Incidental Mutation 'IGL00979:Hephl1'
ID 28261
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Hephl1
Ensembl Gene ENSMUSG00000031936
Gene Name hephaestin-like 1
Synonyms zyklopen, thd, cw, Zp, LOC244698
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # IGL00979
Quality Score
Status
Chromosome 9
Chromosomal Location 14963137-15023404 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 14978341 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 855 (T855K)
Ref Sequence ENSEMBL: ENSMUSP00000124518 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159985]
AlphaFold Q3V1H3
Predicted Effect probably benign
Transcript: ENSMUST00000159985
AA Change: T855K

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000124518
Gene: ENSMUSG00000031936
AA Change: T855K

DomainStartEndE-ValueType
low complexity region 7 22 N/A INTRINSIC
Pfam:Cu-oxidase_3 97 209 2.8e-12 PFAM
Pfam:Cu-oxidase_2 289 365 2.4e-9 PFAM
Pfam:Cu-oxidase_3 452 564 1.2e-9 PFAM
Blast:FA58C 604 703 9e-9 BLAST
Pfam:Cu-oxidase_3 805 908 1.6e-7 PFAM
Pfam:Cu-oxidase_2 946 1067 9e-14 PFAM
transmembrane domain 1115 1137 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427I04Rik A T 4: 123,754,338 (GRCm39) K84M probably damaging Het
A4gnt T A 9: 99,502,489 (GRCm39) Y216* probably null Het
Abcb1b A G 5: 8,875,293 (GRCm39) probably benign Het
Ankrd50 G A 3: 38,506,563 (GRCm39) probably benign Het
Catsperb A G 12: 101,381,584 (GRCm39) T89A probably benign Het
Ccdc15 C T 9: 37,227,786 (GRCm39) S236N probably benign Het
Cd34 A C 1: 194,631,816 (GRCm39) T151P possibly damaging Het
Col28a1 A T 6: 8,014,810 (GRCm39) V865E probably damaging Het
Csf2rb T A 15: 78,232,304 (GRCm39) V537E probably damaging Het
Cux2 A G 5: 122,011,777 (GRCm39) F553L probably damaging Het
Dolk A T 2: 30,174,743 (GRCm39) L434Q probably damaging Het
Dsg2 C A 18: 20,715,824 (GRCm39) D255E probably damaging Het
Endov T C 11: 119,391,444 (GRCm39) V144A probably damaging Het
Grik2 T C 10: 49,232,034 (GRCm39) N499D probably damaging Het
Hif1a A G 12: 73,988,784 (GRCm39) D557G probably damaging Het
Idh1 G A 1: 65,210,308 (GRCm39) T75I probably damaging Het
Ighv1-37 A G 12: 114,860,070 (GRCm39) S47P probably benign Het
Irx4 A G 13: 73,416,341 (GRCm39) probably benign Het
Itpr1 C T 6: 108,448,081 (GRCm39) A1871V probably damaging Het
Klkb1 A G 8: 45,747,105 (GRCm39) probably benign Het
Lrrc8e T C 8: 4,285,080 (GRCm39) L435P probably damaging Het
Megf11 T A 9: 64,416,009 (GRCm39) Y73N probably damaging Het
Nfe2 T C 15: 103,157,607 (GRCm39) D128G probably damaging Het
Or13a22 A G 7: 140,072,614 (GRCm39) E21G probably benign Het
Or4k51 T A 2: 111,584,771 (GRCm39) M59K probably damaging Het
Pak6 C A 2: 118,526,963 (GRCm39) L653I probably damaging Het
Pde4dip T A 3: 97,655,074 (GRCm39) probably benign Het
Pds5a A G 5: 65,789,066 (GRCm39) V831A probably benign Het
Prc1 G T 7: 79,957,444 (GRCm39) probably null Het
Ptprs C T 17: 56,765,243 (GRCm39) G14S probably damaging Het
