Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02165:Zfp740'

282645

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp740

Ensembl Gene

ENSMUSG00000046897

Gene Name

zinc finger protein 740

Synonyms

1110034O07Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.199) question?

Stock #

IGL02165

Quality Score

Status

Chromosome

Chromosomal Location

102112080-102124045 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 102121109 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Valine at position 141 (F141V)

Ref Sequence

ENSEMBL: ENSMUSP00000155827 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000001327] [ENSMUST00000118729] [ENSMUST00000119168] [ENSMUST00000119800] [ENSMUST00000121206] [ENSMUST00000230867] [ENSMUST00000133986] [ENSMUST00000139960] [ENSMUST00000141465] [ENSMUST00000229886]

AlphaFold

Q6NZQ6

Predicted Effect

probably benign
Transcript: ENSMUST00000001327

SMART Domains

Protein: ENSMUSP00000001327
Gene: ENSMUSG00000001281

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
PSI	44	92	6.35e-6	SMART
INB	50	476	2.82e-273	SMART
VWA	151	383	7.52e-2	SMART
low complexity region	537	557	N/A	INTRINSIC
Pfam:EGF_2	605	635	2.6e-7	PFAM
Integrin_B_tail	645	721	4.22e-18	SMART
low complexity region	732	744	N/A	INTRINSIC
Integrin_b_cyt	746	792	7.82e-22	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000118729
AA Change: F166V

PolyPhen 2 Score 0.256 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000112985
Gene: ENSMUSG00000046897
AA Change: F166V

Domain	Start	End	E-Value	Type
low complexity region	53	62	N/A	INTRINSIC
ZnF_C2H2	76	98	3.07e-1	SMART
ZnF_C2H2	104	126	1.69e-3	SMART
ZnF_C2H2	132	152	4.99e1	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000119168
AA Change: S136R

Predicted Effect

probably benign
Transcript: ENSMUST00000119800
AA Change: F178V

PolyPhen 2 Score 0.338 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000113770
Gene: ENSMUSG00000046897
AA Change: F178V

Domain	Start	End	E-Value	Type
low complexity region	65	74	N/A	INTRINSIC
ZnF_C2H2	88	110	3.07e-1	SMART
ZnF_C2H2	116	138	1.69e-3	SMART
ZnF_C2H2	144	164	4.99e1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000119830

SMART Domains

Protein: ENSMUSP00000113281
Gene: ENSMUSG00000046897

Domain	Start	End	E-Value	Type
ZnF_C2H2	25	47	3.07e-1	SMART
ZnF_C2H2	53	75	1.69e-3	SMART
ZnF_C2H2	81	101	4.99e1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000121206

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000123528

Predicted Effect

possibly damaging
Transcript: ENSMUST00000230867
AA Change: F141V

PolyPhen 2 Score 0.663 (Sensitivity: 0.86; Specificity: 0.91)

Predicted Effect

probably benign
Transcript: ENSMUST00000133986

SMART Domains

Protein: ENSMUSP00000122429
Gene: ENSMUSG00000046897

Domain	Start	End	E-Value	Type
low complexity region	65	74	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000229440

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000230550

Predicted Effect

probably benign
Transcript: ENSMUST00000139960

SMART Domains

Protein: ENSMUSP00000117024
Gene: ENSMUSG00000046897

Domain	Start	End	E-Value	Type
low complexity region	65	74	N/A	INTRINSIC
Blast:ZnF_C2H2	88	107	9e-7	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000141465

