Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02156:Or7g34'

282233

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or7g34

Ensembl Gene

ENSMUSG00000095667

Gene Name

olfactory receptor family 7 subfamily G member 34

Synonyms

MOR147-3, GA_x6K02T2PVTD-13313295-13312357, Olfr854

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.379) question?

Stock #

IGL02156

Quality Score

Status

Chromosome

Chromosomal Location

19477731-19478678 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19478494 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 59 (M59T)

Ref Sequence

ENSEMBL: ENSMUSP00000148270 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072419] [ENSMUST00000212872]

AlphaFold

Q8VFF1

Predicted Effect

probably damaging
Transcript: ENSMUST00000072419
AA Change: M62T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000072248
Gene: ENSMUSG00000095667
AA Change: M62T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	34	311	2.3e-51	PFAM
Pfam:7TM_GPCR_Srsx	38	308	9.6e-7	PFAM
Pfam:7tm_1	44	293	1.9e-23	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000212872
AA Change: M59T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930408O17Rik	G	A	12: 104,837,566 (GRCm39)		noncoding transcript	Het
Adam33	G	A	2: 130,895,078 (GRCm39)		probably benign	Het
Akr7a5	C	A	4: 139,041,580 (GRCm39)	A163D	probably damaging	Het
Arap1	T	C	7: 101,037,937 (GRCm39)		probably benign	Het
Asf1a	C	T	10: 53,482,239 (GRCm39)	A17V	probably benign	Het
Atp1a4	A	T	1: 172,085,529 (GRCm39)	S25T	probably benign	Het
Cbln4	T	C	2: 171,884,128 (GRCm39)	I31V	probably benign	Het
Ccdc93	T	G	1: 121,376,005 (GRCm39)	L172R	possibly damaging	Het
Ceacam9	T	C	7: 16,457,544 (GRCm39)		probably benign	Het
Crhr1	C	A	11: 104,054,709 (GRCm39)	N107K	probably benign	Het
Cyp11b1	T	A	15: 74,707,646 (GRCm39)	M488L	probably benign	Het
Dnah7a	A	G	1: 53,458,882 (GRCm39)	V3752A	probably benign	Het
Dnhd1	G	A	7: 105,370,951 (GRCm39)	V4744M	probably damaging	Het
Dstyk	C	A	1: 132,377,664 (GRCm39)	N423K	probably benign	Het
Exph5	T	C	9: 53,286,941 (GRCm39)	S1341P	probably damaging	Het
Fam161b	T	C	12: 84,401,527 (GRCm39)	H409R	probably benign	Het
Fbxo21	A	G	5: 118,132,733 (GRCm39)		probably benign	Het
Flt1	A	G	5: 147,618,551 (GRCm39)	I230T	probably damaging	Het
Gm9931	T	C	1: 147,157,366 (GRCm39)		noncoding transcript	Het
Grk6	T	C	13: 55,597,174 (GRCm39)	F36L	possibly damaging	Het
Grm1	G	T	10: 10,595,720 (GRCm39)	A636D	probably damaging	Het
Hectd1	A	T	12: 51,800,916 (GRCm39)		probably benign	Het
Hltf	G	A	3: 20,146,971 (GRCm39)	V577I	possibly damaging	Het
Hrob	C	T	11: 102,145,865 (GRCm39)	S47F	probably damaging	Het
Lrrc8c	A	G	5: 105,755,359 (GRCm39)	D378G	probably damaging	Het
Mcoln1	C	A	8: 3,562,657 (GRCm39)	S6*	probably null	Het
Meis1	A	T	11: 18,961,292 (GRCm39)	S194T	probably benign	Het
Myo1h	A	C	5: 114,491,972 (GRCm39)		probably benign	Het
Nop9	T	A	14: 55,990,740 (GRCm39)	C557*	probably null	Het
Nrap	T	C	19: 56,309,432 (GRCm39)	D1619G	probably damaging	Het
Or10d1c	T	A	9: 38,893,842 (GRCm39)	Y166F	possibly damaging	Het
Or4f61	A	T	2: 111,922,361 (GRCm39)	H228Q	probably benign	Het
Pard3b	T	A	1: 61,807,109 (GRCm39)	D41E	possibly damaging	Het
Parp14	G	T	16: 35,678,967 (GRCm39)	Q334K	probably benign	Het
Phf3	A	T	1: 30,847,859 (GRCm39)	I1228K	probably damaging	Het
Polr1b	T	A	2: 128,965,799 (GRCm39)	F814I	probably benign	Het
Prr5	A	G	15: 84,654,236 (GRCm39)	I306V	possibly damaging	Het
Rsph1	T	G	17: 31,477,090 (GRCm39)	S282R	probably benign	Het
Son	T	C	16: 91,452,992 (GRCm39)	S580P	possibly damaging	Het
Sptbn5	G	T	2: 119,878,098 (GRCm39)		probably benign	Het
Ssr2	T	A	3: 88,491,095 (GRCm39)		probably null	Het
Tfpt	A	G	7: 3,632,039 (GRCm39)	S24P	probably damaging	Het
Tg	A	G	15: 66,577,197 (GRCm39)	T1507A	probably benign	Het
Trpm7	A	G	2: 126,641,163 (GRCm39)		probably benign	Het
Wwox	G	A	8: 115,174,899 (GRCm39)		probably null	Het
Ythdf2	C	T	4: 131,931,819 (GRCm39)	R447H	possibly damaging	Het
Zfp385c	A	G	11: 100,519,845 (GRCm39)	F368S	probably damaging	Het
Zfp488	A	G	14: 33,692,357 (GRCm39)	S269P	possibly damaging	Het
Zhx1	A	C	15: 57,917,445 (GRCm39)	V267G	possibly damaging	Het

