Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02167:Zfp68'

282771

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp68

Ensembl Gene

ENSMUSG00000058291

Gene Name

zinc finger protein 68

Synonyms

KRAZ2, Zfp70, Zfp68, KRAB3

Accession Numbers

Essential gene?

Probably essential (E-score: 0.771) question?

Stock #

IGL02167

Quality Score

Status

Chromosome

Chromosomal Location

138601914-138618005 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 138604629 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 565 (M565L)

Ref Sequence

ENSEMBL: ENSMUSP00000069615 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063262] [ENSMUST00000085852] [ENSMUST00000110905]

AlphaFold

Q9Z116

Predicted Effect

probably benign
Transcript: ENSMUST00000063262
AA Change: M565L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000069615
Gene: ENSMUSG00000058291
AA Change: M565L

Domain	Start	End	E-Value	Type
KRAB	10	70	1.11e-30	SMART
ZnF_C2H2	317	339	1.58e-3	SMART
ZnF_C2H2	345	367	3.16e-3	SMART
ZnF_C2H2	373	395	5.5e-3	SMART
ZnF_C2H2	401	423	2.27e-4	SMART
ZnF_C2H2	429	451	3.44e-4	SMART
ZnF_C2H2	457	479	3.07e-1	SMART
ZnF_C2H2	485	507	2.09e-3	SMART
ZnF_C2H2	513	535	3.29e-1	SMART
ZnF_C2H2	541	563	2.99e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000085852
AA Change: M527L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000083013
Gene: ENSMUSG00000058291
AA Change: M527L

Domain	Start	End	E-Value	Type
KRAB	1	32	6e-1	SMART
ZnF_C2H2	279	301	1.58e-3	SMART
ZnF_C2H2	307	329	3.16e-3	SMART
ZnF_C2H2	335	357	5.5e-3	SMART
ZnF_C2H2	363	385	2.27e-4	SMART
ZnF_C2H2	391	413	3.44e-4	SMART
ZnF_C2H2	419	441	3.07e-1	SMART
ZnF_C2H2	447	469	2.09e-3	SMART
ZnF_C2H2	475	497	3.29e-1	SMART
ZnF_C2H2	503	525	2.99e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000110905
AA Change: M565L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000106530
Gene: ENSMUSG00000058291
AA Change: M565L

Domain	Start	End	E-Value	Type
KRAB	10	70	1.11e-30	SMART
ZnF_C2H2	317	339	1.58e-3	SMART
ZnF_C2H2	345	367	3.16e-3	SMART
ZnF_C2H2	373	395	5.5e-3	SMART
ZnF_C2H2	401	423	2.27e-4	SMART
ZnF_C2H2	429	451	3.44e-4	SMART
ZnF_C2H2	457	479	3.07e-1	SMART
ZnF_C2H2	485	507	2.09e-3	SMART
ZnF_C2H2	513	535	3.29e-1	SMART
ZnF_C2H2	541	563	2.99e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000119137