Pygb A G 2: 150,661,833 (GRCm39) K520E probably benign Het
Rimbp2 A G 5: 128,883,505 (GRCm39) S92P probably benign Het
Samd4b A T 7: 28,113,638 (GRCm39) L109Q probably damaging Het
Saxo4 T C 19: 10,451,863 (GRCm39) *428W probably null Het
Scn8a A T 15: 100,853,287 (GRCm39) probably benign Het
Sdc3 A G 4: 130,545,991 (GRCm39) I23V unknown Het
Sec61a2 A G 2: 5,876,831 (GRCm39) Y350H possibly damaging Het
Slc4a3 A T 1: 75,530,891 (GRCm39) Q759L probably damaging Het
Speg C T 1: 75,387,378 (GRCm39) P1378L probably damaging Het
Spta1 T G 1: 174,035,956 (GRCm39) Y1087* probably null Het
Tenm4 A G 7: 96,378,598 (GRCm39) E401G probably damaging Het
Tom1 C A 8: 75,781,331 (GRCm39) probably benign Het
Ttc3 T A 16: 94,257,577 (GRCm39) V1273D probably damaging Het
Vmn2r106 G T 17: 20,497,837 (GRCm39) D467E possibly damaging Het
Washc4 A T 10: 83,386,747 (GRCm39) T124S probably benign Het
Zfp790 A G 7: 29,529,034 (GRCm39) E573G probably benign Het
Other mutations in Hephl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01105:Hephl1 APN 9 15,000,320 (GRCm39) missense possibly damaging 0.95
IGL01731:Hephl1 APN 9 14,981,066 (GRCm39) missense probably damaging 1.00
IGL02010:Hephl1 APN 9 15,001,852 (GRCm39) nonsense probably null
IGL02112:Hephl1 APN 9 14,993,111 (GRCm39) splice site probably benign
IGL02227:Hephl1 APN 9 14,981,089 (GRCm39) missense probably damaging 1.00
IGL02490:Hephl1 APN 9 14,964,981 (GRCm39) missense probably benign 0.06
IGL02960:Hephl1 APN 9 14,995,615 (GRCm39) missense probably damaging 1.00
IGL03265:Hephl1 APN 9 14,972,255 (GRCm39) missense probably benign 0.14
R0006:Hephl1 UTSW 9 14,988,060 (GRCm39) missense probably benign 0.16
R0006:Hephl1 UTSW 9 14,988,060 (GRCm39) missense probably benign 0.16
R0007:Hephl1 UTSW 9 14,997,471 (GRCm39) missense possibly damaging 0.58
R0092:Hephl1 UTSW 9 15,001,899 (GRCm39) frame shift probably null
R0421:Hephl1 UTSW 9 14,970,456 (GRCm39) missense probably benign 0.05
R0448:Hephl1 UTSW 9 14,988,222 (GRCm39) missense probably damaging 1.00
R0563:Hephl1 UTSW 9 14,993,241 (GRCm39) missense probably damaging 1.00
R0602:Hephl1 UTSW 9 15,000,347 (GRCm39) missense probably damaging 0.99
R0631:Hephl1 UTSW 9 14,995,820 (GRCm39) missense probably benign 0.04
R0747:Hephl1 UTSW 9 14,965,297 (GRCm39) splice site probably benign
R1123:Hephl1 UTSW 9 14,991,436 (GRCm39) missense probably benign 0.00
R1386:Hephl1 UTSW 9 14,988,050 (GRCm39) missense probably benign
R1711:Hephl1 UTSW 9 14,970,542 (GRCm39) missense probably damaging 1.00
R1743:Hephl1 UTSW 9 15,001,364 (GRCm39) missense probably damaging 0.99
R1833:Hephl1 UTSW 9 14,988,224 (GRCm39) missense probably damaging 0.99
R1908:Hephl1 UTSW 9 14,985,420 (GRCm39) nonsense probably null
R1918:Hephl1 UTSW 9 14,988,114 (GRCm39) missense probably benign 0.16
R1938:Hephl1 UTSW 9 14,965,283 (GRCm39) missense possibly damaging 0.88
R1986:Hephl1 UTSW 9 14,965,848 (GRCm39) missense probably damaging 1.00
R3122:Hephl1 UTSW 9 15,000,265 (GRCm39) missense possibly damaging 0.90
