Incidental Mutation 'IGL02167:Orc2'
ID 282780
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Orc2
Ensembl Gene ENSMUSG00000026037
Gene Name origin recognition complex, subunit 2
Synonyms Orc2l
Accession Numbers
Essential gene? Probably essential (E-score: 0.962) question?
Stock # IGL02167
Quality Score
Status
Chromosome 1
Chromosomal Location 58501930-58544268 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to T at 58522798 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000139869 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027198] [ENSMUST00000114325] [ENSMUST00000114337] [ENSMUST00000190695]
AlphaFold Q60862
Predicted Effect probably benign
Transcript: ENSMUST00000027198
SMART Domains Protein: ENSMUSP00000027198
Gene: ENSMUSG00000026037

DomainStartEndE-ValueType
low complexity region 176 201 N/A INTRINSIC
Pfam:ORC2 254 563 2.5e-110 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114325
SMART Domains Protein: ENSMUSP00000109964
Gene: ENSMUSG00000026037

DomainStartEndE-ValueType
low complexity region 128 153 N/A INTRINSIC
Pfam:ORC2 206 517 1.2e-108 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114337
SMART Domains Protein: ENSMUSP00000109976
Gene: ENSMUSG00000026036

DomainStartEndE-ValueType
Pfam:NIF3 31 324 4e-61 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151723
Predicted Effect probably benign
Transcript: ENSMUST00000190695
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass T A 6: 23,122,721 (GRCm39) probably benign Het
Cacna1f T C X: 7,482,258 (GRCm39) Y581H probably damaging Het
Camsap1 C T 2: 25,824,312 (GRCm39) R1416H probably damaging Het
Ccdc117 T C 11: 5,481,333 (GRCm39) E266G possibly damaging Het
Ccdc9 A T 7: 16,018,284 (GRCm39) L8* probably null Het
Cited2 T C 10: 17,600,018 (GRCm39) S109P probably benign Het
Cnot4 T C 6: 35,033,159 (GRCm39) D286G possibly damaging Het
Col5a1 T C 2: 27,908,568 (GRCm39) I52T probably benign Het
Cry2 T C 2: 92,264,166 (GRCm39) N68S possibly damaging Het
Cul4a T C 8: 13,172,826 (GRCm39) F153S probably damaging Het
Ddr1 T C 17: 36,000,963 (GRCm39) S261G possibly damaging Het
Depdc5 G A 5: 33,061,145 (GRCm39) R324Q probably damaging Het
Dmgdh A G 13: 93,857,135 (GRCm39) probably benign Het
Epha8 A T 4: 136,658,405 (GRCm39) M990K probably damaging Het
Gpr137c G T 14: 45,517,412 (GRCm39) G383C probably damaging Het
Hydin T A 8: 111,145,055 (GRCm39) I802N possibly damaging Het
Ifne A G 4: 88,798,065 (GRCm39) Y118H possibly damaging Het
Kansl2 T C 15: 98,431,396 (GRCm39) probably benign Het
Lig4 T A 8: 10,021,821 (GRCm39) N653I probably benign Het
Nagk A G 6: 83,778,088 (GRCm39) D246G probably damaging Het
Nav1 A G 1: 135,398,699 (GRCm39) S628P probably damaging Het
Ncoa3 A G 2: 165,912,056 (GRCm39) Y1401C probably damaging Het
Ndufa9 A G 6: 126,821,748 (GRCm39) probably benign Het
Nynrin G T 14: 56,100,792 (GRCm39) R194L probably damaging Het
Or10a4 A T 7: 106,696,868 (GRCm39) R65S probably benign Het
Or10ag53 G A 2: 87,082,542 (GRCm39) C87Y probably benign Het
Or13a17 T A 7: 140,271,664 (GRCm39) V282D probably damaging Het
Oxgr1 T A 14: 120,259,342 (GRCm39) R288S probably damaging Het
Pgap6 T C 17: 26,338,045 (GRCm39) S450P probably damaging Het
Prkcg T C 7: 3,371,097 (GRCm39) probably null Het
Prox1 T C 1: 189,893,477 (GRCm39) N323D probably benign Het
Prrt1 A C 17: 34,850,829 (GRCm39) E215A possibly damaging Het
Rab2b T C 14: 52,506,153 (GRCm39) D103G probably damaging Het
Sardh G T 2: 27,081,987 (GRCm39) N846K probably damaging Het
