Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02156:Zfp385c'

282240

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp385c

Ensembl Gene

ENSMUSG00000014198

Gene Name

zinc finger protein 385C

Synonyms

A930006D11Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.178) question?

Stock #

IGL02156

Quality Score

Status

Chromosome

Chromosomal Location

100518369-100583281 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 100519845 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 368 (F368S)

Ref Sequence

ENSEMBL: ENSMUSP00000099408 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000017981] [ENSMUST00000051947] [ENSMUST00000103119] [ENSMUST00000107376] [ENSMUST00000142993]

AlphaFold

A2A5E6

Predicted Effect

probably benign
Transcript: ENSMUST00000017981

SMART Domains

Protein: ENSMUSP00000017981
Gene: ENSMUSG00000017837

Domain	Start	End	E-Value	Type
Pfam:Arf	1	168	4.3e-9	PFAM
Pfam:Roc	6	124	2.2e-13	PFAM
Pfam:MMR_HSR1	6	165	3.1e-6	PFAM
Pfam:Ras	6	170	2.9e-27	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000051947

SMART Domains

Protein: ENSMUSP00000059559
Gene: ENSMUSG00000017837

Domain	Start	End	E-Value	Type
Pfam:Arf	1	168	5.6e-9	PFAM
Pfam:Miro	6	123	2.2e-21	PFAM
Pfam:Ras	6	170	4.5e-27	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000103119
AA Change: F368S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000099408
Gene: ENSMUSG00000014198
AA Change: F368S

Domain	Start	End	E-Value	Type
low complexity region	2	24	N/A	INTRINSIC
ZnF_U1	72	108	4.36e-2	SMART
ZnF_C2H2	77	99	1.51e0	SMART
low complexity region	125	141	N/A	INTRINSIC
low complexity region	143	161	N/A	INTRINSIC
low complexity region	181	200	N/A	INTRINSIC
ZnF_U1	225	259	5.72e-4	SMART
ZnF_C2H2	228	252	7.11e0	SMART
ZnF_U1	294	328	7.44e-3	SMART
ZnF_C2H2	297	321	4.34e0	SMART
low complexity region	347	365	N/A	INTRINSIC
low complexity region	382	405	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000107376

SMART Domains

Protein: ENSMUSP00000102999
Gene: ENSMUSG00000017837

Domain	Start	End	E-Value	Type
Pfam:Arf	1	168	5.6e-9	PFAM
Pfam:Miro	6	123	2.2e-21	PFAM
Pfam:Ras	6	170	4.5e-27	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127547

Predicted Effect

probably benign
Transcript: ENSMUST00000142993

SMART Domains

Protein: ENSMUSP00000114456
Gene: ENSMUSG00000017837

Domain	Start	End	E-Value	Type
Pfam:Arf	1	151	1.3e-8	PFAM
Pfam:Miro	6	123	1.4e-21	PFAM
Pfam:MMR_HSR1	6	145	4.5e-6	PFAM
Pfam:Ras	6	153	2.9e-25	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148560

