Incidental Mutation 'IGL02153:Tas2r126'
ID282106
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r126
Ensembl Gene ENSMUSG00000048284
Gene Nametaste receptor, type 2, member 126
SynonymsT2R12, mt2r35, T2R26, mGR26, Tas2r26
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #IGL02153
Quality Score
Status
Chromosome6
Chromosomal Location42434535-42435464 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 42434664 bp
ZygosityHeterozygous
Amino Acid Change Serine to Alanine at position 44 (S44A)
Ref Sequence ENSEMBL: ENSMUSP00000056581 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059534]
Predicted Effect probably benign
Transcript: ENSMUST00000059534
AA Change: S44A

PolyPhen 2 Score 0.321 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000056581
Gene: ENSMUSG00000048284
AA Change: S44A

DomainStartEndE-ValueType
Pfam:TAS2R 1 303 2.5e-97 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik T C 2: 152,441,241 I275T probably benign Het
BC005561 A G 5: 104,521,083 E1157G probably benign Het
Chd9 A T 8: 90,956,494 K521* probably null Het
Csn3 A T 5: 87,930,097 N154I possibly damaging Het
Dock2 A G 11: 34,230,670 S1716P probably benign Het
Dock7 A T 4: 98,958,067 S18T probably benign Het
Esrra G A 19: 6,913,822 T190I probably benign Het
F13b T C 1: 139,516,377 I483T probably damaging Het
Foxb1 T A 9: 69,759,703 M182L probably benign Het
Fsip2 T C 2: 82,978,721 F1795L probably benign Het
Gkn2 G A 6: 87,373,408 probably null Het
Gm8439 G A 4: 120,609,590 A93T unknown Het
Ift22 T C 5: 136,911,696 S72P probably benign Het
Kcnmb2 A G 3: 32,178,844 K24E probably damaging Het
Kcnq3 C A 15: 66,025,191 V287L probably damaging Het
Lrriq1 T A 10: 103,170,479 M1262L probably benign Het
Mb21d2 A G 16: 28,929,488 I59T probably benign Het
Mogat2 A T 7: 99,223,554 M141K possibly damaging Het
Mtdh C T 15: 34,131,250 L409F possibly damaging Het
Muc5ac C T 7: 141,818,800 Q2724* probably null Het
Myo15 T G 11: 60,498,397 L2040R probably damaging Het
Nodal C T 10: 61,424,545 T325I probably damaging Het
Pappa A T 4: 65,297,437 T1194S probably damaging Het
Pcdhb13 A C 18: 37,443,685 D372A probably damaging Het
Phf14 T A 6: 11,934,016 N292K probably damaging Het
Pigr T A 1: 130,849,056 probably null Het
Plcb1 T C 2: 135,387,853 I1131T probably benign Het
Plch1 T A 3: 63,781,351 D132V probably damaging Het
Plxnb2 C A 15: 89,165,813 E502* probably null Het
Prox2 T C 12: 85,087,929 N526S probably damaging Het
Rdm1 T A 11: 101,628,454 probably null Het
Rxfp1 C T 3: 79,660,120 E308K probably benign Het
Sgca T C 11: 94,963,284 T120A probably damaging Het
Sh3tc1 G A 5: 35,703,352 R1054W probably damaging Het
Smarcal1 C T 1: 72,633,055 probably benign Het
Spata45 T A 1: 191,039,761 M60K probably benign Het
St8sia6 T C 2: 13,656,905 M372V probably damaging Het
Tcea3 T A 4: 136,273,634 probably benign Het
Tln1 T C 4: 43,546,857 I840V possibly damaging Het
Ttn T C 2: 76,898,341 probably benign Het
Ubr4 T A 4: 139,460,160 Y3846* probably null Het
Usp47 G A 7: 112,104,049 D1171N probably benign Het
Vmn2r114 G A 17: 23,291,808 T566I probably benign Het
Wdr35 G A 12: 9,008,535 R575Q probably null Het
Xkr5 A T 8: 18,933,667 C454S probably benign Het
Other mutations in Tas2r126
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00915:Tas2r126 APN 6 42435349 missense possibly damaging 0.67
IGL01327:Tas2r126 APN 6 42434750 missense probably benign 0.09
IGL01690:Tas2r126 APN 6 42435307 missense probably benign 0.02
IGL02291:Tas2r126 APN 6 42435287 missense probably benign 0.00
IGL03365:Tas2r126 APN 6 42435457 missense probably benign 0.36
R0091:Tas2r126 UTSW 6 42435102 missense probably benign
R0486:Tas2r126 UTSW 6 42435291 missense probably benign 0.01
R0611:Tas2r126 UTSW 6 42435091 missense probably damaging 0.99
R1527:Tas2r126 UTSW 6 42435136 missense probably benign 0.03
R1529:Tas2r126 UTSW 6 42434568 missense probably benign 0.00
R1883:Tas2r126 UTSW 6 42435027 missense probably benign
R1884:Tas2r126 UTSW 6 42435027 missense probably benign
R2039:Tas2r126 UTSW 6 42434623 missense probably benign 0.22
R4863:Tas2r126 UTSW 6 42435390 missense probably benign 0.02
R5975:Tas2r126 UTSW 6 42435000 missense possibly damaging 0.69
R7127:Tas2r126 UTSW 6 42434805 missense probably damaging 1.00
R7351:Tas2r126 UTSW 6 42435306 missense probably benign 0.02
Posted On2015-04-16