Predicted Effect

probably benign
Transcript: ENSMUST00000229886

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1cf	T	A	19: 31,904,586 (GRCm39)	M199K	possibly damaging	Het
Abo	C	A	2: 26,733,441 (GRCm39)	V255L	probably damaging	Het
Alas1	A	T	9: 106,115,982 (GRCm39)	M344K	probably damaging	Het
Ap1m1	A	G	8: 73,003,653 (GRCm39)	I118V	probably benign	Het
Ap5m1	A	T	14: 49,316,185 (GRCm39)	I252F	possibly damaging	Het
Arhgef2	G	A	3: 88,553,527 (GRCm39)	R886H	probably damaging	Het
Atp13a4	T	C	16: 29,252,828 (GRCm39)	E706G	probably damaging	Het
Baz2a	C	A	10: 127,955,218 (GRCm39)	A775E	probably benign	Het
C3	A	T	17: 57,532,092 (GRCm39)	F210I	probably benign	Het
Casq1	A	G	1: 172,040,948 (GRCm39)	L280P	probably damaging	Het
Cebpz	A	G	17: 79,229,598 (GRCm39)	F919L	probably damaging	Het
Commd1b	A	T	11: 22,932,072 (GRCm39)		probably benign	Het
Dclre1c	T	A	2: 3,451,418 (GRCm39)		probably benign	Het
Dsc3	T	G	18: 20,116,709 (GRCm39)	M276L	probably benign	Het
Dync2i2	T	C	2: 29,922,172 (GRCm39)	T430A	probably benign	Het
Eftud2	A	G	11: 102,742,573 (GRCm39)		probably benign	Het
Elfn2	T	A	15: 78,557,618 (GRCm39)	T310S	probably benign	Het
Ep300	A	G	15: 81,525,592 (GRCm39)	K1472R	probably benign	Het
Fbxl2	T	C	9: 113,847,099 (GRCm39)	D8G	probably benign	Het
Galnt5	T	A	2: 57,888,877 (GRCm39)	M159K	probably benign	Het
Hars2	T	A	18: 36,916,447 (GRCm39)	M1K	probably null	Het
Hk1	T	C	10: 62,117,667 (GRCm39)	T619A	probably damaging	Het
Ifi44	C	T	3: 151,455,067 (GRCm39)	V53M	probably damaging	Het
Ippk	T	A	13: 49,600,011 (GRCm39)	V339D	possibly damaging	Het
Kcnma1	G	T	14: 23,387,035 (GRCm39)	N875K	possibly damaging	Het
Kdm5a	T	A	6: 120,392,251 (GRCm39)	V991E	probably damaging	Het
Larp6	A	G	9: 60,620,595 (GRCm39)	E36G	probably benign	Het
Lonp2	A	T	8: 87,435,654 (GRCm39)	D210V	probably damaging	Het
Lrrc4c	G	A	2: 97,459,378 (GRCm39)	M1I	probably null	Het
Mmp2	A	G	8: 93,559,847 (GRCm39)	K270R	probably null	Het
Nexmif	C	T	X: 103,128,360 (GRCm39)	V1186I	probably benign	Het
Or11g2	A	G	14: 50,856,468 (GRCm39)	Y263C	probably damaging	Het
Or1x2	A	T	11: 50,918,470 (GRCm39)	I214F	probably benign	Het
Pld2	T	C	11: 70,446,503 (GRCm39)	L763P	probably damaging	Het
Pold1	A	T	7: 44,187,484 (GRCm39)	F644L	probably damaging	Het
Prrc2b	T	C	2: 32,104,652 (GRCm39)	S1377P	probably damaging	Het
Rps18-ps6	T	G	13: 97,896,648 (GRCm39)	K150T	probably benign	Het
Rttn	A	G	18: 89,061,165 (GRCm39)	D1111G	probably benign	Het
Slc27a5	A	G	7: 12,728,875 (GRCm39)	V130A	probably damaging	Het
Slfn8	T	C	11: 82,908,022 (GRCm39)	R174G	probably benign	Het
Slitrk6	G	A	14: 110,989,249 (GRCm39)	P153S	probably benign	Het
Sorcs3	T	C	19: 48,642,511 (GRCm39)	I388T	probably benign	Het
Star	A	T	8: 26,302,843 (GRCm39)	T262S	possibly damaging	Het
Strn	A	T	17: 78,995,049 (GRCm39)	W2R	probably damaging	Het
Tnmd	T	C	X: 132,763,701 (GRCm39)	S172P	probably damaging	Het
Togaram2	A	G	17: 72,004,861 (GRCm39)	K305R	probably benign	Het
Trhde	C	A	10: 114,428,066 (GRCm39)	W410L	probably damaging	Het
Trim5	C	T	7: 103,928,566 (GRCm39)	R125Q	probably damaging	Het
Unc45b	C	T	11: 82,831,007 (GRCm39)		probably benign	Het
Vmn1r80	T	A	7: 11,927,379 (GRCm39)	M163K	probably benign	Het
Wnk4	C	A	11: 101,166,117 (GRCm39)		probably benign	Het
Zfp277	T	A	12: 40,365,802 (GRCm39)	I430F	possibly damaging	Het
Zfp566	A	T	7: 29,777,255 (GRCm39)	C309S	probably damaging	Het
Zfp87	T	A	13: 67,665,989 (GRCm39)	I158F	probably damaging	Het
Zswim3	C	A	2: 164,663,035 (GRCm39)	A505D	possibly damaging	Het

Other mutations in Zfp740

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0432:Zfp740	UTSW	15	102,121,094 (GRCm39)	missense	possibly damaging	0.66
R0659:Zfp740	UTSW	15	102,121,094 (GRCm39)	missense	possibly damaging	0.66
R0661:Zfp740	UTSW	15	102,121,094 (GRCm39)	missense	possibly damaging	0.66
R1666:Zfp740	UTSW	15	102,116,753 (GRCm39)	missense	probably damaging	1.00
R1830:Zfp740	UTSW	15	102,116,336 (GRCm39)	missense	probably damaging	1.00
R3983:Zfp740	UTSW	15	102,116,678 (GRCm39)	missense	probably benign	0.06
R4686:Zfp740	UTSW	15	102,117,184 (GRCm39)	unclassified	probably benign
R4991:Zfp740	UTSW	15	102,116,714 (GRCm39)	splice site	probably null
R5170:Zfp740	UTSW	15	102,117,640 (GRCm39)	missense	probably damaging	1.00
R5213:Zfp740	UTSW	15	102,121,082 (GRCm39)	missense	possibly damaging	0.68
R5782:Zfp740	UTSW	15	102,116,801 (GRCm39)	unclassified	probably benign
R6088:Zfp740	UTSW	15	102,117,243 (GRCm39)	missense	probably damaging	1.00
R6848:Zfp740	UTSW	15	102,117,243 (GRCm39)	missense	probably benign	0.24
R8526:Zfp740	UTSW	15	102,116,726 (GRCm39)	missense	probably null	1.00

Posted On

2015-04-16