Slc38a8 T A 8: 120,214,099 (GRCm39) T248S probably benign Het
Slc6a18 T C 13: 73,814,591 (GRCm39) probably null Het
Smcp T C 3: 92,491,506 (GRCm39) T114A unknown Het
Trpv1 A G 11: 73,145,623 (GRCm39) N754D probably damaging Het
Txnrd1 A T 10: 82,717,745 (GRCm39) H243L probably benign Het
Wdfy3 T C 5: 102,109,023 (GRCm39) M125V probably damaging Het
Wnk2 T C 13: 49,224,601 (GRCm39) probably null Het
Wrn T C 8: 33,807,583 (GRCm39) M292V probably damaging Het
Zbtb17 T C 4: 141,189,140 (GRCm39) L20P possibly damaging Het
Zfp608 T C 18: 55,121,296 (GRCm39) H97R probably damaging Het
Zfp68 T A 5: 138,604,629 (GRCm39) M565L probably benign Het
Zfp687 T C 3: 94,917,841 (GRCm39) T644A probably benign Het
Zfp777 C T 6: 48,021,460 (GRCm39) G54D probably damaging Het
Other mutations in Orc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00434:Orc2 APN 1 58,532,875 (GRCm39) missense possibly damaging 0.81
IGL00549:Orc2 APN 1 58,520,201 (GRCm39) missense probably benign 0.00
IGL01343:Orc2 APN 1 58,532,014 (GRCm39) critical splice donor site probably null
IGL01357:Orc2 APN 1 58,536,552 (GRCm39) missense probably benign 0.00
IGL01357:Orc2 APN 1 58,536,551 (GRCm39) missense probably benign 0.26
IGL02343:Orc2 APN 1 58,508,825 (GRCm39) critical splice donor site probably null
IGL02548:Orc2 APN 1 58,505,281 (GRCm39) unclassified probably benign
R0557:Orc2 UTSW 1 58,508,846 (GRCm39) missense probably damaging 1.00
R1470:Orc2 UTSW 1 58,520,317 (GRCm39) unclassified probably benign
R1886:Orc2 UTSW 1 58,510,247 (GRCm39) critical splice acceptor site probably null
R2065:Orc2 UTSW 1 58,508,854 (GRCm39) missense probably damaging 1.00
R3848:Orc2 UTSW 1 58,520,151 (GRCm39) missense probably benign 0.08
R4389:Orc2 UTSW 1 58,514,020 (GRCm39) missense probably benign 0.21
R4393:Orc2 UTSW 1 58,506,809 (GRCm39) critical splice donor site probably null
R4613:Orc2 UTSW 1 58,539,468 (GRCm39) nonsense probably null
R5183:Orc2 UTSW 1 58,513,977 (GRCm39) missense possibly damaging 0.83
R5652:Orc2 UTSW 1 58,505,231 (GRCm39) missense probably damaging 0.99
R5793:Orc2 UTSW 1 58,536,547 (GRCm39) start codon destroyed probably null 0.27
R5997:Orc2 UTSW 1 58,511,547 (GRCm39) missense probably damaging 1.00
R6007:Orc2 UTSW 1 58,506,851 (GRCm39) missense probably benign 0.03
R6330:Orc2 UTSW 1 58,539,493 (GRCm39) missense probably benign
R6656:Orc2 UTSW 1 58,532,818 (GRCm39) critical splice donor site probably null
R6923:Orc2 UTSW 1 58,539,534 (GRCm39) missense probably benign 0.01
R6934:Orc2 UTSW 1 58,539,523 (GRCm39) missense probably benign 0.28
R7354:Orc2 UTSW 1 58,508,906 (GRCm39) missense possibly damaging 0.96
R7718:Orc2 UTSW 1 58,519,476 (GRCm39) missense possibly damaging 0.65
R7950:Orc2 UTSW 1 58,506,827 (GRCm39) missense possibly damaging 0.64
R8820:Orc2 UTSW 1 58,515,639 (GRCm39) missense probably benign 0.30
R8858:Orc2 UTSW 1 58,532,857 (GRCm39) missense probably benign 0.28
R8956:Orc2 UTSW 1 58,505,221 (GRCm39) missense probably damaging 0.98
R8978:Orc2 UTSW 1 58,511,499 (GRCm39) missense possibly damaging 0.82
R9126:Orc2 UTSW 1 58,515,628 (GRCm39) missense probably benign 0.41
R9210:Orc2 UTSW 1 58,515,695 (GRCm39) missense probably damaging 1.00
R9212:Orc2 UTSW 1 58,515,695 (GRCm39) missense probably damaging 1.00
R9406:Orc2 UTSW 1 58,506,842 (GRCm39) missense probably damaging 1.00
R9746:Orc2 UTSW 1 58,536,610 (GRCm39) missense probably damaging 1.00
Z1088:Orc2 UTSW 1 58,515,675 (GRCm39) missense probably benign
Posted On 2015-04-16