid1b	C	T	17: 5,364,243 (GRCm39)	S1019F	probably damaging	Het
Armc3	G	A	2: 19,290,948 (GRCm39)		probably null	Het
Ass1	T	C	2: 31,382,336 (GRCm39)	I169T	probably damaging	Het
Ccser1	A	G	6: 61,288,692 (GRCm39)	D285G	possibly damaging	Het
Cenpf	A	G	1: 189,381,209 (GRCm39)	V2737A	probably benign	Het
Chrm5	A	G	2: 112,310,913 (GRCm39)	Y68H	probably damaging	Het
Cops4	A	G	5: 100,681,456 (GRCm39)	T164A	probably benign	Het
Cox4i1	A	G	8: 121,399,604 (GRCm39)	S72G	probably benign	Het
Cpox	A	G	16: 58,494,787 (GRCm39)	T275A	possibly damaging	Het
Cyb5a	T	C	18: 84,891,281 (GRCm39)	I68T	probably benign	Het
Efna5	T	C	17: 62,958,055 (GRCm39)	D67G	probably benign	Het
Enpp3	T	C	10: 24,649,900 (GRCm39)	E842G	probably damaging	Het
Fam210b	A	G	2: 172,193,423 (GRCm39)	K79E	probably benign	Het
Gm4799	T	C	10: 82,790,589 (GRCm39)		noncoding transcript	Het
Gpr146	A	T	5: 139,378,467 (GRCm39)	R90W	probably damaging	Het
H2ac10	A	G	13: 23,718,451 (GRCm39)	H124R	probably benign	Het
Hal	A	G	10: 93,339,404 (GRCm39)	I498V	possibly damaging	Het
Hnrnpm	C	T	17: 33,877,386 (GRCm39)	G365R	probably damaging	Het
Jakmip3	A	G	7: 138,627,217 (GRCm39)	D407G	probably damaging	Het
Kank1	A	G	19: 25,405,536 (GRCm39)	I1185V	possibly damaging	Het
Kcnj16	A	T	11: 110,916,036 (GRCm39)	M233L	probably benign	Het
Klhl5	A	T	5: 65,306,143 (GRCm39)	Q370L	probably damaging	Het
L3hypdh	C	T	12: 72,123,917 (GRCm39)		probably null	Het
Las1l	A	G	X: 94,996,908 (GRCm39)	V130A	probably damaging	Het
Liat1	A	G	11: 75,894,051 (GRCm39)	I143V	probably benign	Het
Lrp2bp	A	T	8: 46,476,081 (GRCm39)	Y274F	probably damaging	Het
Morc2b	T	A	17: 33,356,917 (GRCm39)	K285M	probably damaging	Het
Mpp3	A	T	11: 101,916,216 (GRCm39)	Y45*	probably null	Het
Muc4	T	A	16: 32,598,023 (GRCm39)		probably benign	Het
Muc5ac	T	C	7: 141,353,914 (GRCm39)	C837R	possibly damaging	Het
Nr2f6	T	A	8: 71,828,810 (GRCm39)	I155F	probably damaging	Het
Nsg1	A	G	5: 38,302,145 (GRCm39)	F50L	probably benign	Het
Or14a258	T	A	7: 86,035,251 (GRCm39)	M206L	probably benign	Het
Ostf1	C	A	19: 18,567,822 (GRCm39)	G101C	probably damaging	Het
Pam	C	T	1: 97,768,474 (GRCm39)	R552Q	probably damaging	Het
Pkd1l3	A	G	8: 110,395,924 (GRCm39)	N2108S	probably damaging	Het
Prkdc	A	T	16: 15,487,149 (GRCm39)	H484L	probably benign	Het
Pwwp3a	A	G	10: 80,075,812 (GRCm39)	D466G	probably damaging	Het
Rfx5	G	A	3: 94,864,493 (GRCm39)	R213Q	probably damaging	Het
Ryr1	T	C	7: 28,751,440 (GRCm39)	S3715G	possibly damaging	Het
Sall2	A	G	14: 52,552,971 (GRCm39)	S73P	probably damaging	Het
Sec22c	G	A	9: 121,513,845 (GRCm39)	A264V	probably benign	Het
Sis	A	C	3: 72,796,319 (GRCm39)		probably benign	Het
Spam1	T	A	6: 24,800,802 (GRCm39)		probably benign	Het
Spmip2	T	C	3: 79,252,839 (GRCm39)	I18T	possibly damaging	Het
St13	T	A	15: 81,250,583 (GRCm39)	I318F	probably damaging	Het
Syne1	T	C	10: 5,374,382 (GRCm39)	I142V	probably damaging	Het
Tasor2	C	T	13: 3,635,371 (GRCm39)	E479K	probably benign	Het
Trpm6	A	T	19: 18,809,903 (GRCm39)	T1100S	possibly damaging	Het
Ttll6	G	A	11: 96,026,366 (GRCm39)	W90*	probably null	Het
Txndc12	T	A	4: 108,691,989 (GRCm39)	C9*	probably null	Het
Ubr7	C	T	12: 102,734,535 (GRCm39)	Q270*	probably null	Het
Vps33b	A	G	7: 79,934,817 (GRCm39)	S302G	probably benign	Het
Xylt1	T	A	7: 117,233,997 (GRCm39)	V508E	probably damaging	Het
Zbtb26	A	T	2: 37,326,703 (GRCm39)	L111Q	possibly damaging	Het
Zfp410	T	C	12: 84,379,702 (GRCm39)		probably benign	Het

