Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02165:Vmn1r80'

282646

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r80

Ensembl Gene

ENSMUSG00000115744

Gene Name

vomeronasal 1 receptor 80

Synonyms

V1rg3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.135) question?

Stock #

IGL02165

Quality Score

Status

Chromosome

Chromosomal Location

11926892-11927818 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 11927379 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 163 (M163K)

Ref Sequence

ENSEMBL: ENSMUSP00000153967 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075053] [ENSMUST00000227205] [ENSMUST00000227471] [ENSMUST00000227755] [ENSMUST00000228028] [ENSMUST00000228578]

AlphaFold

L7N1Z3

Predicted Effect

probably benign
Transcript: ENSMUST00000075053
AA Change: M163K

PolyPhen 2 Score 0.310 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000074564
Gene: ENSMUSG00000115744
AA Change: M163K

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	301	5.4e-11	PFAM
Pfam:7tm_1	23	290	5.3e-7	PFAM
Pfam:V1R	31	298	3e-31	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000227205
AA Change: M163K

PolyPhen 2 Score 0.310 (Sensitivity: 0.90; Specificity: 0.89)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000227240

Predicted Effect

probably benign
Transcript: ENSMUST00000227471
AA Change: M163K

PolyPhen 2 Score 0.264 (Sensitivity: 0.91; Specificity: 0.88)

Predicted Effect

probably benign
Transcript: ENSMUST00000227755
AA Change: M163K

PolyPhen 2 Score 0.310 (Sensitivity: 0.90; Specificity: 0.89)

Predicted Effect

probably benign
Transcript: ENSMUST00000228028
AA Change: M163K

PolyPhen 2 Score 0.264 (Sensitivity: 0.91; Specificity: 0.88)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000228047

Predicted Effect

probably benign
Transcript: ENSMUST00000228578
AA Change: M163K

PolyPhen 2 Score 0.310 (Sensitivity: 0.90; Specificity: 0.89)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000228563

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1cf	T	A	19: 31,904,586 (GRCm39)	M199K	possibly damaging	Het
Abo	C	A	2: 26,733,441 (GRCm39)	V255L	probably damaging	Het
Alas1	A	T	9: 106,115,982 (GRCm39)	M344K	probably damaging	Het
Ap1m1	A	G	8: 73,003,653 (GRCm39)	I118V	probably benign	Het
Ap5m1	A	T	14: 49,316,185 (GRCm39)	I252F	possibly damaging	Het
Arhgef2	G	A	3: 88,553,527 (GRCm39)	R886H	probably damaging	Het
Atp13a4	T	C	16: 29,252,828 (GRCm39)	E706G	probably damaging	Het
Baz2a	C	A	10: 127,955,218 (GRCm39)	A775E	probably benign	Het
C3	A	T	17: 57,532,092 (GRCm39)	F210I	probably benign	Het
Casq1	A	G	1: 172,040,948 (GRCm39)	L280P	probably damaging	Het
Cebpz	A	G	17: 79,229,598 (GRCm39)	F919L	probably damaging	Het
Commd1b	A	T	11: 22,932,072 (GRCm39)		probably benign	Het
Dclre1c	T	A	2: 3,451,418 (GRCm39)		probably benign	Het
Dsc3	T	G	18: 20,116,709 (GRCm39)	M276L	probably benign	Het
Dync2i2	T	C	2: 29,922,172 (GRCm39)	T430A	probably benign	Het
Eftud2	A	G	11: 102,742,573 (GRCm39)		probably benign	Het
Elfn2	T	A	15: 78,557,618 (GRCm39)	T310S	probably benign	Het
Ep300	A	G	15: 81,525,592 (GRCm39)	K1472R	probably benign	Het
Fbxl2	T	C	9: 113,847,099 (GRCm39)	D8G	probably benign	Het
Galnt5	T	A	2: 57,888,877 (GRCm39)	M159K	probably benign	Het
Hars2	T	A	18: 36,916,447 (GRCm39)	M1K	probably null	Het
Hk1	T	C	10: 62,117,667 (GRCm39)	T619A	probably damaging	Het
Ifi44	C	T	3: 151,455,067 (GRCm39)	V53M	probably damaging	Het
Ippk	T	A	13: 49,600,011 (GRCm39)	V339D	possibly damaging	Het
Kcnma1	G	T	14: 23,387,035 (GRCm39)	N875K	possibly damaging	Het
Kdm5a	T	A	6: 120,392,251 (GRCm39)	V991E	probably damaging	Het
Larp6	A	G	9: 60,620,595 (GRCm39)	E36G	probably benign	Het
Lonp2	A	T	8: 87,435,654 (GRCm39)	D210V	probably damaging	Het
Lrrc4c	G	A	2: 97,459,378 (GRCm39)	M1I	probably null	Het
Mmp2	A	G	8: 93,559,847 (GRCm39)	K270R	probably null	Het
Nexmif	C	T	X: 103,128,360 (GRCm39)	V1186I	probably benign	Het
Or11g2	A	G	14: 50,856,468 (GRCm39)	Y263C	probably damaging	Het
Or1x2	A	T	11: 50,918,470 (GRCm39)	I214F	probably benign	Het
Pld2	T	C	11: 70,446,503 (GRCm39)	L763P	probably damaging	Het
Pold1	A	T	7: 44,187,484 (GRCm39)	F644L	probably damaging	Het
Prrc2b	T	C	2: 32,104,652 (GRCm39)	S1377P	probably damaging	Het
Rps18-ps6	T	G	13: 97,896,648 (GRCm39)	K150T	probably benign	Het
Rttn	A	G	18: 89,061,165 (GRCm39)	D1111G	probably benign	Het
Slc27a5	A	G	7: 12,728,875 (GRCm39)	V130A	probably damaging	Het
Slfn8	T	C	11: 82,908,022 (GRCm39)	R174G	probably benign	Het
Slitrk6	G	A	14: 110,989,249 (GRCm39)	P153S	probably benign	Het
Sorcs3	T	C	19: 48,642,511 (GRCm39)	I388T	probably benign	Het
Star	A	T	8: 26,302,843 (GRCm39)	T262S	possibly damaging	Het
Strn	A	T	17: 78,995,049 (GRCm39)	W2R	probably damaging	Het
Tnmd	T	C	X: 132,763,701 (GRCm39)	S172P	probably damaging	Het
Togaram2	A	G	17: 72,004,861 (GRCm39)	K305R	probably benign	Het
Trhde	C	A	10: 114,428,066 (GRCm39)	W410L	probably damaging	Het
Trim5	C	T	7: 103,928,566 (GRCm39)	R125Q	probably damaging	Het
Unc45b	C	T	11: 82,831,007 (GRCm39)		probably benign	Het
Wnk4	C	A	11: 101,166,117 (GRCm39)		probably benign	Het
Zfp277	T	A	12: 40,365,802 (GRCm39)	I430F	possibly damaging	Het
Zfp566	A	T	7: 29,777,255 (GRCm39)	C309S	probably damaging	Het
Zfp740	T	G	15: 102,121,109 (GRCm39)	F141V	possibly damaging	Het
Zfp87	T	A	13: 67,665,989 (GRCm39)	I158F	probably damaging	Het
Zswim3	C	A	2: 164,663,035 (GRCm39)	A505D	possibly damaging	Het