R3832:Hephl1 UTSW 9 14,981,044 (GRCm39) missense probably damaging 1.00
R3833:Hephl1 UTSW 9 14,981,044 (GRCm39) missense probably damaging 1.00
R4280:Hephl1 UTSW 9 15,023,330 (GRCm39) missense probably benign 0.05
R4434:Hephl1 UTSW 9 14,988,092 (GRCm39) missense probably damaging 0.99
R4790:Hephl1 UTSW 9 14,970,467 (GRCm39) missense probably damaging 1.00
R4793:Hephl1 UTSW 9 15,009,286 (GRCm39) missense probably benign 0.34
R4960:Hephl1 UTSW 9 14,997,586 (GRCm39) missense probably damaging 1.00
R5125:Hephl1 UTSW 9 14,997,468 (GRCm39) missense probably damaging 0.98
R5152:Hephl1 UTSW 9 14,991,481 (GRCm39) missense probably damaging 1.00
R5178:Hephl1 UTSW 9 14,997,468 (GRCm39) missense probably damaging 0.98
R5288:Hephl1 UTSW 9 14,988,150 (GRCm39) missense possibly damaging 0.83
R5372:Hephl1 UTSW 9 15,009,195 (GRCm39) nonsense probably null
R5377:Hephl1 UTSW 9 14,981,084 (GRCm39) missense probably damaging 1.00
R5788:Hephl1 UTSW 9 14,995,579 (GRCm39) missense possibly damaging 0.93
R5795:Hephl1 UTSW 9 14,981,056 (GRCm39) missense probably damaging 0.99
R6210:Hephl1 UTSW 9 15,001,860 (GRCm39) missense possibly damaging 0.57
R6303:Hephl1 UTSW 9 15,001,448 (GRCm39) missense possibly damaging 0.69
R6394:Hephl1 UTSW 9 14,985,397 (GRCm39) missense probably benign 0.00
R6653:Hephl1 UTSW 9 14,993,260 (GRCm39) missense probably damaging 0.99
R6764:Hephl1 UTSW 9 15,000,217 (GRCm39) missense possibly damaging 0.88
R7114:Hephl1 UTSW 9 14,981,111 (GRCm39) missense probably damaging 0.96
R7143:Hephl1 UTSW 9 14,972,106 (GRCm39) missense possibly damaging 0.80
R7404:Hephl1 UTSW 9 14,981,047 (GRCm39) missense possibly damaging 0.84
R7446:Hephl1 UTSW 9 15,009,347 (GRCm39) missense probably damaging 1.00
R7447:Hephl1 UTSW 9 15,009,178 (GRCm39) critical splice donor site probably null
R7715:Hephl1 UTSW 9 14,972,081 (GRCm39) missense probably benign 0.36
R8013:Hephl1 UTSW 9 14,965,905 (GRCm39) missense possibly damaging 0.78
R8156:Hephl1 UTSW 9 14,972,210 (GRCm39) missense possibly damaging 0.77
R8755:Hephl1 UTSW 9 15,023,280 (GRCm39) missense probably damaging 1.00
R8755:Hephl1 UTSW 9 14,985,563 (GRCm39) missense probably benign
R8777:Hephl1 UTSW 9 14,972,090 (GRCm39) missense probably benign 0.24
R8777-TAIL:Hephl1 UTSW 9 14,972,090 (GRCm39) missense probably benign 0.24
R9090:Hephl1 UTSW 9 14,988,236 (GRCm39) missense probably damaging 1.00
R9155:Hephl1 UTSW 9 15,000,375 (GRCm39) missense probably damaging 1.00
R9271:Hephl1 UTSW 9 14,988,236 (GRCm39) missense probably damaging 1.00
R9287:Hephl1 UTSW 9 14,995,775 (GRCm39) missense probably benign 0.01
R9487:Hephl1 UTSW 9 14,995,830 (GRCm39) missense possibly damaging 0.84
X0026:Hephl1 UTSW 9 14,995,524 (GRCm39) critical splice donor site probably null
X0066:Hephl1 UTSW 9 14,964,964 (GRCm39) missense probably benign 0.00
Z1088:Hephl1 UTSW 9 14,965,017 (GRCm39) missense probably damaging 1.00
Z1177:Hephl1 UTSW 9 15,001,350 (GRCm39) missense probably damaging 1.00
Posted On 2013-04-17