Incidental Mutation 'IGL02159:Lrrc41'
ID 282359
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc41
Ensembl Gene ENSMUSG00000028703
Gene Name leucine rich repeat containing 41
Synonyms MUF1, D630045E04Rik, D730026A16Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.430) question?
Stock # IGL02159
Quality Score
Status
Chromosome 4
Chromosomal Location 115932466-115954240 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 115945683 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 133 (F133I)
Ref Sequence ENSEMBL: ENSMUSP00000030471 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030471]
AlphaFold Q8K1C9
Predicted Effect probably benign
Transcript: ENSMUST00000030471
AA Change: F133I

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000030471
Gene: ENSMUSG00000028703
AA Change: F133I

DomainStartEndE-ValueType
low complexity region 30 45 N/A INTRINSIC
low complexity region 280 291 N/A INTRINSIC
low complexity region 314 325 N/A INTRINSIC
low complexity region 352 382 N/A INTRINSIC
low complexity region 417 429 N/A INTRINSIC
SCOP:d1yrga_ 449 742 4e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133799
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134983
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138952
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik T C 10: 100,446,527 (GRCm39) L257S probably damaging Het
Abca13 A G 11: 9,264,545 (GRCm39) S2976G probably benign Het
Afmid T C 11: 117,727,252 (GRCm39) W267R probably damaging Het
Ahi1 A G 10: 20,934,076 (GRCm39) K969R probably benign Het
Aldh1l1 A G 6: 90,571,638 (GRCm39) probably benign Het
Ank3 A G 10: 69,644,722 (GRCm39) H62R probably damaging Het
Arid2 T C 15: 96,256,793 (GRCm39) probably benign Het
Caps2 G A 10: 112,039,928 (GRCm39) V457M probably benign Het
Capza1 T C 3: 104,771,687 (GRCm39) D3G possibly damaging Het
Cav1 T A 6: 17,307,971 (GRCm39) V41E possibly damaging Het
Celf2 G T 2: 6,608,988 (GRCm39) C264* probably null Het
Clec4a2 C T 6: 123,116,285 (GRCm39) S150L probably benign Het
D7Ertd443e A T 7: 133,951,129 (GRCm39) D181E possibly damaging Het
Epyc A G 10: 97,506,493 (GRCm39) E100G probably benign Het
Hdac11 A G 6: 91,150,084 (GRCm39) I294M probably damaging Het
Hrob G A 11: 102,150,991 (GRCm39) probably null Het
Hsdl1 A G 8: 120,293,153 (GRCm39) V73A probably benign Het
Kmt2c A T 5: 25,516,341 (GRCm39) S2501T probably benign Het
Map3k19 C A 1: 127,750,907 (GRCm39) G815C probably benign Het
Muc13 C A 16: 33,619,849 (GRCm39) T199K unknown Het
Nif3l1 G T 1: 58,487,105 (GRCm39) probably null Het
Nlrp12 A T 7: 3,298,175 (GRCm39) probably benign Het
Nup205 T C 6: 35,166,113 (GRCm39) S244P probably damaging Het
Or7a37 A T 10: 78,805,735 (GRCm39) N84I probably damaging Het
Parl G A 16: 20,098,838 (GRCm39) probably benign Het
Pax8 A G 2: 24,330,800 (GRCm39) I211T possibly damaging Het
Pglyrp4 A G 3: 90,638,160 (GRCm39) E158G possibly damaging Het
Plekhm1 A G 11: 103,271,057 (GRCm39) L478P probably benign Het
Prss3b T C 6: 41,009,891 (GRCm39) T148A probably benign Het
Serpina1a C T 12: 103,820,965 (GRCm39) G338R probably damaging Het
Serpina5 T C 12: 104,071,557 (GRCm39) L388P possibly damaging Het
Sorbs1 A G 19: 40,316,040 (GRCm39) V367A probably damaging Het
Srgap2 A G 1: 131,247,404 (GRCm39) probably benign Het
Surf1 A G 2: 26,805,663 (GRCm39) L26P probably damaging Het
Taf4 A G 2: 179,580,263 (GRCm39) S486P probably benign Het
Tdrd6 A T 17: 43,939,281 (GRCm39) V589E probably damaging Het
Tuba3b T G 6: 145,565,392 (GRCm39) S287A probably benign Het
Txnrd3 G A 6: 89,646,306 (GRCm39) R295H probably damaging Het
Ubr5 G T 15: 37,991,623 (GRCm39) probably benign Het
Unc45b C T 11: 82,831,007 (GRCm39) probably benign Het
Usp32 A G 11: 84,896,628 (GRCm39) probably null Het
Utp23 G A 15: 51,745,761 (GRCm39) R87K probably benign Het
Vps8 T C 16: 21,285,234 (GRCm39) I405T possibly damaging Het
Other mutations in Lrrc41
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01309:Lrrc41 APN 4 115,953,663 (GRCm39) missense probably damaging 0.97
IGL01358:Lrrc41 APN 4 115,932,784 (GRCm39) missense probably benign 0.16
IGL01734:Lrrc41 APN 4 115,950,331 (GRCm39) critical splice donor site probably null
IGL01986:Lrrc41 APN 4 115,946,519 (GRCm39) missense probably benign 0.27
IGL02892:Lrrc41 APN 4 115,946,032 (GRCm39) missense possibly damaging 0.68
IGL03135:Lrrc41 APN 4 115,945,728 (GRCm39) missense probably benign
R1478:Lrrc41 UTSW 4 115,952,405 (GRCm39) nonsense probably null
R1765:Lrrc41 UTSW 4 115,946,248 (GRCm39) missense possibly damaging 0.94
R2233:Lrrc41 UTSW 4 115,953,582 (GRCm39) missense possibly damaging 0.66
R4080:Lrrc41 UTSW 4 115,937,743 (GRCm39) splice site probably null
R4677:Lrrc41 UTSW 4 115,952,332 (GRCm39) missense probably benign
R4833:Lrrc41 UTSW 4 115,950,374 (GRCm39) unclassified probably benign
R4877:Lrrc41 UTSW 4 115,936,602 (GRCm39) missense probably damaging 0.99
R4926:Lrrc41 UTSW 4 115,946,521 (GRCm39) missense possibly damaging 0.46
R6459:Lrrc41 UTSW 4 115,945,977 (GRCm39) missense possibly damaging 0.95
R6817:Lrrc41 UTSW 4 115,946,502 (GRCm39) missense possibly damaging 0.66
R6834:Lrrc41 UTSW 4 115,953,726 (GRCm39) missense possibly damaging 0.46
R7479:Lrrc41 UTSW 4 115,946,238 (GRCm39) missense probably damaging 0.96
R7512:Lrrc41 UTSW 4 115,950,191 (GRCm39) missense possibly damaging 0.66
R7593:Lrrc41 UTSW 4 115,950,141 (GRCm39) missense possibly damaging 0.94
R8006:Lrrc41 UTSW 4 115,952,085 (GRCm39) missense possibly damaging 0.79
R8810:Lrrc41 UTSW 4 115,932,488 (GRCm39) unclassified probably benign
R9134:Lrrc41 UTSW 4 115,945,782 (GRCm39) missense possibly damaging 0.89
R9495:Lrrc41 UTSW 4 115,932,806 (GRCm39) critical splice donor site probably null
Posted On 2015-04-16