Incidental Mutation 'IGL02155:Dnajc22'
ID282185
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dnajc22
Ensembl Gene ENSMUSG00000038009
Gene NameDnaJ heat shock protein family (Hsp40) member C22
Synonyms2810451A06Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.101) question?
Stock #IGL02155
Quality Score
Status
Chromosome15
Chromosomal Location99093170-99104737 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 99101005 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Histidine at position 24 (Y24H)
Ref Sequence ENSEMBL: ENSMUSP00000055482 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061295]
Predicted Effect probably damaging
Transcript: ENSMUST00000061295
AA Change: Y24H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000055482
Gene: ENSMUSG00000038009
AA Change: Y24H

DomainStartEndE-ValueType
Pfam:TM2 1 50 1e-10 PFAM
transmembrane domain 76 98 N/A INTRINSIC
transmembrane domain 105 124 N/A INTRINSIC
transmembrane domain 139 161 N/A INTRINSIC
transmembrane domain 206 228 N/A INTRINSIC
DnaJ 276 335 1.09e-19 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146173
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aacs A G 5: 125,506,286 H302R probably null Het
Abi3bp A T 16: 56,587,964 H254L probably damaging Het
Adcy3 G A 12: 4,212,142 W1064* probably null Het
Arvcf C T 16: 18,403,900 P70S probably damaging Het
Ceacam3 A G 7: 17,162,981 D624G possibly damaging Het
Cntrl T A 2: 35,160,238 probably benign Het
Cyp2a5 T A 7: 26,843,046 F491Y probably benign Het
Disp2 C T 2: 118,791,804 R1006C probably damaging Het
Fat2 A G 11: 55,262,419 F3656L probably benign Het
Fbxo31 A G 8: 121,559,075 F212S probably damaging Het
Fsip2 T C 2: 82,998,352 M6831T probably benign Het
Gpi1 G T 7: 34,230,189 Q9K possibly damaging Het
Hmcn1 T A 1: 150,563,598 S5495C probably damaging Het
Ift74 A G 4: 94,679,251 I394V probably benign Het
Kcnh5 G A 12: 75,176,538 probably benign Het
Lars2 A G 9: 123,454,982 D745G probably damaging Het
Mitd1 T A 1: 37,885,275 I65F probably benign Het
Mlxip T C 5: 123,453,392 M878T probably benign Het
Mrgpra4 T C 7: 47,981,544 Y103C probably damaging Het
Notch2 T C 3: 98,138,490 I1657T probably damaging Het
Olfr1028 T A 2: 85,952,008 M315K probably benign Het
Orc1 T A 4: 108,590,677 D40E probably benign Het
Rnf40 T C 7: 127,590,716 probably benign Het
Sema4d A G 13: 51,703,267 V643A probably benign Het
Taf7 A T 18: 37,643,511 M1K probably null Het
Tnfsf10 A T 3: 27,335,231 D147V possibly damaging Het
Trove2 C T 1: 143,761,269 probably null Het
Usp45 T A 4: 21,798,743 probably null Het
Wdr62 T C 7: 30,262,643 D2G probably damaging Het
Zp2 T A 7: 120,144,117 I50F probably benign Het
Other mutations in Dnajc22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00091:Dnajc22 APN 15 99101178 missense possibly damaging 0.73
IGL00922:Dnajc22 APN 15 99101579 missense possibly damaging 0.89
IGL02726:Dnajc22 APN 15 99101000 missense probably damaging 1.00
IGL03074:Dnajc22 APN 15 99101522 missense probably damaging 1.00
F5770:Dnajc22 UTSW 15 99101482 missense probably damaging 0.99
R1138:Dnajc22 UTSW 15 99104427 small deletion probably benign
R1628:Dnajc22 UTSW 15 99100936 start codon destroyed probably null 1.00
R2018:Dnajc22 UTSW 15 99101233 missense probably benign 0.06
R2146:Dnajc22 UTSW 15 99104383 missense probably benign 0.04
R4342:Dnajc22 UTSW 15 99104464 nonsense probably null
R4950:Dnajc22 UTSW 15 99101734 missense probably benign 0.29
V7580:Dnajc22 UTSW 15 99101482 missense probably damaging 0.99
V7581:Dnajc22 UTSW 15 99101482 missense probably damaging 0.99
V7582:Dnajc22 UTSW 15 99101482 missense probably damaging 0.99
V7583:Dnajc22 UTSW 15 99101482 missense probably damaging 0.99
Posted On2015-04-16