Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02162:Lipo5'

282528

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lipo5

Ensembl Gene

ENSMUSG00000086875

Gene Name

lipase, member O5

Synonyms

Gm8975

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

IGL02162

Quality Score

Status

Chromosome

Chromosomal Location

33437523-33450581 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 33446163 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000156818

SMART Domains

Protein: ENSMUSP00000121547
Gene: ENSMUSG00000086875

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:Abhydro_lipase	37	99	4e-25	PFAM
Pfam:Abhydrolase_1	80	217	3.3e-16	PFAM
Pfam:Abhydrolase_5	80	222	1.5e-7	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ang5	T	C	14: 44,199,966 (GRCm39)	L10S	probably damaging	Het
Cdk5rap1	T	C	2: 154,177,489 (GRCm39)	T577A	probably damaging	Het
Clca3a1	G	T	3: 144,460,564 (GRCm39)	P297T	probably damaging	Het
Col9a2	A	T	4: 120,911,531 (GRCm39)		probably benign	Het
Ctss	A	G	3: 95,454,132 (GRCm39)	K227R	probably benign	Het
Dmxl1	G	A	18: 50,094,230 (GRCm39)	R2902Q	probably benign	Het
Dnah10	G	T	5: 124,881,810 (GRCm39)	A2862S	probably damaging	Het
Elp1	A	G	4: 56,796,502 (GRCm39)		probably null	Het
Fbxw5	C	A	2: 25,393,283 (GRCm39)	Q16K	probably damaging	Het
Fcgbp	G	A	7: 27,774,660 (GRCm39)	C78Y	probably damaging	Het
Gm20547	T	A	17: 35,076,003 (GRCm39)	Y688F	possibly damaging	Het
Gpaa1	T	C	15: 76,216,353 (GRCm39)		probably benign	Het
Grik2	T	C	10: 49,298,671 (GRCm39)	H63R	possibly damaging	Het
Ikbke	A	G	1: 131,201,452 (GRCm39)	S132P	possibly damaging	Het
Kirrel2	A	G	7: 30,153,089 (GRCm39)	I340T	probably benign	Het
Nfkbie	T	G	17: 45,867,242 (GRCm39)		probably null	Het
Ntng1	G	T	3: 109,842,311 (GRCm39)	S154*	probably null	Het
Or6c208	C	T	10: 129,223,973 (GRCm39)	P157L	probably benign	Het
Or8b12b	A	G	9: 37,684,227 (GRCm39)	I91V	probably benign	Het
Pbld2	T	C	10: 62,907,179 (GRCm39)		probably benign	Het
Phaf1	C	T	8: 105,966,605 (GRCm39)		probably benign	Het
Plec	C	T	15: 76,064,360 (GRCm39)	M1971I	probably benign	Het
Ppp1r3a	A	T	6: 14,717,714 (GRCm39)	F1067I	probably damaging	Het
Qpctl	A	G	7: 18,878,606 (GRCm39)	F290L	possibly damaging	Het
Sorcs3	A	T	19: 48,523,970 (GRCm39)	Y288F	probably damaging	Het
St8sia3	A	G	18: 64,398,651 (GRCm39)	N37D	probably benign	Het
Vmn2r109	T	C	17: 20,774,422 (GRCm39)	D311G	probably benign	Het
Zbtb44	A	G	9: 30,964,688 (GRCm39)	I33V	probably benign	Het
Zfp267	T	C	3: 36,218,210 (GRCm39)	F78L	probably benign	Het
Zfp541	C	A	7: 15,813,393 (GRCm39)	T682K	possibly damaging	Het

Other mutations in Lipo5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02210:Lipo5	APN	19	33,445,277 (GRCm39)	missense	unknown
IGL02689:Lipo5	APN	19	33,445,186 (GRCm39)	missense	unknown
IGL03276:Lipo5	APN	19	33,445,242 (GRCm39)	missense	unknown
bradybunch	UTSW	19	33,445,317 (GRCm39)	missense	unknown
PIT4382001:Lipo5	UTSW	19	33,443,339 (GRCm39)	missense	probably null
R1456:Lipo5	UTSW	19	33,443,273 (GRCm39)	splice site	probably benign
R1820:Lipo5	UTSW	19	33,441,995 (GRCm39)	splice site	probably null
R3770:Lipo5	UTSW	19	33,445,200 (GRCm39)	missense	unknown
R4658:Lipo5	UTSW	19	33,441,922 (GRCm39)	missense	unknown
R4906:Lipo5	UTSW	19	33,443,348 (GRCm39)	missense	unknown
R4951:Lipo5	UTSW	19	33,446,251 (GRCm39)	missense	probably damaging	0.98
R5304:Lipo5	UTSW	19	33,445,149 (GRCm39)	missense	unknown
R5526:Lipo5	UTSW	19	33,445,284 (GRCm39)	missense	unknown
R6087:Lipo5	UTSW	19	33,443,375 (GRCm39)	missense	unknown
R6110:Lipo5	UTSW	19	33,445,317 (GRCm39)	missense	unknown
R7077:Lipo5	UTSW	19	33,445,170 (GRCm39)	missense
R7094:Lipo5	UTSW	19	33,446,249 (GRCm39)	missense	probably damaging	0.99
R8500:Lipo5	UTSW	19	33,441,849 (GRCm39)	critical splice donor site	probably null
R8955:Lipo5	UTSW	19	33,450,530 (GRCm39)	missense

Posted On

2015-04-16