Other mutations in Or7g34

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00930:Or7g34	APN	9	19,478,471 (GRCm39)	missense	probably damaging	1.00
IGL02072:Or7g34	APN	9	19,478,245 (GRCm39)	missense	probably benign	0.00
IGL02187:Or7g34	APN	9	19,478,393 (GRCm39)	missense	probably benign	0.16
IGL02252:Or7g34	APN	9	19,478,267 (GRCm39)	missense	probably damaging	0.99
R0519:Or7g34	UTSW	9	19,478,245 (GRCm39)	missense	probably benign	0.21
R0755:Or7g34	UTSW	9	19,478,415 (GRCm39)	missense	possibly damaging	0.94
R0899:Or7g34	UTSW	9	19,477,843 (GRCm39)	missense	probably damaging	1.00
R1832:Or7g34	UTSW	9	19,478,492 (GRCm39)	missense	possibly damaging	0.88
R2115:Or7g34	UTSW	9	19,478,618 (GRCm39)	missense	probably benign	0.12
R4326:Or7g34	UTSW	9	19,478,318 (GRCm39)	missense	possibly damaging	0.95
R4328:Or7g34	UTSW	9	19,478,318 (GRCm39)	missense	possibly damaging	0.95
R4329:Or7g34	UTSW	9	19,478,318 (GRCm39)	missense	possibly damaging	0.95
R4379:Or7g34	UTSW	9	19,478,038 (GRCm39)	missense	probably benign	0.15
R4381:Or7g34	UTSW	9	19,478,038 (GRCm39)	missense	probably benign	0.15
R5576:Or7g34	UTSW	9	19,478,369 (GRCm39)	missense	probably benign
R6102:Or7g34	UTSW	9	19,478,318 (GRCm39)	missense	possibly damaging	0.87
R7449:Or7g34	UTSW	9	19,478,162 (GRCm39)	missense	probably benign	0.06
R7515:Or7g34	UTSW	9	19,477,949 (GRCm39)	missense	probably damaging	1.00
R8143:Or7g34	UTSW	9	19,478,587 (GRCm39)	missense	probably benign	0.04
R8813:Or7g34	UTSW	9	19,477,895 (GRCm39)	missense	probably damaging	1.00
R9515:Or7g34	UTSW	9	19,478,396 (GRCm39)	missense	possibly damaging	0.74
Z1176:Or7g34	UTSW	9	19,477,822 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16