Other mutations in Zscan18

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01930:Zscan18	APN	7	12,509,275 (GRCm39)	unclassified	probably benign
IGL02236:Zscan18	APN	7	12,503,251 (GRCm39)	missense	probably benign	0.02
IGL02591:Zscan18	APN	7	12,509,206 (GRCm39)	unclassified	probably benign
IGL02619:Zscan18	APN	7	12,508,793 (GRCm39)	unclassified	probably benign
IGL02711:Zscan18	APN	7	12,509,044 (GRCm39)	unclassified	probably benign
IGL03397:Zscan18	APN	7	12,507,488 (GRCm39)	missense	probably damaging	0.97
R0014:Zscan18	UTSW	7	12,503,344 (GRCm39)	missense	possibly damaging	0.48
R0465:Zscan18	UTSW	7	12,509,413 (GRCm39)	unclassified	probably benign
R0548:Zscan18	UTSW	7	12,508,103 (GRCm39)	missense	probably damaging	1.00
R1506:Zscan18	UTSW	7	12,508,129 (GRCm39)	missense	probably damaging	1.00
R1725:Zscan18	UTSW	7	12,504,784 (GRCm39)	missense	probably damaging	1.00
R2323:Zscan18	UTSW	7	12,509,386 (GRCm39)	unclassified	probably benign
R5034:Zscan18	UTSW	7	12,508,072 (GRCm39)	missense	probably damaging	1.00
R5180:Zscan18	UTSW	7	12,509,216 (GRCm39)	unclassified	probably benign
R5579:Zscan18	UTSW	7	12,509,308 (GRCm39)	unclassified	probably benign
R5635:Zscan18	UTSW	7	12,504,791 (GRCm39)	missense	probably benign	0.00
R5708:Zscan18	UTSW	7	12,508,383 (GRCm39)	missense	probably benign	0.01
R6088:Zscan18	UTSW	7	12,509,125 (GRCm39)	unclassified	probably benign
R6320:Zscan18	UTSW	7	12,509,147 (GRCm39)	unclassified	probably benign
R7048:Zscan18	UTSW	7	12,508,671 (GRCm39)	unclassified	probably benign
R7610:Zscan18	UTSW	7	12,503,237 (GRCm39)	missense	probably damaging	0.98
R7683:Zscan18	UTSW	7	12,503,532 (GRCm39)	nonsense	probably null
R8287:Zscan18	UTSW	7	12,509,298 (GRCm39)	missense	unknown
R8674:Zscan18	UTSW	7	12,504,827 (GRCm39)	splice site	probably benign
R8735:Zscan18	UTSW	7	12,503,625 (GRCm39)	missense	probably benign	0.16
R8928:Zscan18	UTSW	7	12,509,120 (GRCm39)	nonsense	probably null
R9028:Zscan18	UTSW	7	12,506,116 (GRCm39)	intron	probably benign
R9290:Zscan18	UTSW	7	12,508,054 (GRCm39)	missense	probably damaging	0.99
R9342:Zscan18	UTSW	7	12,505,612 (GRCm39)	missense	probably damaging	1.00
R9471:Zscan18	UTSW	7	12,508,343 (GRCm39)	missense	possibly damaging	0.70
R9522:Zscan18	UTSW	7	12,503,297 (GRCm39)	missense	possibly damaging	0.91
R9631:Zscan18	UTSW	7	12,505,657 (GRCm39)	missense	possibly damaging	0.90
RF055:Zscan18	UTSW	7	12,508,352 (GRCm39)	small deletion	probably benign
Z1088:Zscan18	UTSW	7	12,509,020 (GRCm39)	unclassified	probably benign
Z1088:Zscan18	UTSW	7	12,508,994 (GRCm39)	missense	probably benign	0.18

Posted On

2015-04-16