Other mutations in Vmn1r80

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01610:Vmn1r80	APN	7	11,927,307 (GRCm39)	missense	possibly damaging	0.69
IGL01652:Vmn1r80	APN	7	11,927,063 (GRCm39)	missense	probably benign	0.19
IGL02102:Vmn1r80	APN	7	11,927,618 (GRCm39)	missense	probably damaging	1.00
IGL02328:Vmn1r80	APN	7	11,927,405 (GRCm39)	missense	probably benign	0.12
IGL02336:Vmn1r80	APN	7	11,927,181 (GRCm39)	missense	probably benign	0.23
IGL02606:Vmn1r80	APN	7	11,926,959 (GRCm39)	missense	probably damaging	1.00
R0310:Vmn1r80	UTSW	7	11,927,775 (GRCm39)	missense	probably benign	0.00
R0399:Vmn1r80	UTSW	7	11,927,244 (GRCm39)	missense	possibly damaging	0.88
R1983:Vmn1r80	UTSW	7	11,927,588 (GRCm39)	missense	probably benign	0.01
R2079:Vmn1r80	UTSW	7	11,927,121 (GRCm39)	missense	probably damaging	1.00
R4278:Vmn1r80	UTSW	7	11,927,454 (GRCm39)	missense	probably benign	0.00
R4501:Vmn1r80	UTSW	7	11,927,318 (GRCm39)	missense	probably benign	0.39
R5894:Vmn1r80	UTSW	7	11,927,654 (GRCm39)	missense	probably damaging	0.99
R5991:Vmn1r80	UTSW	7	11,927,423 (GRCm39)	missense	probably benign	0.09
R6552:Vmn1r80	UTSW	7	11,927,684 (GRCm39)	missense	probably damaging	0.98
R7560:Vmn1r80	UTSW	7	11,927,750 (GRCm39)	missense	probably damaging	0.98
R7659:Vmn1r80	UTSW	7	11,926,977 (GRCm39)	missense	probably damaging	1.00
R8313:Vmn1r80	UTSW	7	11,926,994 (GRCm39)	missense	probably benign	0.00
R9171:Vmn1r80	UTSW	7	11,927,124 (GRCm39)	missense	possibly damaging	0.88
Z1189:Vmn1r80	UTSW	7	11,927,360 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16