Incidental Mutation 'IGL02161:Vmn2r28'
ID 282466
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r28
Ensembl Gene ENSMUSG00000066820
Gene Name vomeronasal 2, receptor 28
Synonyms EG665255
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # IGL02161
Quality Score
Status
Chromosome 7
Chromosomal Location 5483455-5496850 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 5491123 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 375 (S375P)
Ref Sequence ENSEMBL: ENSMUSP00000083477 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086297]
AlphaFold L7N203
Predicted Effect possibly damaging
Transcript: ENSMUST00000086297
AA Change: S375P

PolyPhen 2 Score 0.883 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000083477
Gene: ENSMUSG00000066820
AA Change: S375P

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 470 1.7e-26 PFAM
Pfam:NCD3G 512 565 9.8e-21 PFAM
Pfam:7tm_3 598 833 2.8e-56 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 A T 12: 118,838,490 (GRCm39) V1024D probably benign Het
Alox5 T A 6: 116,400,154 (GRCm39) M262L probably benign Het
Arid5b T C 10: 67,932,498 (GRCm39) T1135A probably benign Het
Ascc3 T A 10: 50,726,623 (GRCm39) Y2177* probably null Het
Birc6 A C 17: 74,855,832 (GRCm39) H214P probably damaging Het
Catsperb T A 12: 101,375,674 (GRCm39) probably benign Het
Ccr1l1 G A 9: 123,778,000 (GRCm39) T149I possibly damaging Het
Cfap57 T G 4: 118,436,569 (GRCm39) R942S possibly damaging Het
Crocc G A 4: 140,761,302 (GRCm39) A941V probably benign Het
Csde1 A G 3: 102,957,654 (GRCm39) Q471R probably damaging Het
Csmd1 C T 8: 16,408,426 (GRCm39) V380I probably damaging Het
Dhx8 A T 11: 101,648,432 (GRCm39) Q857L probably damaging Het
Eftud2 A G 11: 102,745,702 (GRCm39) probably benign Het
Fat3 C A 9: 15,908,346 (GRCm39) R2552I probably benign Het
Fat3 T A 9: 15,908,347 (GRCm39) R2552* probably null Het
Fbln7 A T 2: 128,731,711 (GRCm39) K166I probably benign Het
Glrx2 C T 1: 143,615,421 (GRCm39) S8L possibly damaging Het
Grin2d T G 7: 45,503,846 (GRCm39) I630L possibly damaging Het
Gsap T A 5: 21,458,377 (GRCm39) W423R probably damaging Het
Kifc2 A G 15: 76,550,245 (GRCm39) E468G probably damaging Het
Kpnb1 A G 11: 97,059,762 (GRCm39) S566P probably benign Het
Lemd2 A G 17: 27,409,625 (GRCm39) S509P probably damaging Het
Lepr T C 4: 101,602,875 (GRCm39) F221S probably damaging Het
Nynrin T C 14: 56,101,441 (GRCm39) F370S probably damaging Het
Or51a10 C A 7: 103,698,797 (GRCm39) V255L possibly damaging Het
Pcdhb15 T A 18: 37,608,555 (GRCm39) S596T possibly damaging Het
Prkcq G T 2: 11,281,887 (GRCm39) S472I probably benign Het
Rabgef1 T C 5: 130,235,940 (GRCm39) probably benign Het
Rnd3 C T 2: 51,024,088 (GRCm39) V164M probably benign Het
Rtn4rl1 G A 11: 75,156,666 (GRCm39) R366Q probably damaging Het
Sesn2 A T 4: 132,224,229 (GRCm39) I393N probably damaging Het
St8sia2 T C 7: 73,626,430 (GRCm39) N46S probably benign Het
Svopl A G 6: 38,013,750 (GRCm39) probably benign Het
Tbr1 C T 2: 61,635,583 (GRCm39) Q178* probably null Het
Vax2 T C 6: 83,714,885 (GRCm39) S267P probably damaging Het
Vmn1r47 T A 6: 89,999,298 (GRCm39) Y143* probably null Het
Vmn2r44 A T 7: 8,380,814 (GRCm39) Y360N possibly damaging Het
Zc3h6 G A 2: 128,835,146 (GRCm39) S94N possibly damaging Het
Other mutations in Vmn2r28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Vmn2r28 APN 7 5,491,068 (GRCm39) missense probably benign 0.12
IGL01061:Vmn2r28 APN 7 5,491,183 (GRCm39) missense probably damaging 1.00
IGL01160:Vmn2r28 APN 7 5,489,477 (GRCm39) missense probably damaging 0.99
IGL01335:Vmn2r28 APN 7 5,484,087 (GRCm39) missense possibly damaging 0.67
IGL01532:Vmn2r28 APN 7 5,489,463 (GRCm39) missense probably benign 0.16
IGL01791:Vmn2r28 APN 7 5,491,161 (GRCm39) missense probably benign 0.00
IGL01875:Vmn2r28 APN 7 5,484,302 (GRCm39) missense probably benign 0.30
IGL02499:Vmn2r28 APN 7 5,493,568 (GRCm39) missense probably damaging 0.98