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155840

Predicted Effect

probably benign
Transcript: ENSMUST00000151589

SMART Domains

Protein: ENSMUSP00000119259
Gene: ENSMUSG00000014198

Domain	Start	End	E-Value	Type
ZnF_U1	40	74	6.04e-3	SMART
ZnF_C2H2	43	67	6.31e1	SMART
low complexity region	79	104	N/A	INTRINSIC
ZnF_U1	152	188	4.36e-2	SMART
ZnF_C2H2	157	179	1.51e0	SMART
low complexity region	205	221	N/A	INTRINSIC
low complexity region	223	241	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930408O17Rik	G	A	12: 104,837,566 (GRCm39)		noncoding transcript	Het
Adam33	G	A	2: 130,895,078 (GRCm39)		probably benign	Het
Akr7a5	C	A	4: 139,041,580 (GRCm39)	A163D	probably damaging	Het
Arap1	T	C	7: 101,037,937 (GRCm39)		probably benign	Het
Asf1a	C	T	10: 53,482,239 (GRCm39)	A17V	probably benign	Het
Atp1a4	A	T	1: 172,085,529 (GRCm39)	S25T	probably benign	Het
Cbln4	T	C	2: 171,884,128 (GRCm39)	I31V	probably benign	Het
Ccdc93	T	G	1: 121,376,005 (GRCm39)	L172R	possibly damaging	Het
Ceacam9	T	C	7: 16,457,544 (GRCm39)		probably benign	Het
Crhr1	C	A	11: 104,054,709 (GRCm39)	N107K	probably benign	Het
Cyp11b1	T	A	15: 74,707,646 (GRCm39)	M488L	probably benign	Het
Dnah7a	A	G	1: 53,458,882 (GRCm39)	V3752A	probably benign	Het
Dnhd1	G	A	7: 105,370,951 (GRCm39)	V4744M	probably damaging	Het
Dstyk	C	A	1: 132,377,664 (GRCm39)	N423K	probably benign	Het
Exph5	T	C	9: 53,286,941 (GRCm39)	S1341P	probably damaging	Het
Fam161b	T	C	12: 84,401,527 (GRCm39)	H409R	probably benign	Het
Fbxo21	A	G	5: 118,132,733 (GRCm39)		probably benign	Het
Flt1	A	G	5: 147,618,551 (GRCm39)	I230T	probably damaging	Het
Gm9931	T	C	1: 147,157,366 (GRCm39)		noncoding transcript	Het
Grk6	T	C	13: 55,597,174 (GRCm39)	F36L	possibly damaging	Het
Grm1	G	T	10: 10,595,720 (GRCm39)	A636D	probably damaging	Het
Hectd1	A	T	12: 51,800,916 (GRCm39)		probably benign	Het
Hltf	G	A	3: 20,146,971 (GRCm39)	V577I	possibly damaging	Het
Hrob	C	T	11: 102,145,865 (GRCm39)	S47F	probably damaging	Het
Lrrc8c	A	G	5: 105,755,359 (GRCm39)	D378G	probably damaging	Het
Mcoln1	C	A	8: 3,562,657 (GRCm39)	S6*	probably null	Het
Meis1	A	T	11: 18,961,292 (GRCm39)	S194T	probably benign	Het
Myo1h	A	C	5: 114,491,972 (GRCm39)		probably benign	Het
Nop9	T	A	14: 55,990,740 (GRCm39)	C557*	probably null	Het
Nrap	T	C	19: 56,309,432 (GRCm39)	D1619G	probably damaging	Het
Or10d1c	T	A	9: 38,893,842 (GRCm39)	Y166F	possibly damaging	Het
Or4f61	A	T	2: 111,922,361 (GRCm39)	H228Q	probably benign	Het
Or7g34	A	G	9: 19,478,494 (GRCm39)	M59T	probably damaging	Het
Pard3b	T	A	1: 61,807,109 (GRCm39)	D41E	possibly damaging	Het
Parp14	G	T	16: 35,678,967 (GRCm39)	Q334K	probably benign	Het
Phf3	A	T	1: 30,847,859 (GRCm39)	I1228K	probably damaging	Het
Polr1b	T	A	2: 128,965,799 (GRCm39)	F814I	probably benign	Het
Prr5	A	G	15: 84,654,236 (GRCm39)	I306V	possibly damaging	Het
Rsph1	T	G	17: 31,477,090 (GRCm39)	S282R	probably benign	Het
Son	T	C	16: 91,452,992 (GRCm39)	S580P	possibly damaging	Het
Sptbn5	G	T	2: 119,878,098 (GRCm39)		probably benign	Het
Ssr2	T	A	3: 88,491,095 (GRCm39)		probably null	Het
Tfpt	A	G	7: 3,632,039 (GRCm39)	S24P	probably damaging	Het
Tg	A	G	15: 66,577,197 (GRCm39)	T1507A	probably benign	Het
Trpm7	A	G	2: 126,641,163 (GRCm39)		probably benign	Het
Wwox	G	A	8: 115,174,899 (GRCm39)		probably null	Het
Ythdf2	C	T	4: 131,931,819 (GRCm39)	R447H	possibly damaging	Het
Zfp488	A	G	14: 33,692,357 (GRCm39)	S269P	possibly damaging	Het
Zhx1	A	C	15: 57,917,445 (GRCm39)	V267G	possibly damaging	Het

Other mutations in Zfp385c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02542:Zfp385c	APN	11	100,520,742 (GRCm39)	missense	probably damaging	1.00
IGL02579:Zfp385c	APN	11	100,521,605 (GRCm39)	missense	probably damaging	1.00
IGL03243:Zfp385c	APN	11	100,525,573 (GRCm39)	missense	probably damaging	1.00
R0054:Zfp385c	UTSW	11	100,520,782 (GRCm39)	missense	probably benign	0.08
R0054:Zfp385c	UTSW	11	100,520,782 (GRCm39)	missense	probably benign	0.08
R1158:Zfp385c	UTSW	11	100,520,709 (GRCm39)	unclassified	probably benign
R1884:Zfp385c	UTSW	11	100,521,532 (GRCm39)	missense	probably benign
R1892:Zfp385c	UTSW	11	100,528,630 (GRCm39)	missense	probably damaging	1.00
R6010:Zfp385c	UTSW	11	100,548,363 (GRCm39)	missense	probably benign	0.00
R6020:Zfp385c	UTSW	11	100,523,594 (GRCm39)	missense	probably benign
R6901:Zfp385c	UTSW	11	100,523,585 (GRCm39)	missense	probably benign	0.06
R7008:Zfp385c	UTSW	11	100,521,513 (GRCm39)	missense	probably damaging	0.99
R7272:Zfp385c	UTSW	11	100,520,865 (GRCm39)	missense	possibly damaging	0.50
R8271:Zfp385c	UTSW	11	100,548,291 (GRCm39)	missense	probably damaging	1.00
Z1177:Zfp385c	UTSW	11	100,548,257 (GRCm39)	missense	probably damaging	0.99
Z1177:Zfp385c	UTSW	11	100,528,599 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16