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000175175

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000197654

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aass	T	A	6: 23,122,721 (GRCm39)		probably benign	Het
Cacna1f	T	C	X: 7,482,258 (GRCm39)	Y581H	probably damaging	Het
Camsap1	C	T	2: 25,824,312 (GRCm39)	R1416H	probably damaging	Het
Ccdc117	T	C	11: 5,481,333 (GRCm39)	E266G	possibly damaging	Het
Ccdc9	A	T	7: 16,018,284 (GRCm39)	L8*	probably null	Het
Cited2	T	C	10: 17,600,018 (GRCm39)	S109P	probably benign	Het
Cnot4	T	C	6: 35,033,159 (GRCm39)	D286G	possibly damaging	Het
Col5a1	T	C	2: 27,908,568 (GRCm39)	I52T	probably benign	Het
Cry2	T	C	2: 92,264,166 (GRCm39)	N68S	possibly damaging	Het
Cul4a	T	C	8: 13,172,826 (GRCm39)	F153S	probably damaging	Het
Ddr1	T	C	17: 36,000,963 (GRCm39)	S261G	possibly damaging	Het
Depdc5	G	A	5: 33,061,145 (GRCm39)	R324Q	probably damaging	Het
Dmgdh	A	G	13: 93,857,135 (GRCm39)		probably benign	Het
Epha8	A	T	4: 136,658,405 (GRCm39)	M990K	probably damaging	Het
Gpr137c	G	T	14: 45,517,412 (GRCm39)	G383C	probably damaging	Het
Hydin	T	A	8: 111,145,055 (GRCm39)	I802N	possibly damaging	Het
Ifne	A	G	4: 88,798,065 (GRCm39)	Y118H	possibly damaging	Het
Kansl2	T	C	15: 98,431,396 (GRCm39)		probably benign	Het
Lig4	T	A	8: 10,021,821 (GRCm39)	N653I	probably benign	Het
Nagk	A	G	6: 83,778,088 (GRCm39)	D246G	probably damaging	Het
Nav1	A	G	1: 135,398,699 (GRCm39)	S628P	probably damaging	Het
Ncoa3	A	G	2: 165,912,056 (GRCm39)	Y1401C	probably damaging	Het
Ndufa9	A	G	6: 126,821,748 (GRCm39)		probably benign	Het
Nynrin	G	T	14: 56,100,792 (GRCm39)	R194L	probably damaging	Het
Or10a4	A	T	7: 106,696,868 (GRCm39)	R65S	probably benign	Het
Or10ag53	G	A	2: 87,082,542 (GRCm39)	C87Y	probably benign	Het
Or13a17	T	A	7: 140,271,664 (GRCm39)	V282D	probably damaging	Het
Orc2	A	T	1: 58,522,798 (GRCm39)		probably benign	Het
Oxgr1	T	A	14: 120,259,342 (GRCm39)	R288S	probably damaging	Het
Pgap6	T	C	17: 26,338,045 (GRCm39)	S450P	probably damaging	Het
Prkcg	T	C	7: 3,371,097 (GRCm39)		probably null	Het
Prox1	T	C	1: 189,893,477 (GRCm39)	N323D	probably benign	Het
Prrt1	A	C	17: 34,850,829 (GRCm39)	E215A	possibly damaging	Het
Rab2b	T	C	14: 52,506,153 (GRCm39)	D103G	probably damaging	Het
Sardh	G	T	2: 27,081,987 (GRCm39)	N846K	probably damaging	Het
Slc38a8	T	A	8: 120,214,099 (GRCm39)	T248S	probably benign	Het
Slc6a18	T	C	13: 73,814,591 (GRCm39)		probably null	Het
Smcp	T	C	3: 92,491,506 (GRCm39)	T114A	unknown	Het
Trpv1	A	G	11: 73,145,623 (GRCm39)	N754D	probably damaging	Het
Txnrd1	A	T	10: 82,717,745 (GRCm39)	H243L	probably benign	Het
Wdfy3	T	C	5: 102,109,023 (GRCm39)	M125V	probably damaging	Het
Wnk2	T	C	13: 49,224,601 (GRCm39)		probably null	Het
Wrn	T	C	8: 33,807,583 (GRCm39)	M292V	probably damaging	Het
Zbtb17	T	C	4: 141,189,140 (GRCm39)	L20P	possibly damaging	Het
Zfp608	T	C	18: 55,121,296 (GRCm39)	H97R	probably damaging	Het
Zfp687	T	C	3: 94,917,841 (GRCm39)	T644A	probably benign	Het
Zfp777	C	T	6: 48,021,460 (GRCm39)	G54D	probably damaging	Het

Other mutations in Zfp68

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0040:Zfp68	UTSW	5	138,606,041 (GRCm39)	missense	probably benign	0.24
R0040:Zfp68	UTSW	5	138,606,041 (GRCm39)	missense	probably benign	0.24
R0152:Zfp68	UTSW	5	138,604,875 (GRCm39)	missense	probably damaging	1.00
R0390:Zfp68	UTSW	5	138,605,487 (GRCm39)	missense	probably benign	0.14
R1490:Zfp68	UTSW	5	138,605,091 (GRCm39)	missense	probably benign	0.16
R4688:Zfp68	UTSW	5	138,614,743 (GRCm39)	nonsense	probably null
R4992:Zfp68	UTSW	5	138,605,599 (GRCm39)	missense	possibly damaging	0.50
R5072:Zfp68	UTSW	5	138,604,579 (GRCm39)	missense	probably benign	0.01
R7076:Zfp68	UTSW	5	138,605,201 (GRCm39)	missense	possibly damaging	0.49
R7117:Zfp68	UTSW	5	138,604,580 (GRCm39)	missense	probably benign	0.01
R7332:Zfp68	UTSW	5	138,604,830 (GRCm39)	missense	possibly damaging	0.90
R8399:Zfp68	UTSW	5	138,606,082 (GRCm39)	missense	probably benign	0.02
R9012:Zfp68	UTSW	5	138,605,283 (GRCm39)	missense	probably damaging	1.00
R9041:Zfp68	UTSW	5	138,604,699 (GRCm39)	nonsense	probably null
R9475:Zfp68	UTSW	5	138,605,517 (GRCm39)	missense	probably benign

Posted On

2015-04-16