IGL02858:Vmn2r28 APN 7 5,484,003 (GRCm39) missense probably damaging 0.99
IGL03061:Vmn2r28 APN 7 5,487,015 (GRCm39) missense probably damaging 0.98
G1patch:Vmn2r28 UTSW 7 5,491,408 (GRCm39) missense probably benign 0.13
R0288:Vmn2r28 UTSW 7 5,491,020 (GRCm39) missense probably damaging 1.00
R0361:Vmn2r28 UTSW 7 5,496,715 (GRCm39) missense probably benign 0.00
R0396:Vmn2r28 UTSW 7 5,491,513 (GRCm39) missense probably benign 0.05
R0480:Vmn2r28 UTSW 7 5,493,456 (GRCm39) missense probably benign 0.00
R0485:Vmn2r28 UTSW 7 5,491,689 (GRCm39) missense probably damaging 1.00
R0837:Vmn2r28 UTSW 7 5,491,026 (GRCm39) missense probably damaging 0.99
R1282:Vmn2r28 UTSW 7 5,484,301 (GRCm39) missense probably damaging 0.99
R1296:Vmn2r28 UTSW 7 5,484,544 (GRCm39) missense possibly damaging 0.81
R1829:Vmn2r28 UTSW 7 5,496,810 (GRCm39) missense probably benign
R1853:Vmn2r28 UTSW 7 5,484,246 (GRCm39) nonsense probably null
R1869:Vmn2r28 UTSW 7 5,489,345 (GRCm39) missense probably benign 0.00
R1887:Vmn2r28 UTSW 7 5,491,288 (GRCm39) missense possibly damaging 0.90
R1961:Vmn2r28 UTSW 7 5,484,070 (GRCm39) missense possibly damaging 0.85
R1998:Vmn2r28 UTSW 7 5,491,313 (GRCm39) missense possibly damaging 0.87
R2392:Vmn2r28 UTSW 7 5,487,130 (GRCm39) missense probably damaging 0.98
R2432:Vmn2r28 UTSW 7 5,491,701 (GRCm39) missense probably damaging 0.99
R3055:Vmn2r28 UTSW 7 5,484,391 (GRCm39) missense probably damaging 0.98
R3753:Vmn2r28 UTSW 7 5,491,026 (GRCm39) missense probably damaging 0.99
R3877:Vmn2r28 UTSW 7 5,491,357 (GRCm39) missense probably damaging 1.00
R4307:Vmn2r28 UTSW 7 5,493,707 (GRCm39) missense probably damaging 0.99
R5023:Vmn2r28 UTSW 7 5,489,463 (GRCm39) missense probably benign 0.16
R5057:Vmn2r28 UTSW 7 5,489,463 (GRCm39) missense probably benign 0.16
R5083:Vmn2r28 UTSW 7 5,483,671 (GRCm39) missense possibly damaging 0.77
R5427:Vmn2r28 UTSW 7 5,489,376 (GRCm39) missense probably damaging 0.99
R5472:Vmn2r28 UTSW 7 5,490,943 (GRCm39) critical splice donor site probably null
R5511:Vmn2r28 UTSW 7 5,487,011 (GRCm39) missense possibly damaging 0.61
R5731:Vmn2r28 UTSW 7 5,491,668 (GRCm39) missense probably benign 0.41
R6091:Vmn2r28 UTSW 7 5,496,790 (GRCm39) missense possibly damaging 0.88
R6179:Vmn2r28 UTSW 7 5,491,003 (GRCm39) nonsense probably null
R6276:Vmn2r28 UTSW 7 5,493,730 (GRCm39) missense probably benign 0.01
R6441:Vmn2r28 UTSW 7 5,491,474 (GRCm39) missense probably benign 0.00
R6463:Vmn2r28 UTSW 7 5,489,435 (GRCm39) missense probably benign 0.07
R6528:Vmn2r28 UTSW 7 5,493,684 (GRCm39) missense probably benign 0.12
R6725:Vmn2r28 UTSW 7 5,491,408 (GRCm39) missense probably benign 0.13
R6760:Vmn2r28 UTSW 7 5,484,229 (GRCm39) missense probably damaging 0.97
R6849:Vmn2r28 UTSW 7 5,483,806 (GRCm39) missense probably damaging 1.00
R7110:Vmn2r28 UTSW 7 5,493,733 (GRCm39) missense probably benign 0.06
R7146:Vmn2r28 UTSW 7 5,484,495 (GRCm39) missense probably benign 0.05
R7407:Vmn2r28 UTSW 7 5,484,308 (GRCm39) missense probably damaging 1.00
R7563:Vmn2r28 UTSW 7 5,491,200 (GRCm39) missense probably benign 0.00
R7611:Vmn2r28 UTSW 7 5,484,255 (GRCm39) missense probably benign 0.02
R7808:Vmn2r28 UTSW 7 5,496,678 (GRCm39) missense probably damaging 0.98
R7862:Vmn2r28 UTSW 7 5,493,613 (GRCm39) missense probably benign 0.00
R7916:Vmn2r28 UTSW 7 5,483,818 (GRCm39) missense probably damaging 1.00
R8183:Vmn2r28 UTSW 7 5,491,147 (GRCm39) missense probably damaging 1.00
R8334:Vmn2r28 UTSW 7 5,487,059 (GRCm39) missense probably damaging 1.00
R8519:Vmn2r28 UTSW 7 5,489,347 (GRCm39) missense probably benign 0.31
R8989:Vmn2r28 UTSW 7 5,493,473 (GRCm39) missense probably benign 0.00
R9066:Vmn2r28 UTSW 7 5,491,596 (GRCm39) missense probably damaging 1.00
R9422:Vmn2r28 UTSW 7 5,483,747 (GRCm39) missense probably damaging 1.00
R9469:Vmn2r28 UTSW 7 5,487,118 (GRCm39) missense probably damaging 0.99
R9608:Vmn2r28 UTSW 7 5,491,220 (GRCm39) missense probably benign 0.05
Posted On 2015-04-16