Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02162:Qpctl'

282518

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Qpctl

Ensembl Gene

ENSMUSG00000030407

Gene Name

glutaminyl-peptide cyclotransferase-like

Synonyms

1810019P04Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.229) question?

Stock #

IGL02162

Quality Score

Status

Chromosome

Chromosomal Location

18874142-18883121 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 18878606 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 290 (F290L)

Ref Sequence

ENSEMBL: ENSMUSP00000032566 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032566] [ENSMUST00000053109]

AlphaFold

Q8BH73

Predicted Effect

possibly damaging
Transcript: ENSMUST00000032566
AA Change: F290L

PolyPhen 2 Score 0.657 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000032566
Gene: ENSMUSG00000030407
AA Change: F290L

Domain	Start	End	E-Value	Type
low complexity region	27	48	N/A	INTRINSIC
Pfam:Peptidase_M28	151	377	2.3e-50	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000053109

SMART Domains

Protein: ENSMUSP00000055692
Gene: ENSMUSG00000050428

Domain	Start	End	E-Value	Type
low complexity region	274	292	N/A	INTRINSIC
low complexity region	337	358	N/A	INTRINSIC
low complexity region	366	375	N/A	INTRINSIC
low complexity region	415	424	N/A	INTRINSIC
FBOX	476	516	1.9e-5	SMART
low complexity region	591	603	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000205979

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ang5	T	C	14: 44,199,966 (GRCm39)	L10S	probably damaging	Het
Cdk5rap1	T	C	2: 154,177,489 (GRCm39)	T577A	probably damaging	Het
Clca3a1	G	T	3: 144,460,564 (GRCm39)	P297T	probably damaging	Het
Col9a2	A	T	4: 120,911,531 (GRCm39)		probably benign	Het
Ctss	A	G	3: 95,454,132 (GRCm39)	K227R	probably benign	Het
Dmxl1	G	A	18: 50,094,230 (GRCm39)	R2902Q	probably benign	Het
Dnah10	G	T	5: 124,881,810 (GRCm39)	A2862S	probably damaging	Het
Elp1	A	G	4: 56,796,502 (GRCm39)		probably null	Het
Fbxw5	C	A	2: 25,393,283 (GRCm39)	Q16K	probably damaging	Het
Fcgbp	G	A	7: 27,774,660 (GRCm39)	C78Y	probably damaging	Het
Gm20547	T	A	17: 35,076,003 (GRCm39)	Y688F	possibly damaging	Het
Gpaa1	T	C	15: 76,216,353 (GRCm39)		probably benign	Het
Grik2	T	C	10: 49,298,671 (GRCm39)	H63R	possibly damaging	Het
Ikbke	A	G	1: 131,201,452 (GRCm39)	S132P	possibly damaging	Het
Kirrel2	A	G	7: 30,153,089 (GRCm39)	I340T	probably benign	Het
Lipo5	A	T	19: 33,446,163 (GRCm39)		probably benign	Het
Nfkbie	T	G	17: 45,867,242 (GRCm39)		probably null	Het
Ntng1	G	T	3: 109,842,311 (GRCm39)	S154*	probably null	Het
Or6c208	C	T	10: 129,223,973 (GRCm39)	P157L	probably benign	Het
Or8b12b	A	G	9: 37,684,227 (GRCm39)	I91V	probably benign	Het
Pbld2	T	C	10: 62,907,179 (GRCm39)		probably benign	Het
Phaf1	C	T	8: 105,966,605 (GRCm39)		probably benign	Het
Plec	C	T	15: 76,064,360 (GRCm39)	M1971I	probably benign	Het
Ppp1r3a	A	T	6: 14,717,714 (GRCm39)	F1067I	probably damaging	Het
Sorcs3	A	T	19: 48,523,970 (GRCm39)	Y288F	probably damaging	Het
St8sia3	A	G	18: 64,398,651 (GRCm39)	N37D	probably benign	Het
Vmn2r109	T	C	17: 20,774,422 (GRCm39)	D311G	probably benign	Het
Zbtb44	A	G	9: 30,964,688 (GRCm39)	I33V	probably benign	Het
Zfp267	T	C	3: 36,218,210 (GRCm39)	F78L	probably benign	Het
Zfp541	C	A	7: 15,813,393 (GRCm39)	T682K	possibly damaging	Het

Other mutations in Qpctl

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R5807:Qpctl	UTSW	7	18,877,132 (GRCm39)	missense	probably damaging	1.00
R6223:Qpctl	UTSW	7	18,877,134 (GRCm39)	missense	probably damaging	1.00
R6283:Qpctl	UTSW	7	18,882,345 (GRCm39)	missense	probably benign	0.03
R6453:Qpctl	UTSW	7	18,875,222 (GRCm39)	missense	probably damaging	1.00
R6805:Qpctl	UTSW	7	18,883,079 (GRCm39)	missense	probably benign
R7042:Qpctl	UTSW	7	18,880,943 (GRCm39)	missense	probably benign	0.00
R7197:Qpctl	UTSW	7	18,882,944 (GRCm39)	missense	probably damaging	1.00
R7267:Qpctl	UTSW	7	18,878,852 (GRCm39)	missense	probably benign	0.03
R7295:Qpctl	UTSW	7	18,883,055 (GRCm39)	missense	probably benign	0.12
R8309:Qpctl	UTSW	7	18,882,398 (GRCm39)	missense	probably benign	0.00
R9056:Qpctl	UTSW	7	18,880,961 (GRCm39)	missense	probably damaging	1.00
R9152:Qpctl	UTSW	7	18,883,025 (GRCm39)	missense	probably damaging	1.00
R9352:Qpctl	UTSW	7	18,878,599 (GRCm39)	missense	possibly damaging	0.55
R9355:Qpctl	UTSW	7	18,875,146 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16